Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2 diabetes mellitus: a meta-analysis
Open accessAbstract
Background Physical exercise has been used to mitigate the metabolic effects of diabetes mellitus. Objective To evaluate the effect of resistance exercise when compared to aerobic exercise without insulin therapy on metabolic and clinical outcomes in patients with type 2 diabetes mellitus. Methods Papers were searched on the databases MEDLINE/PubMed, CINAHL, SPORTDiscus, LILACS, and SCIELO, without language or date of publication limits. Clinical trials that compared resistance exercise to aerobic exercise in adults with type 2 diabetes mellitus who did not use insulin therapy were included. The quality of evidence and risk of bias were assessed using the GRADE system and the Cochrane Risk of Bias tool, respectively. Meta-analysis was also used, whenever possible. Two reviewers extracted the data independently. Eight eligible articles were included in this study, with a total of 336 individuals, with a mean age of 48-58 years. The protocols of aerobic and resistance exercise varied in duration from eight to 22 weeks, 30-60min/day, three to five times/week. Results Overall the available evidence came from a very low quality of evidence and there was an increase in Maximal oxygen consumption (mean difference: -2.86; 95% CI: -3.90 to -1.81; random effect) for the resistance exercise and no difference was found in Glycated hemoglobin, Body mass index, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, triglycerides, and total cholesterol. Conclusions Resistance exercise appears to be more effective in promoting an increase in Maximal oxygen consumption in protocols longer than 12 weeks and there is no difference in the control of glycemic and lipid levels between the two types of exercise.
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A meta-analysis on type 2 diabetic patients describes higher maximum O2 consumption with resistance exercise, but no differences in BMI, glycemic control and lipid profile.
“An MA carried out on type 2 diabetic patients describes a higher maximum O2 consumption with resistance exercise, but no differences were found in BMI, glycemic control and lipid profile [31].”
From A systematic review and meta-analysis of exercise-based intervention to prevent gestational diabetes in women with overweight or obesity (2025) · cites this paper as [31]
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- Authors
- Nery, C., Moraes, S. R. A. D., Novaes, K. A., Bezerra, M. A., Silveira, P. V. D. C., & Lemos, A.
- Affiliations
- Universidade Federal de Pernambuco (BR)
- Universidade Federal do Ceará (BR)
- Venue
- Brazilian Journal of Physical Therapy
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 21
- Issue
- 6
- Pages
- 400-415
- ISSN
- 1413-3555 (ISSN-L)
- PMC
- PMC5693273
- OpenAlex
- W2732160435
- Cited by
- 95
- References
- 47
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 13 · 2023: 34 · 2022: 13 · 2021: 8 · 2020: 6 · 2019: 2 · 2018: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brazilian Journal of Physical Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Restructuring and Expansion of Federal Universities (REUNI)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- resistance training, aerobic exercise, type 2 diabetes, insulin therapy, VO2max, HbA1c, glycemic control, lipid profile, body mass index, exercise training duration
- MeSH terms
- Diabetes Mellitus, Type 2, Exercise Therapy, Humans, Insulin, Oxygen Consumption, Exercise, Resistance Training
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