Therapeutic peptides: Historical perspectives, current development trends, and future directions

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Items 201–300 of 1,001

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2. Therapeutic Advances in Oncology
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3. Green solvents for the formation of amide linkages
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4. Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities
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5. Bicyclic peptides: types, synthesis and applications
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6. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study
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7. Snake Venom Cathelicidins as Natural Antimicrobial Peptides
   Elizângela de Barros, Regina Meneses Gonçalves, Marlon Henrique e Silva Cardoso, Nuno C. Santos, Octávio Luiz Franco, Elizabete de Souza Cândido · 2019 · Frontiers in Pharmacology
8. Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation
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9. Screening of Novel Bioactive Peptides from Goat Casein: In Silico to In Vitro Validation
   Ezequiel R. Coscueta, Patrícia Batista, José Erick Galindo Gomes, Roberto da Silva, Maria Manuela Pintado · 2022 · International Journal of Molecular Sciences
10. The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules
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11. Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019
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12. Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery
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13. Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides
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14. 2017 FDA Peptide Harvest
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15. Peptides and peptidomimetics as inhibitors of protein–protein interactions involving β-sheet secondary structures
    José Laxio Arenas, Julia Kaffy, Sandrine Ongeri · 2019 · Current Opinion in Chemical Biology
16. Mechanoenzymatic Transformations in the Absence of Bulk Water: A More Natural Way of Using Enzymes
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17. 2D green SPPS: green solvents for on-resin removal of acid sensitive protecting groups and lactamization
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18. Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy
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19. Peptide Shuttles for Blood–Brain Barrier Drug Delivery
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20. Virtual Screening of Peptide Libraries: The Search for Peptide-Based Therapeutics Using Computational Tools
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21. Designing stapled peptides to inhibit protein‐protein interactions: An analysis of successes in a rapidly changing field
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22. Injectables and Depots to Prolong Drug Action of Proteins and Peptides
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23. Automatic construction of molecular similarity networks for visual graph mining in chemical space of bioactive peptides: an unsupervised learning approach
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24. Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition
    Olivia Zhang, Jeffrey W. Schubert · 2020 · The Journal of Organic Chemistry
25. Strategies for recombinant production of antimicrobial peptides with pharmacological potential
    Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite, Gisele Regina Rodrigues, Harry Morales Duque, Rosiane Andrade da Costa, Victor Albuquerque Cunha, Lorena Sousa de Loiola Costa, Nicolau Brito da Cunha, Octávio Luiz Franco, Simoni Campos Dias · 2020 · Expert Review of Clinical Pharmacology
26. iACVP: markedly enhanced identification of anti-coronavirus peptides using a dataset-specific word2vec model
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27. Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment
    Shakir Ahamad, Shahnawaz Ali Bhat · 2022 · Journal of Medicinal Chemistry
28. From lead to market: chemical approaches to transform peptides into therapeutics
    Caitlin L Gare, Andrew M. White, Lara R. Malins · 2025 · Trends in Biochemical Sciences
29. Nanosponges as protein delivery systems: Insulin, a case study
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30. Versatile Ru‐Photoredox‐Catalyzed Functionalization of Dehydro‐Amino Acids and Peptides
    Tobias Brandhofer, Olga Garcı́a Mancheño · 2019 · ChemCatChem
31. Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool
    Li, Yang, Li, Wang, Xu, Zhengshuang · 2021 · Marine Drugs
32. Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue
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33. Biphasic electrochemical peptide synthesis
    Shingo Nagahara, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba · 2021 · Chemical Science
34. Strategies for Heterologous Expression, Synthesis, and Purification of Animal Venom Toxins
    Esperanza Rivera‐de‐Torre, Charlotte Rimbault, Timothy P. Jenkins, Christoffer V. Sørensen, Anna Damsbo, Natalie J. Saez, Yoan Duhoo, Celeste Menuet Hackney, Lars Ellgaard, Andreas H. Laustsen · 2022 · Frontiers in Bioengineering and Biotechnology
35. Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins
    Yu Ping Tian, Matthew Tirrell, James L. LaBelle · 2022 · Advanced Healthcare Materials
36. Development of Anticancer Peptides Using Artificial Intelligence and Combinational Therapy for Cancer Therapeutics
    Ji Su Hwang, Seok Gi Kim, Tae Hwan Shin, Yong Eun Jang, Do Hyeon Kwon, Gwang Lee · 2022 · Pharmaceutics
37. Dehydroalanine modification sees the light: a photochemical conjugate addition strategy
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38. Advances in solid-phase peptide synthesis in aqueous media (ASPPS)
    Da’san M. M. Jaradat, Othman Al Musaimi, Fernando Alberício · 2022 · Green Chemistry
39. Discovery of Cyclic Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy
    John Fetse, Zhen Zhao, Hao Liu, Umar‐Farouk Mamani, Bahaa Mustafa, Pratik Adhikary, Nurudeen Mohammed Ibrahim, Yanli Liu, Pratikkumar Patel, Maryam Nakhjiri et al. · 2022 · Journal of Medicinal Chemistry
40. Photoredox Ni-catalyzed peptide C(sp 2 )–O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization
    Hyelee Lee, Nicolas C. Boyer, Qiaolin Deng, Hai‐Young Kim, Tomi K. Sawyer, Nunzio Sciammetta · 2019 · Chemical Science
41. New approaches towards the discovery and evaluation of bioactive peptides from natural resources
    Nam Joo Kang, Hyeon‐Su Jin, Sung‐Eun Lee, Hyun Jung Kim, Hong Koh, Dong‐Woo Lee · 2019 · Critical Reviews in Environmental Science and Technology
42. Glycopeptide drugs: A pharmacological dimension between “Small Molecules” and “Biologics”
    Christopher R. Apostol, Meredith Hay, Robin L. Polt · 2020 · Peptides
43. Role of Anti-Cancer Peptides as Immunomodulatory Agents: Potential and Design Strategy
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44. Advancing oral delivery of biologics: Machine learning predicts peptide stability in the gastrointestinal tract
    Fanjin Wang, Nannapat Sangfuang, Laura E. McCoubrey, Vipul Yadav, Moe Elbadawi, Mine Orlu, Simon Gaisford, Abdul W. Basit · 2023 · International Journal of Pharmaceutics
45. Engineered therapeutic proteins for sustained-release drug delivery systems
    Thoa Thi Kim Nguyen, Khang‐Yen Pham, Simmyung Yook · 2023 · Acta Biomaterialia
46. Reprogramming biological peptides to combat infectious diseases
    Marcelo D. T. Torres, César de la Fuente‐Núñez · 2019 · Chemical Communications
47. Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy
    Jinbiao Jiao, Guanzhen Wang, Xi‐Le Hu, Yi Zang, Stéphane Maisonneuve, Adam C. Sedgwick, Jonathan L. Sessler, Juan Xie, Jia Xuan Li, Xiao‐Peng He et al. · 2019 · Journal of the American Chemical Society
48. Recent progress in hydrophobic ion-pairing and lipid-based drug delivery systems for enhanced oral delivery of biopharmaceuticals
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49. Oral Delivery of Biologics in Inflammatory Bowel Disease Treatment
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50. Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer
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51. Bacterial outer membrane vesicles as a candidate tumor vaccine platform
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52. Peptide Synthesis Utilizing Micro‐flow Technology
    Shinichiro Fuse, Yuma Otake, Hiroyuki Nakamura · 2018 · Chemistry - An Asian Journal
53. Game Change from Reagent- to Substrate-Controlled Peptide Synthesis
    Wataru Muramatsu, Tomohiro Hattori, Hisashi Yamamoto · 2020 · Bulletin of the Chemical Society of Japan
54. Artificial intelligence and machine learning for protein toxicity prediction using proteomics data
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55. Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL
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56. An expanding horizon of complex injectable products: development and regulatory considerations
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57. A frog peptide provides new strategies for the intervention against skin wound healing
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58. Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
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59. Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation
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60. Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?
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61. Advances in Asymmetric Amino Acid Synthesis Enabled by Radical Chemistry
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62. An update - Prolonging the action of protein and peptide drugs
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63. Colon tissue-accumulating mesoporous carbon nanoparticles loaded with Musca domestica cecropin for ulcerative colitis therapy
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64. Aptamer-displaying peptide amphiphile micelles as a cell-targeted delivery vehicle of peptide cargoes
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65. Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?
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66. Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis
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67. Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review
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68. CD4 + T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis
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69. Improved Tag-Assisted Liquid-Phase Peptide Synthesis: Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate
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70. Catalysts for the Enzymatic Lipidation of Peptides
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71. Discovery of bioactive peptides as therapeutic agents for skin wound repair
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72. Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment
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73. Harnessing the Microbiome: CRISPR-Based Gene Editing and Antimicrobial Peptides in Combating Antibiotic Resistance and Cancer
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74. Sequence and structure-based peptides as potent amyloid inhibitors: A review
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75. Novel formulations and drug delivery systems to administer biological solids
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76. TargetAntiAngio: A Sequence-Based Tool for the Prediction and Analysis of Anti-Angiogenic Peptides
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77. Chemical Protein Synthesis in Medicinal Chemistry
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78. Marine Arthropods as a Source of Antimicrobial Peptides
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79. Recent Patents and FDA-Approved Drugs Based on Antiviral Peptides and Other Peptide-Related Antivirals
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80. Targeting ALK in Cancer: Therapeutic Potential of Proapoptotic Peptides
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81. Site-Selective Modification of α-Amino Acids and Oligopeptides via Native Amine-Directed γ-C(sp3)-H Arylation
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82. A Method for Predicting Hemolytic Potency of Chemically Modified Peptides From Its Structure
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83. N‐Butylpyrrolidinone for Solid‐Phase Peptide Synthesis is Environmentally Friendlier and Synthetically Better than DMF
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84. Metal‐Catalyzed C(sp 2 )−H Functionalization Processes of Phenylalanine‐ and Tyrosine‐Containing Peptides
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85. Expanding the range of sub/supercritical fluid chromatography: Advantageous use of methanesulfonic acid in water-rich modifiers for peptide analysis
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86. Peptipedia: a user-friendly web application and a comprehensive database for peptide research supported by Machine Learning approach
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87. Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors
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88. In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases
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89. Targeting Adiponectin in Breast Cancer
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90. Predicting Protein–Peptide Interactions: Benchmarking Deep Learning Techniques and a Comparison with Focused Docking
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91. Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages
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92. Recent progress in non-opioid analgesic peptides
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93. Optoregulated Protein Release from an Engineered Living Material
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94. Immunomodulatory significance of natural peptides in mammalians: Promising agents for medical application
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95. 1,3‐Dipolar Cycloaddition between Dehydroalanines and C,N‐Cyclic Azomethine Imines: Application to Late‐Stage Peptide Modification
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96. Advances in understanding of Netherton syndrome and therapeutic implications
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97. Maize bioactive peptides: From structure to human health
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98. Recent advances in γ-C(sp3)–H bond activation of amides, aliphatic amines, sulfanilamides and amino acids
    Shao‐Fei Ni, Guanglong Huang, Chen Yong-hui, James S. Wright, Ming‐De Li, Li Dang · 2021 · Coordination Chemistry Reviews
99. Electromembrane extraction of peptides using deep eutectic solvents as liquid membrane
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100. A story of peptides, lipophilicity and chromatography – back and forth in time
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