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Cited by 27Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Mean Girls: Social Stress Models for Female Rodents

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Kuske, Jace X., Trainor, Brian C.·2021·Current Topics in Behavioral Neurosciences
DOI 10.1007/7854_2021_247PMC PMC9812211
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Abstract

Social stressors are known to have strong negative impacts on mental health. There is a long history of preclinical social defeat stress studies in rodents focusing on males that has produced important insights into the neural mechanisms that modulate depression- and anxiety-related behavior. Despite these impressive results, a historical weakness of rodent social stress models has been an under-representation of studies in females. This is problematic because rates of depression and anxiety are higher in women versus men. Recently there has been a surge of interest in adapting social stress methods for female rodents. Here we review new rodent models that have investigated numerous facets of social stress in females. The different models have different strengths and weaknesses, with some model systems having stronger ethological validity with other models having better access to molecular tools to manipulate neural circuits. Continued use and refinement of these complementary models will be critical for addressing gaps in understanding the function of neural circuits modulating depression- and anxiety-related behavior in females.

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Cited by

Sorted by citations

Authors
Kuske, J. X., & Trainor, B. C.
Affiliations
University of California, Davis (US)
Corresponding author
Trainor, Brian C.
ORCID
Trainor, Brian C.
Venue
Current Topics in Behavioral Neurosciences
Publisher
Springer International Publishing
Published
2021
Volume
54
Pages
95-124
ISSN
  • 1866-3370 (ISSN-L)
  • 1866-3389
DOI
10.1007/7854_2021_247
PMC
PMC9812211
OpenAlex
W3199169544
Cited by
27
References
28
Citations by year
2026: 4 · 2025: 4 · 2024: 10 · 2023: 2 · 2022: 7
FWCI
11.88
Type
book chapter
Language
en
Open access
Licence
Locations
  • Current topics in behavioral neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Mental Health (R01MH121829)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
social stress, female rodents, social defeat stress, sex differences, depression, anxiety, rodent models, neural circuits, sex bias in research
MeSH terms
Animals, Anxiety, Anxiety Disorders, Female, Humans, Male, Rodentia, Social Behavior, Stress, Psychological

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