Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility

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Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory

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Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

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Sex differences in cognitive flexibility are driven by the estrous cycle and stress-dependent

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Orexins (hypocretins): The intersection between homeostatic and hedonic feeding

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The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse

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Mean Girls: Social Stress Models for Female Rodents

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Age- and sex-dependent impact of repeated social stress on morphology of rat prefrontal cortex pyramidal neurons

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Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study

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Sex differences in stress-induced sleep deficits

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Sex Differences in Serotonin 5-HT 1A Receptor Responses to Repeated Restraint Stress in Adult Male and Female Rats

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A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache

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Acute restraint stress alters food-foraging behavior in rats: Taking the easier Way while suffered

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From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective

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Anterior cingulate cortex orexin signaling mediates early-life stress-induced social impairment in females

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Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)-mediated plasticity in the paraventricular thalamic nucleus promotes a fundamental adaptation to stress

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Hypocretin/orexin antagonists decrease cocaine self-administration by female rhesus monkeys

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Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides

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Organic chromium modifies the expression of orexin and glucose transporters of ovarian in heat-stressed laying hens

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Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice

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Sex-dependent differences in animal cognition

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A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice

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Chemogenetic Signaling in Space and Time: Considerations for Designing Neuroscience Experiments Using DREADDs

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Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons

Pignatelli, J., de Sevilla, M. E. F., Sperber, J. E., Horrillo, D., Medina‐Gómez, G., & Torres‐Alemán, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094679 · Cited by 12 · see citing works

Intracerebroventricular infusion of the selective orexin 1 receptor antagonist SB-334867 impairs cognitive flexibility in a sex-dependent manner

Durairaja, A., Steinecke, C.-S., & Fendt, M. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113791 · Cited by 12 · see citing works

FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety

Corbett, B. F., Luz, S., Sotuyo, N. P., Pearson-Leary, J., Moorthy, G. S., Zuppa, A. F., & Bhatnagar, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113556 · Cited by 11 · see citing works

Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging

Wang, Y., Wang, Y., Liu, Y., Hua, C., Dagnew, T. M., Xu, Y., & Wang, C. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s404992 · Cited by 10 · see citing works

Cognitive flexibility assessment with a new Reversal learning task paradigm compared with the Wisconsin card sorting test exploring the moderating effect of gender and stress

Monni, A., Scandola, M., Hélie, S., & Scalas, L. F. (2022) · Psychological Research · doi:10.1007/s00426-022-01763-y · Cited by 10 · see citing works

The effect of diet-induced obesity on sleep and breathing in female mice

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The role of orexin-1 receptors within the ventral tegmental area in the extinction and reinstatement of methamphetamine place preference

Zamanirad, F., Fattahi, M., Amirteymori, H., Mousavi, Z., & Haghparast, A. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114608 · Cited by 10 · see citing works

Heart rate variability measures indicating sex differences in autonomic regulation during anxiety-like behavior in rats

Frasier, R. M., Sergio, T. D. O., Starski, P. A., Grippo, A. J., & Hopf, F. W. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1244389 · Cited by 9 · see citing works

Impact of daytime light intensity on the central orexin (hypocretin) system of a diurnal rodent ( Arvicanthis niloticus )

Lonstein, J. S., Linning‐Duffy, K., Tang, Y., Moody, A., & Yan, L. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15248 · Cited by 9 · see citing works

Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment

Demidova, A., Kahl, E., & Fendt, M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110517 · Cited by 9 · see citing works

Effect of consumption of blue maize tortilla on anxiety-like behaviour, learning, memory and hippocampal BDNF expression in a chronic stress model in rats

Octavio, A. L. L., Pérez, J. R. C., Santerre, A., Moreno, Y. S., Anda, Y. H. D., & Pineda, J. B. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2126757 · Cited by 9 · see citing works

Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking

Rojo, A. L. A., Barnhardt, T. R., Pham, T. Q., Heim, B., Cai, L., Tseng, G. C., & Huang, Y. H. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf047 · Cited by 8 · see citing works

Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex

Fariborzi, M., Park, S. B., Ozgur, A., & Lür, G. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100295 · Cited by 8 · see citing works

Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress

Corbett, B. F., Urban, K. R., Luz, S., Yan, J. H., Arner, J., & Bhatnagar, S. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00460-0 · Cited by 8 · see citing works

Orexin/Hypocretin Modulates Neuroinflammatory Response to LPS in a Sex and Brain‐Region Specific Manner in Young Rats

Frick, M. A., Woodruff, J. L., Caudillo, Y. M., Pikel, K., Rehm, J. V., Maciejewska, N., Grillo, C. A., Reagan, L. P., & Fadel, J. R. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70175 · Cited by 7 · see citing works

A direct estrogenic involvement in the expression of human hypocretin

Li, H., Chen, X., Dong, J., Liu, R., Duan, J., Huang, M., Hu, S., & Lü, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122581 · Cited by 7 · see citing works

Sex-dimorphic functions of orexin in neuropsychiatric disorders

Zhang, J., Jin, K., Chen, B., Cheng, S., Jin, J., Yang, X., Lü, J., & Song, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36402 · Cited by 7 · see citing works

The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol‐induced unconsciousness in male rats

Bian, H., Huang, L., Li, B., Hu, Q., Liang, X., Tang, J., & Zhang, J. H. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24414 · Cited by 7 · see citing works

Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States

Yaeger, J. D. W., James, M. H., & Summers, C. H. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.11.004 · Cited by 6 · see citing works

Orexinergic lateral hypothalamus-anterior cingulate cortex circuit alleviates chronic stress-induced anxiety-like behaviors

Liu, D., Zheng, X., Wang, L., Zhang, W., Che, Y., Du, J., Du, Z., Yu, G., Ren, B., Wu, F., et al. (2025) · Current Biology · doi:10.1016/j.cub.2025.10.083 · Cited by 6 · see citing works

Appetitive Behavior in the Social Transmission of Food Preference Paradigm Predicts Activation of Orexin-A producing Neurons in a Sex-Dependent Manner

Agee, L. A., Nemchek, V., Malone, C. A., Lee, H. J., & Monfils, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.032 · Cited by 6 · see citing works

Reward maximization assessed using a sequential patch depletion task in a large sample of heterogeneous stock rats

Gancarz, A. M., Mitchell, S. H., George, A. M., Martin, C. D., Turk, M. C., Bool, H. M., Aktar, F., Kwarteng, F., Palmer, A. A., Meyer, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34179-8 · Cited by 6 · see citing works

Applying the Research Domain Criteria to Rodent Studies of Sex Differences in Chronic Stress Susceptibility

Campbell, H. M., Guo, J. D., & Kuhn, C. M. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.05.016 · Cited by 7 · see citing works

Orexins/hypocretins and sex

Jöhren, O. (2017) · Peptides · doi:10.1016/j.peptides.2017.10.014 · Cited by 6 · see citing works

Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability

Ma, Y., Sardar, H., Benabou, M. E., Yu, A. C., Morningstar, A. R., Fajardo, R. N., Kandil, I. F., Rogers, E. T., Vassalli, A., Kauer, J. A., et al. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100617 · Cited by 5 · see citing works

Sex-dependent role of orexin deficiency in feeding behavior and affective state of mice following intermittent access to a Western diet – Implications for binge-like eating behavior

Faesel, N., Koch, M., & Fendt, M. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114069 · Cited by 5 · see citing works

Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress

Kim, H. J. J., Zagzoog, A., Ceni, C., Ferrisi, R., Janz, N., & Laprairie, R. B. (2023) · Brain Sciences · doi:10.3390/brainsci13020314 · Cited by 4 · see citing works

Divergent Modulation of Dopaminergic Neurons by Hypocretin/Orexin Receptors 1 and 2 Shapes Dopaminergic Cell Activity and Socioemotional Behavior

Tzanoulinou, S., Astori, S., Grandi, L. C., Gullo, F., Kalusivikako, R., Rai, S., Limorenko, G., Tafti, M., Becchetti, A., & Vassalli, A. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.05.022 · Cited by 4 · see citing works

Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder

Costello, A., Linning‐Duffy, K., Shi, J., Lonstein, J. S., & Yan, L. (2026) · Annals of Medicine · doi:10.1080/07853890.2025.2611202 · Cited by 4 · see citing works

Hypocretin in the nucleus accumbens shell modulates social approach in female but not male California mice

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Plasticity of the hypocretinergic/orexinergic system after a chronic treatment with suvorexant in rats. Role of the hypocretinergic/orexinergic receptor 1 as an autoreceptor

Carrera-Cañas, C., de Andrés, I., Callejo, M., & Garzón, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1013182 · Cited by 4 · see citing works

LPS-induced inflammation in rats during pregnancy reduces maternal melatonin and impairs neurochemistry and behavior of adult male offspring

Spilla, C. S. G., de Souza, A. L. D. M., Campos, L. M. G., Cruz‐Machado, S. D. S., & Pinato, L. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148692 · Cited by 3 · see citing works

Sex differences in body temperature and neural power spectra in response to repeated restraint stress

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Sex-dependent effects of monomeric α-synuclein on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin

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Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle

Nogueira, D. D. S., Corwin, C., Rakholia, Y., Punnuru, V., Nampally, M., Kohtz, A. S., & Aston‐Jones, G. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100178 · Cited by 3 · see citing works

Sex and Orexins: Uncovering a Mechanism Underlying Sex Differences in Stress Susceptibility

Holmes, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.005 · Cited by 2 · see citing works

The contribution of orexins to sex differences in the stress response

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76. Role of Orexins in Mediating Sex Differences and Resilience to Repeated Stress

Bhatnager, S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.090

Orexins and stress

Grafe, L. A., & Bhatnagar, S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.003 · Cited by 134 · see citing works

Orexin deficiency modulates cognitive flexibility in a sex‐dependent manner

Durairaja, A., & Fendt, M. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12707 · Cited by 35 · see citing works