The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract
Abstract
Olive leaves, an agricultural waste, have great potential as a natural antioxidant. The current study was made to assess the antioxidant and antimicrobial activities of both the individual and combined phenolics in olive leaf extract. A combined phenolics mixture was prepared by amount ratios of the phenolic compounds in the olive leaf extract. The results showed that both the individual and combined phenolics exhibited good radical scavenging abilities, and also revealed superoxide dismutase (SOD)-like activity. In terms of antimicrobial activity, both oleuropein and caffeic acid showed inhibition effects against microorganisms. Furthermore, the antimicrobial effect of the combined phenolics was significantly higher than those of the individual phenolics. These results show that the combination of olive leaf extract phenolics possessed antioxidant and antimicrobial activities. This study indicates that olive leaf extract might be a valuable bioactive source, and would seem to be applicable in both the health and medical food.
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“Additionally, in general, in the mixed form, individual components can modify their properties and interact synergistically, producing improved effects [18,25,39].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Studies report that the antimicrobial and antioxidant efficiency of the olive leaf extracts are directly related with their content of polyphenols [18,20,33,34].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Some studies have already reported the antioxidant capacity of olive [17,18,22] and mimosa leaf [8,71] extracts.”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Among all by-products, olives leaves have attracted growing attention as they contain an array of simple phenolics (phenylethanoids, hydroxybenzoic acids, and hydroxycinnamic acids) and polyphenolic compounds (secoiridoids and flavonoids) with biological properties, including antioxidant and antimicrobial [16,17,18,19,20,21,22,23].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
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Investigation of the effects of oleuropein rich diet on rat enteric bacterial flora
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“Olive leaves as a rich source of polyphenolic compounds have better antioxidant, anti-inflam-matory, antihypertensive, anticancer, antimicrobial, gastroprotective, anti-atherosclerotic, antidiabetic, wound healing, and radical scavenging effects[16-20].”
BackgroundHerbal monographs including herbal medicinal products and food supplements
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“Thus, with the recovery of discarded leaves, extracts with high bioactive capacity can be obtained [2].”
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Olive leaf extract-based eye drop formulations for corneal wound healing
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“In their study on the antioxidant effects of phenolic compounds found in olive leaves, Lee and Lee (2010) revealed that olive leaf extract also has a radical scavenging effect like SOD.”
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Zeb, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-74768-8_13 · Cited by 2
Alimosazadeh, P., Khan, M. S., & Sanei, S. J. (2023) · Journal of Herbmed Pharmacology · doi:10.34172/jhp.2023.45000 · Cited by 2
“Although OLE has been mainly tested for antibacterial activity (9,11,12,17,37), the results of this experiment revealed the antifungal activity of OLE in line with other experiments on Candida spp. (8,19,37-40).”
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“Both studied compounds have exerted a powerful antioxidant activity in olive leaves (Lee and Lee 2010) and have been fluorescently characterized by a similar methodology by Cabrera-Bañegil et al. (2018) in “Arbequina” olive samples subjected to water stress.”
MethodAtividade antimicrobiana de produtos naturais: erva-mate e resíduos agroindustriais
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“Many potentially bioactive substances in olive leaves can have antioxidant, antimicrobial, antihypertensive, antiviral, anti-inflammatory, hypoglycemic, neuroprotective, and anticancer properties [13–20].”
Natural Wisdom in Blood Sugar Regulation: Investigating Trigonella foenum-graecum and Olea europaea
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ANTIOXIDANT, ANTIMICROBIAL AND ANTI-INFLAMMATORY POTENTIALOF OLIVE LEAVES
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“Those phenolic compounds have anticholinesterase activities (Lee and Lee, 2010) antioxidant, and antimicrobial (Cumaoglu et al., 2011; Amoo, et al., 2012).”
BackgroundEffect of salinity on phenolic composition and antioxidant activity of halophytes
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Effects of Olive Leaf Extract on Myoclonic and Tonico-Clonic Seizures in Mice
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“Phenolic compounds confer to the olive leaves interesting anti-carcinogenic, antimicrobial (Lee and Lee, 2010) and antioxidant activities.”
BackgroundGuo, W., Xu, Y., He, X., Wang, J. P., Xiang, J., Li, P., & Luo, D. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17149
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“Furthermore, olive leaf extract has been shown to attenuate systemic oxidative stress through its SOD-like activity [24,30] and protects against renal oxidative stress by directly scavenging free radicals and preserving endogenous antioxidant enzymes from oxidative damage without altering their…”
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“Moreover, similar compounds act as antibacterial agents by disrupting bacterial growth and reproduction processes, thereby accelerating wound healing (Lee & Lee, 2010).”
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Metadata
- Authors
- Lee, O.-H., & Lee, B.-Y.
- Affiliations
- CHA University (KR)
- Corresponding author
- Lee, Ok-Hwan
- Lee, Boo-Yong
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 101
- Issue
- 10
- Pages
- 3751-3754
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2055194600
- Cited by
- 382
- References
- 16
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 21 · 2023: 21 · 2022: 25 · 2021: 38 · 2020: 43 · 2019: 36 · 2018: 29 · 2017: 26 · 2016: 30 · 2015: 23 · 2014: 22 · 2013: 13 · 2012: 21
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- olive leaf extract, Olea europaea, phenolic compounds, antioxidant activity, antimicrobial activity, free radical scavenging, superoxide dismutase-like activity, oleuropein, caffeic acid, agricultural waste valorization, bioactive compounds
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Microbial Sensitivity Tests, Plant Extracts, Superoxide Dismutase, Plant Leaves, Olea
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