Cited by 756Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Gene regulatory network inference: Data integration in dynamic models—A review

Hecker, Michael, Lambeck, Sandro, Toepfer, Susanne, van Someren, Eugene, Guthke, Reinhard·2009·Biosystems

Abstract

Systems biology aims to develop mathematical models of biological systems by integrating experimental and theoretical techniques. During the last decade, many systems biological approaches that base on genome-wide data have been developed to unravel the complexity of gene regulation. This review deals with the reconstruction of gene regulatory networks (GRNs) from experimental data through computational methods. Standard GRN inference methods primarily use gene expression data derived from microarrays. However, the incorporation of additional information from heterogeneous data sources, e.g. genome sequence and protein-DNA interaction data, clearly supports the network inference process. This review focuses on promising modelling approaches that use such diverse types of molecular biological information. In particular, approaches are discussed that enable the modelling of the dynamics of gene regulatory systems. The review provides an overview of common modelling schemes and learning algorithms and outlines current challenges in GRN modelling.

Integrity signals

Registry

Crossref · 10.1016/j.biosystems.2008.12.004

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  • Integration of multiple data types increases the accuracy of the resulting predictions.

    “Overall, integration of multiple data types increases the accuracy of the resulting predictions [13, 147].”
  • A focus on TFs is rarely sufficient, and integration of multiple data types is often required to increase the accuracy and usefulness of the resulting networks.

    “However, a focus on TFs is rarely sufficient, and integration of multiple data types is often required to increase the accuracy and usefulness of the resulting networks [13, 147].”

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Authors
Hecker, M., Lambeck, S., Toepfer, S., van Someren, E., & Guthke, R.
Affiliations
  • Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
  • BioControl Jena (Germany) (DE)
Corresponding author
Guthke, Reinhard
Venue
Biosystems
Publisher
Elsevier BV
Published
2009-04
Volume
96
Issue
1
Pages
86-103
ISSN
0303-2647 (ISSN-L)
OpenAlex
W1963522244
Cited by
755
References
132
Citations by year
2026: 8 · 2025: 22 · 2024: 37 · 2023: 22 · 2022: 30 · 2021: 33 · 2020: 32 · 2019: 48 · 2018: 63 · 2017: 50 · 2016: 62 · 2015: 71 · 2014: 56 · 2013: 62 · 2012: 61
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Locations
  • Biosystems (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung (0313078D, 0313692D)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
gene regulatory network inference, data integration, gene expression microarrays, genome sequence data, genome-wide data, learning algorithms
MeSH terms
Computer Simulation, Database Management Systems, Gene Expression Regulation, Models, Biological, Signal Transduction, Systems Integration, Proteome, Gene Expression Profiling, Databases, Protein, Systems Biology

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