The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
Open accessAbstract
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown promising results in preclinical and clinical trials. However, challenges such as limited drug loading capacity, stability issues, and potential side effects need to be addressed to enhance clinical translation. Researchers are exploring strategies to improve drug loading capacity, such as modifying nanoparticle surfaces or developing novel drug encapsulation techniques. By increasing drug loading, the therapeutic efficacy of these systems can be significantly enhanced. Stability issues also pose a hurdle in clinical translation. To overcome stability issues, researchers are investigating methods to enhance the stability of nanoparticles, such as using protective coatings or optimising the formulation. Additionally, efforts are being made to minimise potential side effects by carefully selecting biocompatible materials for nanoparticle synthesis and conducting rigorous toxicity studies before moving forward with clinical trials.
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Cites
Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery
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Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells
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Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone
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Cited by
Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review
Al-Thani, A. N., Jan, A. G., Abbas, M., Geetha, M., & Sadasivuni, K. K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122899 · Cited by 323
PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy
Kesharwani, P., Kumar, V., Goh, K. W., Gupta, G., Alsayari, A., Wahab, S., & Sahebkar, A. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02410-x · Cited by 132
Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics
Alum, E., Izah, S., Uti, D., Ugwu, O., Betiang, P., Basajja, M., & Ejemot-Nwadiaro, R. (2025) · Drug Design, Development and Therapy · doi:10.2147/dddt.s543211 · Cited by 63
Advances in 2,3-Dimethylmaleic Anhydride (DMMA)-Modified Nanocarriers in Drug Delivery Systems
Wan, D., Wu, Y., Liu, Y., Liu, Y., & Pan, J. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060809 · Cited by 7
Metadata
- Authors
- Elumalai, K., Srinivasan, S., & Shanmugam, A.
- Venue
- Biomedical Technology
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 5
- Pages
- 109-122
- ISSN
- 2949-723X (ISSN-L)
- OpenAlex
- W4387204689
- Cited by
- 649
- References
- 79
- FWCI
- 35.73
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Elumalai, K., Srinivasan, S., & Shanmugam, A. (2024). Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment. Biomedical Technology. https://doi.org/10.1016/j.bmt.2023.09.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
