Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?
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MDD has had notable difficulties with genetic discovery due to relatively low twin-heritability, but focusing on severe cases and increasing sample sizes has been fruitful.
“As a common disorder with relatively low twin-heritability (Levinson et al., 2014), MDD has had notable difficulties with genetic discovery, but focusing on severe cases (CONVERGE Consortium, 2015) and increasing sample sizes has been particularly fruitful (Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 2018).”
From Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders (2019) · cites this paper as Levinson et al., 2014
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- Authors
- Levinson, D. F., Mostafavi, S., Milaneschi, Y., Rivera, M., Ripke, S., Wray, N. R., & Sullivan, P. F.
- Affiliations
- Stanford University (US)
- Amsterdam Neuroscience (NL)
- Universidad de Granada (ES)
- Broad Institute (US)
- The University of Queensland (AU)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Levinson, Douglas F.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 76
- Issue
- 7
- Pages
- 510-512
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4740915
- OpenAlex
- W1991928779
- Cited by
- 159
- References
- 10
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 17 · 2020: 13 · 2019: 28 · 2018: 15 · 2017: 20 · 2016: 14 · 2015: 23 · 2014: 3
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Kingâs College London
- National Institutes of Health (U01 MH094421, U01 MH094411)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- major depressive disorder, genome-wide association study, genetic susceptibility, psychiatric genetics, schizophrenia, bipolar disorder, gene pathways
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Polymorphism, Single Nucleotide, Genome-Wide Association Study, DNA Copy Number Variations
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