Atypical Lateralization in Neurodevelopmental and Psychiatric Disorders: What Is the Role of Stress?
Abstract
Hemispheric asymmetries are a major organizational principle of the human brain. In different neurodevelopmental and psychiatric disorders, like schizophrenia, autism spectrum disorders, depression, dyslexia and posttraumatic stress disorder, functional and/or structural hemispheric asymmetries are altered compared to healthy controls. The question, why these disorders all share the common characteristic of altered hemispheric asymmetries despite vastly different etiologies and symptoms remains one of the unsolved mysteries of laterality research. This review is aimed at reviewing potential reasons for why atypical lateralization is so common in many neurodevelopmental and psychiatric disorders. To this end, we review the evidence for overlaps in the genetic and non-genetic factors involved in the ontogenesis of different disorders and hemispheric asymmetries. While there is evidence for genetic overlap between different disorders, only few asymmetry-related loci have also been linked to disorders and importantly, those effects are mostly specific to single disorders. However, there is evidence for shared non-genetic influences between disorders and hemispheric asymmetries. Most neurodevelopmental and psychiatric disorders show alterations in the hypothalamic-pituitary adrenocortical (HPA) axis and maternal as well as early life stress have been implicated in their etiology. Stress has also been suggested to affect hemispheric asymmetries. We propose a model in which early life stress as well as chronic stress not only increases the risk for psychiatric and neurodevelopmental disorders but also changes structural and functional hemispheric asymmetries leading to the aberrant lateralization patterns seen in these disorders. Thus, pathology-related changes in hemispheric asymmetries are not a factor causing disorders, but rather a different phenotype that is affected by partly overlapping ontogenetic factors, primarily stress.
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Brain asymmetry has been linked to several developmental neurological disorders.
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From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Berretz et al., 2020
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Stress Effects on Learning and Memory in Humans
Wolf, O. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00031-0 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166 · see citing works
- Authors
- Berretz, G., Wolf, O. T., Güntürkün, O., & Ocklenburg, S.
- Affiliations
- Ruhr University Bochum (DE)
- University of Duisburg-Essen (DE)
- Corresponding author
- Ocklenburg, Sebastian
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 125
- Pages
- 215-232
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W2999832486
- Cited by
- 100
- References
- 200
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 21 · 2022: 23 · 2021: 20 · 2020: 8
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- hemispheric lateralization, atypical lateralization, neurodevelopmental disorders, mental illness, early life stress, chronic stress, hypothalamic-pituitary-adrenal axis, schizophrenia, autism spectrum disorder, depression, dyslexia, post-traumatic stress disorder, genetic overlap, ontogeny
- MeSH terms
- Autism Spectrum Disorder, Brain, Humans, Functional Laterality, Magnetic Resonance Imaging, Schizophrenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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