Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects
Open accessAbstract
Biochemical conversion of lignocellulosic feedstocks to advanced biofuels and other commodities through a sugar-platform process involves a pretreatment step enhancing the susceptibility of the cellulose to enzymatic hydrolysis. A side effect of pretreatment is formation of lignocellulose-derived by-products that inhibit microbial and enzymatic biocatalysts. This review provides an overview of the formation of inhibitory by-products from lignocellulosic feedstocks as a consequence of using different pretreatment methods and feedstocks as well as an overview of different strategies used to alleviate problems with inhibitors. As technologies for biorefining of lignocellulose become mature and are transferred from laboratory environments to industrial contexts, the importance of management of inhibition problems is envisaged to increase as issues that become increasingly relevant will include the possibility to use recalcitrant feedstocks, obtaining high product yields and high productivity, minimizing the charges of enzymes and microorganisms, and using high solids loadings to obtain high product titers.
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Saccharification of accumulated sugars to monomeric units is needed because fermenting microorganisms can only convert fermentable forms of sugars into ethanol.
“The next step is the saccharification of the accumulated sugars to monomeric units, as fermenting microorganisms can only convert the fermentable forms of sugars (disaccharides and monosaccharides, usually hexoses and pentoses) into ethanol [104].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [104]
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- Authors
- Jönsson, L. J., & Martín, C.
- Affiliations
- Umeå University (SE)
- Corresponding author
- Jönsson, Leif J.
- ORCID
- Jönsson, Leif J.
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 199
- Pages
- 103-112
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2148269983
- Cited by
- 2,147
- References
- 78
- Citations by year
- 2026: 172 · 2025: 173 · 2024: 161 · 2023: 187 · 2022: 233 · 2021: 288 · 2020: 250 · 2019: 258 · 2018: 221 · 2017: 145 · 2016: 57 · 2015: 2
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Bioresource Technology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Funders
- Vetenskapsrådet (621-2011-4388)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Keywords
- lignocellulosic biomass pretreatment, enzymatic hydrolysis, advanced biofuels, biorefining, high solid loading, enzyme cost, microbial inhibition
- MeSH terms
- Carbohydrates, Lignin, Refuse Disposal, Bioreactors, Biofuels
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