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A Metabolic Mechanism for Anaesthetic Suppression of Cortical Synaptic Function in Mouse Brain Slices—A Pilot Investigation

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Oxidative stress, inflammation and the metabolic EpOME are associated with occupational exposure to isoflurane

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Are “GABAergic” Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro

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Deficiency of Mitochondrial Functions and Peroxidation of Frontoparietal Cortex Enhance Isoflurane Sensitivity in Aging Mice

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Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice

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Brain-penetrant microtubule-stabilizer epothilone B delays isoflurane-induced unconsciousness in mice

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Changes in Acupuncture‐Induced Specific Acupoint Neurotransmitters are Possibly Related to Their Physiological Functions in Rats

Nguyen, H. T. M., Lee, D., Liu, C., & Hsieh, C. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/4849528 · Cited by 5 · see citing works

Impact of dietary ketosis on volatile anesthesia toxicity in a model of Leigh syndrome

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Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry

Beitchman, J. A., Krishna, G., Bromberg, C. E., & Thomas, T. C. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00822-3 · Cited by 5 · see citing works

Metabolomics and Whole-Exome Sequencing in Patients with Differential Sensitivity to Sevoflurane: A Protocol for a Prospective Observational Trial

Wei, Y., Zhang, D., & Zuo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.621159 · Cited by 4 · see citing works

Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles

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CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice

Xu, Q., Xiong, J., Xu, L., Wu, Y., Li, M., Li, Q., Jiang, T., Luo, A., & Zhang, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824871 · Cited by 4 · see citing works

Protective effect of isoflurane preconditioning on neurological function in rats with HIE

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Contributions of synaptic and astrocyte physiology to the anaesthetised encephalogram revealed using a computational model

Hadjipavlou, G., Warnaby, C. E., FitzGerald, J. J., & SLEIGH, J. W. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.01.034 · Cited by 4 · see citing works

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

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Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

Jung, S., Ramirez, J., Sedensky, M. M., & Morgan, P. G. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005910 · Cited by 3 · see citing works

NDUFA10 ‐Mediated ATP Reduction in Medial Prefrontal Cortex Exacerbates Burst Suppression in Aged Mice

Zhang, H., Fang, P., Qiu, G., Wang, D., Zhang, J., Yang, Z., Liu, H., Shen, Q., & Liu, X. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70453 · Cited by 3 · see citing works

Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets

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Xenobiotics Triggering Acute Intermittent Porphyria and Their Effect on Mouse Brain Respiratory Complexes

Zuccoli, J. R., Martínez, M. D. C., Vallecorsa, P., & Buzaleh, A. M. (2024) · Journal of Xenobiotics · doi:10.3390/jox14010019 · Cited by 2 · see citing works

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

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Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice

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Isoflurane titration improves detection of hippocampal lactate by 1H-MRS

Frame, A. K., Khazaee, R., Courchesne, M. C. J., Wilson, S. K., Bellyou, M., Li, A. X., Bartha, R., & Cumming, R. C. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00305 · Cited by 1 · see citing works

Bioblasts, anaesthesia, and power failure: rein in the excitement

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Long-term effects of anesthesia on the brain: an update on neurotoxicity

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Protective effect of isoflurane preconditioning on neurological function in rats with HIEPreprint

Wang, Y., Chen, T., Huangfu, L., Zhou, H., Xiao, Q., Xu, F., Xiong, L., & Wang, T. (2022) · Research Square · doi:10.21203/rs.3.rs-1561903/v1

Faculty Opinions recommendation of Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice.

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Faculty Opinions recommendation of Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice.

Mulkey, D. K., & Cleary, C. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734986474.793573875

Protective effect of isoflurane preconditioning on neurological function in rats with HIEPreprint

Wang, Y., Chen, T., Huangfu, L., Zhou, H., Xiao, Q., Xu, F., Xiong, L., & Wang, T. (2022) · Research Square · doi:10.21203/rs.3.rs-1561903/v2

The Nature and Dynamics of General Anesthetics SitesPreprint

Katz, Y., & Hoffman, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4119220

Potassium Leak Channels and Mitochondrial Complex I Interact in Glutamatergic Interneurons of the Mouse Spinal Cord

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In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility

Dubey, P., Datta, R., Eckenhoff, R. G., & Bedell, V. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0316959

Additional file 1 of Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study

Wei, Y., Zhang, D., Liu, J., Ou, M., Liang, P., Zuo, Y., & Zhou, C. (2021) · Figshare · doi:10.6084/m9.figshare.14234986

Additional file 1 of Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy

Eun, J. D., Jimenez, H. T., Adrien, L. R., Wolin, A., Marambaud, P., Davies, P., & Koppel, J. L. (2022) · Figshare · doi:10.6084/m9.figshare.20347460

Immunomodulatory effects of anesthetic drugs and their implications in neurodegenerative disease progression

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Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning

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Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization

Kordas, B. (2026) · Cells · doi:10.3390/cells15161486

A simple, anesthesia-free infusion technique for in vivo metabolic tracing

Kim, Y., Caldwell, S., Long, M., ABRAHAMS, D., Baldwin, M. W., & DeNicola, G. M. (2026) · Science Advances · doi:10.1126/sciadv.aeg1157

Isoflurane inhibition of endocytosis is an anesthetic mechanism of action

Jung, S., Zimin, P. I., Woods, C. B., Kayser, E., Haddad, D., Reczek, C. R., Nakamura, K., Ramirez, J., Sedensky, M. M., & Morgan, P. G. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.037 · Cited by 62 · see citing works

Mitochondrial Effects on Anesthetic Sensitivity and Anesthetic Induced Neurodegeneration

Zimin, P. I., Sedensky, M. M., & Morgan, P. G. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.033

Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function

Zimin, P. I., Woods, C. B., Quintana, A., Ramirez, J., Morgan, P. G., & Sedensky, M. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.020 · Cited by 40 · see citing works

Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

Jung, S., Ramirez, J., Sedensky, M. M., & Morgan, P. G. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005910 · Cited by 3 · see citing works

Volatile anaesthetics depolarize neural mitochondria by inhibiton of the electron transport chain

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