The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe–Nx moieties hosted by MOF derived porous carbon
Open accessAbstract
Due to robustness, easy large-scale preparation and low cost, nanomaterials with enzyme-like characteristics (defined as ‘nanozymes’) are attracting increasing interest for various applications. However, most of currently developed nanozymes show much lower activity in comparison with natural enzymes, and the deficiency greatly hinders their use in sensing and biomedicine. Single-atom catalysts (SACs) offer the unique feature of maximum atomic utilization, providing a potential pathway to improve the catalytic activity of nanozymes. Herein, we propose a Fe-N-C single-atom nanozyme (SAN) that exhibits unprecedented peroxidase-mimicking activity. The SAN consists of atomically dispersed Fe─Nx moieties hosted by metal–organic frameworks (MOF) derived porous carbon. Thanks to the 100% single-atom active Fe dispersion and the large surface area of the porous support, the Fe-N-C SAN provided a specific activity of 57.76 U mg−1, which was almost at the same level as natural horseradish peroxidase (HRP). Attractively, the SAN presented much better storage stability and robustness against harsh environments. As a proof-of-concept application, highly sensitive biosensing of butyrylcholinesterase (BChE) activity using the Fe-N-C SAN as a substitute for natural HRP was further verified.
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Cites
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Cited by
Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Self-citationSynthesis Strategies, Catalytic Applications, and Performance Regulation of Single‐Atom Catalysts
Xi, J., Jung, H. S., Xu, Y., Xiao, F., Bae, J. W., & Wang, S. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008318 · Cited by 282
Zhang, S., Li, Y., Sun, S., Liu, L., Mu, X., Liu, S., Jiao, M., Chen, X., Chen, K., Ma, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32411-z · Cited by 280
Metadata
- Authors
- Niu, X., Shi, Q., Zhu, W., Liu, D., Tian, H., Fu, S., Cheng, N., Li, S., Smith, J. N., Du, D., & Lin, Y.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 142
- Pages
- 111495
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2959158634
- Cited by
- 292
- References
- 43
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Niu, X., Shi, Q., Zhu, W., Liu, D., Tian, H., Fu, S., Cheng, N., Li, S., Smith, J. N., Du, D., & Lin, Y. (2019). Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe–Nx moieties hosted by MOF derived porous carbon. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2019.111495
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