Cited by 382Edible Oils Quality and AnalysisPhytochemicals and Antioxidant ActivitiesEssential Oils and Antimicrobial Activity

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Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract

Lee, Ok-Hwan, Lee, Boo-Yong·2010·Bioresource Technology

DOI 10.1016/j.biortech.2009.12.052

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Abstract

Olive leaves, an agricultural waste, have great potential as a natural antioxidant. The current study was made to assess the antioxidant and antimicrobial activities of both the individual and combined phenolics in olive leaf extract. A combined phenolics mixture was prepared by amount ratios of the phenolic compounds in the olive leaf extract. The results showed that both the individual and combined phenolics exhibited good radical scavenging abilities, and also revealed superoxide dismutase (SOD)-like activity. In terms of antimicrobial activity, both oleuropein and caffeic acid showed inhibition effects against microorganisms. Furthermore, the antimicrobial effect of the combined phenolics was significantly higher than those of the individual phenolics. These results show that the combination of olive leaf extract phenolics possessed antioxidant and antimicrobial activities. This study indicates that olive leaf extract might be a valuable bioactive source, and would seem to be applicable in both the health and medical food.

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BackgroundInfluential
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“Olive leaf extract (OLE) can be considered a plant antimicrobial with both antimicrobial and antioxidant activities (Lee and Lee, 2010).”
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Background
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“13,14 17 Recently, Mohagheghi and colleagues have reported that OLE has a neuroprotective effect against focal cerebral ischemia in rats.”
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Background
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“Many phenolic compounds occurring in olive leaves had significant radical scavenging activity [9,10].”
Background
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“However, Lee and Lee (2010) and Albertos et al. (2017) found no inhibitory activity of olive leaf extract against E. coli, even though there was inhibition against other bacterial species.”
Background
Antimicrobial resistance and synergy in herbal medicine
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“The results reported in the present study show similarity with previous ones (Markin et al., 2003; Pereira et al., 2007; Sudjana et al., 2009; Lee and Lee, 2010; G€okmen et al., 2014) about the antimicrobial activity of olive leaves extracts.”
BackgroundResult
Antibacterial effect of olive ( Olea europaea L.) leaves extract in raw peeled undeveined shrimp ( Penaeus semisulcatus )
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“Olive leaves polyphenols become a subject of intense investigation because of their several beneficial effects on health due to their anti-hypertensive, anti-diabetic, anticarcinogenic, anti-atherosclerotic, anti-inflammatory, and antimicrobial activities [6–11].”
Background
The Effects of Olive Leaf Extract on The Testis, Sperm Quality and Testicular Germ Cell Apoptosis in Male Rats Exposed to Busulfan.
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“) is commonly used as a part of traditional herbal medicine to treat disease in the Mediterranean area (7).”
Background
Beneficial health applications and medicinal values of Pedicularis plants: A review
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“Polyphenolic compounds from OLE act as free radical scavengers breaking the free radical chain reaction [10].”
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Potential of Deep Eutectic Solvents in the Extraction of Organic Compounds from Food Industry By-Products and Agro-Industrial Waste
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Antimicrobial activity of mangrove plant (Lumnitzera littorea)
Saad, S., Taher, M., Darnis, D. S., Qaralleh, H., & Rahim, N. A. B. A. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60138-7 · Cited by 58
“Plant extracts and products are used in the treatment of infectious disease[8-10].”
Background
Fish spoilage bacterial growth and their biogenic amine accumulation: Inhibitory effects of olive by-products
Küley, E., Durmuş, M., Balikçi, E., Uçar, Y., Regenstein, J. M., & Özoğul, F. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1193516 · Cited by 58
“The major physiologically active compounds of OL are hydroxytyrosol, tyrosol, caffeic acid, p-coumaric acid, vanillic acid, vanillin, oleuropein, luteolin, diosmetin, rutin, verbascoside, luteolin-7-glucoside, apigenin-7-glucoside, and diosmetin-7-glucoside.([26]) In the past few years the demand for OL for use in foo…”
Background
EVALUATION OF NATURAL ANTIMICROBIAL PHENOLIC COMPOUNDS AGAINST FOODBORNE PATHOGENS
Cetin‐Karaca, H. (2011) · UKnowledge (University of Kentucky) · Cited by 58
Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes
Pirković, A., Živković, L., Žukovec, D., Djelić, N., Bajić, V., Dekanski, D., & Spremo‐Potparević, B. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.12.014 · Cited by 56
Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth
Karygianni, L., Cecere, M., Argyropoulou, A., Hellwig, E., Skaltsounis, A., Wittmer, A., Tchorz, J. P., & Al‐Ahmad, A. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2461-4 · Cited by 56
Oleuropein: Chemistry, extraction techniques and nutraceutical perspectives-An update
Khalil, A. A., Rahman, M. M., Rauf, A., Islam, M. R., Manna, S. J., Khan, A. A., Ullah, S., Akhtar, M. N., Aljohani, A. S. M., Abdulmonem, W. A., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2218495 · Cited by 55
“Oleuropein molecule exerts significant inhibitory effect on Salmonella enteritidis , nevertheless the combination of different phenolic compounds extracted from olive leaves have reported more antimicrobial potentials (Lee and Lee 2010).”
Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase
Amini, A., Liu, M., & Ahmad, Z. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.087 · Cited by 55
Essential oil‐based active polymer‐based packaging system: A review of its effect on the antimicrobial, antioxidant, and sensory properties of beef and chicken meat
Chacha, J. S., Ofoedu, C. E., & Xiao, K. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16933 · Cited by 73
Supercritical impregnation of olive leaf extract to obtain bioactive films effective in cherry tomato preservation
Bastante, C. C., Casas, L., Fernández-Ponce, M. T., Mantell, C., & de la Ossa, E. J. M. (2019) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2019.100338 · Cited by 54
Biological Activity of Oleuropein and its Derivatives
Bulotta, S., Oliverio, M., Russo, D., & Procopio, A. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_156 · Cited by 53
Evaluation of antioxidant and antimicrobial properties of Manilkara zapota L. (chiku) leaves by sequential soxhlet extraction method
Kaneria, M., & Chanda, S. V. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60448-1 · Cited by 53
Bioavailability of Bioactive Molecules from Olive Leaf Extracts and its Functional Value
Martín‐Vertedor, D., Garrido, M., Pariente, J. A., Espino, J., & Delgado, J. (2016) · Phytotherapy Research · doi:10.1002/ptr.5625 · Cited by 53
Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation
Cabrerizo, S., Cruz, J. P. D. L., López-Villodres, J. A., Muñoz-Marín, J., Guerrero, A., Reyes, J. J., Manzanares, M. T. L., & Correa, J. A. G. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.007 · Cited by 52
“Hydroxytyrosol (2-(3,4-dihydroxyphenylethanol) is a natural antioxidant [1,2] derived from the chemical [3] or enzymatic [4] hydrolysis of glycoside oleuropein.”
Background
Recovery of Bioactive Extracts from Olive Leaves Using Conventional and Microwave-Assisted Extraction with Classical and Deep Eutectic Solvents
Boli, E., Prinos, N., Louli, V., Pappa, G. D., Stamatis, H., Magoulas, K. G., & Voutsas, E. C. (2022) · Separations · doi:10.3390/separations9090255 · Cited by 51
Olive leaf phenolics and cardiovascular risk reduction: Physiological effects and mechanisms of action
Lockyer, S., Yaqoob, P., Spencer, J. P. E., & Rowland, I. R. (2012) · Nutrition and Aging · doi:10.3233/nua-2012-0011 · Cited by 49
“The antioxidant potential of OLE has been observed in vitro [58], with HT proposed to scavenge predominantly peroxyl radicals near membrane surfaces and oleuropein also acting on chain-propagating lipid peroxyl radicals within cell membranes [114].”
Background
Olive leaf extract suppresses messenger RNA expression of proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with streptozotocin and high-fat diet–induced diabetes
Liu, Y., Jung, J., Park, H., & Kim, H. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.04.007 · Cited by 49
“[15] Lee OH, Lee BY.”
Background
Effects of olive leaf extract addition on fermentative and oxidative processes of table olives and their nutritional properties
Caponio, F., Difonzo, G., Calasso, M. P., Cosmai, L., & Angelis, M. D. (2018) · Food Research International · doi:10.1016/j.foodres.2018.10.020 · Cited by 49
Medicinal plants in the treatment of Helicobacter pylori infections
Safavi, M., Shams‐Ardakani, M., & Foroumadi, A. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.952837 · Cited by 47
“Olive leaf has been widely used in folk medicine for the cure of malaria and associated fever (Lee & Lee, 2010).”
Background
Antioxidant and antimicrobial activity of oils obtained from a mixture of citrus by-products using a modified supercritical carbon dioxide
Ndayishimiye, J., 임덕점, & Chun, B. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.08.041 · Cited by 47
Wild Italian Prunus spinosa L. Fruit Exerts In Vitro Antimicrobial Activity and Protects Against In Vitro and In Vivo Oxidative Stress
Pozzo, L., Russo, R., Frassinetti, S., Vizzarri, F., Árvay, J., Vornoli, A., CASAMASSIMA, D., Palazzo, M., Croce, C. M. D., & Longo, V. G. (2019) · Foods · doi:10.3390/foods9010005 · Cited by 47
“The crude extracts can be more advantageous than the isolated components, since a single bioactive molecule can change its properties with the presence of other compounds in the extracts [36].”
Background
Antibacterial finishing of cotton fabrics by dyeing with olive tree leaves fallen during olive harvesting
Yılmaz, F., & Bahtiyari, M. İ. (2020) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2020.122068 · Cited by 46
In vitro assays of the antibacterial and antioxidant activity of aqueous leaf extracts from different Prunus salicina Lindl. cultivars
Delgado, J., Fernández-León, M. F., Velardo, B., & González‐Gómez, D. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.024 · Cited by 46
Olive leaf extract as a crosslinking agent for the preparation of electrospun zein fibers
Erdoğan, İ., Demir, M., & Bayraktar, O. (2014) · Journal of Applied Polymer Science · doi:10.1002/app.41338 · Cited by 45
Chemical composition and biological activities of essential oil and extracts from Ocimum sanctum
Hussain, A. I., Chatha, S. A. S., Kamal, G. M., Ali, M. A., Hanif, M. A., & Lazhari, M. I. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1214145 · Cited by 45
“The presence of such bioactive compounds promotes the therapeutic uses of medicinal plants also.([5,7])”
Background
Efficacy of olive leaf extract (Olea europaea L. cv Gentile di Larino) in marinated anchovies (Engraulis encrasicolus, L.) process
Testa, B., Lombardi, S. J., Macciola, V., Succi, M., Tremonte, P., & Iorizzo, M. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01727 · Cited by 45
“…olive leaf extract (OLE) and its use as food additive, both for its high phenolic content and also for its antimicrobial and antioxidant activity (Lee and Lee, 2010; De Leonardis et al., 2008, 2018); like other phenolic compounds naturally occurring in numerous food and known for their…”
Background
Synthesis and preparation of responsive poly(Dimethyl acrylamide/gelatin and pomegranate extract) as a novel food packaging material
Alpaslan, D., Dudu, T. E., Şahiner, N., & Aktaş, N. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110339 · Cited by 48
Eco-friendly extraction for the recovery of bioactive compounds from Brazilian olive leaves
da Rosa, G. S., Martiny, T. R., Dotto, G. L., Vanga, S. K., Parrine, D., Gariépy, Y., Lefsrud, M. G., & Raghavan, V. (2021) · Sustainable materials and technologies · doi:10.1016/j.susmat.2021.e00276 · Cited by 45
Phenolic compounds and in vitro immunomodulatory properties of three Andalusian olive leaf extracts
Talhaoui, N., Vezza, T., Gómez‐Caravaca, A. M., Fernández‐Gutiérrez, A., Gálvez, J., & Segura‐Carretero, A. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.01.037 · Cited by 44
Enzymatic hydrolysis of olive wastewater for hydroxytyrosol enrichment
Khoufi, S., Hamza, M., & Sayadi, S. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.07.048 · Cited by 44
Antioxidant and Antimicrobial Activities of Ethanol Extract from the Stem and Leaf of Impatiens balsamina L. (Balsaminaceae) at Different Harvest Times
Kang, S., Goo, Y., Yang, M.-R., Ibrahim, R. I. H., Cho, J., Kim, I.-S., & Lee, O. (2013) · Molecules · doi:10.3390/molecules18066356 · Cited by 44
“Traditionally, the dried herb is either boiled in water to make tea to treat systemic bacterial and fungal infections or applied directly on the skin or nails in a plaster form to treat local infections [16,17].”
BackgroundMethod
Olive glutaraldehyde-like compounds against plant pathogenic bacteria and fungi
Brenes, M., García-Borrego, A., Santos, B. D. L., Medina, E., Romero, C., de Castro, A., & Romero, F. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.10.055 · Cited by 44
Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats
Çoban, J., Öztezcan, S., Doğru‐Abbasoğlu, S., Bingül, İ., Yeşil-Mizrak, K., & Uysal, M. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12192 · Cited by 43
Olive Leaves Extract from Algerian Oleaster (Olea europaea var. sylvestris) on Microbiological Safety and Shelf-life Stability of Raw Halal Minced Beef during Display
Djenane, D., Gómez, D., Yangüela, J., Roncalés, P., & Ariño, A. A. (2018) · Foods · doi:10.3390/foods8010010 · Cited by 43
Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria
Ramata‐Stunda, A., Petriņa, Z., Valkovska, V., Borodušķis, M., Gibnere, L., Gurkovska, E., & Nikolajeva, V. (2022) · Antibiotics · doi:10.3390/antibiotics11020160 · Cited by 42
Biologically active compounds from two members of the Asteraceae family:Tragopogon dubiusScop. andTussilago farfaraL.
Uysal, Ş., Şenkardeş, İ., Mollica, A., Zengin, G., Bulut, G., Doğan, A., Glamočlija, J., Sokóvić, M., Lobine, D., & Mahomoodally, M. F. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1506361 · Cited by 46
“…intermediates such as chlorogenic acid (Sung & Lee, 2010) rosmarinic acid (Abedini et al., 2013; Gohari et al., 2009), hesperidin (Iranshahi, Rezaee, Parhiz, Roohbakhsh, & Soltani, 2015) and caffeic acid (Lee & Lee, 2010) presented in T. dubius and T. farfara have been demonstrated experimentally.”
Background
Investigation of phenolic compounds and antioxidant activity of leaves extracts from seventeen cultivars of Iranian olive (Olea europaea L.)
Ghasemi, S., Koohi, D. E., Emmamzadehhashemi, M. S. B., Khamas, S. S., Moazen, M., Hashemi, A. K., Amin, G., Golfakhrabadi, F., Yousefi, Z., & Yousefbeyk, F. (2018) · Journal of Food Science and Technology · doi:10.1007/s13197-018-3398-1 · Cited by 42
Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations
Nunes, A., Gonçalves, L., Marto, J. M., Martins, A. M., Silva, A. N., Pinto, P. C., Martins, M., Fraga, C., & Ribeiro, H. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040465 · Cited by 42
Use of colorimetric hydrogel as an indicator for food packaging applications
Alpaslan, D. (2019) · Bulletin of Materials Science · doi:10.1007/s12034-019-1908-z · Cited by 39
Antimicrobial and Antivirulence Impacts of Phenolics on Salmonella Enterica Serovar Typhimurium
Alvarado‐Martinez, Z., Bravo, P. F., Kennedy, N.-F., Krishna, M., Hussain, S., Young, A., & Biswas, D. (2020) · Antibiotics · doi:10.3390/antibiotics9100668 · Cited by 39

Authors: Lee, O.-H., & Lee, B.-Y.
Affiliations: CHA University (KR)
Corresponding author: Lee, Ok-Hwan
Lee, Boo-Yong
ORCID: Lee, Ok-Hwan
Lee, Boo-Yong
Venue: Bioresource Technology
Publisher: Elsevier BV
Published: 2010-05
Volume: 101
Issue: 10
Pages: 3751-3754
ISSN: 0960-8524 (ISSN-L)
DOI: 10.1016/j.biortech.2009.12.052
OpenAlex: W2055194600
Cited by: 382
References: 16
Citations by year: 2026: 9 · 2025: 10 · 2024: 21 · 2023: 21 · 2022: 25 · 2021: 38 · 2020: 43 · 2019: 36 · 2018: 29 · 2017: 26 · 2016: 30 · 2015: 23 · 2014: 22 · 2013: 13 · 2012: 21
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bioresource Technology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords: olive leaf extract, Olea europaea, phenolic compounds, antioxidant activity, antimicrobial activity, free radical scavenging, superoxide dismutase-like activity, oleuropein, caffeic acid, agricultural waste valorization, bioactive compounds
MeSH terms: Anti-Bacterial Agents, Antioxidants, Microbial Sensitivity Tests, Plant Extracts, Superoxide Dismutase, Plant Leaves, Olea

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Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract

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