Opportunities to overcome the current limitations and challenges for efficient microbial production of optically pure lactic acid
Abstract
There has been growing interest in the microbial production of optically pure lactic acid due to the increased demand for lactic acid-derived environmentally friendly products, for example biodegradable plastic (poly-lactic acid), as an alternative to petroleum-derived materials. To maximize the market uptake of these products, their cost should be competitive and this could be achieved by decreasing the production cost of the raw material, that is, lactic acid. It is of great importance to isolate and develop robust and highly efficient microbial lactic acid producers. Alongside the fermentative substrate and concentration, the yield and productivity of lactic acid are key parameters and major factors in determining the final production cost of lactic acid. In this review, we will discuss the current limitations and challenges for cost-efficient microbial production of optically pure lactic acid. The main obstacles to effective fermentation are the use of food resources, indirect utilization of polymeric sugars, sensitivity to inhibitory compounds released during biomass treatments, substrate inhibition, decreased lactic acid yield and productivity, inefficient utilization of mixed sugars, end product inhibition, increased use of neutralizing agents, contamination problems, and decreased optical purity of lactic acid. Furthermore, opportunities to address and overcome these limitations, either by fermentation technology or metabolic engineering approaches, will be introduced and discussed.
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Lactic acid is traditionally produced by the fermentation of sugars and conversion into monomers after hydrolysis.
“Although lactic acid, the monomer of polylactic acid, can be easily obtained in nature, it is traditionally produced by the fermentation of sugars and conversion into monomers after hydrolysis [8].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [8]
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Synthesis and Biological Application of Polylactic Acid
Li, G., Zhao, M., Xu, F., Yang, B., Li, X., Meng, X., Teng, L., Sun, F., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25215023 · Cited by 492 · see citing works
“Although lactic acid, the monomer of polylactic acid, can be easily obtained in nature, it is traditionally produced by the fermentation of sugars and conversion into monomers after hydrolysis [8].”
Background
- Authors
- Abdel-Rahman, M. A., & Sonomoto, K.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Sonomoto, Kenji
- ORCID
- Sonomoto, Kenji
- Venue
- Journal of Biotechnology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 236
- Pages
- 176-192
- ISSN
- 0168-1656 (ISSN-L)
- OpenAlex
- W2514492826
- Cited by
- 236
- References
- 139
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 20 · 2023: 26 · 2022: 31 · 2021: 37 · 2020: 25 · 2019: 24 · 2018: 21 · 2017: 16 · 2016: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- lactic acid fermentation, polylactic acid, biodegradable plastics, substrate inhibition, product inhibition, optical purity, metabolic engineering, fermentation contamination, production cost reduction
- MeSH terms
- Fermentation, Lactobacillus, Lignin, Stereoisomerism, Biomass, Bioreactors, Lactic Acid, Microalgae, Metabolic Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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