Stresses as First-Line Tools for Enhancing Lipid and Carotenoid Production in Microalgae
Open accessAbstract
Microalgae can produce high-value-added products such as lipids and carotenoids using light or sugars, and their biosynthesis mechanism can be triggered by various stress conditions. Under nutrient deprivation or environmental stresses, microalgal cells accumulate lipids as an energy-rich carbon storage battery and generate additional amounts of carotenoids to alleviate the oxidative damage induced by stress conditions. Though stressful conditions are unfavorable for biomass accumulation and can induce oxidative damage, stress-based strategies are widely used in this field due to their effectiveness and economy. For the overproduction of different target products, it is required and meaningful to deeply understand the effects and mechanisms of various stress conditions so as to provide guidance on choosing the appropriate stress conditions. Moreover, the underlying molecular mechanisms under stress conditions can be clarified by omics technologies, which exhibit enormous potential in guiding rational genetic engineering for improving lipid and carotenoid biosynthesis.
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Primary carotenoids associated with growth are degraded under stress.
“Although studies have shown that nutrient deprivation can increase carotenoid production [66,67], it is also known that the primary carotenoids which are associated with growth are degraded under stress [68,69].”
From Response to nutrient variation on lipid productivity in green microalgae captured using second derivative FTIR and Raman spectroscopy (2022) · cites this paper as [68]
Primary carotenoids are growth coupled metabolites that can degrade under nutrient stress.
“As known, that primary carotenoids are growth coupled metabolites that can degrade under nutrient stress [68].”
From Response to nutrient variation on lipid productivity in green microalgae captured using second derivative FTIR and Raman spectroscopy (2022) · cites this paper as [68]
Studies have shown that primary carotenoids coupled with growth metabolites degrade with stress, while secondary carotenoids increase with lipid accumulation under stress.
“Studies have shown that primary carotenoids that are coupled with growth metabolites degrade with stress, on the other hand, secondary carotenoids increase with lipid accumulation under stress [68,70].”
From Response to nutrient variation on lipid productivity in green microalgae captured using second derivative FTIR and Raman spectroscopy (2022) · cites this paper as [68]
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- Authors
- Shi, T.-Q., Wang, L.-R., Zhang, Z.-X., Sun, X.-M., & Huang, H.
- Affiliations
- Nanjing Normal University (CN)
- Corresponding author
- Sun, Xiao-Man
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2020-07-23
- Volume
- 8
- Pages
- 610-610
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC7396513
- OpenAlex
- W3028285691
- Cited by
- 182
- References
- 85
- Citations by year
- 2026: 43 · 2025: 41 · 2024: 34 · 2023: 27 · 2022: 23 · 2021: 14
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- microalgae, lipid production, carotenoid production, nutrient deprivation, oxidative stress, lipid accumulation, carotenoid biosynthesis, genetic engineering, omics technologies
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