Therapeutic peptides: Historical perspectives, current development trends, and future directions

A new antibiotic kills pathogens without detectable resistance

Ling, L. L., Schneider, T., Peoples, A. J., Spoering, A. L., Engels, I., Conlon, B. P., Müller, A., Schäberle, T. F., Hughes, D. E., Epstein, S. S., et al. (2015) · Nature · doi:10.1038/nature14098 · Cited by 2,428

American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis — 2016--Executive Summary

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Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

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Advances in Fmoc solid‐phase peptide synthesis

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Untitled work

(1922) · PubMed · Cited by 753

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Chang, Y. S., Graves, B. J., Guerlavais, V., Tovar, C., Packman, K. E., To, K.-H., Olson, K. A., Kesavan, K. P., Gangurde, P., Mukherjee, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303002110 · Cited by 681

Strategic Approaches to Optimizing Peptide ADME Properties

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Large-scale manufacture of peptide therapeutics by chemical synthesis

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Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Del Solar, M., Zhu, B., York, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.063 · Cited by 591

The emerging landscape of peptide-based inhibitors of PCSK9

Tombling, B. J., Zhang, Y., Huang, Y., Craik, D. J., & Wang, C. K. L. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.06.903 · Cited by 34

Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by 1H NMR and All-Atom Molecular Dynamics Simulations

Hjalte, J., Hossain, S., Hugerth, A., Sjögren, H., Wahlgren, M., Larsson, P., & Lundberg, D. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00883 · Cited by 35

Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases

Liu, J., Ting, J. P., Al-Azzam, S., Ding, Y., & Afshar, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062805 · Cited by 37

Studying Peptide-Metal Ion Complex Structures by Solution-State NMR

Shalev, D. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415957 · Cited by 33

Shaping the Future of Antimicrobial Therapy: Harnessing the Power of Antimicrobial Peptides in Biomedical Applications

Tripathi, A. K., Singh, J., Trivedi, R., & Ranade, P. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14110539 · Cited by 34

Peptide Therapeutics: Unveiling the Potential against Cancer—A Journey through 1989

Musaimi, O. A. (2024) · Cancers · doi:10.3390/cancers16051032 · Cited by 37

Focus on therapeutic peptides and their delivery

Rosson, E., Lux, F., David, L., Godfrin, Y., Tillement, O., & Thomas, E. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125555 · Cited by 36

Overview of intranasally delivered peptides: key considerations for pharmaceutical development

Bakri, W. A., Donovan, M. D., Cueto, M. A., Wu, Y., Orekie, C., & Yang, Z. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1517742 · Cited by 34

Receptor selectivity from minimal backbone modification of a polypeptide agonist

Liu, S., Cheloha, R. W., Watanabe, T., Gardella, T. J., & Gellman, S. H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815294115 · Cited by 34

Blue light-promoted N–H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates: Synthesis of unnatural α-aryl amino acid derivatives

Okada, C. Y., dos Santos, C. Y., & Jurberg, I. D. (2020) · Tetrahedron · doi:10.1016/j.tet.2020.131316 · Cited by 34

Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease

Subramanian, K., Iovino, F., Tsikourkitoudi, V. P., Merkl, P., Ahmed, S., Berry, S. B., Aschtgen, M., Svensson, M., Bergman, P., Sotiriou, G. A., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012695 · Cited by 33

Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins

Sindhikara, D., Wagner, M., Gkeka, P., Güssregen, S., Tiwari, G., Heßler, G., Yapici, E., Li, Z., & Evers, A. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01500 · Cited by 35

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19

Shah, J. N., Guo, G., Krishnan, A., Ramesh, M., Katari, N. K., Shahbaaz, M., Abdellattif, M. H., Singh, S. K., & Dua, K. (2021) · Therapies · doi:10.1016/j.therap.2021.09.007 · Cited by 38

Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

Bagheri-Ziari, S., Shahbazzadeh, D., Sardari, S., Sabatier, J., & Bagheri, K. P. (2021) · Molecules · doi:10.3390/molecules26092580 · Cited by 33

Clickable tryptophan modification for late-stage diversification of native peptides

Xiao, Y., Zhou, H., Shi, P., Zhao, X., Liu, H., & Li, X. (2024) · Science Advances · doi:10.1126/sciadv.adp9958 · Cited by 33

Expanding the Design Space of Polymer–Metal Organic Framework (MOF) Gels by Understanding Polymer–MOF Interactions

Verma, P., Bannon, M. S., Kuenen, M. K., Raj, S. S. S., Dhakal, A., Stone, K. H., Nichols, A. W., Machan, C. W., Colón, Y. J., Letteri, R. A., et al. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.4c00112 · Cited by 33

Methods for engineering therapeutic peptides

Li, Y., Clark, K. A., & Tan, Z. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.05.027 · Cited by 33

Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography

Luca, C. D., Felletti, S., Macis, M., Cabri, W., Lievore, G., Chenet, T., Pasti, L., Morbidelli, M., Cavazzini, A., Catani, M., et al. (2019) · Journal of Chromatography A · doi:10.1016/j.chroma.2019.460789 · Cited by 33

Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide

Smith, S. J., Li, C. M., Lingeman, R. G., Hickey, R. J., Liu, Y., Malkas, L. H., & Raoof, M. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.03.025 · Cited by 33

Therapeutic peptides for chemotherapy: Trends and challenges for advanced delivery systems

Ilangala, A. B., Lechanteur, A., Fillet, M., & Piel, G. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.07.010 · Cited by 35

The application of anisole in greener solid-phase peptide synthesis protocols – Compatibility with green bases in Fmoc removal and new green binary mixture for coupling

Přibylka, A., Pastorek, M., Grepl, M., & Schütznerová, E. (2021) · Tetrahedron · doi:10.1016/j.tet.2021.132452 · Cited by 33

S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases

Kurpet, K., & Chwatko, G. (2022) · Molecules · doi:10.3390/molecules27196640 · Cited by 33

Editorial: Antimicrobial peptides and their druggability, bio-safety, stability, and resistance

Ma, X., Aminov, R. I., Franco, O. L., de la Fuente‐Núñez, C., Wang, G., & Wang, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1425952 · Cited by 33

A Review on Forced Degradation Strategies to Establish the Stability of Therapeutic Peptide Formulations

Patel, S., Vyas, V. K., & Mehta, P. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10492-8 · Cited by 35

Propedia v2.3: A novel representation approach for the peptide-protein interaction database using graph-based structural signatures

Martins, P., Mariano, D., Carvalho, F. C., Bastos, L. L., Moraes, L., Paixão, V. M., & de Melo-Minardi, R. C. (2023) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2023.1103103 · Cited by 35

Stapled β-Hairpin Antimicrobial Peptides with Improved Stability and Activity against Drug-Resistant Gram-Negative Bacteria

Selvarajan, V., Tram, N. D. T., Xu, J. X., Ngen, S. T. Y., Koh, J.-J., Teo, J. W. P., Yuen, T., & Ee, P. L. R. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00140 · Cited by 33

Regenerative therapies as a potential treatment of erectile dysfunction

Chung, D. Y., Ryu, J., & Yin, G. N. (2023) · Korean journal of urology · doi:10.4111/icu.20230104 · Cited by 32

Design of an Anti-HMGB1 Synthetic Antibody for In Vivo Ischemic/Reperfusion Injury Therapy

Koide, H., Kiyokawa, C., Okishima, A., Saito, K., Yoshimatsu, K., Fukuta, T., Hoshino, Y., Asai, T., Nishimura, Y., Miura, Y., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c06799 · Cited by 33

Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis

Wu, W., Li, G., Dong, S., Chu, C. H., Ma, S., Zhang, Z.-W., Yuan, S., Jin, W., Guo, Z., Shen, Y., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111423 · Cited by 33

Bridging machine learning and peptide design for cancer treatment: a comprehensive review

Rezaee, K., & Eslami, H. (2025) · Artificial Intelligence Review · doi:10.1007/s10462-025-11148-3 · Cited by 34

Marine Antimicrobial Peptides: A Promising Source of New Generation Antibiotics and Other Bio-active Molecules

Bertrand, B., & Muñóz-Garay, C. (2018) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-018-9789-3 · Cited by 33

How to overcome endosomal entrapment of cell‐penetrating peptides to release the therapeutic potential of peptides?

Nadal‐Bufí, F., & Henriques, S. T. (2020) · Peptide Science · doi:10.1002/pep2.24168 · Cited by 33

Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls

Monty, O. B. C., Simmons, N., Chamakuri, S., Matzuk, M. M., & Young, D. W. (2020) · ACS Combinatorial Science · doi:10.1021/acscombsci.0c00144 · Cited by 32

Bacterial Persister-Cells and Spores in the Food Chain: Their Potential Inactivation by Antimicrobial Peptides (AMPs)

Liu, S., Brul, S., & Zaat, S. A. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238967 · Cited by 34

Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids

Spitalieri, P., Centofanti, F., Murdocca, M., Scioli, M. G., Latini, A., Cesare, S. D., Citro, G., Rossi, A., Orlandi, A., Miersch, S., et al. (2022) · Cells · doi:10.3390/cells11071235 · Cited by 31

Late‐Stage Functionalization of Histidine in Unprotected Peptides

Noisier, A. F. M., Johansson, M. J., Knerr, L., Hayes, M. A., Drury, W. J., Valeur, E., Malins, L. R., & Gopalakrishnan, R. (2019) · Angewandte Chemie · doi:10.1002/ange.201910888 · Cited by 32

Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Dergunova, L. V., Filippenkov, I. B., Limborska, S. A., & Myasoedov, N. F. (2023) · Genes · doi:10.3390/genes14050953 · Cited by 34

Biomaterials for Protein Delivery: Opportunities and Challenges to Clinical Translation

Gorantla, A., Hall, J., Troidle, A., & Janjic, J. M. (2024) · Micromachines · doi:10.3390/mi15040533 · Cited by 31

Hitting Undruggable Targets: Viewing Stabilized Peptide Development through the Lens of Quantitative Systems Pharmacology

Atangcho, L., Navaratna, T. A., & Thurber, G. M. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.11.008 · Cited by 33

Quality Control of Therapeutic Peptides by 1H NMR HiFSA Sequencing

Choules, M. P., Bisson, J. I., Gao, W., Lankin, D. C., McAlpine, J. B., Niemitz, M., Jaki, B. U., Franzblau, S. G., & Pauli, G. F. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02704 · Cited by 31

Strategies to Enhance Metabolic Stabilities

Khatri, B., Nuthakki, V. R., & Chatterjee, J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_2 · Cited by 32

Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods

Javaid, N., Yasmeen, F., & Choi, S. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090441 · Cited by 31

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

Csire, G., Canabady‐Rochelle, L., Averlant‐Petit, M., Selmeczi, K., & Stefan, L. (2020) · Metallomics · doi:10.1039/d0mt00103a · Cited by 38

Silanol: a bifunctional group for peptide synthesis and late-stage functionalization

Hu, Q.-L., Hou, K., Li, J., Yang, G., Song, Z., Chan, A. S. C., & Xiong, X. (2020) · Chemical Science · doi:10.1039/d0sc02439b · Cited by 31

Computational structure modeling for diverse categories of macromolecular interactions

Aderinwale, T. W., Christoffer, C. W., Sarkar, D., Alnabati, E., & Kihara, D. (2020) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2020.05.017 · Cited by 31

Targeting epigenetic reader domains by chemical biology

Cipriano, A., Sbardella, G., & Ciulli, A. (2020) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2020.05.006 · Cited by 30

Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum

Sekar, J., Teng, W., Dahms‬, H.-U., Liu, W., Ponnusamy, V. K., Chiu, C. C.-C., Kumar, B. S., & Sivakumar, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-70516-x · Cited by 31

Effects of Glycosylation and d -Amino Acid Substitution on the Antitumor and Antibacterial Activities of Bee Venom Peptide HYL

Wu, M., Su, A., Chen, Q., Chen, X.-Y., Li, H., Li, Y., & Zhao, X. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00355 · Cited by 32

Identification, protein antiglycation, antioxidant, antiproliferative, and molecular docking of novel bioactive peptides produced from hydrolysis of Lens culinaris

Kuerban, A., Al‐Malki, A. L., Kumosani, T. A., Sheikh, R. A., Al-Abbasi, F. A., Alshubaily, F. A., Abulnaja, K. O., & Moselhy, S. S. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13494 · Cited by 31

Tyrosine-Specific Modification via a Dearomatization–Rearomatization Strategy: Access to Azobenzene Functionalized Peptides

Wang, P., Cheng, Y., Wu, C., Zhou, Y., Cheng, Z., Li, H., Wang, R., Su, W., & Fang, L. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c01013 · Cited by 31

Anticancer activity of protein fractions from chia ( Salvia hispanica L .)

Bojórquez, N. D. C. Q., Carrillo‐Cocom, L. M., Hernández‐Álvarez, A. J., & Campos, M. R. S. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15780 · Cited by 31

Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections

Monroe, M. K., Wang, H., Anderson, C. F., Jia, H., Flexner, C. W., & Cui, H. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.037 · Cited by 31

Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine

Stefanov, B., & Fussenegger, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.986210 · Cited by 31

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Hansen, S., Zhang, Y., Hwang, S., Nabhan, A. N., Li, W., Fuhrmann, J., Kschonsak, Y. T., Zhou, L., Nile, A. H., Gao, X., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207327119 · Cited by 30

Peptide‐Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization**

Liu, X., Ji, X., Heinis, C., & Waser, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202306036 · Cited by 31

Characterization of Synthetic Peptide Therapeutics Using Liquid Chromatography–Mass Spectrometry: Challenges, Solutions, Pitfalls, and Future Perspectives

Lian, Z., Wang, N., Tian, Y., & Huang, L. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00479 · Cited by 30

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Liu, X., Cai, W., Ronceray, N., Rađenović, A., Fierz, B., & Waser, J. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c09261 · Cited by 30

Enantioselective organocatalytic strategies to access noncanonical α-amino acids

Pecchini, P., Fochi, M., Bartoccini, F., Piersanti, G., & Bernardi, L. (2024) · Chemical Science · doi:10.1039/d4sc01081g · Cited by 30

Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides

Ruhl, K. E., Maso, M. J. D., Rose, H. B., Schultz, D. M., Lévesque, F., Grosser, S. T., Silverman, S. M., Li, S., Sciammetta, N., & Mansoor, U. F. (2024) · Organic Process Research & Development · doi:10.1021/acs.oprd.4c00165 · Cited by 33

Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation

Streefkerk, D. E., Schmidt, M., Ippel, H., Hackeng, T. M., Nuijens, T., Timmerman, P., & van Maarseveen, J. H. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b00378 · Cited by 30

On‐Resin Preparation of Allenamidyl Peptides: A Versatile Chemoselective Conjugation and Intramolecular Cyclisation Tool

Cameron, A. J., Harris, P. W. R., & Brimble, M. A. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202004656 · Cited by 30

Automated affinity selection for rapid discovery of peptide binders

Zhang, G., Li, C., Quartararo, A. J., Loas, A., & Pentelute, B. L. (2021) · Chemical Science · doi:10.1039/d1sc02587b · Cited by 30

Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics

Sun, H. R., Qiao, B., Choi, W., Hampu, N., McCallum, N. C., Thompson, M. P., Oktawiec, J., Weigand, S. L., Ebrahim, O. M., de la Cruz, M. O., et al. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c01149 · Cited by 31

Non-Covalent Albumin Ligands in FDA-Approved Therapeutic Peptides and Proteins

Zaragoza, F. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01021 · Cited by 30

The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies

Koran, K., Çalışkan, E., Öztürk, D. A., Çapan, İ., Tekin, S., Sandal, S., & Görgülü, A. O. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106338 · Cited by 30

Diabetic Neuropathy of the Retina and Inflammation: Perspectives

Мухаррамовна, Б. Г., Oshitari, T., & Bikbov, M. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119166 · Cited by 32

Trifluoromethylthiolation of Tryptophan and Tyrosine Derivatives: A Tool for Enhancing the Local Hydrophobicity of Peptides

Gregorc, J., Lensen, N., Chaume, G., Iskra, J., & Brigaud, T. (2023) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c01373 · Cited by 30

Macrocyclization of Biaryl-Bridged Peptides through Late-Stage Palladium-Catalyzed C(sp2)–H Arylation

Bai, Q., Bai, Z., & Wang, H. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b02945 · Cited by 29

Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery

Li, Y., Cao, X., Tian, C., & Zheng, J. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.04.015 · Cited by 29

Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction

Wu, Y., Tam, W., Chau, H.-F., Kaur, S., Thor, W., Aik, W. S., Chan, W., Zweckstetter, M., & Wong, K. (2020) · Chemical Science · doi:10.1039/d0sc04849f · Cited by 29

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, D., Olander, T., Sjöblom, M., Hedeland, M., & Lennernäs, H. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.019 · Cited by 29

Microwell Plate-Based Dynamic Light Scattering as a High-Throughput Characterization Tool in Biopharmaceutical Development

Dauer, K., Pfeiffer‐Marek, S., Kamm, W., & Wagner, K. G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020172 · Cited by 29

Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time In Situ Release Kinetics in Peptide-Liposome Formulations

Doyen, C., Larquet, É., Coureux, P., Frances, O., Herman, F., Sablé, S., Burnouf, J.-P., Sizun, C., & Lescop, E. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00037 · Cited by 29

Hydrophobic-hydrophilic Alternation: An effective Pattern to de novo Designed Antimicrobial Peptides

Zeng, P., & Cheng, Q. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220902124856 · Cited by 31

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Afonin, S., Babii, O., Reuter, A., Middel, V., Takamiya, M., Strähle, U., Komarov, I. V., & Ulrich, A. S. (2020) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.16.6 · Cited by 29

Mutexa: A Computational Ecosystem for Intelligent Protein Engineering

Yang, Z. J., Shao, Q., Jiang, Y., Jurich, C., Ran, X., Juarez, R. J., Yan, B., Stull, S. L., Gollu, A., & Ding, N. (2023) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.3c00602 · Cited by 28

Construction of Targeting-Peptide-Based Imaging Reagents and Their Application in Bioimaging

Zhang, L., Wang, X., Zhao, J., Sun, B., & Wang, W. (2023) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.3c00104 · Cited by 28

Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety

Sepúlveda-Rivas, S., Fritz, H. F., Valenzuela, C., Santiviago, C. A., & Morales, J. O. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030103 · Cited by 28

A selective comprehensive reversed-phase×reversed-phase 2D-liquid chromatography approach with multiple complementary detectors as advanced generic method for the quality control of synthetic and therapeutic peptides

Karongo, R., Ikegami, T., Stoll, D. R., & Lämmerhofer, M. (2020) · Journal of Chromatography A · doi:10.1016/j.chroma.2020.461430 · Cited by 28

A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin

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