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Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract
Abstract
Olive leaves, an agricultural waste, have great potential as a natural antioxidant. The current study was made to assess the antioxidant and antimicrobial activities of both the individual and combined phenolics in olive leaf extract. A combined phenolics mixture was prepared by amount ratios of the phenolic compounds in the olive leaf extract. The results showed that both the individual and combined phenolics exhibited good radical scavenging abilities, and also revealed superoxide dismutase (SOD)-like activity. In terms of antimicrobial activity, both oleuropein and caffeic acid showed inhibition effects against microorganisms. Furthermore, the antimicrobial effect of the combined phenolics was significantly higher than those of the individual phenolics. These results show that the combination of olive leaf extract phenolics possessed antioxidant and antimicrobial activities. This study indicates that olive leaf extract might be a valuable bioactive source, and would seem to be applicable in both the health and medical food.
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“Additionally, in general, in the mixed form, individual components can modify their properties and interact synergistically, producing improved effects [18,25,39].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Studies report that the antimicrobial and antioxidant efficiency of the olive leaf extracts are directly related with their content of polyphenols [18,20,33,34].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Some studies have already reported the antioxidant capacity of olive [17,18,22] and mimosa leaf [8,71] extracts.”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
In the citing paper
“Among all by-products, olives leaves have attracted growing attention as they contain an array of simple phenolics (phenylethanoids, hydroxybenzoic acids, and hydroxycinnamic acids) and polyphenolic compounds (secoiridoids and flavonoids) with biological properties, including antioxidant and antimicrobial [16,17,18,19,20,21,22,23].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [18]
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The Effect of Drying Methods and Extraction Techniques on Oleuropein Content in Olive Leaves
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“Nitrite-scavenging activity was processed according to the procedure described by Lee and Lee (2010) with slight modification.”
MethodCharacterization of antioxidant enzymes and peroxisomes of olive (Olea europaea L.) fruits
López‐Huertas, E., & del Río, L. A. (2014) · Journal of Plant Physiology · doi:10.1016/j.jplph.2014.06.014 · Cited by 37
Makowska‐Wąs, J., Galanty, A., Gdula‐Argasińska, J., Tyszka‐Czochara, M., Szewczyk, A., Nunes, R., Carvalho, I. S., Michalik, M., & Paśko, P. (2016) · Chemistry & Biodiversity · doi:10.1002/cbdv.201600331 · Cited by 37
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“leaf extract, finding that they exhibit good radical scavenging abilities and superoxide dismutase-like activity.([8]) Indeed, olive leaves have been used widely in traditional remedies in European and Mediterranean countries; they have been used in the human diet as extracts, herbal teas and powders.”
MethodLee, S.-W., Lim, J., Mohan, H., Kamala‐Kannan, S., Park, Y., Lee, J., & Oh, B. (2020) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2019.12.003 · Cited by 37
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Antifungal Activity of Oleuropein against Candida albicans—The In Vitro Study
Zorić, N., Kopjar, N., Bobnjarić, I., Horvat, I., Tomić, S., & Kosalec, I. (2016) · Molecules · doi:10.3390/molecules21121631 · Cited by 36
Djenane, D., Aboudaou, M., Djenane, F., García‐Gonzalo, D., & Pagán, R. (2020) · Foods · doi:10.3390/foods9091336 · Cited by 36
“Such antioxidant activity has been explained by two corresponding phenom na: Hy r lysis of oleurop in t hydroxytyrosol with the corresponding increase in the antioxidant capacity of the extract, as well as the synergistic effect of phenols on the whole OLE [35,60,61].”
BackgroundMarchetti, C., Clericuzio, M., Borghesi, B., Cornara, L., Ribulla, S., Gosetti, F., Marengo, E., & Burlando, B. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/908493 · Cited by 36
Antimicrobial Efficacy of Natural Phenolic Compounds against Gram Positive Foodborne Pathogens
Cetin‐Karaca, H., & Newman, M. C. (2015) · Journal of Food Research · doi:10.5539/jfr.v4n6p14 · Cited by 35
“However, Lee & Lee (2010) reported rutin (100 µg/ml) had no antimicrobial activity against B. cereus.”
BackgroundPacheco, C., González, E. G., Robert, P. S., & Parada, J. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.037 · Cited by 35
“…the idea of include these compounds into common, easily accessible foods, such as wheat flour-based food (Ahmadvand et al., 2014; Beirao-Da-Costa et al., 2013; Lee & Lee, 2010; Polzonetti et al., 2010; Ronkart et al., 2007; Sudjana et al., 2009; Vissers, Zock, Roodenburg, Leenen, & Katan, 2002).”
BackgroundYeo, H. J., Baek, S., Sathasivam, R., Kim, J. K., & Park, S. U. (2021) · Applied Biological Chemistry · doi:10.1186/s13765-020-00574-2 · Cited by 35
“Free radical scavenging might be important, in which the phenolic molecule can be degraded in the free radical chain reaction [56].”
BackgroundTaamalli, A., Abaza, L., Arraéz-Román, D., Segura‐Carretero, A., Fernández‐Gutiérrez, A., Zarrouk, M., & Youssef, N. B. (2013) · Phytochemical Analysis · doi:10.1002/pca.2450 · Cited by 35
“Concomitantly, because of their biological activities, including anti-oxidant (Lee and Lee, 2010), anti-microbial (Micol et al., 2005) and therapeutic (Sedef and Karakaya, 2009) properties, scientific attention to olive leaves has been increasing during recent years.”
BackgroundKhodaie, L., Moghaddam, S. B., Delazar, A., & Nazemiyeh, H. (2012) · Europe PMC (PubMed Central) · doi:10.5681/bi.2012.006 · Cited by 34
Assar, D. H., Ragab, A. E., Abdel-Sattar, E. A., Salah, A. S., Salem, S. M. R., Hendam, B. M., Jaouni, S. A., Wakeel, R. A. A., El‐Kader, M. F. A., & Elbialy, Z. I. (2023) · Animals · doi:10.3390/ani13132229 · Cited by 33
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“…widely used in pharmaceutical drugs because of its antibacterial and antioxidant properties, as well as its bioactivity in the reduction of blood pressure and with respect to its hypoglycaemic function (Calzada et al ., 2017; Kreft, 2016; Lee and Lee, 2010; Wang et al ., 2013; Yang et al ., 2008).”
BackgroundZorić, N., Kopjar, N., Kraljić, K., Oršolić, N., Tomić, S., & Kosalec, I. (2016) · Acta Pharmaceutica · doi:10.1515/acph-2016-0033 · Cited by 33
Dedousi, M., Μαμουδάκη, Π. Β., Grigorakis, S., & Makris, D. P. (2017) · Environments · doi:10.3390/environments4020031 · Cited by 33
“The antioxidant activity measured in OLL extracts has been suggested to be the outcome of interactions amongst the various polyphenolic substances [26], a claim further supported by studies that assessed the antiradical behaviour of mixtures of pure antioxidants and extracts [27].”
ResultHydrolysis Conditions of Porcine Blood Proteins and Antimicrobial Effects of Their Hydrolysates
Jin, S.-K., Choi, J., & Yim, D.-G. (2020) · Food Science of Animal Resources · doi:10.5851/kosfa.2020.e2 · Cited by 33
The role of prophetic medicine in the management of diabetes mellitus: A review of literature
Sheikh, B. Y. (2016) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2015.12.002 · Cited by 37
Effects of medical plants on alleviating the effects of heat stress on chickens
Mahasneh, Z. M. H., Abuajamieh, M., Abedal-Majed, M. A., Al‐Qaisi, M., Abdelqader, A., & Al-Fataftah, A.-R. A. (2024) · Poultry Science · doi:10.1016/j.psj.2023.103391 · Cited by 32
“The antioxidant result of olive oil or its leaf extracts has been stated previously (Lee and Lee, 2010), by increasing plasma SOD levels and diminishing MDA integrity, thus enhancing the health and redox status balance of the chickens.”
BackgroundPlant Phenols as Antibiotic Boosters: In Vitro Interaction of Olive Leaf Phenols with Ampicillin
Lim, A., Subhan, N., Jazayeri, J. A., John, G., Vanniasinkam, T., & Obied, H. K. (2016) · Phytotherapy Research · doi:10.1002/ptr.5562 · Cited by 32
Mkaouar, S., Gelicus, A., Bahloul, N., Allaf, K. S., & Kechaou, N. (2016) · Separation and Purification Technology · doi:10.1016/j.seppur.2016.02.002 · Cited by 31
Optimization of ultrasound-assisted aqueous two phase extraction of polyphenols from olive leaves
Wang, W., Yang, J., & Yang, J. (2020) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2020.1861012 · Cited by 31
Sarıca, Ş., & Ürkmez, D. (2016) · Archiv für Geflügelkunde · doi:10.1399/eps.2016.121 · Cited by 35
Lee, Y., Kim, K., Park, K., Yoon, B., Lim, J., & Lee, O. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011428 · Cited by 30
Palmeri, R., Monteleone, J. I., Spagna, G., Restuccia, C., Raffaele, M., Vanella, L., Volti, G. L., & Barbagallo, I. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00143 · Cited by 30
“…pleiotropic effects including antioxidant activity (Somova et al., 2003) as well as antimicrobial activity against Helicobacter pylori, Campylobacter jejuni, Staphylococcus aureus (Sudjana et al., 2009), and Bacillus cereus, Escherichia coli, and Salmonella enteritidis (Lee and Lee, 2010).”
BackgroundMkaouar, S., Krichen, F., Bahloul, N., Allaf, K. S., & Kechaou, N. (2018) · Food and Bioprocess Technology · doi:10.1007/s11947-018-2098-1 · Cited by 29
Isolation of an antiviral compound from Tunisian olive twig cultivars
Abaza, L., Bouslama, L., Benzekri, R., Trabelsi, N., Taamalli, A., Jellouli, S., & Zarrouk, M. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.01.012 · Cited by 29
Olive leaf extract modulates glycerol-induced kidney and liver damage in rats
Abugomaa, A., & Elbadawy, M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08371-6 · Cited by 29
“Studies have demonstrated the capability of olive leaves for the medicament of various diseases with biochemical, physiological, and pathological changes (El and Karakaya 2009; Grawish et al. 2011; Kumral et al. 2015; Lee and Lee 2010; Omagari et al. 2010).”
BackgroundMethodInfluentialZare, L., Esmaeili‐Mahani, S., Abbasnejad, M., Rasoulian, B., Sheibani, V., Sahraei, H., & Kaeidi, A. (2012) · Phytotherapy Research · doi:10.1002/ptr.4634 · Cited by 29
Sarıca, Ş., & Toptas, S. (2014) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12192 · Cited by 29
“…of the bioactive polyphenolic compounds in the olive leaf extract to act as a free radical scavenger is partly related to their standard one-electron reduction potential by either donating hydrogen or electron or breaking the free radical chain reaction (Lee and Lee, 2010; Hayes et al., 2011).”
Background(2018) · Records of Natural Products · doi:10.25135/rnp.23.17.07.126 · Cited by 28
“According to the literature survey, it has been reported that crude extract of the olive leaves and its some phenolic compounds have antioxidant [10,19,20-23], antimicrobial [23] and anticholinesterase activities [24].”
Backgroundβ-Cyclodextrin complexation of extracts of olive leaves obtained by pressurized liquid extraction
Jaski, J. M., Barão, C. E., Lião, L. M., Pinto, V. S., Zanoelo, É. F., & Cardozo‐Filho, L. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.12.045 · Cited by 28
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Rameshkumar, A., & Thilagar, S. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60332-3 · Cited by 27
“Ok-Hwan Lee and Boo-Yong Lee[27] have purified the phenolic compounds from olive leaves and tested them for antioxidant and antimicrobial activities.”
BackgroundPlant By-Products and Food Industry Waste: A Source of Nutraceuticals and Biopolymers
Routray, W., & Orsat, V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811413-1.00008-5 · Cited by 30
African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment
Gulumian, M., Yahaya, E. S., & Steenkamp, V. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/4089541 · Cited by 33
Ayahuasca Beverages: Phytochemical Analysis and Biological Properties
Gonçalves, J., Luís, Â., Gradillas, A., Garcı́a, A., Restolho, J., Fernández, N., Domingues, F., Gallardo, E., & Duarte, A. P. (2020) · Antibiotics · doi:10.3390/antibiotics9110731 · Cited by 29
Soil fluoride spiking effects on olive trees (Olea europaea L. cv. Chemlali)
Zouari, N., Ahmed, C. B., Fourati, R., Delmail, D., Rouina, B. B., Labrousse, P., & Abdallah, F. B. (2014) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2014.06.022 · Cited by 27
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“Lee and Lee (15) have suggested that the olive leaf extracts have great potential as a functional food ingredient, particularly as a source of phenolic compounds that are effective in lipid-oxidation reactions.”
BackgroundEthnoveterinary medicine in Turkey: a comprehensive review
ERARSLAN, Z. B., & Kültür, Ş. (2019) · TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES · doi:10.3906/vet-1904-8 · Cited by 27
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“Olive leaf extract polyphenols exhibit antimicrobial activity against various pathogenic microorganisms, particularly E. coli , and the combined phenolics exert antioxidant and antimicrobial effects comparable to or better than individual phenolics (64).”
BackgroundŞahin, S., & Bilgin, M. (2012) · Separation Science and Technology · doi:10.1080/01496395.2012.666311 · Cited by 26
Aliyari, M. A., Salami, M., Hosseini, E., Emam‐Djomeh, Z., Karboune, S., & Waglay, A. (2021) · Food Biophysics · doi:10.1007/s11483-021-09671-1 · Cited by 26
Quality assessment of marketed food supplements and herbal tea products of olive leaf in Turkey
Güzelmeriç, E., Çevik, D., & Yeşilada, E. (2020) · Journal of Research in Pharmacy · doi:10.35333/jrp.2020.123 · Cited by 25
“Previous bioactivity studies on olive leaf extracts and some of the isolated secondary metabolites revealed their antidiabetic [5], anticancer [6,7], antimicrobial [8], antioxidant [9], antihypertensive [10], antiinflammatory [11], antinociceptive [3], gastroprotective [12], wound healing [13] and neuroprotective acti…”
BackgroundZorić, N., Kopjar, N., Rodríguez, J. V., Tomić, S., & Kosalec, I. (2020) · Acta Pharmaceutica · doi:10.2478/acph-2021-0003 · Cited by 27
“Several studies have investigated the ability of OLP and HT to scavenge DPPH radicals and ABTS∙+; however, limited data exist against other radicals (1, 3, 21).”
BackgroundAlpaslan, D., Dudu, T. E., & Aktaş, N. (2020) · Soft Materials · doi:10.1080/1539445x.2020.1765802 · Cited by 27
Kırbaşlar, Ş. İ., & Şahin, S. (2021) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-020-01194-y · Cited by 25
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“Furthermore, it has been reported that OLE and HT have synergistic effects as their combinations showed greater in vitro antioxidant and anti-bacterial effects as compared to that of the individual compounds alone (Lee and Lee 2010; Peres et al. 2015).”
BackgroundBiochemical and biological characterization of two Brassicaceae after their commercial expiry date
Ombra, M. N., Cozzolino, A., Nazzaro, F., d’Acierno, A., Tremonte, P., Coppola, R., & Fratianni, F. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.09.082 · Cited by 25
Effect of light irradiation on the antioxidant stability of oleuropein
Longo, E., Morozova, K., & Scampicchio, M. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.099 · Cited by 25
St‐Pierre, A., Blondeau, D., Lajeunesse, A., Bley, J., Bourdeau, N., & Desgagné‐Penix, I. (2018) · Molecules · doi:10.3390/molecules23071739 · Cited by 24
Utilization of Eggshell Membrane and Olive Leaf Extract for the Preparation of Functional Materials
Bayraktar, O., Galanakis, C. M., Aldawoud, T. M. S., Ibrahim, S. A., Köse, M. D., & Uslu, M. E. (2021) · Foods · doi:10.3390/foods10040806 · Cited by 24
“Hydroxytyrosol, verbascoside, luteolin, diosmetin, rutin, luteolin-7-glucoside, and apigenin-7-glucoside are the other phenolic compounds present in the olive leaf extract [17,18].”
BackgroundSelective Encapsulation of the Polyphenols on Silk Fibroin Nanoparticles: Optimization Approaches
Bayraktar, O., Oder, G., Erdem, C., Kose, M. D., & Cheaburu-Yilmaz, C. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119327 · Cited by 23
“Plant-based bioactive compounds have gained interest thanks to their antioxidant and antimicrobial properties [2,3] and their use within medical, cosmetic, food, and pharmaceutical industries has become competitive [4].”
BackgroundPotential therapeutic of olive oil industry by-products in skin health: A review
Nunes, A., Marto, J., Gonçalves, L., Martins, A. M., Fraga, C., & Ribeiro, H. M. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15384 · Cited by 24
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Integrated membranes for the recovery and concentration of antioxidant from olive mill wastewater
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Olive leaf extract inhibits lead poisoning-induced brain injury.
Wang, Y., Wang, S., Cui, W., He, J., Wang, Z., & Yang, X. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.22.001 · Cited by 23
“Like many natural herbs, olive leaves contain some powerful antioxidants [26-36] .”
BackgroundPharmacological Activities ofOlea europaeaLeaves
Salem, M. B., Affes, H., Ksouda, K., Sahnoun, Z., Zeghal, K. M., & Hammami, S. (2014) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12341 · Cited by 23
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Nitrite scavenging impact of fermented soy sauce in vitro and in a pork sausage model
Choi, J.-H., Song, D., Hong, J.-S., Ham, Y., Ha, J.-H., Choi, Y., & Kim, H. (2019) · Meat Science · doi:10.1016/j.meatsci.2019.01.001 · Cited by 22
Bisignano, C., Filocamo, A., Ginestra, G., Giofrè, S. V., Navarra, M., Romeo, R., & Mandalari, G. (2014) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-13-24 · Cited by 22
“Other authors have reported on the antioxidant and antimicrobial activities of individual and combined phenolics in Olea europea leaf extract: oleuropein and caffeic acid were active against Salmonella enteridis, Bacillus cereus and Escherichia coli and the antimicrobial effect of the combined phenolics was significan…”
BackgroundSIMONETTI, E., ETHUR, M. E., CASTRO, L. C., Kauffmann, C., Giacomin, A. C., Ledur, A., Arossi, K., Pacheco, L. A., Goettert, M. I., Faleiro, D., et al. (2016) · Revista Brasileira de Plantas Medicinais · doi:10.1590/1983-084x/15_005 · Cited by 22
Maheshwari, M., Althubiani, A. S., Abulreesh, H. H., Qais, F. A., Khan, M. S., & Ahmad, I. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.12.008 · Cited by 23
“Most of the researches have shown that whole plant extracts or combinations of compounds are more effective antimicrobials than isolated constituents (Lee and Lee, 2010; Garvey et al., 2011; Ncube et al., 2012; Wang et al., 2014), which are accordance with the results of the present study.”
ResultSharma, R., & Kaur, R. (2020) · PeerJ · doi:10.7717/peerj.8267 · Cited by 21
“Apart from this, DEP stimulated moderate accumulation of phenols in S. polyrhiza which may be due to the activation of acetate and hexose-monophosphate pathway accompanied by releasing bound phenols in stressed plant cells (Lee & Lee, 2010).”
BackgroundOlea europaea as Potential Source of Bioactive Compounds for Diseases Prevention
Talhaoui, N., Trabelsi, N., Taamalli, A., Verardo, V., Gómez‐Caravaca, A. M., Fernández‐Gutiérrez, A., & Arraéz-Román, D. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64057-4.00012-0 · Cited by 24
Türkez, H., & Toğar, B. (2011) · The Journal of Toxicological Sciences · doi:10.2131/jts.36.531 · Cited by 23
“Lee and Lee (2010) reported that the combination of olive leaf extract phenolics possessed antioxidant activity.”
BackgroundTezcan, G., Taşkapılıoğlu, M. Ö., Tunca, B., Bekâr, A., Demirci, H., Kocaelı, H., Aksoy, S. A., Egelí, Ü., Çeçener, G., & Tolunay, Ş. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.022 · Cited by 21
“Other components of OLE that occur in smaller concentrations include oleanolic acid [46], vanillin and vanillic acid, [47], as well as tocopherols and carotene [48].”
BackgroundImproving quality and shelf-life of minced beef using irradiated olive leaf extract
Shalaby, A. R., Anwar, M. M., & Sallam, E. M. (2018) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.13789 · Cited by 21
Cecchi, L., Piazzini, V., D’Ambrosio, M., Luceri, C., Rocco, F. D., Innocenti, M., Vanti, G., Mulinacci, N., & Bergonzi, M. C. (2020) · Molecules · doi:10.3390/molecules25143198 · Cited by 24
“The phytocomplex, that is a whole or partially purified extract of a plant constituent, offers greater efficacy and more advantages than a single isolated ingredient, thanks to synergistic interactions [25,26], and this is also true for the biological effects exerted by phenolic compounds from Olea europaea L.”
BackgroundKaranović, D., Mihailovic‐Stanojevic, N., Miloradović, Z., Ivanov, M., Vajić, U.-J., Grujić-Milanović, J. D., Markovic‐Lipkovski, J., Dekanski, D., & Jovović, D. (2020) · Phytotherapy Research · doi:10.1002/ptr.6920 · Cited by 20
“Also, OLE reduced protein oxidation that could be attributed to antioxidant enzymes protection by OLE against oxidative damage without affecting their protein expressions, indicating to a good radical-scavenging ability of OLE (Lee & Lee, 2010).”
BackgroundKhodaie, L., Delazar, A., Lotfipour, F., & Nazemiyeh, H. (2012) · Europe PMC (PubMed Central) · doi:10.5681/apb.2012.012 · Cited by 20
Esmailidehaj, M., Bajoovand, S., Rezvani, M. E., Sherifidehaj, M., Hafezimoghadam, Z., & Hafizibarjin, Z. (2016) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2016.08.002 · Cited by 20
“animals and human beings including antioxidant [9,11,12], antiinflammatory [13], antidiabetic [7,14], anticancer [15,16], hypoglycemic [17], hypolipidemic [17].”
BackgroundFourati, R., Scopa, A., Ahmed, C. B., Abdallah, F. B., Terzano, R., Gattullo, C. E., Allegretta, I., Galgano, F., Caruso, M. C., & Sofo, A. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.11.041 · Cited by 20
In vitro antifungal properties of Pistacia atlantica and olive extracts on different fungal species
Shialy, Z., Zarrin, M., Sadeghi-Nejad, B., & Naanaie, S. Y. (2015) · Current Medical Mycology · doi:10.18869/acadpub.cmm.1.4.40 · Cited by 20
“In addition, in a previous study, combined phenolics in olive leaf extracts showed similar or better antioxidant and antimicrobial activities than individual phenolic compounds [6].”
BackgroundErragued, R., Braga, M. E. M., Bouaziz, M. A., & Gando‐Ferreira, L. M. (2022) · Separation and Purification Technology · doi:10.1016/j.seppur.2022.121751 · Cited by 19
Mahasneh, Z. M. H., Abdelnour, S. A., Ebrahim, A., Almasodi, A. G. S., Moustafa, M., Alshaharni, M. O., Algopish, U., Téllez‐Isaías, G., & El-Hack, M. E. A. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103348 · Cited by 19
“The antioxidant effects of OL or olive leaf extract have been previously reported (Lee and Lee, 2010).”
BackgroundChanda, S. V., Amrutiya, N., & Rakholiya, K. (2013) · American Journal of Food Technology · doi:10.3923/ajft.2013.173.182 · Cited by 19
Antimicrobial Activities of Essential Oils, Plant Extracts and their Applications in Foods- A Review
Cordery, A., Rao, A. P., & Ravishankar, S. (2018) · Journal of Agriculture and Environmental Sciences · doi:10.15640/jaes.v7n2a9 · Cited by 20
Miraj, S., Pourafzali, S. M., Ahmadabadi, Z. V., & Rafiei, Z. (2020) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_545_18 · Cited by 19
“[9] The antimicrobial and antifungal properties of olive leaf extracts have also been reported.[10] Olive oil is a major source of fat in the Mediterranean diet, which is associated with a reduced incidence of cancer and heart disease.”
Fabiano, A., Migone, C., Cerri, L., Piras, A. M., Mezzetta, A., Maisetta, G., Esin, S., Batoni, G., Stefano, R. D., & Zambito, Y. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122195 · Cited by 18
An overview of the effect of medicinal herbs on pain
Yousofvand, N., & Moloodi, B. (2022) · Phytotherapy Research · doi:10.1002/ptr.7697 · Cited by 18
“The antinociceptive effects of this plant have been reported (Esmaeili-Mahani et al., 2010; Lee & Lee, 2010).”
BackgroundNelson, V. K., Nuli, M. V., Ausali, S., Gupta, S. K., Sanga, V., Mishra, R., Jaini, P. K., Kallam, S. D. M., Sudhan, H. H., Mayasa, V., et al. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106687 · Cited by 18
Özvural, E. B. (2019) · British Poultry Science · doi:10.1080/00071668.2019.1656799 · Cited by 18
“Olive leaf (Olea europea L.) has been used frequently in the Mediterranean countries and islands for thousands of years, particularly in the treatment of diseases such as fever and malaria (Ciafardini and Zullo 2002; Lee et al. 2009; Lee and Lee 2010).”
BackgroundRouibah, Z., Mensour, A. B., Rekik, O., Boumendjel, M., Taïbi, F., Bouaziz, M. A., Feki, A. E., Messarah, M., & Boumendjel, A. (2019) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1679827 · Cited by 18
Bioactive compounds from Nauclea latifolia leaf extracts
Ajayi, O. S., Aderogba, M. A., Akinkunmi, E. O., Obuotor, E. M., & Majinda, R. R. T. (2020) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2020.03.031 · Cited by 18
Marco, A., Ferrer, C. B., Velasco, L., Rodrigo, D., Muguerza, B., & Martínez, A. (2011) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2010.0712 · Cited by 18
“Recently, Lee and Lee (2010) demonstrated that a mixture of polyphenols presented higher inhibition effects than the individual compounds, and the application of a mixture of polyphenols has great potential as a functional food ingredient.”
Oleuropein as a novel anti-diabetic nutraceutical. An overview
Annunziata, G. (2018) · Archives of Diabetes & Obesity · doi:10.32474/ado.2018.01.000113 · Cited by 18
“Several activities were attributed to OLE and its derivatives, including hypoglycemic, cardioprotective, antioxidant, anticancer and anti-obesity activities [18].”
BackgroundVizzarri, V., Ienco, A., Benincasa, C., Perri, E., Pucci, N., Cesari, E., Novellis, C., Rizzo, P., Pellegrino, M., Zaffina, F., et al. (2023) · Biology · doi:10.3390/biology12081141 · Cited by 17
“Interestingly, according to Lee and Lee [71] leaf extracts were more effective than single phenols, suggesting a synergistic effect of the phenolic component.”
BackgroundWu, B., Li, X., Wang, R., Liu, L., Huang, D., Ye, L., & Wang, Z. (2024) · Small · doi:10.1002/smll.202406441 · Cited by 18
Prevete, G., Donati, E., Ruggiero, A. P., Fardellotti, S., Lilla, L., Ramundi, V., Nicoletti, I., Mariani, F., & Mazzonna, M. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c13302 · Cited by 17
Vural, N., Çavuldak, Ö. A., Kenar, A., & Akay, M. A. (2019) · Separation Science and Technology · doi:10.1080/01496395.2019.1606014 · Cited by 15
Lee, S. J., Kim, H. S., Eom, J. S., Choi, Y., Jo, S. U., Chu, G. M., Lee, Y., Seo, J., Kim, K.-H., & Lee, S. S. (2021) · Animals · doi:10.3390/ani11072008 · Cited by 22
“Although many studies have investigated the antibacterial activity of OLs, the mechanism of action of the antimicrobial activity has not been fully elucidated [40].”
Background
Metadata
- Authors
- Lee, O.-H., & Lee, B.-Y.
- Affiliations
- CHA University (KR)
- Corresponding author
- Lee, Ok-Hwan
- Lee, Boo-Yong
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 101
- Issue
- 10
- Pages
- 3751-3754
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2055194600
- Cited by
- 382
- References
- 16
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 21 · 2023: 21 · 2022: 25 · 2021: 38 · 2020: 43 · 2019: 36 · 2018: 29 · 2017: 26 · 2016: 30 · 2015: 23 · 2014: 22 · 2013: 13 · 2012: 21
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- olive leaf extract, Olea europaea, phenolic compounds, antioxidant activity, antimicrobial activity, free radical scavenging, superoxide dismutase-like activity, oleuropein, caffeic acid, agricultural waste valorization, bioactive compounds
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Microbial Sensitivity Tests, Plant Extracts, Superoxide Dismutase, Plant Leaves, Olea
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