Cited by 338Neural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional DevelopmentChild Abuse and Trauma

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Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms

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Hanson, Jamie L., Hariri, Ahmad R., Williamson, Douglas E.·2015·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.05.010PMC PMC4593720

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Abstract

Background Emotional neglect is associated with multiple negative outcomes, particularly increased risk for depression. Motivated by increasing evidence of reward-related ventral striatum (VS) dysfunction in depression, we investigated the role of developmental changes in VS activity on the emergence of depressive symptomatology as a function of emotional neglect. Methods We examined relationships between longitudinal neuroimaging of reward-related VS activity, assessments of mood, and measures of emotional neglect in 106 participants first scanned between ages 11 to 15 and then 2 years later. Results We found that greater levels of emotional neglect were associated with blunted development of reward-related VS activity between the first and second assessments (as indexed by lower residualized change scores). Additionally, we found that decreases in this reward-related VS activity were related to greater depressive symptomatology and partially mediated the association between emotional neglect and subsequent depressive symptomatology. Conclusions Our results provide an important demonstration that blunted development of reward-related VS activity as a function of emotional neglect predicts the emergence of depressive symptoms in adolescents. Further, our results are consistent with emerging evidence for the importance of reward-related VS dysfunction in the etiology and pathophysiology of depression. These results are a first step toward developing the ability to predict, prevent, and treat stress-related psychopathology through the targeting of specific neural phenotypes.

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Authors: Hanson, J. L., Hariri, A. R., & Williamson, D. E.
Affiliations: Duke University (US)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Hanson, Jamie L.
ORCID: Hanson, Jamie L.
Hariri, Ahmad R.
Williamson, Douglas E.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2015-11
Volume: 78
Issue: 9
Pages: 598-605
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.05.010
PMC: PMC4593720
OpenAlex: W1854033343
Cited by: 338
References: 111
Citations by year: 2026: 30 · 2025: 31 · 2024: 27 · 2023: 28 · 2022: 38 · 2021: 34 · 2020: 52 · 2019: 28 · 2018: 23 · 2017: 25 · 2016: 16 · 2015: 5
FWCI: 13.82
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA016274)
National Institute on Drug Abuse (R01DA033369, R01DA031579)
National Institute of Mental Health (MH087493)
National Institute on Drug Abuse through the Center for the Study of Adolescent Risk and Resilience (P30DA023026)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: ventral striatum, emotional neglect, depressive symptoms, adolescence, reward processing, neural development, depression risk, mediation, stress-related psychopathology, neural phenotypes
MeSH terms: Adolescent, Psychology, Adolescent, Brain Mapping, Cerebrovascular Circulation, Child, Child Abuse, Depression, Emotions, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Prognosis, Reward, Adolescent Development, Ventral Striatum

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Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms

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