The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Transfusion-related immunomodulation (TRIM): An update
Open accessAbstract
Allogeneic blood transfusion (ABT)-related immunomodulation (TRIM) encompasses the laboratory immune aberrations that occur after ABT and their established or purported clinical effects. TRIM is a real biologic phenomenon resulting in at least one established beneficial clinical effect in humans, but the existence of deleterious clinical TRIM effects has not yet been confirmed. Initially, TRIM encompassed effects attributable to ABT by immunomodulatory mechanisms (e.g., cancer recurrence, postoperative infection, or virus activation). More recently, TRIM has also included effects attributable to ABT by pro-inflammatory mechanisms (e.g., multiple-organ failure or mortality). TRIM effects may be mediated by: (1) allogeneic mononuclear cells; (2) white-blood-cell (WBC)-derived soluble mediators; and/or (3) soluble HLA peptides circulating in allogeneic plasma. This review categorizes the available randomized controlled trials based on the inference(s) that they permit about possible mediator(s) of TRIM, and examines the strength of the evidence available for relying on WBC reduction or autologous transfusion to prevent TRIM effects.
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1 retracted
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Villanueva, C., Colomo, A., Bosch, A., Concepción, M., Hernandez-Gea, V., Aracil, C., Graupera, I., Poca, M., Alvarez-Urturi, C., Gordillo, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211801 · Cited by 1,735
Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology
Kozek-Langenecker, S. A., Afshari, A., Albaladejo, P., Santullano, C. A. A., De Robertis, E., Filipescu, D. C., Fries, D., Görlinger, K., Haas, T., Imberger, G., et al. (2013) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e32835f4d5b · Cited by 909
Vamvakas, E. C., & Blajchman, M. A. (2009) · Blood · doi:10.1182/blood-2008-10-167643 · Cited by 621
Self-citation2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery
Pagano, D., Milojevic, M., Meesters, M. I., Benedetto, U., Bolliger, D., von Heymann, C., Jeppsson, A., Koster, A., Osnabrugge, R. L., Ranucci, M., et al. (2018) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx325 · Cited by 481
2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery
Boer, C., Meesters, M. I., Milojevic, M., Benedetto, U., Bolliger, D., von Heymann, C., Jeppsson, A., Koster, A., Osnabrugge, R. L., Ranucci, M., et al. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.06.026 · Cited by 466
Metadata
- Authors
- Vamvakas, E. C., & Blajchman, M. A.
- Venue
- Blood Reviews
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 21
- Issue
- 6
- Pages
- 327-348
- ISSN
- 0268-960X (ISSN-L)
- OpenAlex
- W2050065318
- Cited by
- 664
- References
- 98
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
