Therapeutic peptides: Historical perspectives, current development trends, and future directions

A new antibiotic kills pathogens without detectable resistance

Ling, L. L., Schneider, T., Peoples, A. J., Spoering, A. L., Engels, I., Conlon, B. P., Müller, A., Schäberle, T. F., Hughes, D. E., Epstein, S. S., et al. (2015) · Nature · doi:10.1038/nature14098 · Cited by 2,428

American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis — 2016--Executive Summary

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Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Stupp, R., Hegi, M. E., Gorlia, T., Erridge, S. C., Perry, J., Hong, Y.-K., Aldape, K. D., Lhermitte, B., Pietsch, T., Grujicic, D., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70379-1 · Cited by 1,052

Advances in Fmoc solid‐phase peptide synthesis

Behrendt, R., White, P., & Offer, J. (2016) · Journal of Peptide Science · doi:10.1002/psc.2836 · Cited by 767

Untitled work

(1922) · PubMed · Cited by 753

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Chang, Y. S., Graves, B. J., Guerlavais, V., Tovar, C., Packman, K. E., To, K.-H., Olson, K. A., Kesavan, K. P., Gangurde, P., Mukherjee, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303002110 · Cited by 681

Strategic Approaches to Optimizing Peptide ADME Properties

Di, L. (2015) · The AAPS Journal · doi:10.1208/s12248-014-9687-3 · Cited by 669

Large-scale manufacture of peptide therapeutics by chemical synthesis

Bray, B. L. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1133 · Cited by 601

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Del Solar, M., Zhu, B., York, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.063 · Cited by 591

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Arifian, H., Maharani, R., Megantara, S., Gazzali, A. M., & Muchtaridi, M. (2022) · Molecules · doi:10.3390/molecules27217631 · Cited by 46

Deep learning for advancing peptide drug development: Tools and methods in structure prediction and design

Wu, X., Lin, H., Bai, R., & Duan, H. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116262 · Cited by 52

Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics

Swenson, C., Mandava, G., Thomas, D. M., & Moellering, R. E. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00423 · Cited by 55

Cancer-Targeted Delivery Systems Based on Peptides

Chatzisideri, T., Leonidis, G., & Sarli, V. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0174 · Cited by 46

Discovery of novel fungal RiPP biosynthetic pathways and their application for the development of peptide therapeutics

Vogt, E., & Künzler, M. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09893-x · Cited by 45

Targeted and MMP-2/9 responsive peptides for the treatment of rheumatoid arthritis

Li, N., Qiao, Y., Xue, L., Xu, S., & Zhang, N. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118625 · Cited by 45

Bioactive Peptides as Therapeutic Adjuvants for Cancer

Bojórquez, N. D. C. Q., & Campos, M. R. S. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1813316 · Cited by 45

Gold(III) Aryl Complexes as Reagents for Constructing Hybrid Peptide-Based Assemblies via Cysteine S -Arylation

Stauber, J. M., Rheingold, A. L., & Spokoyny, A. M. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c00087 · Cited by 46

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Onyango, I. G., Bennett, J. P., & Stokin, G. B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.303007 · Cited by 45

Design of Protein Segments and Peptides for Binding to Protein Targets

Gupta, S., Azadvari, N., & Hosseinzadeh, P. (2022) · BioDesign Research · doi:10.34133/2022/9783197 · Cited by 47

2024 FDA TIDES (Peptides and Oligonucleotides) Harvest

Musaimi, O. A., Shaer, D. A., de la Torre, B. G., & Alberício, F. (2025) · Pharmaceuticals · doi:10.3390/ph18030291 · Cited by 45

Recent Advances in Peptide-Based Approaches for Cancer Treatment

Conibear, A. C., Schmid, A., Kamalov, M., Becker, C. F. W., & Bello, C. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171123204851 · Cited by 44

Peptide-Based Therapeutics for Oncology

Fisher, E. N., Pavlenko, K. A., Vlasov, A. M., & Ramenskaya, G. V. (2019) · Pharmaceutical Medicine · doi:10.1007/s40290-018-0261-7 · Cited by 45

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

Levine, P. M., Balana, A. T., Sturchler, E., Koole, C., Noda, H., Zarzycka, B. A., Daley, E. J., Truong, T. T., Katritch, V., Gardella, T. J., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b05365 · Cited by 44

Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment

Walrave, L., Vinken, M., Leybaert, L., & Smolders, I. J. (2020) · Biomolecules · doi:10.3390/biom10111578 · Cited by 44

Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition

Taleb, M., Atabakhshi‐Kashi, M., Wang, Y., Alanagh, H. R., Sabet, Z. F., Li, F., Cheng, K., Li, C., Qi, Y., Nie, G., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100051 · Cited by 44

Nonalcoholic fatty liver disease: Current therapies and future perspectives in drug delivery

Domingues, I., Leclercq, I. A., & Beloqui, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.040 · Cited by 45

Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Doostmohammadi, M., Ameri, A., Mohammadinejad, R., Noudeh, N. D., Banat, I. M., Ohadi, M., & Dehghannoudeh, G. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s217211 · Cited by 43

Synthetic molecular evolution of antimicrobial peptides

Chen, C. H., Bepler, T., Pepper, K., Fu, D., & Lu, T. K. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102718 · Cited by 43

Cyclization and Docking Protocol for Cyclic Peptide–Protein Modeling Using HADDOCK2.4

Charitou, V., van Keulen, S. C., & Bonvin, A. M. J. J. (2022) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.2c00075 · Cited by 43

Bicyclic peptides: Paving the road for therapeutics of the future

Ullrich, S., & Nitsche, C. (2023) · Peptide Science · doi:10.1002/pep2.24326 · Cited by 42

Peptide-nanoparticle conjugates as a theranostic platform

Kim, S., No, Y. H., Sluyter, R., Konstantinov, K., Kim, J. H., & Kim, J. H. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215530 · Cited by 46

Multi_CycGT: A Deep Learning-Based Multimodal Model for Predicting the Membrane Permeability of Cyclic Peptides

Cao, L., Xu, Z., Shang, T., Zhang, C., Wu, X., Wu, Y., Zhai, S., Zhan, Z., & Duan, H. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01611 · Cited by 55

Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

Yeboue, Y., Jean, M., Subra, G., Martínez, J., Lamaty, F., & Métro, T. (2021) · Organic Letters · doi:10.1021/acs.orglett.0c03209 · Cited by 42

Biomedical applications of the peptide decorated gold nanoparticles

Rai, A., & Ferreira, L. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1853031 · Cited by 42

Genome‐Mining‐Based Discovery of the Cyclic Peptide Tolypamide and TolF, a Ser/Thr Forward O‐Prenyltransferase

Purushothaman, M., Sarkar, S., Morita, M., Gugger, M. F., Schmidt, E. W., & Morinaka, B. I. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202015975 · Cited by 42

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

Saldías, M. P., Maureira, D., Orellana‐Serradell, O., Silva, I., Lavanderos, B. J., Cruz, P., Torres, C., Cáceres, M., & Cerda, O. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.621614 · Cited by 46

Visible‐Light Mediated Tryptophan Modification in Oligopeptides Employing Acylsilanes

Reimler, J., & Studer, A. (2021) · Chemistry - A European Journal · doi:10.1002/chem.202102749 · Cited by 42

Development and Regulatory Challenges for Peptide Therapeutics

Zane, D., Feldman, P. L., Sawyer, T. K., Sobol, Z., & Hawes, J. J. (2020) · International Journal of Toxicology · doi:10.1177/1091581820977846 · Cited by 42

Influence of Production Process and Scale on Quality of Polypeptide Drugs: a Case Study on GLP-1 Analogs

Staby, A., Steensgaard, D. B., Haselmann, K. F., Marino, J. S., Bartholdy, C., Videbæk, N., Schelde, O., Bosch‐Traberg, H., Spang, L. T., & Asgreen, D. J. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02817-9 · Cited by 40

MultiPep: a hierarchical deep learning approach for multi-label classification of peptide bioactivities

Grønning, A. G. B., Kacprowski, T., & Scheele, C. C. (2021) · Biology Methods and Protocols · doi:10.1093/biomethods/bpab021 · Cited by 41

Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer

Lu, Y., Yang, Y., Zhu, G., Zeng, H., Fan, Y., Guo, F., Xu, D., Wang, B., Chen, D., & Ge, G. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83026 · Cited by 42

Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis

Chamieh, J., Tarrat, A. D., Doudou, C., Jannin, V., Demarne, F., & Cottet, H. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.01.039 · Cited by 41

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by Traceless Staudinger Ligation

Itoh, H., Miura, K., Kamiya, K., Yamashita, T., & Inoue, M. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916517 · Cited by 41

Natural and grafted cyclotides in cancer therapy: An insight

Mehta, L., Dhankhar, R., Gulati, P., Kapoor, R. K., Mohanty, A., & Kumar, S. (2020) · Journal of Peptide Science · doi:10.1002/psc.3246 · Cited by 41

Plant Bioactive Peptides: Current Status and Prospects Towards Use on Human Health

Chai, T., Ee, K. Y., Kumar, D. T., Manan, F. A., & Wong, F. (2020) · Protein and Peptide Letters · doi:10.2174/0929866527999201211195936 · Cited by 42

Ocular Delivery of Therapeutic Agents by Cell-Penetrating Peptides

Nhàn, N. T. T., Maidana, D. E., & Yamada, K. H. (2023) · Cells · doi:10.3390/cells12071071 · Cited by 40

Perspectives in Searching Antimicrobial Peptides (AMPs) Produced by the Microbiota

Gallardo-Becerra, L., Cervantes-Echeverría, M., Cornejo‐Granados, F., Vazquez-Morado, L. E., & Ochoa‐Leyva, A. (2023) · Microbial Ecology · doi:10.1007/s00248-023-02313-8 · Cited by 41

Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice

Kao, C., Chandna, R., Ghode, A., D’Souza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y. Z., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.06.004 · Cited by 40

The Untapped Pharmacopeic Potential of Helminths

Janina, K., Brattig, N. W., & Liebau, E. (2018) · Trends in Parasitology · doi:10.1016/j.pt.2018.05.011 · Cited by 41

Proteasome Activation to Combat Proteotoxicity

Jones, C. L., & Tepe, J. J. (2019) · Molecules · doi:10.3390/molecules24152841 · Cited by 43

Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples

Pourahadi, A., Nojavan, S., & Davarani, S. S. H. (2020) · Talanta · doi:10.1016/j.talanta.2020.121025 · Cited by 40

Quantitative measurement of cytosolic penetration using the chloroalkane penetration assay

Deprey, K. L., & Kritzer, J. A. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.03.003 · Cited by 39

Homing Peptides for Cancer Therapy

Lingasamy, P., & Teesalu, T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_2 · Cited by 42

Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches

Monti, A., Vitagliano, L., Caporale, A., Ruvo, M., & Doti, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097842 · Cited by 43

Design and Synthesis of A PD-1 Binding Peptide and Evaluation of Its Anti-Tumor Activity

Abbas, A. B., Lin, B., Liu, C., Morshed, A., Hu, J., & Xu, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030572 · Cited by 39

Peptide Antiviral Strategies as an Alternative to Treat Lower Respiratory Viral Infections

Nyanguile, O. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01366 · Cited by 39

The anti‐ageing effects of a natural peptide discovered by artificial intelligence

Kennedy, K., Cal, R., Casey, R., Lopez, C., Adelfio, A., Molloy, B., Wall, A. M., Holton, T. A., & Khaldi, N. (2020) · International Journal of Cosmetic Science · doi:10.1111/ics.12635 · Cited by 39

To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models

Cavaco, M. C., Pérez‐Peinado, C., Valle, J., Silva, R. D. M., Correia, J. D. G., Andreu, D., Castanho, M. A. R. B., & Neves, V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.552035 · Cited by 39

Oral delivery of peptide therapeutics in infants: Challenges and opportunities

Gleeson, J. P., Fein, K. C., & Whitehead, K. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.011 · Cited by 39

The role of peptide-based therapeutics in oncotherapy

Timur, S. S., & Gürsoy, R. N. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1906884 · Cited by 40

Plant Antimicrobial Peptides: Insights into Structure-Function Relationships for Practical Applications

Slezina, M. P., & Odintsova, T. I. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040239 · Cited by 39

A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide

Venanzi, M., Savioli, M., Cimino, R., Gatto, E., Palleschi, A., Ripani, G., Cicero, D. O., Placidi, E., Orvieto, F., & Bianchi, E. (2020) · Soft Matter · doi:10.1039/d0sm01011a · Cited by 40

Harnessing molecular recognition for localized drug delivery

Liu, R., Zuo, R., & Hudalla, G. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.008 · Cited by 37

Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases

Martelli, G., Cantelmi, P., Palladino, C., Mattellone, A., Corbisiero, D., Fantoni, T., Tolomelli, A., Macis, M., Ricci, A., Cabri, W., et al. (2021) · Green Chemistry · doi:10.1039/d1gc02634h · Cited by 40

Self-assembling peptides as immunomodulatory biomaterials

Hernández, A., Hartgerink, J. D., & Young, S. W. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1139782 · Cited by 39

Conquering chemoresistance in pancreatic cancer: Exploring novel drug therapies and delivery approaches amidst desmoplasia and hypoxia

Chintamaneni, P. K., Pindiprolu, S. K. S. S., Swain, S. S., Karri, V. V. S. R., Nesamony, J., Selvam, C., & Bhaskaran, M. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216782 · Cited by 38

Organoboron catalysis for direct amide/peptide bond formation

Koshizuka, M., Takahashi, N., & Shimada, N. (2024) · Chemical Communications · doi:10.1039/d4cc02994a · Cited by 38

Bio-nanomaterials: Promising anticancer properties and treatment strategies

Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 42

Peptides as epigenetic modulators: therapeutic implications

Janssens, Y., Wynendaele, E., Berghe, W. V., & Spiegeleer, B. M. J. D. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0700-7 · Cited by 37

C–H Olefination of Tryptophan Residues in Peptides: Control of Residue Selectivity and Peptide–Amino Acid Cross-linking

Terrey, M. J., Holmes, A., Perry, C. C., & Cross, W. B. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b02894 · Cited by 38

Glypican-3 (GPC3) targeted Fe 3 O 4 core/Au shell nanocomplex for fluorescence/MRI/photoacoustic imaging-guided tumor photothermal therapy

Tian, R., Zhu, L., Qin, Z., Wang, G., Wang, J., & Zhang, H. (2019) · Biomaterials Science · doi:10.1039/c9bm01248f · Cited by 39

Advantageous use of SFC for separation of crude therapeutic peptides and peptide libraries

Ventura, M. C. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113227 · Cited by 38

Macrocyclization of an all- d linear α-helical peptide imparts cellular permeability

Kannan, S., Aronica, P. G. A., Ng, S., Lian, D. T. G., Frosi, Y., Chee, S. M. Q., Jiang, S., Yuen, T. Y., Sadruddin, A., Kaan, H. Y. K., et al. (2020) · Chemical Science · doi:10.1039/c9sc06383h · Cited by 38

The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluation

Conner, K. P., Devanaboyina, S. C., Thomas, V. A., & Rock, D. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107574 · Cited by 39

Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury

Denning, N., Aziz, M., Ochani, M., Prince, J. M., & Wang, P. (2020) · Surgery · doi:10.1016/j.surg.2020.04.010 · Cited by 38

Peptides that immunoactivate the tumor microenvironment

Furukawa, N., & Popel, A. S. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188486 · Cited by 39

Measuring the oral bioavailability of protein hydrolysates derived from food sources: A critical review of current bioassays

Abeer, M. M., Trajkovic, S., & Brayden, D. J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112275 · Cited by 40

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design

Düzgüneş, N., Fernández‐Fuentes, N., & Konopka, K. (2021) · Pathogens · doi:10.3390/pathogens10121599 · Cited by 38

Tyrosine bioconjugation with hypervalent iodine

Declas, N., Maynard, J. R. J., Menin, L., Gasilova, N., Götze, S., Sprague, J. L., Stallforth, P., Matile, S., & Waser, J. (2022) · Chemical Science · doi:10.1039/d2sc04558c · Cited by 38

Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases

Gattu, R., Ramesh, S. S., Nadigar, S., Channe Gowda, D., & Ramesh, S. (2023) · Antibiotics · doi:10.3390/antibiotics12030532 · Cited by 40

The Beneficial Effects of Soybean Proteins and Peptides on Chronic Diseases

Hu, S., Liu, C., & Liu, X. (2023) · Nutrients · doi:10.3390/nu15081811 · Cited by 40

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α 1

Schmidt, M., Toplak, A., Rozeboom, H. J., Wijma, H. J., Quaedflieg, P. J. L. M., van Maarseveen, J. H., Janssen, D. B., & Nuijens, T. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob02812a · Cited by 37

Hydrophobic ion pairing (HIP) of (poly)peptide drugs: Benefits and drawbacks of different preparation methods

Wibel, R., Friedl, J. D., Zaichik, S., & Bernkop‐Schnürch, A. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.04.004 · Cited by 37

Harnessing cyclotides to design and develop novel peptide GPCR ligands

Muratspahić, E., Koehbach, J., Gruber, C. W., & Craik, D. J. (2020) · RSC Chemical Biology · doi:10.1039/d0cb00062k · Cited by 36

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water

Mishra, A. K., Tessier, R., Hari, D. P., & Waser, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202106458 · Cited by 37

Asymmetric biomimetic transamination of α-keto amides to peptides

Cai, W., Qiao, X., Zhang, H., Li, B., Guo, J., Zhang, L., Chen, W., & Zhao, B. (2021) · Nature Communications · doi:10.1038/s41467-021-25449-y · Cited by 37

Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size

Fein, K. C., Gleeson, J. P., Newby, A. N., & Whitehead, K. A. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.11.010 · Cited by 37

Machine Learning Advances in Predicting Peptide/Protein‐Protein Interactions Based on Sequence Information for Lead Peptides Discovery

Ye, J., Li, A., Zheng, H., Yang, B., & Lu, Y. (2023) · Advanced Biology · doi:10.1002/adbi.202200232 · Cited by 37

Side-Selective Solid-Phase Metallaphotoredox N(in)-Arylation of Peptides

Delgado, J. A. C., Tian, Y., Marcon, M., König, B., & Paixão, M. W. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c10792 · Cited by 36

PepCNN deep learning tool for predicting peptide binding residues in proteins using sequence, structural, and language model features

Chandra, A. A., Sharma, A. K., Dehzangi, A., Tsunoda, T., & Sattar, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-47624-5 · Cited by 38

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

Kumar, A., Sharma, A., de la Torre, B. G., & Alberício, F. (2019) · Molecules · doi:10.3390/molecules24214004 · Cited by 36

Successful development of a method for the incorporation of Fmoc-Arg(Pbf)-OH in solid-phase peptide synthesis using N -butylpyrrolidinone (NBP) as solvent

de la Torre, B. G., Kumar, A., Alhassan, M., Bucher, C., Alberício, F., & Lopez, J. C. (2020) · Green Chemistry · doi:10.1039/c9gc03784e · Cited by 36

Artificial chaperones: From materials designs to applications

Hanpanich, O., & Maruyama, A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120150 · Cited by 36

Insights into Fast Amide Couplings in Aqueous Nanomicelles

Sharma, S., Kaur, G., & Handa, S. (2021) · Organic Process Research & Development · doi:10.1021/acs.oprd.1c00203 · Cited by 37

Late-Stage C–H Acylation of Tyrosine-Containing Oligopeptides with Alcohols

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