The DOI matches its Crossref record; 98 of the 100 references it cites were found in a registry or an index.
Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–A review
Abstract
Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.
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In the citing paper
“Moreover, nutrient limitation have been shown to further increase the carbohydrate and lipid content in microalgae (Chen et al., 2017;Nagappan et al., 2019aNagappan et al., , 2019b)).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
In the citing paper
“Both whole cell H. pluvialis and extracted astaxanthin are used as feed additives (1.5% in range) in the aquaculture industry (Chen et al., 2017).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
In the citing paper
“Pigments like carotenoids, which give microalgal functional properties like antioxidant activity to fishes, are easily degraded (Chen et al., 2017).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
Citations
Cites
Chisti, Y. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.02.001 · Cited by 9,524
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Microalgae biorefinery: High value products perspectives
Chew, K. W., Yap, J. Y., Show, P. L., Suan, N. H., Juan, J. C., Ling, T. C., Lee, D.-J., & Chang, J.-S. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.01.006 · Cited by 1,336
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Microalgae biofuels: A critical review of issues, problems and the way forward
Lam, M. K., & Lee, K. T. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.11.008 · Cited by 960
Juneja, A., Ceballos, R., & Murthy, G. (2013) · Energies · doi:10.3390/en6094607 · Cited by 835
Lipid accumulation and CO2 utilization of Nannochloropsis oculata in response to CO2 aeration
Chiu, S.-Y., Kao, C.-Y., Tsai, M.-T., Ong, S.-C., Chen, C.-H., & Lin, C.-S. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2008.06.061 · Cited by 825
Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 747
Cited by
Sorted by citations
Shahid, A., Malik, S., Zhu, H., Xu, J., Nawaz, M. Z., Nawaz, S., Alam, M. A., & Mehmood, M. A. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135303 · Cited by 457
Sustainability of direct biodiesel synthesis from microalgae biomass: A critical review
Goh, B. H. H., Ong, H. C., Cheah, M. Y., Chen, W., Yu, K. L., & Mahlia, T. M. I. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.02.012 · Cited by 406
Potential of microalgae as a sustainable feed ingredient for aquaculture
Nagappan, S., Das, P., AbdulQuadir, M., Thaher, M., Khan, S., Mahata, C., Al-Jabri, H., Vatland, A. K., & Kumar, G. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.09.003 · Cited by 364
Minimizing carbon footprint via microalgae as a biological capture
Onyeaka, H. N., Miri, T., Obileke, K. C., Hart, A., Anumudu, C. K., & Al-Sharify, Z. T. (2021) · Carbon Capture Science & Technology · doi:10.1016/j.ccst.2021.100007 · Cited by 345
Recent developments and key barriers to advanced biofuels: A short review
Oh, Y., Hwang, K.-R., Kim, C., Kim, J. R., & Lee, J. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.02.089 · Cited by 327
Metadata
- Authors
- Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Dalian University of Technology (CN)
- National Cheng Kung University (TW)
- Corresponding author
- Zhao, Xinqing
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 244
- Issue
- Pt 2
- Pages
- 1198-1206
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2620135990
- Cited by
- 346
- References
- 100
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 27 · 2023: 37 · 2022: 48 · 2021: 58 · 2020: 50 · 2019: 50 · 2018: 15 · 2017: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21536006)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- microalgae, lipid production, stress tolerance, nitrogen starvation, high salinity, microalgae biorefinery, genetic engineering of microalgae, multi-omics, synthetic biology, value-added products, metabolite synthesis
- MeSH terms
- Biotechnology, Lipids, Stress, Physiological, Biofuels, Microalgae
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