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Cited by 518Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study

Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

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Heine, Martin, Groc, Laurent, Frischknecht, Renato, Béïque, Jean-Claude, Lounis, Brahim, Rumbaugh, Gavin, Huganir, Richard L., Cognet, Laurent +1 more·2008·Science
DOI 10.1126/science.1152089PMC PMC2715948
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Abstract

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.

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  • Many synaptic proteins are remarkably dynamic, including AMPARs, NMDARs, CaMKII, and scaffolding proteins such as PSD-95.

    “These studies show that many synaptic proteins are remarkably dynamic, including AMPARs (237, 249, 327, 328), NMDARs (329), CaMKII (330), and scaffolding proteins, such as PSD-95 (331).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [328]

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Cited by

Sorted by citations

Authors
Heine, M., Groc, L., Frischknecht, R., Béïque, J.-C., Lounis, B., Rumbaugh, G., Huganir, R. L., Cognet, L., & Choquet, D.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • CNRS, UMR 5091, Université Bordeaux, Bordeaux, France.
Corresponding author
  • Heine, Martin
  • Choquet, Daniel
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2008-04-11
Volume
320
Issue
5873
Pages
201-205
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1152089
PMC
PMC2715948
OpenAlex
W1995949213
Cited by
518
References
5
Citations by year
2026: 8 · 2025: 26 · 2024: 28 · 2023: 19 · 2022: 13 · 2021: 33 · 2020: 23 · 2019: 20 · 2018: 27 · 2017: 26 · 2016: 20 · 2015: 30 · 2014: 39 · 2013: 37 · 2012: 36
FWCI
19.18
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
AMPA receptors, receptor lateral diffusion, synaptic depression, recovery from depression, receptor desensitization, postsynaptic density, hippocampus, receptor clustering, calcium signaling
MeSH terms
Action Potentials, Animals, Calcium, Cells, Cultured, Diffusion, Hippocampus, Kynurenic Acid, Synaptic Transmission, Neuronal Plasticity, Neurons, Recombinant Fusion Proteins, Synapses, Transfection, Rats, Sprague-Dawley, Receptors, AMPA, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Glutamic Acid, Excitatory Postsynaptic Potentials, Fluorescence Recovery After Photobleaching, Rats

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