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Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics

Alum, Esther, Izah, Sylvester, Uti, Daniel, Ugwu, Okechukwu, Betiang, Peter, Basajja, Mariam, Ejemot-Nwadiaro, Regina·2025·Drug Design, Development and Therapy
DOI 10.2147/dddt.s543211PMC PMC12456441
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  • PET imaging probes targeting SA-β-Gal, such as [68Ga]Ga-BGal, have demonstrated efficacy in preclinical models.

    “For example, probes targeting SA-β-Gal, such as [68Ga]Ga-BGal, have demonstrated efficacy in preclinical models112,113.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [113]

    The Clinical Validation of Senescence Biomarkers section (page unavailable) says SA-β-galactosidase shows promise as a marker in experimental models and discusses molecular imaging as a potential monitoring approach. It does not identify [68Ga]Ga-BGal or report that an SA-β-Gal-targeted PET probe demonstrated efficacy in preclinical models. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Metadata

Authors
Alum, E., Izah, S., Uti, D., Ugwu, O., Betiang, P., Basajja, M., & Ejemot-Nwadiaro, R.
Venue
Drug Design, Development and Therapy
Publisher
Informa UK Limited
Published
2025-09
Volume
Volume 19
Pages
8489-8522
ISSN
1177-8881
DOI
10.2147/dddt.s543211
PMC
PMC12456441
Cited by
63
References
36
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (unspecified)

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