The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease
Open accessAbstract
Fibroblast growth factor 23 (FGF-23), dentin matrix protein 1 (DMP1), and matrix extracellular phosphoglycoprotein (MEPE) are skeletal proteins involved in the regulation of phosphate homeostasis and bone metabolism. Circulating FGF-23 levels are increased in patients with chronic kidney disease (CKD); however, FGF-23 skeletal expression and its regulation by DMP1 and MEPE have yet to be evaluated. Thus, expression of these three proteins was characterized by immunohistochemistry in 32 pediatric and young adult patients with CKD stages 2–5. When compared to normal controls, bone FGF-23 and DMP1 expression were increased in all stages of CKD; significant differences in bone FGF-23 and DMP1 expression were not detected between pre-dialysis CKD and dialysis patients. Bone MEPE expression in CKD did not differ from controls. FGF-23 was expressed in osteocyte cell bodies located at the trabecular periphery. DMP1 was widely expressed in osteocyte cell bodies and dendrites throughout bone. MEPE was also expressed throughout bone, but only in osteocyte cell bodies. Bone FGF-23 expression correlated directly with plasma levels of the protein (r=0.43, p<0.01) and with bone DMP1 expression (r=0.54, p<0.01) and expression of both proteins were inversely related to osteoid accumulation. Bone MEPE expression was inversely related to bone volume. In conclusion, skeletal FGF-23 and DMP1 expression are increased in CKD and are related to skeletal mineralization. The patterns of expression of FGF-23, MEPE, and DMP1 differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions. Increases in bone FGF-23 and DMP1 expression suggest that osteocyte function is altered early in the course of CKD.
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Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
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“growth factor 23 (FGF-23), dentin matrix protein 1 (DMP1), and matrix extracellular phosphoglycoprotein (MEPE), may regulate each other through direct or indirect mechanisms (1;2), and circulating levels of FGF-23 are markedly elevated in patients with CKD (3).”
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Self-citationDetermination of vitamin D status by radioimmunoassay with an 125I-labeled tracer
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Gowen, L. C., Petersen, D. N., Mansolf, A. L., Qi, H., Stock, J. L., Tkalcevic, G. T., Simmons, H. A., Crawford, D. T., Chidsey-Frink, K. L., Ke, H. Z., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203250200 · Cited by 298
Cited by
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
Robling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539
Woo, S. M., Rosser, J., Dusevich, V., Kalajzic, I., & Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.465 · Cited by 243
Jüppner, H. (2011) · Kidney International · doi:10.1038/ki.2011.27 · Cited by 191
Self-citationDussold, C., Gerber, C., White, S., Wang, X., Qi, L., Francis, C., Capella, M., Courbon, G., Wang, J., Li, C., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0051-1 · Cited by 96
Metadata
- Authors
- Pereira, R. C., Jűppner, H., Azucena-Serrano, C. E., Yadin, O., Salusky, I. B., & Wesseling-Perry, K.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 45
- Issue
- 6
- Pages
- 1161-1168
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W1982290615
- Cited by
- 272
- References
- 33
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Pereira, R. C., Jűppner, H., Azucena-Serrano, C. E., Yadin, O., Salusky, I. B., & Wesseling-Perry, K. (2009). Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. Bone. https://doi.org/10.1016/j.bone.2009.08.008
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