Cited by 294Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsIsoquinoline Alkaloid Synthesis

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Open access

Abstract

The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule.

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Crossref · 10.1016/j.bmc.2008.10.075

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  1. Wilk, 1991, Biomed. Biochim. Acta, 50, 471

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Items 201–294 of 294

Metadata

Authors
Fenical, W., Jensen, P. R., Palladino, M. A., Lam, K. S., Lloyd, G. K., & Potts, B. C.
Affiliations
Scripps Institution of Oceanography (US)
Corresponding author
Potts, Barbara C.
Venue
Bioorganic & Medicinal Chemistry
Publisher
Elsevier BV
Published
2009-03
Volume
17
Issue
6
Pages
2175-2180
ISSN
0968-0896 (ISSN-L)
OpenAlex
W2016098671
Cited by
291
References
48
Citations by year
2026: 7 · 2025: 7 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 21 · 2015: 22 · 2014: 30 · 2013: 24 · 2012: 29
FWCI
14.06
Type
journal article
Language
en
Open access
Locations
  • Bioorganic & Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (CA44848, R01CA044848, R37CA044848)
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
Keywords
salinosporamide A, NPI-0052, anticancer agents, marine natural products, drug discovery, drug development, clinical trials, university-industry collaboration, marine environment
MeSH terms
Antineoplastic Agents, Lactones, Pyrroles, Molecular Structure, Drugs, Investigational, Drug Discovery

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