Therapeutic peptides: Historical perspectives, current development trends, and future directions

A new antibiotic kills pathogens without detectable resistance

Ling, L. L., Schneider, T., Peoples, A. J., Spoering, A. L., Engels, I., Conlon, B. P., Müller, A., Schäberle, T. F., Hughes, D. E., Epstein, S. S., et al. (2015) · Nature · doi:10.1038/nature14098 · Cited by 2,428

American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis — 2016--Executive Summary

Camacho, P. M., Petak, S. M., Binkley, N., Clarke, B. L., Harris, S. T., Hurley, D. L., Kleerekoper, M., Lewiecki, E. M., Miller, P. D., Narula, H. S., et al. (2016) · Endocrine Practice · doi:10.4158/ep161435.esgl · Cited by 1,140

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Stupp, R., Hegi, M. E., Gorlia, T., Erridge, S. C., Perry, J., Hong, Y.-K., Aldape, K. D., Lhermitte, B., Pietsch, T., Grujicic, D., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70379-1 · Cited by 1,052

Advances in Fmoc solid‐phase peptide synthesis

Behrendt, R., White, P., & Offer, J. (2016) · Journal of Peptide Science · doi:10.1002/psc.2836 · Cited by 767

Untitled work

(1922) · PubMed · Cited by 753

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Finan, B., Ma, T., Ottaway, N., Müller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007218 · Cited by 696

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Chang, Y. S., Graves, B. J., Guerlavais, V., Tovar, C., Packman, K. E., To, K.-H., Olson, K. A., Kesavan, K. P., Gangurde, P., Mukherjee, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303002110 · Cited by 681

Strategic Approaches to Optimizing Peptide ADME Properties

Di, L. (2015) · The AAPS Journal · doi:10.1208/s12248-014-9687-3 · Cited by 669

Large-scale manufacture of peptide therapeutics by chemical synthesis

Bray, B. L. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1133 · Cited by 601

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Del Solar, M., Zhu, B., York, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.063 · Cited by 591

Hyperbaric oxygen therapy decreases blood pressure in patients with chronic wounds.

Château‐Degat, M., & Belley, R. (2012) · PubMed · Cited by 11

Discovery of d -Miniprotein Inhibitors of PD-1/PD-L1 Interaction via Mirror-Image Phage Display against Synthetic d -PD-1

Zhou, H., Wu, H., Zhong, Z., Blasco, P., Zeng, J., Wang, J., Liu, H., & Li, X. (2025) · JACS Au · doi:10.1021/jacsau.5c01181 · Cited by 10

(R)‐α‐Trifluoromethylalanine as a 19F NMR Probe for the Monitoring of Protease Digestion of Peptides

Devillers, E., Chelain, E., Dalvit, C., Brigaud, T., & Pytkowicz, J. (2021) · ChemBioChem · doi:10.1002/cbic.202100470 · Cited by 10

Impact of Organ Impairment on the Pharmacokinetics of Therapeutic Peptides and Proteins

Fletcher, E. P., Sahre, M. D., Hon, Y. Y., Balakrishnan, A., Zhou, L., Sun, Q., Wang, J., Maxfield, K., Naik, R., Huang, S. M., et al. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00819-0 · Cited by 10

IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Exhibits Extended In Vivo Half-Life and Synergistic Antiviral Effect When Combined with Neutralizing Antibodies

Su, X., Huang, Z., Xu, W., Wang, Q., Xing, L., Lu, L., Jiang, S., & Xia, S. (2023) · Biomolecules · doi:10.3390/biom13091283 · Cited by 9

Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

Panou, D., Pedersen, S. F., Kristensen, M., & Nielsen, H. M. (2023) · Frontiers in Drug Delivery · doi:10.3389/fddev.2023.1221628 · Cited by 12

Microgels for bioprinting: recent advancements and challenges

Xie, M., Wang, J., Wu, S., Yan, S., & He, Y. (2024) · Biomaterials Science · doi:10.1039/d3bm01733h · Cited by 10

The Development of a Stable Peptide-Loaded Long-Acting Injection Formulation through a Comprehensive Understanding of Peptide Degradation Mechanisms: A QbD-Based Approach

Xiong, Y., Wang, J., Zhou, X. W., & Li, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020266 · Cited by 10

Glycine-Conjugated α-Mangostins as Potential Estrogen Receptor Alpha (ERα) Antagonists through Pharmacophore Modeling, Docking Analysis, and Molecular Dynamics Simulations

Arifian, H., Maharani, R., Megantara, S., Ikram, N. K. K., & Muchtaridi, M. (2024) · Applied Sciences · doi:10.3390/app14135549 · Cited by 10

Targeting MDM2-p53 interaction in Glioblastoma: Transcriptomic analysis and Peptide-Based inhibition strategy

Han, M., Kakar, M., Li, W., Iqbal, I., Hu, X., Liu, Y., Tang, Q., Sun, L., Shakir, Y., & Liu, T. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107620 · Cited by 10

PepCA: Unveiling protein-peptide interaction sites with a multi-input neural network model

Huang, J., Li, W., Xiao, B., Zhao, C., Zheng, H., Li, Y., & Wang, J. (2024) · iScience · doi:10.1016/j.isci.2024.110850 · Cited by 10

Solid phase peptide synthesis using side-chain unprotected arginine and histidine with Oxyma Pure/TBEC in green solvents

Fantoni, T., Orlandin, A., Stefano, I. D., Macis, M., Tolomelli, A., Ricci, A., Cabri, W., & Ferrazzano, L. (2024) · Green Chemistry · doi:10.1039/d4gc03209h · Cited by 11

Deep Learning for Parkinson’s Disease Diagnosis: A Graph Neural Network (GNN) Based Classification Approach with Graph Wavelet Transform (GWT) Using Protein–Peptide Datasets

Mohanraj, P., Raman, V., & Ramanathan, S. (2024) · Diagnostics · doi:10.3390/diagnostics14192181 · Cited by 10

After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N-Terminal Peptide Sequencing

Deol, H., Raeisbahrami, A., Ngo, P. H. T., Swaminathan, J., Papoulas, O., Marcotte, E. M., & Anslyn, E. V. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c03385 · Cited by 11

Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media

Bordignon, F., Scarso, A., & Angelini, A. (2025) · ChemBioChem · doi:10.1002/cbic.202500099 · Cited by 13

Influence of the neurotensin signaling system on feeding and satiety

Thompson, K. D., & Leinninger, G. M. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110496 · Cited by 10

Inhibition of Pathological Retinal Neovascularization by a Small Peptide Derived from Human Tissue-Type Plasminogen Kringle 2

Sun, Q., Shen, Y., Su, L., & Xu, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01639 · Cited by 10

Macromolecules and Antibody-Based Drugs

Su, X., & Yao, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3266-5_20 · Cited by 11

Hydrogen bonds in anoplin peptides aid in identification of a structurally stable therapeutic drug scaffold

Ranade, S. S., & Rajasekaran, R. (2020) · Journal of Molecular Modeling · doi:10.1007/s00894-020-04380-x · Cited by 10

In-silico screening of bioactive phytopeptides for novel anti-ageing therapeutics

Salekeen, R., Ahmed, A., Islam, M. E., Billah, M. M., Rahman, H., & Islam, K. M. D. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1859411 · Cited by 11

Solid-Phase Synthesis of Gly-Ψ[CH(CF3)NH]-Peptides

Sgorbati, C., Presti, E. L., Bergamaschi, G., Sani, M., & Volonterio, A. (2021) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.1c00853 · Cited by 10

Review and Comparative Analysis of Machine Learning-based Predictors for Predicting and Analyzing Anti-angiogenic Peptides

Charoenkwan, P., Chiangjong, W., Hasan, M. M., Nantasenamat, C., & Shoombuatong, W. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210810145806 · Cited by 10

In Silico Design of Chemically Modified Cell-Penetrating Peptides

Kumar, V. D., & Raghava, G. P. S. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1752-6_4 · Cited by 10

Nickel-Catalyzed Cross-Coupling of Amino-Acid-Derived Alkylzinc Reagents with Alkyl Bromides/Chlorides: Access to Diverse Unnatural Amino Acids

Gou, F., Ma, M.-J., Wang, A., Zhao, L., Wang, H., Tong, J., Wang, Z., Wang, Z., & He, C. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c03884 · Cited by 10

Preclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats

Yang, X., Li, J., Chen, S., Xiao, L., Cao, D., Wu, X., Li, H., Ni, G., Wang, T., Chen, G., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9869293 · Cited by 10

Dual-responsive bioconjugates bearing a bifunctional adaptor for robust cytosolic peptide delivery

Gao, X. Y., Yuan, C., Tan, E., Li, Z., Cheng, Y., Xiao, J., & Rong, G. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.02.014 · Cited by 10

Computational design of cyclic peptides to inhibit protein-peptide interactions

Delaunay, M., & Ha‐Duong, T. (2023) · Biophysical Chemistry · doi:10.1016/j.bpc.2023.106987 · Cited by 10

The Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro

Ayusso, G. M., Sanches, P. R. D. S., Carvalho, T., Santos, I. A., Martins, D. O. S., Lima, M. L. D., da Conceição, P. J. P., Bittar, C., Merits, A., Cilli, E. M., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16101389 · Cited by 10

Expedient and divergent synthesis of unnatural peptides through cobalt-catalyzed diastereoselective umpolung hydrogenation

Song, X., Bai, S., Li, Y., Yi, T., Long, X., Pu, Q., Dang, T., Ma, M., Ren, Q., & Qin, X. (2023) · Science Advances · doi:10.1126/sciadv.adk4950 · Cited by 10

Synthetic Peptide Libraries: From Random Mixtures to In Vivo Testing

Sandomenico, A., Caporale, A., Doti, N., Cross, S., Cruciani, G., Chambery, A., Falco, S. D., & Ruvo, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180716110833 · Cited by 10

Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

Inada, H., Shibuya, M., & Yamamoto, Y. (2019) · Organic Letters · doi:10.1021/acs.orglett.8b03910 · Cited by 10

Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides

Kannan, S., Aronica, P. G. A., Tan, Y. S., & Verma, C. S. (2019) · ACS Omega · doi:10.1021/acsomega.9b00097 · Cited by 10

Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers

Salnikov, E. S., Zotti, M. D., Bobone, S., Mazzuca, C., Raya, J., Siano, Á., Peggion, C., Toniolo, C., Stella, L., & Bechinger, B. (2019) · ChemBioChem · doi:10.1002/cbic.201900263 · Cited by 10

Recent Advances in System Based Study for Anti-Malarial Drug Development Process

Yadav, B. S., Chaturvedi, N., & Marina, N. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190902162105 · Cited by 10

Supercomputer docking with a large number of degrees of freedom

Sulimov, A. V., Kutov, D. C., Ilin, I. S., Zheltkov, D. A., Tyrtyshnikov, E. E., & Sulimov, V. B. (2019) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2019.1659412 · Cited by 10

1,4-Benzenedimethanethiol (1,4-BDMT) as a scavenger for greener peptide resin cleavages

Pawlas, J., Svensson, T., & Rasmussen, J. H. (2019) · RSC Advances · doi:10.1039/c9ra08553j · Cited by 10

Recent Advances of Nanocarriers for Effective Delivery of Therapeutic Peptides

Atabakhshi‐Kashi, M., Geranpayehvaghei, M., Wang, Y., Akhbariyoon, H., Taleb, M., Zhang, Y., Khajeh, K., & Nie, G. (2020) · Precision Nanomedicine · doi:10.33218/001c.13444 · Cited by 11

Peptide and protein engineering by modification of backbone and sidechain functional groups

Kordbacheh, S., & Kasko, A. M. (2021) · Polymer International · doi:10.1002/pi.6208 · Cited by 10

Zwitterion‐Catalyzed Amino‐Dibromination of Nitroalkenes: Scope, Mechanism, and Application to The Synthesis of Glycinamides

Ng, W., Lam, Y., Hu, R., Ng, W., & Yeung, Y. (2021) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202000514 · Cited by 10

Bioactive peptide isolated from sesame seeds inhibits cell proliferation and induces apoptosis and autophagy in leukemic cells

Deesrisak, K., Yingchutrakul, Y., Krobthong, S., Roytrakul, S., Chatupheeraphat, C., Subkorn, P., Anurathapan, U., & Tanyong, D. I. (2021) · EXCLI journal · doi:10.17179/excli2021-3406 · Cited by 10

Computational Design of Structured and Functional Peptide Macrocycles

Berger, S., & Hosseinzadeh, P. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1689-5_5 · Cited by 10

Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases

Gutiérrez-González, L. H., Rivas-Fuentes, S., Guzmán‐Beltrán, S., Flores–Flores, A., Rosas-García, J., & Santos-Mendoza, T. (2021) · Molecules · doi:10.3390/molecules26216367 · Cited by 11

A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections

Schaal, J. B., Eriguchi, Y., Tran, D. Q., Tran, P. A., Hawes, C. E., Cabebe, A. E., Pike, K., Trinh, K. K., Ouellette, A. J., & Selsted, M. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-02619-y · Cited by 10

Recent developments in the utility of saturated azaheterocycles in peptidomimetics

Singh, M. K., & Lakshman, M. K. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob01329g · Cited by 9

Interrogation of solution conformation of complex macrocyclic peptides utilizing a combined SEC-HDX-MS, circular dichroism, and NMR workflow

Adpressa, D. A., Reibarkh, M., Jiang, Y., Saurí, J., & Makarov, A. A. (2021) · The Analyst · doi:10.1039/d1an01619a · Cited by 11

Biophysical and electrochemical approaches for studying molecular recognition of IL-33 binding peptides identified via phage display

Cho, C. H., Son, S.-Y., Bang, J. K., Jeon, Y. H., & Park, J. P. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339522 · Cited by 10

AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels

An, D., Pinheiro-Júnior, E. L., Béress, L., Gladkikh, I. N., Leychenko, E. V., Undheim, E. A. B., Peigneur, S., & Tytgat, J. (2022) · Marine Drugs · doi:10.3390/md20020140 · Cited by 11

PACTS-Assisted Thermal Proteome Profiling for Use in Identifying Peptide-Interacting Proteins

Zhao, T., Tian, J., Wang, X., Hao, Y., Xu, M., Zhao, Y., Liu, X., Chen, Y., & Jia, C. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00581 · Cited by 10

Salting-Out crystallization of glycopeptide Vancomycin: Phase behavior study to control the crystal habit

Pu, S., & Hadinoto, K. (2022) · Chemical Engineering Science · doi:10.1016/j.ces.2022.118057 · Cited by 10

Computationally Repurposed Natural Products Targeting SARS-CoV-2 Attachment and Entry Mechanisms

Quimque, M. T. J., Notarte, K. I., de Leon, V. N., Manzano, J. A., Muñoz, J. E. R., Pilapil, D. Y. H., Lim, J. A. K., & Macabeo, A. P. G. (2022) · Springer eBooks · doi:10.1007/978-3-031-08045-6_25 · Cited by 10

Insights into the Interactions of Peptides with Monolayer-Protected Metal Nanoclusters

Tiwari, V., Garg, S., & Karmakar, T. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00997 · Cited by 10

Towards a general synthesis of di-aza-amino acids containing peptides

Bizet, F., Tonali, N., Soulier, J. L., Oliva, A., Kaffy, J., Crousse, B., & Ongeri, S. (2018) · New Journal of Chemistry · doi:10.1039/c8nj03635g · Cited by 10

Tandem Electrochemical Oxidative Azidation/Heterocyclization of Tryptophan‐Containing Peptides under Buffer Conditions

Weng, Y., Xu, X., Chen, H., Zhang, Y., & Zhuo, X. (2022) · Angewandte Chemie · doi:10.1002/ange.202206308 · Cited by 9

Chemically modified antiviral peptides against SARS‐CoV‐2

Quagliata, M., Papini, A. M., & Rovero, P. (2023) · Journal of Peptide Science · doi:10.1002/psc.3541 · Cited by 9

Bioinspired Synthesis of Allysine for Late‐Stage Functionalization of Peptides

Emenike, B., Shahin, S., & Raj, M. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202403215 · Cited by 9

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders

Gao, X., Kaluarachchi, H., Zhang, Y., Hwang, S., & Hannoush, R. N. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299804 · Cited by 9

Chemically Peptide Synthesis and Role of Arginine and Lysine in the Antimicrobial and Antiviral Activity of Synthetic Peptides: A Comprehensive Review

Sunar, Z. S., Acar, T., & Şahi̇n, F. (2024) · Peptide Science · doi:10.1002/pep2.24368 · Cited by 9

Molecular Mechanism of P53 Peptide Permeation through Lipid Membranes from Solid-State NMR Spectroscopy and Molecular Dynamics Simulations

Li, M., Li, J., Lu, X., Schroder, R. V., Chandramohan, A., Wuelfing, W. P., Templeton, A. C., Xu, W., Gindy, M. E., Kesisoglou, F., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c04230 · Cited by 9

Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery

Bannon, M. S., Ellena, J. F., Gourishankar, A. S., Marsh, S. R., Trevisan-Silva, D., Sherman, N. E., Jourdan, L. J., Gourdie, R. G., & Letteri, R. A. (2024) · Molecular Systems Design & Engineering · doi:10.1039/d4me00072b · Cited by 9

Multifunctional dendrimer-peptide conjugates for MET receptor-specific imaging of cancer cells

Lee, J. W., Nickel, K. P., Minne, R. L., Jeffery, J. J., Aluicio‐Sarduy, E., Kim, C., Kim, D., Rawding, P. A., Poellmann, M. J., Mamidi, N., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102509 · Cited by 9

Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications

Yang, Q., Hu, Z., Jiang, H., Wang, J., Han, H., Shi, W., & Qian, H. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60800-4 · Cited by 11

In silico fragment-based peptide design targeting undruggable proteins for enhanced detection of circulating tumor cells

Kim, J., Park, H. S., Kang, H., Son, C. Y., Kim, H. K., Choi, J. H., Kim, L., Choi, S. C., Kim, Y., Hong, S., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167447 · Cited by 9

Advances in Hydrocarbon Stapled Peptides via Ring‐Closing Metathesis: Synthetic Strategies, Structural Diversity, and Therapeutic Applications

Li, L., Li, R., Jiang, Y., Chao, J., Chen, S., Liao, H., & Li, X. (2025) · ChemBioChem · doi:10.1002/cbic.202500527 · Cited by 12

Snake venom-derived peptides as anticancer candidates: Pioneering next-generation therapies

Almeida, J. R., Pinos-Tamayo, E. A., Mendes, B. D. S., Robles-Loaiza, A. A., Syahputra, R. A., Oliveira, A. G. S., & Ribeiro, R. I. M. D. A. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189479 · Cited by 9

Site-specific single point mutation by anthranilic acid in hIAPP 8–37 enhances anti-amyloidogenic activity

Kalita, S., Kalita, S., Paul, A., Shah, M., Kumar, S., & Mandal, B. (2021) · RSC Chemical Biology · doi:10.1039/d0cb00178c · Cited by 9

Extended Solution-phase Peptide Synthesis Strategy Using Isostearyl-Mixed Anhydride Coupling and a New C-Terminal Silyl Ester-Protecting Group for N-Methylated Cyclic Peptide Production

Nagaya, A., Murase, S., Mimori, Y., Wakui, K., Yoshino, M., Matsuda, A., Kobayashi, Y., Kurasaki, H., Cary, D. R., Masuya, K., et al. (2021) · Organic Process Research & Development · doi:10.1021/acs.oprd.1c00078 · Cited by 9

Studies on the oral absorption of cyclic peptides from Pseudostellaria heterophylla and interacting with membrane receptors

Zhao, L., Yang, H., Jiang, C., Kan, Y., Hu, J., & Pang, W. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.105072 · Cited by 9

Electrochemical Sensing of the Peptide Drug Exendin-4 Using a Versatile Nucleic Acid Nanostructure

Khuda, N., Somasundaram, S., & Easley, C. J. (2022) · ACS Sensors · doi:10.1021/acssensors.1c02336 · Cited by 9

Influence of amino acid residue on chromatographic behaviour of μ-opioid receptor agonist tetrapeptide analogue on crown ether based chiral stationary phase

Upmanis, T., & Kazoka, H. (2022) · Journal of Chromatography A · doi:10.1016/j.chroma.2022.463059 · Cited by 9

Design, Synthesis and Characterization of [G10a]-Temporin SHa Dendrimers as Dual Inhibitors of Cancer and Pathogenic Microbes

Khan, A. I., Nazir, S., Ullah, A., Haque, M. N. U., Maharjan, R., Sımjee, S. U., Olleik, H., Courvoisier‐Dezord, E., Maresca, M., & Shaheen, F. (2022) · Biomolecules · doi:10.3390/biom12060770 · Cited by 9

Bioconjugate Platform for Iterative Backbone N-Methylation of Peptides

Zheng, Y., Ongpipattanakul, C., & Nair, S. K. (2022) · ACS Catalysis · doi:10.1021/acscatal.2c04681 · Cited by 9

Improved docking of peptides and small molecules in iMOLSDOCK

Paul, D. S., & Karthe, P. (2022) · Journal of Molecular Modeling · doi:10.1007/s00894-022-05413-3 · Cited by 9

Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species

Esposito, S., Krick, A., Pasquier, O., Bonche, F., Ingenito, R., Magotti, P., Bianchi, E., Monteagudo, E. S., Gallo, M. L., Cicero, D. O., et al. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115256 · Cited by 9

Non-classical C -saccharide linkage of dehydroalanine: synthesis of C -glycoamino acids and C -glycopeptides

Wang, M., Wang, C., Xie, X., Pan, D., Liu, L., Chen, Q., Li, Z., Zhang, Q., & Xu, Z. (2023) · Chemical Communications · doi:10.1039/d2cc06653j · Cited by 9

Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface

Bugatti, K., Sartori, A., Battistini, L., Coppa, C., Vanhulle, E., Noppen, S., Provinciael, B., Naesens, L. M. J., Stevaert, A., Contini, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108765 · Cited by 9

Patent landscape highlighting therapeutic implications of peptides targeting myristoylated alanine-rich protein kinase-C substrate (MARCKS)

Yadav, V. K., Sharma, A. K., Parashar, G., Parashar, N. C., Ramniwas, S., Jena, M. K., Tuli, H. S., & Yadav, K. (2023) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2023.2240020 · Cited by 9

Combining the Peptide RWQWRWQWR and an Ethanolic Extract of Bidens pilosa Enhances the Activity against Sensitive and Resistant Candida albicans and C. auris Strains

Vargas‐Casanova, Y., Bravo-Chaucanés, C. P., Hernández-Martínez, A. X., Costa, G. M., Contreras-Herrera, J., Medina, R., Monroy, Z. J. R., García‐Castañeda, J. E., & Parra‐Giraldo, C. M. (2023) · Journal of Fungi · doi:10.3390/jof9080817 · Cited by 9

Toxicity Mechanism of Dangerous Scorpion Stings in Iran

Dehghani, R., Ghorbani, A., Varzandeh, M., & Robati, F. K. (2023) · Journal of arthropod-borne diseases · doi:10.18502/jad.v17i2.13616 · Cited by 9

Asymmetric Phase-Transfer Alkylation of Readily Available Aryl Aldehyde Schiff Bases of Amino Acid Ethyl Esters

Lu, J., Huang, L., Liang, H., Wang, Z., Kato, T., Liu, Y., & Maruoka, K. (2024) · Organic Letters · doi:10.1021/acs.orglett.3c04290 · Cited by 9

Computational design of anti-cancer peptides tailored to target specific tumor markers

Naeem, A., Noureen, N., Al-Naemi, S. K., Al-Emadi, J. A., & Khan, M. J. (2024) · BMC Chemistry · doi:10.1186/s13065-024-01143-0 · Cited by 9

Multifunctional Nanomaterials: Recent Advancements in Cancer Therapeutics and Vaccines

Gupta, S. K., Kaur, R., Bhardwaj, A., & Parashar, D. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01274-x · Cited by 10

Stackable molecular chairs

Xie, H., Zhiquan, L., Pavlović, R. Z., Gallucci, J. C., & Badjić, J. D. (2019) · Chemical Communications · doi:10.1039/c9cc01664c · Cited by 9

Inhibiting the fibrillation of a GLP-1-like peptide

Egbu, R., van der Walle, C. F., Brocchini, S., & Williams, G. R. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118923 · Cited by 9

An overview of lantibiotic biosynthetic machinery promiscuity and its impact on antimicrobial discovery

Sandiford, S. K. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1699530 · Cited by 9

Peptidomimetic‐based approach toward inhibitors of microbial trimethylamine lyases

Gabr, M. T., Deganutti, G., & Reynolds, C. A. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13775 · Cited by 10

Bound Protein- and Peptide-Based Strategies for Adeno-Associated Virus Vector-Mediated Gene Therapy: Where Do We Stand Now?

Zhang, X., Chai, Z., Samulski, R. J., & Li, C. (2020) · Human Gene Therapy · doi:10.1089/hum.2020.193 · Cited by 9

Targeting BCL10 by small peptides for the treatment of B cell lymphoma

Bao, W., Sun, C., Sun, X., He, M., Yu, H., Yan, W., Wen, F., Zhang, L., & Yang, C. (2020) · Theranostics · doi:10.7150/thno.47533 · Cited by 9

The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis

Camargo, L. L., Denadai‐Souza, A., Yshii, L., Lima, C., Teixeira, S. A., Cerqueira, A., Gewehr, M. C. F., Fernandes, E. S., Schenka, A. A., Muscará, M. N., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173636 · Cited by 9

Identification and Characterization of a Peptide from the Stony Coral Heliofungia actiniformis

Schmidt, C. A., Wilson, D. T. R., Cooke, I., Potriquet, J., Tungatt, K., Muruganandah, V., Boote, C., Kuek, F., Miles, J. J., Kupz, A., et al. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00981 · Cited by 9

MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice

Boutin, J. A., Jullian, M., Frankiewicz, Ł., Galibert, M., Gloanec, P., Diguarher, T. L., Dupuis, P., Ko, A., Ripoll, L., Bertrand, M., et al. (2021) · Molecules · doi:10.3390/molecules26051291 · Cited by 9

Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression

Malyshev, A. V., Sukhanova, I. A., Ushakova, V. M., Zorkina, Y., Abramova, O. V., Morozova, A. Y., Zubkov, E. A., Mitkin, N. A., Pavshintsev, V. V., Doronin, I. I., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15040462 · Cited by 10

Conformational ensemble of the TNF-derived peptide solnatide in solution

Martín-Malpartida, P., Arrastia-Casado, S., Farrera‐Sinfreu, J., Lucas, R., Fischer, H., Fischer, B. E., Eaton, D. C., Tzotzos, S. J., & Macías, M. J. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.04.031 · Cited by 9

Control of postprandial hyperglycemia by oral administration of the sea anemone mucus-derived α-amylase inhibitor (magnificamide)

Sintsova, O. V., Popkova, D. V., Kalinovskii, A. P., Rasin, A. B., Borozdina, N. A., Шайхутдинова, Э. Р., Климович, А. А., Menshov, A. S., Kim, N., Anastyuk, S. D., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115743 · Cited by 9

Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry

Yao, M., Cai, T., Duchoslav, E., Ma, L. M., Guo, X., & Zhu, M. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.05.012 · Cited by 9

Peptidomimetics for CVD screened via TRADD-TRAF2 complex interface assessments

Alagumuthu, M., Jeevitha, S., & Vusa, L. (2023) · In Silico Pharmacology · doi:10.1007/s40203-023-00166-0 · Cited by 8

Cross‐Linked Pseudopeptides via Pd‐Catalyzed Carbonylative Coupling of α‐Amino Acid Iodides with α‐Amino Acid Esters in the Presence of a CO Surrogate

Rathod, G. K., & Jain, R. (2023) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202301010 · Cited by 8

Rapid Amide Coupling in Water for Undergraduate Laboratories

Sharma, S., Ansari, T. N., Kaur, K., Gorce, A., Braje, W. M., & Handa, S. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00350 · Cited by 8

Targeted Therapy of Central Nervous System Acute Lymphoblastic Leukemia with an Integrin α6-Targeted Self-Assembling Proapoptotic Nanopeptide

Ye, J., Li, W., Chen, M., Shi, Q., Wang, H., Li, X.-L., Li, Y., Yang, J., Wang, Q.-L., Hu, F., et al. (2023) · Engineering · doi:10.1016/j.eng.2023.11.012 · Cited by 8

In Silico Immunogenicity Assessment of Therapeutic Peptides

Li, W., Wei, J., Jiang, Q., Zhou, Y., Yan, X., Xiang, C., & Huang, J. H. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673264899231206093930 · Cited by 8

Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans

Ochiai, H., Elouali, S., Yamamoto, T., Asai, H., Noguchi, M., & Nishiuchi, Y. (2024) · ChemMedChem · doi:10.1002/cmdc.202300692 · Cited by 9

Therapeutic peptides: historical perspectives and current development trends

Lau, J. L., & Dunn, M. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820141-1.00027-3 · Cited by 4

Current Advances in Therapeutic Peptides: Past and Future TrendsPreprint

Chelliah, R., Daliri, E. B., Elahi, F., Yeon, S., Tyagi, A., & Oh, D. (2021) · Preprints.org · doi:10.20944/preprints202102.0265.v1

Regulatory Status of Bioactive Peptides

Ali, F., & Ahmad, J. (2022) · CRC Press eBooks · doi:10.1201/9781003106524-32 · Cited by 2

Clinical and preclinical data on therapeutic peptides

Mahari, S., Shahdeo, D., Banga, I. K., Choudhury, S., & Gandhi, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820141-1.00007-8 · Cited by 1

Peptides as ‘Drugs’: The Journey so Far

Sachdeva, S. (2016) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-016-9534-8 · Cited by 70