Cited by 61Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Temporal memory and its enhancement by estradiol requires surface dynamics of hippocampal CA1 N-Methyl-D-Aspartate receptors

Open access
Potier, Mylène, Georges, François, Brayda-Bruno, Laurent, Ladépêche, Laurent, Lamothe, Valérie, Al Abed, Alice Shaam, Groc, Laurent, Marighetto, Aline·2016·Biological Psychiatry

Abstract

Background Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual associations is known to rely on hippocampal N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity, which depends ex vivo on dynamic organization of surface NMDARs. Whether NMDAR surface trafficking sustains the formation of associative memory, however, remains unknown.Methods We tested this hypothesis, using single nanoparticle imaging, electrophysiology, and behavioral approaches, in hippocampal networks challenged with a potent modulator of NMDAR-dependent synaptic plasticity and memory, 17β-estradiol (E2).Results We demonstrate that E2 modulates NMDAR surface trafficking, a necessary condition for E2-induced potentiation at hippocampal cornu ammonis 1 synapses. Strikingly, cornu ammonis 1 NMDAR surface trafficking controls basal and E2-enhanced mnemonic retention of temporal, but not contextual, associations.Conclusions NMDAR surface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a major component of episodic memory, opening a new and noncanonical research avenue in the physiopathology of cognition.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2015.07.017

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Potier, M., Georges, F., Brayda-Bruno, L., Ladépêche, L., Lamothe, V., Al Abed, A. S., Groc, L., & Marighetto, A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Université de Bordeaux (FR)
Corresponding author
Marighetto, Aline
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2016-05
Volume
79
Issue
9
Pages
735-745
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1479045706
Cited by
61
References
64
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 6
FWCI
2.94
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • l’Institut National de la Santé et de la Recherche Médicale (INSERM)
  • le Centre National de la Recherche Scientifique (CNRS)
  • le Conseil Régional d’Aquitaine, Bordeaux Sciences Agro
  • le Ministère de l’Enseignement Supérieur et de la Recherche
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
temporal memory, episodic memory, estradiol, hippocampal CA1, synaptic plasticity, memory enhancement, sex hormones, temporal association, contextual memory, nanoparticle imaging
MeSH terms
Animals, Cells, Cultured, Estradiol, Male, Memory, Mice, Inbred C57BL, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Protein Transport, CA1 Region, Hippocampal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review