Effect of Anesthetics on Mitochondrial Function
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GPCRs are a major drug target associated with one third of all pharmaceuticals.
“Understanding the mechanism or mechanisms of ligand-GPCR interaction is particularly important due to the fact that GPCRs are a major drug target associated with one third of all pharmaceuticals 103,115 .”
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“Studies by Cohen (122) in the 1970s, demonstrated that volatile anesthetics mildly depressed oxidative phosphorylation.”
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“In addition, the anesthetic nitrous oxide is released into atmosphere in large amounts from soils and oceans.(1-53) Unfortunately, the authors of these papers fail to mention and discuss the fact that many of”
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Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I
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“Inhibition of mitochondrial function has long been acknowledged as a toxic effect of general anesthetics, even before mitochondrial function was fully understood (Cohen 1973).”
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- Authors
- Cohen, P. J.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Cohen, Peter J.
- Venue
- Anesthesiology
- Published
- 1973-08-01
- Volume
- 39
- Issue
- 2
- Pages
- 153-164
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W1996551678
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- anesthetic agents, mitochondrial function, mitochondrial dysfunction
- MeSH terms
- Anesthesia, Inhalation, Anesthetics, Animals, Barbiturates, Dogs, Electron Transport, Guinea Pigs, Halothane, Humans, Malignant Hyperthermia, Mitochondria, NAD, NADH, NADPH Oxidoreductases, Oxidative Phosphorylation, Oxygen Consumption, Succinate Dehydrogenase, Uncoupling Agents, Rats
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