Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works

Bioactive Microbial Metabolites: A Personal View

Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170 · see citing works

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

Richardson, P. G., Barlogie, B., Berenson, J., Singhal, S., Jagannath, S., Irwin, D., Rajkumar, S. V., Srkalovic, G., Alsina, M., Alexanian, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030288 · Cited by 2,632 · see citing works

Structure of 20S proteasome from yeast at 2.4Å resolution

Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H. D., & Huber, R. (1997) · Nature · doi:10.1038/386463a0 · Cited by 2,265 · see citing works

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., & Schreiber, S. L. (1995) · Science · doi:10.1126/science.7732382 · Cited by 1,583 · see citing works

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

Löwe, J., Stock, D., Jap, B. K., Zwickl, P., Baumeister, W. P., & Huber, R. (1995) · Science · doi:10.1126/science.7725097 · Cited by 1,527 · see citing works

Proteasome inhibitors: from research tools to drug candidates.

Kisselev, A., & Goldberg, A. (2001) · Chemistry and Biology · doi:10.1016/s1074-5521(01)00056-4 · Cited by 1,176 · see citing works

Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus <i>Salinospora</i>

Feling, R. H., Buchanan, G. O., Mincer, T. J., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390115 · Cited by 1,057 · see citing works

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Chauhan, D., Catley, L., Li, G., Podar, K., Hideshima, T., Velankar, M., Mitsiades, C., Mitsiades, N., Yasui, H., Letai, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.013 · Cited by 694 · see citing works

Widespread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean Sediments

Mincer, T. J., Jensen, P. R., Kauffman, C. A., & Fenical, W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.10.5005-5011.2002 · Cited by 583 · see citing works

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

Udwary, D., Allen, L. Z., Asolkar, R. N., Singan, V. R., Lapidus, A. L., Fenical, W., Jensen, P. R., & Moore, B. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700962104 · Cited by 537 · see citing works

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.

Ōmura, S., Fujimoto, T., Otoguro, K., Matsuzaki, K., Moriguchi, R., Tanaka, H., & Sasaki, Y. (1991) · The Journal of Antibiotics · doi:10.7164/antibiotics.44.113 · Cited by 510 · see citing works

Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate

Kisselev, A. F., Callard, A., & Goldberg, A. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509043200 · Cited by 415 · see citing works

Approval Summary for Bortezomib for Injection in the Treatment of Multiple Myeloma

Bross, P. F., Kane, R. C., Farrell, A. T., Abraham, S., Benson, K. A., Brower, M. E., Bradley, S. P., Gobburu, J. V. S., Goheer, A., Lee, S., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0781 · Cited by 344 · see citing works

Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae

Maldonado, L. A., Fenical, W., Jensen, P. R., Kauffman, C. A., Mincer, T. J., Ward, A. C., Bull, A. T., & Goodfellow, M. (2005) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63625-0 · Cited by 317 · see citing works

Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Groll, M., Huber, R., & Potts, B. C. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058320b · Cited by 313 · see citing works

Distribution of actinomycetes in near-shore tropical marine sediments

Jensen, P. R., Dwight, R., & Fenical, W. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.4.1102-1108.1991 · Cited by 303 · see citing works

Biological, Biochemical, and Biomedical Aspects of Actinomycetes

(1984) · Elsevier eBooks · doi:10.1016/c2013-0-11265-2 · Cited by 287 · see citing works

Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells.

Ōmura, S., Matsuzaki, K., Fujimoto, T., Kosuge, K., Furuya, T., FUJITA, S., & Nakagawa, A. (1991) · The Journal of Antibiotics · doi:10.7164/antibiotics.44.117 · Cited by 271 · see citing works

A Simple Stereocontrolled Synthesis of Salinosporamide A

Reddy, L. R., Saravanan, P., & Corey, E. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048613p · Cited by 245 · see citing works

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Macherla, V. R., Mitchell, S. S., Manam, R. R., Reed, K. A., Chao, T., Nicholson, B., Deyanat‐Yazdi, G., Mai, B., Jensen, P. R., Fenical, W., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm048995+ · Cited by 235 · see citing works

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

Miller, C. P., Ban, K., Dujka, M. E., McConkey, D. J., Munsell, M., Palladino, M. A., & Chandra, J. (2007) · Blood · doi:10.1182/blood-2006-03-013128 · Cited by 204 · see citing works

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma

Chauhan, D., Singh, A., Brahmandam, M., Podar, K., Hideshima, T., Richardson, P. G. G., Munshi, N. C., Palladino, M. A., & Anderson, K. C. (2007) · Blood · doi:10.1182/blood-2007-08-105601 · Cited by 189 · see citing works

ACTINOMYCETES IN MARINE SEDIMENTS

Goodfellow, M., & Haynes, J. A. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-528620-6.50039-2 · Cited by 180 · see citing works

New Cytotoxic Salinosporamides from the Marine Actinomycete Salinispora tropica

Williams, P. G., Buchanan, G. O., Feling, R. H., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2005) · The Journal of Organic Chemistry · doi:10.1021/jo050511+ · Cited by 170 · see citing works

Concise Total Synthesis of (±)-Salinosporamide A, (±)-Cinnabaramide A, and Derivatives via a Bis-cyclization Process: Implications for a Biosynthetic Pathway?

Ma, G., Nguyen, H. H., & Romo, D. (2007) · Organic Letters · doi:10.1021/ol070616u · Cited by 137 · see citing works

Actinomycetes in North Sea and Atlantic Ocean Sediments

WEYLAND, H. (1969) · Nature · doi:10.1038/223858a0 · Cited by 134 · see citing works

Total Synthesis of Salinosporamide A

Endo, A., & Danishefsky, S. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0522783 · Cited by 134 · see citing works

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Ahn, K. S., Sethi, G., Chao, T., Neuteboom, S., Chaturvedi, M. M., Palladino, M. A., Younes, A., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2007-04-084996 · Cited by 122 · see citing works

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia

Ruiz, S., Krupnik, Y. V., Keating, M. J., Chandra, J., Palladino, M. A., & McConkey, D. J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0066 · Cited by 108 · see citing works

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Cusack, J. C., Liu, R., Xia, L., Chao, T., Pien, C. S., Niu, W., Palombella, V. J., Neuteboom, S., & Palladino, M. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1151 · Cited by 90 · see citing works

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Reed, K. A., Manam, R. R., Mitchell, S. S., Xu, J., Teisan, S., Chao, T., Deyanat‐Yazdi, G., Neuteboom, S., Lam, K. S., & Potts, B. C. M. (2007) · Journal of Natural Products · doi:10.1021/np0603471 · Cited by 88 · see citing works

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Ling, T., Macherla, V. R., Manam, R. R., McArthur, K., & Potts, B. C. M. (2007) · Organic Letters · doi:10.1021/ol0706051 · Cited by 85 · see citing works

Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia

Roccaro, A. M., Leleu, X. P., Sacco, A., Jia, X., Melhem, M. R., Moreau, A., Ngo, H. T., Runnels, J. M., Azab, A., Azab, F., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120972 · Cited by 82 · see citing works

Molecular Pathways in Renal Cell Carcinoma—Rationale for Targeted Treatment

KIM, W., & KAELINJR, W. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.06.001 · Cited by 69 · see citing works

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

Sloss, C. M., Wang, F., Liu, R., Xia, L., Houston, M., Ljungman, D., Palladino, M. A., & Cusack, J. C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4506 · Cited by 67 · see citing works

Stereoselective formal synthesis of the potent proteasome inhibitor: salinosporamide A

Caubert, V., Massé, J., Retailleau, P., & Langlois, N. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.11.087 · Cited by 62 · see citing works

A concise total synthesis of salinosporamide A

Mulholland, N. P., Pattenden, G., & Walters, I. A. S. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b607109k · Cited by 55 · see citing works

Lactacystin, a Proteasome Inhibitor : Discovery and its Application in Cell Biology

Tomoda, H., & Ōmura, S. (2000) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.120.10_935 · Cited by 51 · see citing works

Proteasome Inhibitors in Cancer Therapy

Orlowski, R. Z. (2005) · Humana Press eBooks · doi:10.1385/1-59259-895-1:339 · Cited by 32 · see citing works

A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Denora, N., Potts, B. C. M., & Stella, V. J. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20835 · Cited by 28 · see citing works

Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica

Tsueng, G., & Lam, K. S. (2007) · The Journal of Antibiotics · doi:10.1038/ja.2007.61 · Cited by 26 · see citing works

Proteasome Inhibitors in Cancer Therapy

Adams, J. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-767-3_41 · Cited by 21 · see citing works

Studies on marine microorganisms. 3. Transport of spores of actinomycete into shallow sea mud and the effect of salt and temperature on their survival.

Okami, Y., & Okazaki, T. (1974) · PubMed · Cited by 12 · see citing works

STUDIES ON MARINE MICROORGANISMS. III

Okami, Y., & OKAZAKI, T. (1974) · The Journal of Antibiotics · doi:10.7164/antibiotics.27.240 · Cited by 10 · see citing works

Probing the specificity of the bovine pituitary multicatalytic proteinase complex by inhibitors, activators, and by chemical modification.

Wilk, S., Pereira, M. L., & Yu, B. (1991) · PubMed · Cited by 7 · see citing works

Marine natural products

Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,880 · see citing works

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka, E. A., Vatsa, P., Sanchez, L., Vaillant‐Gaveau, N., Jacquard, C., Klenk, H., Clément, C., Ouhdouch, Y., & van Wezel, G. P. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00019-15 · Cited by 2,244 · see citing works

Drug development from marine natural products

Molinski, T. F., Dalisay, D. S., Lievens, S. C., & Saludes, J. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2487 · Cited by 1,202 · see citing works

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

Chen, D., Frezza, M., Schmitt, S. M., Kanwar, J., & Dou, Q. P. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911794519752 · Cited by 796 · see citing works

The odyssey of marine pharmaceuticals: a current pipeline perspective

Mayer, A. M. S., Glaser, K. B., Cuevas, C., Jacobs, R. S., Kem, W. R., Little, R. D., McIntosh, J. M., Newman, D. J., Potts, B. C. M., & Shuster, D. E. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.02.005 · Cited by 669 · see citing works

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works

Biologically active γ-lactams: synthesis and natural sources

Caruano, J., Muccioli, G. G., & Robiette, R. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01349j · Cited by 442 · see citing works

Marine Natural Products: A New Wave of Drugs?

Montaser, R., & Luesch, H. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.118 · Cited by 439 · see citing works

Pharmaceutically active secondary metabolites of marine actinobacteria

Manivasagan, P., Venkatesan, J., Kannan, S., & Kim, S. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.07.014 · Cited by 416 · see citing works

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Kumar, A., Singh, A. K., Singh, H., Vijayan, V., Kumar, D., Naik, J., Thareja, S., Yadav, J. P., Pathak, P., Grishina, M., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16020299 · Cited by 391 · see citing works

A guide to successful bioprospecting: informed by actinobacterial systematics

Goodfellow, M., & Fiedler, H. (2010) · Antonie van Leeuwenhoek · doi:10.1007/s10482-010-9460-2 · Cited by 356 · see citing works

Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms

Marmann, A., Aly, A., Lin, W., Wang, B., & Proksch, P. (2014) · Marine Drugs · doi:10.3390/md12021043 · Cited by 355 · see citing works

Bio-mining the microbial treasures of the ocean: New natural products

Imhoff, J. F., Labes, A., & Wiese, J. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.03.001 · Cited by 347 · see citing works

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

Ziemert, N., Lechner, A., Wietz, M., Millán‐Aguiñaga, N., Chavarría, K. L., & Jensen, P. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324161111 · Cited by 279 · see citing works

Cnidarians as a Source of New Marine Bioactive Compounds—An Overview of the Last Decade and Future Steps for Bioprospecting

Rocha, J., Peixe, L. M. S. V., Gomes, N. C. M., & Calado, R. (2011) · Marine Drugs · doi:10.3390/md9101860 · Cited by 274 · see citing works

Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development

Newman, D., & Cragg, G. (2014) · Marine Drugs · doi:10.3390/md12010255 · Cited by 250 · see citing works

Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

Potts, B. C. M., Albitar, M. X., Anderson, K. C., Baritaki, S., Berkers, C. R., Bonavida, B., Chandra, J., Chauhan, D., Cusack, J. C., Fenical, W., et al. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911794519716 · Cited by 247 · see citing works

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

Gulder, T. A. M., & Moore, B. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000728 · Cited by 247 · see citing works

Marine-Derived Pharmaceuticals - Challenges and Opportunities

Lindequist, U. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.181 · Cited by 241 · see citing works

The Essentials of Marine Biotechnology

Rotter, A., Barbier, M., Bertoni, F., Bones, A. M., Cancela, M. L., Carlsson, J., Carvalho, M. F., Cegłowska, M., Martorell, J. C., Dalay, M. C., et al. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.629629 · Cited by 234 · see citing works

Actinobacteria in natural products research: Progress and prospects

Jose, P. A., Maharshi, A., & Jha, B. (2021) · Microbiological Research · doi:10.1016/j.micres.2021.126708 · Cited by 223 · see citing works

The shikimate pathway: gateway to metabolic diversity

Shende, V. V., Bauman, K. D., & Moore, B. S. (2024) · Natural Product Reports · doi:10.1039/d3np00037k · Cited by 216 · see citing works

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria

Penn, K., Jenkins, C., Nett, M., Udwary, D., Gontang, E. A., McGlinchey, R. P., Foster, B., Lapidus, A. L., Podell, S. B., Allen, E. E., et al. (2009) · The ISME Journal · doi:10.1038/ismej.2009.58 · Cited by 203 · see citing works

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

Gao, S., Naowarojna, N., Cheng, R., Liu, X., & Liu, P. (2018) · Natural Product Reports · doi:10.1039/c7np00067g · Cited by 203 · see citing works

Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species

Duncan, K., Crüsemann, M., Lechner, A., Sarkar, A., Li, J., Ziemert, N., Wang, M., Bandeira, N., Moore, B. S., Dorrestein, P. C., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.03.010 · Cited by 200 · see citing works

Genome mining methods to discover bioactive natural products

Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021) · Natural Product Reports · doi:10.1039/d1np00032b · Cited by 198 · see citing works

The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

Jensen, P. R., Moore, B. S., & Fenical, W. (2015) · Natural Product Reports · doi:10.1039/c4np00167b · Cited by 186 · see citing works

Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity

Azman, A. S., Othman, I., Velu, S. S., Chan, K., & Lee, L. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00856 · Cited by 181 · see citing works

Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction

Baritaki, S., Chapman, A. M., Yeung, K. C., Spandidos, D. A., Palladino, M. A., & Bonavida, B. (2009) · Oncogene · doi:10.1038/onc.2009.214 · Cited by 168 · see citing works

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play”

Newman, D. M., & Cragg, G. M. L. (2016) · Planta Medica · doi:10.1055/s-0042-101353 · Cited by 160 · see citing works

Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants

Radjasa, O. K., Vaske, Y. S. M., Navarro, G., Vervoort, H. C., Tenney, K., Linington, R. G., & Crews, P. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.07.017 · Cited by 141 · see citing works

“Recycling” Classical Drugs for Malaria

Teixeira, C. A. S., Vale, N., Pérez, B. C., Gomes, A., Gomes, J. R. B., & Gomes, P. A. C. (2014) · Chemical Reviews · doi:10.1021/cr500123g · Cited by 136 · see citing works

Chasing the treasures of the sea — bacterial marine natural products

Gulder, T. A. M., & Moore, B. S. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.002 · Cited by 135 · see citing works

A renaissance in marine pharmacology: From preclinical curiosity to clinical reality

Glaser, K. B., & Mayer, A. M. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.015 · Cited by 133 · see citing works

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Zuffa, S., Schmid, R., Bauermeister, A., Gomes, P. W. P., Caraballo‐Rodríguez, A. M., Abiead, Y. E., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01575-9 · Cited by 125 · see citing works

Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163

Dashti, Y., Grkovic, T., Abdelmohsen, U. R., Hentschel, U., & Quinn, R. J. (2014) · Marine Drugs · doi:10.3390/md12053046 · Cited by 127 · see citing works

Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry

Génin, E., Reboud‐Ravaux, M., & Vidal, J. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610790725515 · Cited by 124 · see citing works

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

Liu, Y., Salvador, L. A., Byeon, S., Ying, Y., Kwan, J. C., Law, B. K., Hong, J., & Luesch, H. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172387 · Cited by 120 · see citing works

The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

Tundo, G. R., Sbardella, D., Santoro, A. M., Coletta, A., Oddone, F., Grasso, G., Milardi, D., Lacal, P. M., Marini, S., Purrello, R., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107579 · Cited by 115 · see citing works

The role of Snail in prostate cancer

Smith, B., & Odero-Marah, V. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.21687 · Cited by 111 · see citing works

Nickel(0)-Catalyzed [2 + 2 + 1] Carbonylative Cycloaddition of Imines and Alkynes or Norbornene Leading to γ-Lactams

Hoshimoto, Y., Ohata, T., Sasaoka, Y., Ohashi, M., & Ogoshi, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja509171a · Cited by 112 · see citing works

Bioprospecting microbial natural product libraries from the marine environment for drug discovery

Liu, X., Ashforth, E. J., Ren, B., Song, F., Dai, H., Liu, M., Wang, J., Xie, Q., & Zhang, L. (2010) · The Journal of Antibiotics · doi:10.1038/ja.2010.56 · Cited by 108 · see citing works

Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom

Penn, K., Wang, J., Fernando, S. C., & Thompson, J. R. (2014) · The ISME Journal · doi:10.1038/ismej.2014.27 · Cited by 106 · see citing works

Molecules to Ecosystems: Actinomycete Natural Products In situ

Behie, S. W., Bonet, B., Zacharia, V. M., McClung, D. J., & Traxler, M. F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02149 · Cited by 105 · see citing works

Ohmyungsamycins A and B: Cytotoxic and Antimicrobial Cyclic Peptides Produced by Streptomyces sp. from a Volcanic Island

Um, S., Choi, T. J., Kim, H., Kim, B., Kim, S.-H., Lee, S. K., Oh, K., Shin, J., & Oh, D. (2013) · The Journal of Organic Chemistry · doi:10.1021/jo401974g · Cited by 104 · see citing works

Actinobacteria of the Extremobiosphere

Bull, A. T. (2010) · Springer eBooks · doi:10.1007/978-4-431-53898-1_58 · Cited by 106 · see citing works

The cave microbiome as a source for drug discovery: Reality or pipe dream?

Ghosh, S. B., Kuisienė, N., & Cheeptham, N. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.11.018 · Cited by 104 · see citing works

Rare taxa and dark microbial matter: novel bioactive actinobacteria abound in Atacama Desert soils

Goodfellow, M., Nouioui, I., Sanderson, R., Xie, F., & Bull, A. T. (2018) · Antonie van Leeuwenhoek · doi:10.1007/s10482-018-1088-7 · Cited by 103 · see citing works

Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin

Palomo, S., González, I., de la Cruz, M., Martı́n, J., Tormo, J. R., Anderson, M. A., Hill, R. T., Vicente, F., Reyes, F., & Genilloud, O. (2013) · Marine Drugs · doi:10.3390/md11041071 · Cited by 103 · see citing works

Bacteria as a treasure house of secondary metabolites with anticancer potential

Mohan, C. D., Rangappa, S., Nayak, S. C., Jadimurthy, R., Wang, L., Sethi, G., Garg, M., & Rangappa, K. S. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.006 · Cited by 100 · see citing works

Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization

Baritaki, S., Yeung, K. C., Palladino, M. A., Berenson, J. R., & Bonavida, B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1069 · Cited by 99 · see citing works

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Pereira, R. B., Evdokimov, N. M., Lefranc, F., Valentão, P., Kornienko, A., Pereira, D. M., Andrade, P. B., & Gomes, N. G. M. (2019) · Marine Drugs · doi:10.3390/md17060329 · Cited by 97 · see citing works

Impact of novel microbial secondary metabolites on the pharma industry

Ramírez-Rendón, D., Passari, A. K., Ruiz‐Villafán, B., Rodrı́guez-Sanoja, R., Sánchez, S., & Demain, A. L. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11821-5 · Cited by 90 · see citing works

Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations

Nguyen, H. H., Ma, G., Gladysheva, T. B., Fremgen, T., & Romo, D. (2010) · The Journal of Organic Chemistry · doi:10.1021/jo101638r · Cited by 88 · see citing works

α,β-Unsaturated Carbonyl System of Chalcone-Based Derivatives Is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV) Positive Cervical Cancer Cells

Bazzaro, M., Anchoori, R. K., Mudiam, M. K. R., Issaenko, O. A., Kumar, S. K., Karanam, B., Lin, Z., Vogel, R. I., Gavioli, R., Destro, F., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100589p · Cited by 87 · see citing works

New trends in synthetic drugs and natural products targeting 20S proteasomes in cancers

Atta, H., Alzahaby, N., Hamdy, N. Μ., Emam, S. H., Sonousi, A. S. M., & Ziko, L. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106427 · Cited by 83 · see citing works

Anticancer Agents from Diverse Natural Sources

Khazir, J., Riley, D. L., Pilcher, L. A., De-Maayer, P., & Mir, B. A. (2014) · Natural Product Communications · doi:10.1177/1934578x1400901130 · Cited by 82 · see citing works

Recently Discovered Naturally Occurring Heterocyclic Organohalogen Compounds

Gribble, G. W. (2011) · Heterocycles · doi:10.3987/rev-11-sr(p)5 · Cited by 82 · see citing works

Challenges and triumphs to genomics-based natural product discovery

Jensen, P. R., Chavarría, K. L., Fenical, W., Moore, B. S., & Ziemert, N. (2013) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-013-1353-8 · Cited by 80 · see citing works

Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment

Beesoo, R., Neergheen, V. S., Bhagooli, R., & Bahorun, T. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.03.005 · Cited by 78 · see citing works

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

Tsukamoto, S., Yamanokuchi, R., Yoshitomi, M., Sato, K., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., van Soest, R. W. M., & Yokosawa, H. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.04.029 · Cited by 77 · see citing works

Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy

Berenson, J. R., Hilger, J. D., Yellin, O., Dichmann, R., Patel‐Donnelly, D., Boccia, R. V., Bessudo, A., Stampleman, L. V., Gravenor, D. S., Eshaghian, S., et al. (2014) · Leukemia · doi:10.1038/leu.2014.27 · Cited by 76 · see citing works

Marine Sediment-Derived Streptomyces Bacteria from British Columbia, Canada Are a Promising Microbiota Resource for the Discovery of Antimicrobial Natural Products

Dalisay, D. S., Williams, D. E., Wang, X. L., Centko, R. M., Chen, J., & Andersen, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077078 · Cited by 76 · see citing works

Nitropyrrolins A−E, Cytotoxic Farnesyl-α-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete Family Streptomycetaceae

Kwon, H. C., Espindola, A. P. D. M., Park, J.-S., Prieto‐Davó, A., Rose, M., Jensen, P. R., & Fenical, W. (2010) · Journal of Natural Products · doi:10.1021/np1006229 · Cited by 76 · see citing works

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R., Kazi, A., Luo, Y., Kendig, R. D., Ge, Y., Jain, S., Daniel, K. G., Santiago, D. N., Guida, W. C., & Sebti, S. M. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.038 · Cited by 76 · see citing works

Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results

Harrison, S. J., Mainwaring, P. N., Price, T. J., Millward, M., Padrik, P., Underhill, C. R., Cannell, P., Reich, S. D., Trikha, M., & Spencer, A. G. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2616 · Cited by 76 · see citing works

Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates

McCauley, E. P., Piña, I. C., Thompson, A. D., Bashir, K., Weinberg, M., Kurz, S. L., & Crews, P. (2020) · The Journal of Antibiotics · doi:10.1038/s41429-020-0330-5 · Cited by 75 · see citing works

New orally active proteasome inhibitors in multiple myeloma

Allegra, A., Alonci, A., Gerace, D., Russo, S., Innao, V., Calabrò, L., & Musolino, C. (2014) · Leukemia Research · doi:10.1016/j.leukres.2013.10.018 · Cited by 74 · see citing works

Microbial Synthesis and Transformation of Inorganic and Organic Chlorine Compounds

Atashgahi, S., Liebensteiner, M. G., Janssen, D. B., Smidt, H., Stams, A. J. M., & Sipkema, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03079 · Cited by 72 · see citing works

High-Throughput Screening of Natural Products for Cancer Therapy

Harvey, A. R., & Cree, I. A. (2010) · Planta Medica · doi:10.1055/s-0030-1250162 · Cited by 73 · see citing works

A1,3-strain enabled retention of chirality during bis-cyclization of β-ketoamides: total synthesis of (−)-salinosporamide A and (−)-homosalinosporamide A

Nguyen, H., Ma, G., & Romo, D. (2010) · Chemical Communications · doi:10.1039/c0cc00607f · Cited by 72 · see citing works

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

Eustáquio, A. S., Nam, S., Penn, K., Lechner, A., Wilson, M. C., Fenical, W., Jensen, P. R., & Moore, B. S. (2010) · ChemBioChem · doi:10.1002/cbic.201000564 · Cited by 72 · see citing works

Recent advances in the Overman rearrangement: synthesis of natural products and valuable compounds

Fernandes, R. A., Kattanguru, P., Gholap, S. P., & Chaudhari, D. A. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob02625g · Cited by 67 · see citing works

Advances toward the Synthesis of Functionalized γ-Lactams

Rivas, F., & Ling, T. (2016) · Organic Preparations and Procedures International · doi:10.1080/00304948.2016.1165059 · Cited by 67 · see citing works

Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis

Ma, J., Zhou, Q., Song, G., Song, Y., Zhao, G., Ding, K., & Zhao, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202017306 · Cited by 66 · see citing works

A metabolomics guided exploration of marine natural product chemical space

Floros, D. J., Jensen, P. R., Dorrestein, P. C., & Koyama, N. (2016) · Metabolomics · doi:10.1007/s11306-016-1087-5 · Cited by 65 · see citing works

New Perspectives on Innovative Drug Discovery: An Overview

Pan, S. Y., Pan, S. L., Yu, Z., Ma, D., Chen, S., Fong, W. F., Han, Y., & Ko, K. (2010) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j39w2g · Cited by 64 · see citing works

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

Potts, B. C. M., & Lam, K. S. (2010) · Marine Drugs · doi:10.3390/md8040835 · Cited by 64 · see citing works

Bahamaolides A and B, Antifungal Polyene Polyol Macrolides from the Marine Actinomycete Streptomyces sp.

Kim, D.-G., Moon, K., Kim, S.-H., Park, S.-H., Park, S., Lee, S. K., Oh, K., Shin, J., & Oh, D. (2012) · Journal of Natural Products · doi:10.1021/np3001915 · Cited by 63 · see citing works

β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets

Fu, D., Zhang, Y., Chang, A., & Li, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112510 · Cited by 61 · see citing works

Exploiting nature's rich source of proteasome inhibitors as starting points in drug development

Graewert, M. A., & Groll, M. (2011) · Chemical Communications · doi:10.1039/c1cc15273d · Cited by 60 · see citing works

Linking species concepts to natural product discovery in the post-genomic era

Jensen, P. R. (2009) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-009-0683-z · Cited by 60 · see citing works

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Deshmukh, S. K., Gupta, M., Prakash, V., & Reddy, M. S. (2018) · Journal of Fungi · doi:10.3390/jof4030101 · Cited by 55 · see citing works

Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

Ling, T., Potts, B. C. M., & Macherla, V. R. (2010) · The Journal of Organic Chemistry · doi:10.1021/jo100432g · Cited by 54 · see citing works

Evolution of Secondary Metabolite Genes in Three Closely Related Marine Actinomycete Species

Freel, K. C., Nam, S., Fenical, W., & Jensen, P. R. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05943-11 · Cited by 54 · see citing works

Marine Microbial Secondary Metabolites

Giordano, D., Coppola, D., Russo, R., Denaro, R., Giuliano, L., Lauro, F. M., di Prisco, G., & Verde, C. (2015) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2015.04.001 · Cited by 53 · see citing works

Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

Rachid, S., Huo, L., Herrmann, J. E., Stadler, M., Köpcke, B., Bitzer, J., & Müller, R. (2011) · ChemBioChem · doi:10.1002/cbic.201100024 · Cited by 53 · see citing works

Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients

Levin, N., Spencer, A. G., Harrison, S. J., Chauhan, D., Burrows, F. J., Anderson, K. C., Reich, S. D., Richardson, P. G. G., & Trikha, M. (2016) · British Journal of Haematology · doi:10.1111/bjh.14113 · Cited by 53 · see citing works

Rhodolith beds in Brazil: a new potential habitat for marine bioprospection

Amado-Filho, G. M., & Pereira‐Filho, G. H. (2012) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2012005000066 · Cited by 52 · see citing works

Probing the Specificity and Activity Profiles of the Proteasome Inhibitors Bortezomib and Delanzomib

Berkers, C. R., Leestemaker, Y., Schuurman, K. G., Ruggeri, B., Jones‐Bolin, S., Williams, M. J., & Ovaa, H. (2012) · Molecular Pharmaceutics · doi:10.1021/mp2004143 · Cited by 52 · see citing works

Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics

Chhabra, S. (2017) · Pharmaceuticals · doi:10.3390/ph10020040 · Cited by 51 · see citing works

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid

Ma, L., Bartholomé, A., Tong, M. H., Qin, Z., Yu, Y., Shepherd, T., Kyeremeh, K., Deng, H., & O’Hagan, D. (2014) · Chemical Science · doi:10.1039/c4sc03540b · Cited by 51 · see citing works

Chiral N‐Heterocyclic Carbene‐Catalyzed Asymmetric Michael–Intramolecular Aldol‐Lactonization Cascade for Enantioselective Construction of β‐Propiolactone‐Fused Spiro[cyclopentane‐oxindoles]

Zhang, J., Li, N., Yin, S., Sun, B., Fan, W., & Wang, X. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201601259 · Cited by 51 · see citing works

Total Synthesis of (−)-Salinosporamide A

Satoh, N., Yokoshima, S., & Fukuyama, T. (2011) · Organic Letters · doi:10.1021/ol200886j · Cited by 50 · see citing works

The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440

Ejje, N., Soe, C. Z., Gu, J., & Codd, R. (2013) · Metallomics · doi:10.1039/c3mt00230f · Cited by 49 · see citing works

Salinispora pacifica sp. nov., an actinomycete from marine sediments

Ahmed, L., Jensen, P. R., Freel, K. C., Brown, R., Jones, A. L., Kim, B., & Goodfellow, M. (2013) · Antonie van Leeuwenhoek · doi:10.1007/s10482-013-9886-4 · Cited by 48 · see citing works

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

Clair, J. J. L. (2010) · Natural Product Reports · doi:10.1039/b909989c · Cited by 48 · see citing works

Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Dalisay, D. S., Tenebro, C. P., Sabido, E. M., Suarez, A. F. L., Paderog, M. J. V., Reyes-Salarda, R., & Saludes, J. P. (2024) · Marine Drugs · doi:10.3390/md22030114 · Cited by 47 · see citing works

Unique Actinomycetes from Marine Caves and Coral Reef Sediments Provide Novel PKS and NRPS Biosynthetic Gene Clusters

Hodges, T. W., Slattery, M., & Olson, J. B. (2011) · Marine Biotechnology · doi:10.1007/s10126-011-9410-7 · Cited by 47 · see citing works

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes

El‐Hawary, S. S., Sayed, A. M., Mohammed, R. A., Khanfar, M. A., Rateb, M. E., Mohammed, T. A.-A. A., Hajjar, D., Hassan, H. M., Gulder, T. A. M., & Abdelmohsen, U. R. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00538 · Cited by 47 · see citing works

From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent

Lam, K. S., Lloyd, G. K., Neuteboom, S., Palladino, M. A., Sethna, K. M., Spear, M. A., & Potts, B. C. M. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559890-00355 · Cited by 11 · see citing works

Marine Microbes as a source of Antimicrobial Compounds

Chakraborty, K., Kizhakkekalam, V. K., Antony, T., Joy, M., & Sreemol, C. K. (2018) · Eprints@CMFRI Open Access Institutional Repository (Central Marine Fisheries Research Institute)

Marine-derived pipeline anticancer natural products: a review of their pharmacotherapeutic potential and molecular mechanisms

Ali‐Seyed, M., & Ayesha, S. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00350-z · Cited by 16 · see citing works

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Macherla, V. R., Mitchell, S. S., Manam, R. R., Reed, K. A., Chao, T., Nicholson, B., Deyanat‐Yazdi, G., Mai, B., Jensen, P. R., Fenical, W., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm048995+ · Cited by 235 · see citing works

The marine tropical environment's potential for the discovery of bioactive chemical entities

Arias, G. S. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)