Cited by 236Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionbiodegradable polymer synthesis and properties

Opportunities to overcome the current limitations and challenges for efficient microbial production of optically pure lactic acid

Abdel-Rahman, Mohamed Ali, Sonomoto, Kenji·2016·Journal of Biotechnology

Abstract

There has been growing interest in the microbial production of optically pure lactic acid due to the increased demand for lactic acid-derived environmentally friendly products, for example biodegradable plastic (poly-lactic acid), as an alternative to petroleum-derived materials. To maximize the market uptake of these products, their cost should be competitive and this could be achieved by decreasing the production cost of the raw material, that is, lactic acid. It is of great importance to isolate and develop robust and highly efficient microbial lactic acid producers. Alongside the fermentative substrate and concentration, the yield and productivity of lactic acid are key parameters and major factors in determining the final production cost of lactic acid. In this review, we will discuss the current limitations and challenges for cost-efficient microbial production of optically pure lactic acid. The main obstacles to effective fermentation are the use of food resources, indirect utilization of polymeric sugars, sensitivity to inhibitory compounds released during biomass treatments, substrate inhibition, decreased lactic acid yield and productivity, inefficient utilization of mixed sugars, end product inhibition, increased use of neutralizing agents, contamination problems, and decreased optical purity of lactic acid. Furthermore, opportunities to address and overcome these limitations, either by fermentation technology or metabolic engineering approaches, will be introduced and discussed.

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Crossref · 10.1016/j.jbiotec.2016.08.008

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  • Lactic acid is traditionally produced by the fermentation of sugars and conversion into monomers after hydrolysis.

    “Although lactic acid, the monomer of polylactic acid, can be easily obtained in nature, it is traditionally produced by the fermentation of sugars and conversion into monomers after hydrolysis [8].”

    From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [8]

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Authors
Abdel-Rahman, M. A., & Sonomoto, K.
Affiliations
Kyushu University (JP)
Corresponding author
Sonomoto, Kenji
Venue
Journal of Biotechnology
Publisher
Elsevier BV
Published
2016-10
Volume
236
Pages
176-192
ISSN
0168-1656 (ISSN-L)
OpenAlex
W2514492826
Cited by
236
References
139
Citations by year
2026: 18 · 2025: 17 · 2024: 20 · 2023: 26 · 2022: 31 · 2021: 37 · 2020: 25 · 2019: 24 · 2018: 21 · 2017: 16 · 2016: 1
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
lactic acid fermentation, polylactic acid, biodegradable plastics, substrate inhibition, product inhibition, optical purity, metabolic engineering, fermentation contamination, production cost reduction
MeSH terms
Fermentation, Lactobacillus, Lignin, Stereoisomerism, Biomass, Bioreactors, Lactic Acid, Microalgae, Metabolic Engineering

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