Temporal memory and its enhancement by estradiol requires surface dynamics of hippocampal CA1 N-Methyl-D-Aspartate receptors
Open accessAbstract
Background Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual associations is known to rely on hippocampal N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity, which depends ex vivo on dynamic organization of surface NMDARs. Whether NMDAR surface trafficking sustains the formation of associative memory, however, remains unknown.Methods We tested this hypothesis, using single nanoparticle imaging, electrophysiology, and behavioral approaches, in hippocampal networks challenged with a potent modulator of NMDAR-dependent synaptic plasticity and memory, 17β-estradiol (E2).Results We demonstrate that E2 modulates NMDAR surface trafficking, a necessary condition for E2-induced potentiation at hippocampal cornu ammonis 1 synapses. Strikingly, cornu ammonis 1 NMDAR surface trafficking controls basal and E2-enhanced mnemonic retention of temporal, but not contextual, associations.Conclusions NMDAR surface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a major component of episodic memory, opening a new and noncanonical research avenue in the physiopathology of cognition.
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Reduction of NMDA-R surface dynamics in the dorsal hippocampus had no effect in the long-term (24 hours) OPP test.
“Reduction of NMDA-R surface dynamics in the dorsal hippocampus had no effect in the long-term (24 hours) OPP test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Potier et al., 2016
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
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“…include the extracellular matrix (Michaluk et al., 2009), secreted proteases (Lesept, Chevilley, & Jezequel, 2016), growth factors (De Rossi, Harde, & Dupuis, 2016), cell surface receptors (Ladepeche et al., 2013; Mikasova et al., 2012) and hormones (Potier et al., 2016; Mikasova et al., 2017).”
BackgroundCo-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
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- Authors
- Potier, M., Georges, F., Brayda-Bruno, L., Ladépêche, L., Lamothe, V., Al Abed, A. S., Groc, L., & Marighetto, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Corresponding author
- Marighetto, Aline
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 79
- Issue
- 9
- Pages
- 735-745
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1479045706
- Cited by
- 61
- References
- 64
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 6
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- l’Institut National de la Santé et de la Recherche Médicale (INSERM)
- le Centre National de la Recherche Scientifique (CNRS)
- le Conseil Régional d’Aquitaine, Bordeaux Sciences Agro
- le Ministère de l’Enseignement Supérieur et de la Recherche
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- temporal memory, episodic memory, estradiol, hippocampal CA1, synaptic plasticity, memory enhancement, sex hormones, temporal association, contextual memory, nanoparticle imaging
- MeSH terms
- Animals, Cells, Cultured, Estradiol, Male, Memory, Mice, Inbred C57BL, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Protein Transport, CA1 Region, Hippocampal
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