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Cited by 267

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Microneedle-based biosensor for minimally-invasive lactate detection

Bollella, Paolo, Sharma, Sanjiv, Cass, Anthony Edward George, Antiochia, Riccarda·2019·Biosensors and Bioelectronics
DOI 10.1016/j.bios.2018.08.010
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Abstract

Here we report the first mediated microneedles-based biosensor for minimally invasive continuous sensing of lactate in the dermal interstitial fluid (ISF). To further demonstrate the capability of microneedle arrays as second generation biosensors we have functionalized gold microneedles with nanocarbons at which mediated electron transfer of lactate oxidase takes place. In particular the gold surface of the microneedles electrode has been modified in 3 subsequent steps: i) electrodeposition of Au-multiwalled carbon nanotubes (MWCNTs); ii) electropolymerization of the mediator, methylene blue (MB); iii) immobilization of the enzyme lactate oxidase (LOX) by drop-casting procedure. The resulting microneedle-based LOX biosensor displays an interference-free lactate detection without compromising its sensitivity, stability, selectivity and response time. The performance of the microneedle array, second generation biosensor for lactate detection was assessed in artificial interstitial fluid and in human serum, both spiked with lactate. The results reveal that the new microneedles lactate sensor holds interesting promise for the development of a real-time monitoring device to be used in sport medicine and clinical care.

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Metadata

Authors
Bollella, P., Sharma, S., Cass, A. E. G., & Antiochia, R.
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2019-01
Volume
123
Pages
152-159
ISSN
0956-5663 (ISSN-L)
DOI
10.1016/j.bios.2018.08.010
OpenAlex
W2885161568
Cited by
267
References
51
FWCI
7.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Microneedle-based biosensor for minimally-invasive lactate detection. https://app.cochat.ai/papers/10.1016/j.bios.2018.08.010
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Bollella, P., Sharma, S., Cass, A. E. G., & Antiochia, R. (2019). Microneedle-based biosensor for minimally-invasive lactate detection. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2018.08.010

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