Information transfer by exosomes: A new frontier in hematologic malignancies

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works

Exosomes – vesicular carriers for intercellular communication

Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,351 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Classification, Functions, and Clinical Relevance of Extracellular Vesicles

van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,756 · see citing works

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works

The Nature and Significance of Platelet Products in Human Plasma

Wolf, P. (1967) · British Journal of Haematology · doi:10.1111/j.1365-2141.1967.tb08741.x · Cited by 1,725 · see citing works

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Wurdinger, T. D., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,648 · see citing works

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

Tetraspanins in Extracellular Vesicle Formation and Function

Andreu, Z., & Yáñez-Mó, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00442 · Cited by 1,401 · see citing works

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123 · see citing works

Hypoxic enhancement of exosome release by breast cancer cells

King, H. W., Michael, M. Z., & Gleadle, J. M. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-421 · Cited by 1,045 · see citing works

Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

Conde, I. D., Shrimpton, C. N., Thiagarajan, P., & López, J. A. (2005) · Blood · doi:10.1182/blood-2004-03-1095 · Cited by 1,030 · see citing works

Active Wnt proteins are secreted on exosomes

Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Chalmin, F., Ladoire, S., Mignot, G., Vincent, J., Bruchard, M., Rémy-Martin, J.-P., Boireau, W., Rouleau, A., Simon, B., Lanneau, D., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40483 · Cited by 999 · see citing works

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Christianson, H. C., Svensson, K. J., van Kuppevelt, T. H., Li, J.-P., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304266110 · Cited by 903 · see citing works

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

Grange, C., Tapparo, M., Collino, F., Vitillo, L., Damasco, C., Deregibus, M. C., Tetta, C., Bussolati, B., & Camussi, G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0241 · Cited by 848 · see citing works

Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K., Tai, Y., Reagan, M. R., Azab, F., Flores, L. M., Campigotto, F., Weller, E. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66517 · Cited by 794 · see citing works

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

Shao, H., Chung, J., Balaj, L., Charest, A., Bigner, D. D., Carter, B. S., Hochberg, F. H., Breakefield, X. O., Weissleder, R., & Lee, H. (2012) · Nature Medicine · doi:10.1038/nm.2994 · Cited by 757 · see citing works

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

Peinado, H., Lavotshkin, S., & Lyden, D. C. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.01.002 · Cited by 657 · see citing works

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 635 · see citing works

Induction of myeloid‐derived suppressor cells by tumor exosomes

Xiang, X., Poliakov, A., Liu, C., Liu, Y., Deng, Z., Wang, J., Cheng, Z., Shah, S. V., Wang, G., Zhang, L., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.24249 · Cited by 597 · see citing works

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., & Théry, C. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18397 · Cited by 581 · see citing works

EVpedia: an integrated database of high‐throughput data for systemic analyses of extracellular vesicles

Kim, D., Kang, B., Kim, O. Y., Choi, D., Lee, J., Kim, S. R., Go, G., Yoon, Y. J., Kim, J. H., Jang, S. C., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20384 · Cited by 566 · see citing works

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

Wieckowski, E. U., Visús, C., Szajnik, M. E., Szczepański, M. J., Storkus, W. J., & Whiteside, T. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900970 · Cited by 560 · see citing works

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 539 · see citing works

Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Kim, J. W., Wieckowski, E. U., Taylor, D. D., Reichert, T. E., Watkins, S. C., & Whiteside, T. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1010.11.3 · Cited by 496 · see citing works

Isolation of biologically-active exosomes from human plasma

Müller, L., Hong, C., Stolz, D. B., Watkins, S. C., & Whiteside, T. L. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.06.007 · Cited by 490 · see citing works

Tumour-released exosomes and their implications in cancer immunity

Iero, M., Valenti, R., Huber, V., Filipazzi, P., Parmiani, G., Fais, S., & Rivoltini, L. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402237 · Cited by 483 · see citing works

Tumor-Derived Tissue FactorBearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy

Zwicker, J. I., Liebman, H. A., Neuberg, D. S., Lacroix, R., Bauer, K. A., Furie, B. C., & Furie, B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0371 · Cited by 481 · see citing works

Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein

Bogdanov, V. Y., Balasubramanian, V., Hathcock, J. J., Vele, O. E., Lieb, M., & Nemerson, Y. (2003) · Nature Medicine · doi:10.1038/nm841 · Cited by 467 · see citing works

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

Szajnik, M. E., Czystowska, M., Szczepański, M. J., Mandapathil, M., & Whiteside, T. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011469 · Cited by 462 · see citing works

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C. H., & Geuze, H. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1259 · Cited by 451 · see citing works

Leukemia cell to endothelial cell communication via exosomal miRNAs

Umezu, T., Ohyashiki, K., Kuroda, M., & Ohyashiki, J. H. (2012) · Oncogene · doi:10.1038/onc.2012.295 · Cited by 446 · see citing works

Bone marrow stromal cell–derived exosomes as communicators in drug resistance in multiple myeloma cells

Wang, J., Hendrix, A., Hernot, S., Lemaire, M., Bruyne, E. D., Valckenborgh, E. V., Lahoutte, T., Wever, O. D., Vanderkerken, K., & Menu, E. (2014) · Blood · doi:10.1182/blood-2014-03-562439 · Cited by 443 · see citing works

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

Szczepański, M. J., Szajnik, M. E., Welsh, A., Whiteside, T. L., & Boyiadzis, M. M. (2011) · Haematologica · doi:10.3324/haematol.2010.039743 · Cited by 421 · see citing works

Extracellular vesicles: emerging targets for cancer therapy

Vader, P., Breakefield, X. O., & Wood, M. J. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.03.002 · Cited by 417 · see citing works

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

Chen, W.-X., Liu, X.-M., Lv, M., Chen, L., Zhao, J.-H., Zhong, S., Ji, M., Hu, Q., Luo, Z., Wu, J.-Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095240 · Cited by 413 · see citing works

Exosome removal as a therapeutic adjuvant in cancer

Marleau, A. M., Chen, C.-S., Joyce, J. A., & Tullis, R. H. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-134 · Cited by 412 · see citing works

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

Whiteside, T. L. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120265 · Cited by 391 · see citing works

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

Taylor, D. D., & Gerçel-Taylor, Ç. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0234-8 · Cited by 386 · see citing works

ExoCarta as a resource for exosomal research

Simpson, R. J., Kalra, H., & Mathivanan, S. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18374 · Cited by 383 · see citing works

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

Aung, T., Chapuy, B., Vogel, D., Wenzel, D., Oppermann, M., Lahmann, M., Weinhage, T., Menck, K., Hupfeld, T., Koch, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102855108 · Cited by 373 · see citing works

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

Federici, C., Petrucci, F., Caimi, S., Cesolini, A., Logozzi, M., Borghi, M., D’Ilio, S., Lugini, L., Violante, N., Azzarito, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088193 · Cited by 356 · see citing works

Exosomes

Zhang, H., & Grizzle, W. E. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.027 · Cited by 352 · see citing works

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., & Grau, G. E. (2009) · Leukemia · doi:10.1038/leu.2009.76 · Cited by 323 · see citing works

Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

Szczepański, M. J., Szajnik, M. E., Czystowska, M., Mandapathil, M., Strauss, L., Welsh, A., Foon, K. A., Whiteside, T. L., & Boyiadzis, M. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3010 · Cited by 304 · see citing works

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

Filipazzi, P., Bürdek, M., Villa, A., Rivoltini, L., & Huber, V. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.005 · Cited by 281 · see citing works

Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells

Schuler, P. J., Saze, Z., Hong, C.-S., Müller, L., Gillespie, D. G., Cheng, D., Harasymczuk, M., Mandapathil, M., Lang, S., Jackson, E. K., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12354 · Cited by 277 · see citing works

T84-Intestinal Epithelial Exosomes Bear MHC Class II/Peptide Complexes Potentiating Antigen Presentation by Dendritic Cells

Mallegol, J., van Niel, G., Lebreton, C., Lepelletier, Y., Candalh, C., Dugave, C., Heath, J. K., Raposo, G., Cerf–Bensussan, N., & Heyman, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.043 · Cited by 271 · see citing works

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

Mineo, M., Garfield, S. H., Taverna, S., Flugy, A. M., Leo, G. D., Alessandro, R., & Kohn, E. C. (2011) · Angiogenesis · doi:10.1007/s10456-011-9241-1 · Cited by 267 · see citing works

Lysosome-related organelles: unusual compartments become mainstream

Marks, M. S., Heijnen, H. F. G., & Raposo, G. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.04.008 · Cited by 266 · see citing works

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A. M., Goloviznina, N. A., Roberts, C. T., & Kurre, P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2184 · Cited by 259 · see citing works

Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner

Lima, L. G., Chammas, R. J., Monteiro, R. Q., Moreira, M. E. C., & Barcinski, M. A. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.03.041 · Cited by 252 · see citing works

Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism

Qazi, K. R., Gehrmann, U., Jordö, E. D., Karlsson, M. C. I., & Gabrielsson, S. (2009) · Blood · doi:10.1182/blood-2008-04-153536 · Cited by 250 · see citing works

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity

Reiners, K. S., Topolar, D., Henke, A., Simhadri, V. R., Keßler, J., Sauer, M., Bessler, M., Hansen, H. P., Tawadros, S., Herling, M., et al. (2013) · Blood · doi:10.1182/blood-2013-01-476606 · Cited by 239 · see citing works

Tumor Vesicle—Associated CD147 Modulates the Angiogenic Capability of Endothelial Cells

Millimaggi, D., Mari, M., D’Ascenzo, S., Carosa, E., Jannini, E. A., Zucker, S., Carta, G., Pavan, A., & Dolo, V. (2007) · Neoplasia · doi:10.1593/neo.07133 · Cited by 237 · see citing works

Plasma Exosomes as Markers of Therapeutic Response in Patients with Acute Myeloid Leukemia

Hong, C., Müller, L., Whiteside, T. L., & Boyiadzis, M. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00160 · Cited by 228 · see citing works

Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression

Ghosh, A. K., Secreto, C. R., Knox, T. R., Ding, W., Mukhopadhyay, D., & Kay, N. E. (2009) · Blood · doi:10.1182/blood-2009-09-242719 · Cited by 227 · see citing works

Tumor-cell-derived microvesicles as carriers of molecular information in cancer

Martins, V. R., Dias, M. S., & Hainaut, P. L. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835b7c81 · Cited by 211 · see citing works

Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis

Taverna, S., Flugy, A. M., Saieva, L., Kohn, E. C., Santoro, A., Meraviglia, S., Leo, G. D., & Alessandro, R. (2011) · International Journal of Cancer · doi:10.1002/ijc.26217 · Cited by 206 · see citing works

Exosomes in Plasma of Patients with Ovarian Carcinoma: Potential Biomarkers of Tumor Progression and Response to Therapy

Derbis, M. S. M. (2012) · Gynecology & Obstetrics · doi:10.4172/2161-0932.s4-003 · Cited by 196 · see citing works

Isolation and Characterization of CD34+ Blast-Derived Exosomes in Acute Myeloid Leukemia

Hong, C. S., Müller, L., Boyiadzis, M. M., & Whiteside, T. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103310 · Cited by 196 · see citing works

Direct stimulation of naïve T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules

Hwang, I., Shen, X., & Sprent, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131852100 · Cited by 188 · see citing works

Extracellular vesicles – vehicles that spread cancer genes

Rak, J. W., & Guha, A. (2012) · BioEssays · doi:10.1002/bies.201100169 · Cited by 184 · see citing works

The Genomic and Proteomic Content of Cancer Cell-Derived Exosomes

Henderson, M. C., & Azorsa, D. O. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00038 · Cited by 178 · see citing works

Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an Interleukin 8-dependent survival of leukemia cells

Corrado, C., Raimondo, S., Saieva, L., Flugy, A. M., Leo, G. D., & Alessandro, R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.03.009 · Cited by 173 · see citing works

The role of bacterial outer membrane vesicles for intra‐ and interspecies delivery

Berleman, J. E., & Auer, M. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12048 · Cited by 169 · see citing works

Microparticles and their emerging role in cancer multidrug resistance

Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G. E., & Bebawy, M. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.06.005 · Cited by 163 · see citing works

Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor‐bearing microparticles: a randomized‐controlled phase II trial (the Microtec study)

Zwicker, J. I., Liebman, H. A., Bauer, K. A., Caughey, T., Campigotto, F., Rosovsky, R. P. G., Mantha, S. H., Kessler, C. M., Eneman, J. D., Raghavan, V. R., et al. (2012) · British Journal of Haematology · doi:10.1111/bjh.12163 · Cited by 142 · see citing works

Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells

Dutta, S., Warshall, C., Bandyopadhyay, C., Dutta, D., & Chandran, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097580 · Cited by 141 · see citing works

Exosomes Derived from Burkitt’s Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

Gutzeit, C., Nagy, N., Gentile, M., Lyberg, K., Gumz, J., Vallhov, H., Puga, I., Klein, E., Gabrielsson, S., Cerutti, A., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302068 · Cited by 129 · see citing works

Human Tumor-Derived vs Dendritic Cell-Derived Exosomes Have Distinct Biologic Roles and Molecular Profiles

Wieckowski, E. U., & Whiteside, T. L. (2006) · Immunologic Research · doi:10.1385/ir:36:1:247 · Cited by 129 · see citing works

Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma

Koch, R., Demant, M., Aung, T., Diering, N., Cicholas, A. K., Chapuy, B., Wenzel, D., Lahmann, M., Güntsch, A., Kiecke, C., et al. (2014) · Blood · doi:10.1182/blood-2013-08-523886 · Cited by 129 · see citing works

Revisited role of microparticles in arterial and venous thrombosis

Lacroix, R., Dubois, C., Leroyer, A. S., Sabatier, F., & Dignat‐George, F. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12268 · Cited by 128 · see citing works

Harnessing the exosome-induced immune response for cancer immunotherapy

Gehrmann, U., Näslund, T. I., Hiltbrunner, S., Larssen, P., & Gabrielsson, S. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.05.003 · Cited by 127 · see citing works

Exosomes and communication between tumours and the immune system: are all exosomes equal?

Bobrie, A., & Théry, C. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120245 · Cited by 122 · see citing works

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia

Nückel, H., Switala, M., Sellmann, L., Horn, P. A., Dürig, J., Dührsen, U., Küppers, R., Grosse‐Wilde, H., & Rebmann, V. (2010) · Leukemia · doi:10.1038/leu.2010.74 · Cited by 110 · see citing works

Dendritic Cells Pulsed with Leukemia Cell-Derived Exosomes More Efficiently Induce Antileukemic Immunities

Yao, Y., Wang, C., Wei, W., Shen, C., Deng, X., Chen, L., Ma, L., & Hao, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091463 · Cited by 87 · see citing works

Protein secretion: How many secretory routes does a plant cell have?

Drakakaki, G., & Dandekar, A. M. (2013) · Plant Science · doi:10.1016/j.plantsci.2012.12.017 · Cited by 75 · see citing works

BCR-ABL1–positive microvesicles transform normal hematopoietic transplants through genomic instability: implications for donor cell leukemia

Zhu, X., You, Y., Li, Q., Zeng, C., Fu, F., Guo, A., Zhang, H., Zou, P., Zhong, Z., Wang, H., et al. (2014) · Leukemia · doi:10.1038/leu.2014.51 · Cited by 68 · see citing works

Effects of Mesenchymal Stromal Cell-Derived Extracellular Vesicles on Tumor Growth

Bruno, S., Collino, F., Iavello, A., & Camussi, G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00382 · Cited by 63 · see citing works

Effects of Cancer on Platelets

van Es, N., Sturk, A., Middeldorp, S., & Nieuwland, R. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.04.015 · Cited by 60 · see citing works

Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients

Taylor, D. D., Bender, D., Gerçel‐Taylor, Ç., Stanson, J., & Whiteside, T. L. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1847 · Cited by 55 · see citing works

Characterization of multiple myeloma vesicles by label‐free relative quantitation

Harshman, S. W., Canella, A., Ciarlariello, P. D., Rocci, A., Agarwal, K., Smith, E. M., Talabere, T., Efebera, Y. A., Hofmeister, C. C., Benson, D. M., et al. (2013) · PROTEOMICS · doi:10.1002/pmic.201300142 · Cited by 47 · see citing works

Unraveling the physiological functions of exosome secretion by tumors

Bobrie, A., & Théry, C. (2013) · OncoImmunology · doi:10.4161/onci.22565 · Cited by 45 · see citing works

Natural killer cells and malignant haemopathies: a model for the interaction of cancer with innate immunity

Sanchez, C., Treut, T. L., Boehrer, A., Knoblauch, B., Imbert, J., Olive, D., & Costello, R. T. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0898-x · Cited by 41 · see citing works

Antileukaemia Immunity: Effect of Exosomes against NB4 Acute Promyelocytic Leukaemia Cells

Shen, C., Hao, S., Zhao, C., Zhu, J., & Wang, C. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900305 · Cited by 39 · see citing works

Exosomes in immunity and cancer—Friends or foes?

Gabrielsson, S., & Scheynius, A. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.06.007 · Cited by 14 · see citing works

Tumor-Derived Exosomes and Their Role in Cancer Progression

Whiteside, T. L. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.12.005 · Cited by 762 · see citing works

Exosomes and tumor-mediated immune suppression

Whiteside, T. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81136 · Cited by 570 · see citing works

Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer

Ludwig, S., Floros, T., Theodoraki, M., Hong, C., Jackson, E. K., Lang, S., & Whiteside, T. L. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2819 · Cited by 334 · see citing works

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

Müller, L., Mitsuhashi, M., Simms, P. E., Gooding, W. E., & Whiteside, T. L. (2016) · Scientific Reports · doi:10.1038/srep20254 · Cited by 310 · see citing works

Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment

Whiteside, T. L. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.003 · Cited by 310 · see citing works

Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion

Ye, L., Zhang, Q., Cheng, Y., Chen, X., Wang, G., Shi, M., Zhang, T., Cao, Y., Hang, P., Zhang, L., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0451-6 · Cited by 296 · see citing works

The emerging roles of tumor-derived exosomes in hematological malignancies

Boyiadzis, M. M., & Whiteside, T. L. (2017) · Leukemia · doi:10.1038/leu.2017.91 · Cited by 193 · see citing works

Residual matrix from different separation techniques impacts exosome biological activity

Paolini, L., Zendrini, A., Noto, G. D., Busatto, S., Lottini, E., Radeghieri, A., Dossi, A., Caneschi, A., Ricotta, D., & Bergese, P. (2016) · Scientific Reports · doi:10.1038/srep23550 · Cited by 179 · see citing works

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

Chiarini, F., Lonetti, A., Evangelisti, C., Buontempo, F., Orsini, E., Evangelisti, C., Cappellini, A., Neri, L. M., McCubrey, J. A., & Martelli, A. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.08.015 · Cited by 149 · see citing works

Exosomes carrying immunoinhibitory proteins and their role in cancer

Whiteside, T. L. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.12974 · Cited by 146 · see citing works

The advances in nanomedicine for bone and cartilage repair

Qiao, K., Xu, L., Tang, J., Wang, Q., Lim, K. S., Hooper, G. J., Woodfield, T. B. F., Liu, G., Tian, K., Zhang, W., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01342-8 · Cited by 131 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities

Eiró, N., González, L. O., Fraile, M., Cid, S., Schneider, J., & Vizoso, F. J. (2019) · Cancers · doi:10.3390/cancers11050664 · Cited by 104 · see citing works

Microfluidic Technology for Clinical Applications of Exosomes

Iliescu, F. S., Vrtačnik, D., Neužil, P., & Iliescu, C. (2019) · Micromachines · doi:10.3390/mi10060392 · Cited by 103 · see citing works

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

Mousavi, S. M., Mahdian, S. M. A., Ebrahimi, M. S., Taghizadieh, M., Vosough, M., Nahand, J. S., Hosseindoost, S., Vousooghi, N., Javar, H. A., Larijani, B. A., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.04.011 · Cited by 99 · see citing works

Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes

Noto, G. D., Bugatti, A., Zendrini, A., Mazzoldi, E. L., Montanelli, A., Caimi, L., Rusnati, M., Ricotta, D., & Bergese, P. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.09.061 · Cited by 88 · see citing works

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

Horiguchi, H., Kobune, M., Kikuchi, S., Yoshida, M., Murata, M., Murase, K., Iyama, S., Takada, K., Sato, T., Ono, K., et al. (2016) · Haematologica · doi:10.3324/haematol.2015.134932 · Cited by 83 · see citing works

The role of microenvironment and immunity in drug response in leukemia

Bakker, E. Y., Qattan, M. Y., Mutti, L., Demonacos, C., & Krstic–Demonacos, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.08.003 · Cited by 80 · see citing works

Tumor-Derived Exosomes in Tumor-Induced Immune Suppression

Hao, Q., Wu, Y., Wu, Y., Wang, P., & Vadgama, J. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031461 · Cited by 80 · see citing works

Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury.

Sun, C., Chen, C., Chang, C.-L., Chiang, H., Sung, P., Chen, K., Chen, Y., Chen, S.-Y., Kao, G., Chang, H., et al. (2017) · PubMed Central · Cited by 74 · see citing works

Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways

Marschalek, R. (2015) · Annals of Laboratory Medicine · doi:10.3343/alm.2016.36.2.85 · Cited by 71 · see citing works

Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art

Fanini, F., & Fabbri, M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.004 · Cited by 69 · see citing works

Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression.

Whiteside, T. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-67577-0_6 · Cited by 70 · see citing works

Extracellular vesicles in leukemia

Pando, A., Reagan, J. L., Quesenberry, P. J., & Fast, L. D. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.11.011 · Cited by 55 · see citing works

Exosomes as emerging players in cancer biology

Couto, N., Caja, S., Maia, J., Moraes, M. C. S., & Costa‐Silva, B. (2018) · Biochimie · doi:10.1016/j.biochi.2018.03.006 · Cited by 52 · see citing works

Exosomes: New insights into cancer mechanisms

Sahebi, R., Langari, H., Fathinezhad, Z., Sani, Z. B., Avan, A., Ghayour‐Mobarhan, M., & Rezayi, M. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29120 · Cited by 50 · see citing works

Exosome-mediated transfer of CD44 from high-metastatic ovarian cancer cells promotes migration and invasion of low-metastatic ovarian cancer cells

Shen, X., Wang, C., Zhu, H., Wang, Y., Wang, X., Cheng, X., Ge, W., & Lü, W. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00776-2 · Cited by 49 · see citing works

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Whiteside, T. L. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.01.62 · Cited by 48 · see citing works

Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready?

Boyiadzis, M. M., & Whiteside, T. L. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2016.1174578 · Cited by 46 · see citing works

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

Giudice, V., Banaszak, L. G., Gutierrez‐Rodrigues, F., Kajigaya, S., Panjwani, R., Ibanez, M. D. P. F., Rios, O. J., Bleck, C. K. E., Stempinski, E., Raffo, D. Q., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.182824 · Cited by 46 · see citing works

Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance

Dörsam, B., Reiners, K. S., & von Strandmann, E. P. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0481 · Cited by 44 · see citing works

The Mantle Exosome and MicroRNAs of Hyriopsis cumingii Involved in Nacre Color Formation

Chen, X., Bai, Z., & Li, J. (2019) · Marine Biotechnology · doi:10.1007/s10126-019-09908-8 · Cited by 41 · see citing works

Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy

Caivano, A., Rocca, F. L., Laurenzana, I., Trino, S., Luca, L. D., Lamorte, D., Vecchio, L. D., & Musto, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061183 · Cited by 40 · see citing works

Exosomes in acute myeloid leukemia inhibit hematopoiesis

Boyiadzis, M. M., & Whiteside, T. L. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000439 · Cited by 39 · see citing works

Comparison of Proteome Composition of Serum Enriched in Extracellular Vesicles Isolated from Polycythemia Vera Patients and Healthy Controls

Fel, A., Bogucka, A. E., Petrides, P. E., & Wiśniewski, J. R. (2019) · Proteomes · doi:10.3390/proteomes7020020 · Cited by 35 · see citing works

Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection

Nassar, F. J., Chamandi, G., Tfaily, M. A., Zgheib, N. K., & Nasr, R. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00028 · Cited by 33 · see citing works

Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: “alliance” or “war” in intercellular signals

Eiró, N., Fraile, M., Fernández-Francos, S., Sánchez, R., Costa, L. A., & Vizoso, F. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00620-6 · Cited by 33 · see citing works

Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells

de Souza, W., Piperni, S. G., Grenho, L., Rocha, L. A., Granjeiro, J. M., Melo, S. A., Fernandes, M. H., & Ribeiro, A. R. (2023) · Biomaterials Science · doi:10.1039/d2bm01854c · Cited by 31 · see citing works

Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy

Kansha, T., Ma, S., Wang, H., Yu, X., Song, Y., Guo, Z., Song, J., Xue, L., & Yang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603855 · Cited by 31 · see citing works

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Xu, C. Y., Jiang, C., Li, Z., Gao, H., Xian, J., Guo, W., He, D., Peng, X., Zhou, D., & Li, D. (2024) · MedComm · doi:10.1002/mco2.660 · Cited by 28 · see citing works

Cellular Immunotherapy of Canine Cancer

Addissie, S., & Klingemann, H. (2018) · Veterinary Sciences · doi:10.3390/vetsci5040100 · Cited by 28 · see citing works

Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies

Gargiulo, E., Morande, P. E., Largeot, A., Moussay, E., & Paggetti, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.580874 · Cited by 28 · see citing works

Human acute myeloid leukemia blast-derived exosomes in patient-derived xenograft mice mediate immune suppression

Hong, C., Danet-Desnoyers, G. A., Shan, X., Sharma, P., Whiteside, T. L., & Boyiadzis, M. M. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.07.005 · Cited by 27 · see citing works

Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche

Niazi, V., Parseh, B., Ahani, M., Karami, F., Gilanchi, S., Atarodi, K., soufi, M., Soleimani, M., Ghafouri‐Fard, S., Taheri, M. N., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110854 · Cited by 26 · see citing works

Description and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies

Li, L., Görgens, A., Mussack, V., Pepeldjiyska, E., Hartz, A. S., Rank, A., Schmohl, J., Kraemer, D. M., Andaloussi, S. E., Pfaffl, M. W., et al. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00466-1 · Cited by 25 · see citing works

Circulating exosomal miRNAs as potential biomarkers for Barrett's esophagus and esophageal adenocarcinoma

Lv, J., Zhao, H., Dai, K., Cheng, Y., Zhang, J., & Guo, L. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i22.2889 · Cited by 23 · see citing works

Deciphering the messages carried by extracellular vesicles in hematological malignancies

Longjohn, M. N., Hudson, J.-A. B. J., Smith, N. C. P., Rise, M. L., Moorehead, P. C., & Christian, S. L. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100734 · Cited by 23 · see citing works

Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates

Schiller, E. A., Cohen, K., Lin, X., El-Khawam, R., & Hanna, N. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032622 · Cited by 22 · see citing works

Exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of hepatocellular carcinoma by inhibiting HIPK3

Yang, X. F., Wu, M., Kong, X., Wang, Y., Hu, C., Zhu, D., Kong, L., Qiu, F., & Jiang, W. (2024) · iScience · doi:10.1016/j.isci.2024.108955 · Cited by 21 · see citing works

Cellular Evidence of CD63-Enriched Exosomes and Multivesicular Bodies within the Seminiferous Tubule during the Spermatogenesis of Turtles

Tarique, I., Haseeb, A., Bai, X., Li, W., Yang, P., Huang, Y., Yang, S. N., Xu, M., Zhang, Y., Vistro, W. A., et al. (2019) · Microscopy and Microanalysis · doi:10.1017/s1431927619015149 · Cited by 20 · see citing works

Diagnostic and Therapeutic Role of Extracellular Vesicles in Articular Cartilage Lesions and Degenerative Joint Diseases

Qiao, K., Chen, Q., Cao, Y., Li, J., Xu, G., Liu, J., Cui, X., Tian, K., & Zhang, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.698614 · Cited by 20 · see citing works

Value of Osteoblast-Derived Exosomes in Bone Diseases

Ge, M., Wu, Y., Ke, R., Cai, T., Yang, J., & Mu, X. (2017) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000003463 · Cited by 19 · see citing works

Liposomes embedded in layer by layer constructs as simplistic extracellular vesicles transfer model

Domínguez-Arca, V., Costa, R. R., Carvalho, A. M., Taboada, P., Reis, R. L., Prieto, G., & Pashkuleva, I. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111813 · Cited by 18 · see citing works

Paediatric pre‐B acute lymphoblastic leukaemia‐derived exosomes regulate immune function in human T cells

Gholipour, E., Kahroba, H., Soltani, N., Samadi, P., Sarvarian, P., Vakili‐Samiani, S., Feizi, A. A. H. P., Soltani‐Zangbar, M. S., Baghersalimi, A., Darbandi, B., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17482 · Cited by 16 · see citing works

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins II: Intercellular Transfer of Matter (Inheritance?) That Matters

Müller, G. A., & Müller, T. D. (2023) · Biomolecules · doi:10.3390/biom13060994 · Cited by 14 · see citing works

Extracellular Vesicles as Biomarkers in Head and Neck Squamous Cell Carcinoma: From Diagnosis to Disease-Free Survival

Chen, B., Leung, L. L., Qu, X., & Chan, J. Y. K. (2023) · Cancers · doi:10.3390/cancers15061826 · Cited by 13 · see citing works

Hematopoietic and leukemic stem cells homeostasis: the role of bone marrow niche

Khattab, S., Elsorady, M., Elghandour, A., Visani, G., & Piccaluga, P. P. (2024) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2024.00262 · Cited by 13 · see citing works

The mantle exosome proteins of Hyriopsis cumingii participate in shell and nacre color formation

Chen, X., Zhang, M., Bai, Z., He, J., & Li, J. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100844 · Cited by 13 · see citing works

Joint features and complementarities of Tspan8 and CD151 revealed in knockdown and knockout models

Yue, S., Zhao, K., Erb, U., Rana, S., & Zöller, M. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160298 · Cited by 13 · see citing works

Exosomes and MicroRNAs in Biomedical Science

Mirzaei, H., Rahimian, N., Mirzaei, H. R., Nahand, J. S., & Hamblin, M. R. (2022) · Synthesis lectures on biomedical engineering · doi:10.2200/s01171ed1v01y202202bme062 · Cited by 26 · see citing works

The role of exosomes in cancer biology by shedding light on their lipid contents

Fayyazpour, P., Fayyazpour, A., Abbasi, K., Vaez-Gharamaleki, Y., Soltani‐Zangbar, M. S., Raeisi, M., & Mehdizadeh, A. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154813 · Cited by 13 · see citing works

Extracellular vesicles derived from head and neck squamous cells carcinoma inhibit NLRP3 inflammasomes

Bottino, L. Z. M. F., Rodrigues‐Junior, D. M., de Farias, I. S., Branco, L. M., Iyer, N. G., de Albuquerque, G. E., Vettore, A. L., & Bortoluci, K. R. (2021) · Current Research in Immunology · doi:10.1016/j.crimmu.2021.10.005 · Cited by 11 · see citing works

Advances in Lymphoma Molecular Diagnostics

Kos, I. A., Thurner, L., Bittenbring, J. T., Christofyllakis, K., & Kaddu‐Mulindwa, D. (2021) · Diagnostics · doi:10.3390/diagnostics11122174 · Cited by 10 · see citing works

Exosomes and Cancer

Mirzaei, H., Rahimian, N., Mirzaei, H. R., Nahand, J. S., & Hamblin, M. R. (2022) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-79177-2_6 · Cited by 9 · see citing works

Extracellular Vesicles in Myeloid Neoplasms

Karantanou, C., Minciacchi, V. R., & Karantanos, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158827 · Cited by 6 · see citing works

A Novel Virtue in Stem Cell Research: Exosomes and Their Role in Differentiation

Abdik, H., Abdik, E. A., Deniz, A. A. H., Taşlı, P. N., & Şahi̇n, F. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_339 · Cited by 6 · see citing works

Circulating cells and exosomes in acute myelogenous leukemia and their role in disease progression and survival.

Miyamoto, K. N., & Bonatto, D. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108489 · Cited by 7 · see citing works

MicroRNA dysregulation in myelodysplastic syndromes: implications for diagnosis, prognosis, and therapeutic response

Micheva, I., & Atanasova, S. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1410656 · Cited by 5 · see citing works

Transcriptome and exosome proteome analyses provide insights into the mantle exosome involved in nacre color formation of pearl oyster Pinctada fucata martensii

Liu, Y., Wang, Z., Guo, C., Li, S., Li, Y., Huang, R., & Deng, Y. (2023) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2023.101151 · Cited by 4 · see citing works

Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARα transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients

Barzegar, M., Farsani, M. A., Rafiee, M., Amiri, ‏., Parkhihdeh, S., Rad, F., & Mohammadi, M. H. (2021) · Annals of Hematology · doi:10.1007/s00277-021-04579-9 · Cited by 3 · see citing works

XDec Simplex Map of Breast Cancer Cell States Enables Precise Modeling and Targeting of Breast CancerPreprint

Murillo, O. D., Petrosyan, V., LaPlante, E. L., Dobrolecki, L. E., Lewis, M. T., & Milosavljevic, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.06.498858 · Cited by 3 · see citing works

Deconvolution of cancer cell states by the XDec-SM method

Murillo, O. D., Petrosyan, V., LaPlante, E. L., Dobrolecki, L. E., Lewis, M. T., & Milosavljevic, A. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011365 · Cited by 2 · see citing works

Role of extracellular vesicles as promotors for activation of leukemia‑derived dendritic cell‑mediated antileukemic immune response against AML‑blasts

Li, L., Görgens, A., Mussack, V., Pepeldjiyska, E., Hartz, A. S., Rejeski, H. A., Rackl, E., Baudrexler, T., Rank, A., Schmohl, J., et al. (2025) · Oncology Reports · doi:10.3892/or.2025.8932 · Cited by 1 · see citing works

Pharmacogenetics and Personalized Medicine

Paolo, A. D., Arrigoni, E., Galimberti, S., & Danesi, R. (2017) · Springer eBooks · doi:10.1007/978-981-10-5187-6_10 · Cited by 1 · see citing works

Microenvironment and its role in acquire drug resistance of leukemia treatment

Qattan, M. Y. (2016) · Journal of Stem Cell Research and Medicine · doi:10.15761/jscrm.1000114 · Cited by 1 · see citing works

Role of EVs as promotors for activation of leukemia-derived dendritic cell (DCleu)-mediated antileukemic immune response against AML-blastsPreprint

Li, L., Görgens, A., Mussack, V., Pepeldjiyska, E., Hartz, A. S., Rejeski, H. A., Rackl, E., Rank, A., Schmohl, J., Kraemer, D. M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3270038/v1 · Cited by 1 · see citing works

Microenvironment and its role in acquiring drug resistance of leukemia treatment

Qattan, M. Y. (2016) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000221

Importancia de la investigación sobre el estroma tumoral en el cáncer de mama

Eiró, N., Cid, S., Fraile, M., & Vizoso, F. J. (2019) · Revista de Senología y Patología Mamaria · doi:10.1016/j.senol.2019.01.001

Potential Effect of Extracellular Vesicles in Clinical Settings of Lymphoma

Mamgain, G., & Yadav, S. R. M. (2023) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-023-01156-x

The emerging roles of tumor-derived exosomes in hematological malignancies

Boyiadzis, M. M., & Whiteside, T. L. (2017) · Leukemia · doi:10.1038/leu.2017.91 · Cited by 193 · see citing works

The Role of Exosomes in the Progression and Therapeutic Resistance of Hematological Malignancies

Wang, H., You, Y., & Zhu, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.887518 · Cited by 14 · see citing works

Role of Exosome in Microenvironment of Hematological Malignancies and Its Diagnostic and Therapeutic Potential

Ying-yu, N., Yao, X., & Yang, Z. H. (2021) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3971/j.issn.1000-8578.2021.20.0617

The central roles of exosomes in hematological malignancies: A new frontier review

Xia, B., Li, M., Yang, R., Wang, X., Shun, C., & Zhang, Y. (2018) · Bioscience Biotechnology Research Communications · doi:10.21786/bbrc/11.3/1 · Cited by 3 · see citing works

Application of cell-derived exosomes in the hematological malignancies therapy

Ghaffari, K., Hasan‐Abad, A. M., Nasab, A. S., Javaheri, J., & Ghasemi, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1263834 · Cited by 28 · see citing works