The Osteocyte: New Insights

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,575 · see citing works

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503 · see citing works

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368 · see citing works

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318 · see citing works

Matrix-embedded cells control osteoclast formation

Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304 · see citing works

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · see citing works

Sensitivity of osteocytes to biomechanical stress in vitro

Klein‐Nulend, J., van der Plas, A., Semeins, C. M., Ajubi, N. E., Erangos, J. A., Nijweide, P. J., & Burger, E. H. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896017 · Cited by 776 · see citing works

Bone remodeling in response to in vivo fatigue microdamage

Burr, D. B., Martin, R. B., Schaffler, M. B., & Radin, E. L. (1985) · Journal of Biomechanics · doi:10.1016/0021-9290(85)90204-0 · Cited by 765 · see citing works

Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo

Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.60 · Cited by 731 · see citing works

Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Bellido, T., Ali, A., Gubrij, I. B., Plotkin, L. I., Fu, Q., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2005-0239 · Cited by 640 · see citing works

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.025 · Cited by 638 · see citing works

New insights into the biology of osteocalcin

Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612 · see citing works

Identification of senescent cells in the bone microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2892 · Cited by 562 · see citing works

Aging and Bone

Boskey, A. L., & Coleman, R. M. (2010) · Journal of Dental Research · doi:10.1177/0022034510377791 · Cited by 555 · see citing works

Establishment of an Osteocyte-like Cell Line, MLO-Y4

Kato, Y., Windle, J. J., Koop, B. A., Mundy, G. R., & Bonewald, L. F. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.12.2014 · Cited by 549 · see citing works

The myokine irisin increases cortical bone mass

Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lü, P., Sartini, L., Comite, M. D., Mori, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516622112 · Cited by 513 · see citing works

Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505 · see citing works

Mechanotransduction and strain amplification in osteocyte cell processes

Han, Y., Cowin, S. C., Schaffler, M. B., & Weinbaum, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407429101 · Cited by 495 · see citing works

Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation

Qing, H., Ardeshirpour, L., Divieti Pajevic, P., Dusevich, V., Jähn, K., Kato, S., Wysolmerski, J., & Bonewald, L. F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1567 · Cited by 489 · see citing works

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Tu, X., Rhee, Y., Condon, K. W., Bivi, N., Allen, M. R., Dwyer, D., Stolina, M., Turner, C. H., Robling, A. G., Plotkin, L. I., et al. (2011) · Bone · doi:10.1016/j.bone.2011.10.025 · Cited by 458 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

Intracortical remodeling in adult rat long bones after fatigue loading

Bentolila, V., Boyce, T. M., Fyhrie, D. P., Drumb, R., Skerry, T. M., & Schaffler, M. B. (1998) · Bone · doi:10.1016/s8756-3282(98)00104-5 · Cited by 439 · see citing works

Osteocytes, strain detection, bone modeling and remodeling

Lanyon, L. E. (1993) · Calcified Tissue International · doi:10.1007/bf01673415 · Cited by 439 · see citing works

Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

Kleinnulend, J., Semeins, C. M., Ajubi, N. E., Nijweide, P. J., & Burger, E. H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2822 · Cited by 425 · see citing works

The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis

PARFITT, A. M. (1982) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(82)90002-9 · Cited by 396 · see citing works

Use of Type I Collagen Green Fluorescent Protein Transgenes to Identify Subpopulations of Cells at Different Stages of the Osteoblast Lineage

Kalajzić, I., Kalajzić, Ž., Kaliterna, M., Gronowicz, G., Clark, S. H., Lichtler, A. C., & Rowe, D. W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.15 · Cited by 392 · see citing works

Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice

Lane, N. E., Yao, W., Balooch, M., Nalla, R. K., Balooch, G., Habelitz, S., Kinney, J. H., & Bonewald, L. F. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051103 · Cited by 355 · see citing works

DMP1-targeted Cre Expression in Odontoblasts and Osteocytes

Lu, Y., Xie, Y., Zhang, S., Dusevich, V., Bonewald, L. F., & Feng, J. Q. (2007) · Journal of Dental Research · doi:10.1177/154405910708600404 · Cited by 350 · see citing works

Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

Cardoso, L., Herman, B. C., Verborgt, O., Laudier, D., Majeska, R. J., & Schaffler, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081210 · Cited by 340 · see citing works

DEVELOPMENT AND EVOLUTIONARY ORIGINS OF VERTEBRATE SKELETOGENIC AND ODONTOGENIC TISSUES

Smith, M. M., & Hall, B. K. (1990) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1990.tb01427.x · Cited by 339 · see citing works

Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO‐Y4 osteocytes

Genetos, D. C., Kephart, C. J., Zhang, Y., Yellowley, C. E., & Donahue, H. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21021 · Cited by 328 · see citing works

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

Xiong, J., Piemontese, M., Onal, M., Campbell, J., Goellner, J. J., Dusevich, V., Bonewald, L., Manolagas, S. C., & O’Brien, C. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138189 · Cited by 323 · see citing works

MLO-Y4 Osteocyte-Like Cells Support Osteoclast Formation and Activation

Zhao, S., Kato, Y., Zhang, Y., Harris, S., Ahuja, S. S., & Bonewald, L. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2068 · Cited by 322 · see citing works

The osteocyte

Tate, M. L. K., Adamson, J., Tami, A., & Bauer, T. W. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00241-3 · Cited by 310 · see citing works

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Colaianni, G., Mongelli, T., Cuscito, C., Pignataro, P., Lippo, L., Spiro, G., Notarnicola, A., Severi, I., Passeri, G., Mori, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02557-8 · Cited by 305 · see citing works

Quantifying the osteocyte network in the human skeleton

Buenzli, P. R., & Sims, N. A. (2015) · Bone · doi:10.1016/j.bone.2015.02.016 · Cited by 300 · see citing works

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro

Spatz, J., Wein, M. N., Gooi, J. H., Qu, Y., Garr, J., Liu, X. S., Barry, K. J., Uda, Y., Lai, F., Dedic, C., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628313 · Cited by 294 · see citing works

Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease

Pereira, R. C., Jüppner, H., Azucena-Serrano, C. E., Yadin, O., Salusky, I. B., & Wesseling‐Perry, K. (2009) · Bone · doi:10.1016/j.bone.2009.08.008 · Cited by 271 · see citing works

Osteocytic osteolysis

Bélanger, L. F. (1969) · Calcified Tissue International · doi:10.1007/bf02279101 · Cited by 270 · see citing works

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

Quarles, L. D. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.218 · Cited by 268 · see citing works

Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability

Bellido, T., & Plotkin, L. I. (2010) · Bone · doi:10.1016/j.bone.2010.08.008 · Cited by 265 · see citing works

Identification of differentially expressed genes between osteoblasts and osteocytes

Paić, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 261 · see citing works

Pulsating Fluid Flow Increases Prostaglandin Production by Cultured Chicken Osteocytes—A Cytoskeleton-Dependent Process

Ajubi, N. E., Klein‐Nulend, J., Nijweide, P. J., Vrijheid-Lammers, T., Alblas, M. J., & Burger, E. H. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1131 · Cited by 260 · see citing works

Osteocyte lacunae tissue strain in cortical bone

Nicolella, D. P., Moravits, D. E., Gale, A. M., Bonewald, L. F., & Lankford, J. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.04.032 · Cited by 253 · see citing works

Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo

Woo, S. M., Rosser, J., Dusevich, V., Kalajzic, I., & Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.465 · Cited by 243 · see citing works

The dual role of IL-6-type cytokines on bone remodeling and bone tumors

Blanchard, F., Duplomb, L., Baud’huin, M., & Royer, B. B.-L. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.11.004 · Cited by 221 · see citing works

Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction

Kogianni, G., Mann, V., & Noble, B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080207 · Cited by 221 · see citing works

Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene

Kalajzić, I., Braut, A., Guo, D., Jiang, X., Kronenberg, M. S., Mina, M., Harris, M. A., Harris, S. E., & Rowe, D. W. (2004) · Bone · doi:10.1016/j.bone.2004.03.006 · Cited by 220 · see citing works

Induction of NO and prostaglandin E2in osteoblasts by wall-shear stress but not mechanical strain

Smalt, R., Mitchell, F. T., Howard, R. L., & Chambers, T. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e751 · Cited by 220 · see citing works

β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.041 · Cited by 219 · see citing works

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

Burra, S., Nicolella, D. P., Francis, W. L., Freitas, C. J., Mueschke, N. J., O’Grady, K. P., & Jiang, J. X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009382107 · Cited by 211 · see citing works

Establishment of an Osteoid Preosteocyte-like Cell MLO-A5 That Spontaneously Mineralizes in Culture

Kato, Y., Boskey, A. L., Spevak, L., Dallas, M., Hori, M., & Bonewald, L. F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1622 · Cited by 207 · see citing works

Osteocyte Shape Is Dependent on Actin Filaments and Osteocyte Processes Are Unique Actin-Rich Projections

Tanaka-Kamioka, K., Kamioka, H., Ris, H., & Lim, S. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.10.1555 · Cited by 203 · see citing works

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

Powell, W. F., Barry, K. J., Tulum, I., Kobayashi, T., Harris, S. E., Bringhurst, F. R., & Pajevic, P. D. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0308 · Cited by 202 · see citing works

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

Chan, B. Y., Fuller, E. S., Russell, A. K., Smith, S. M., Smith, M. M., Jackson, M. T., Cake, M. A., Read, R. A., Bateman, J. F., Sambrook, P. N., et al. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.04.014 · Cited by 198 · see citing works

Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21

Blaber, E. A., Dvorochkin, N., Lee, C., Alwood, J. S., Yousuf, R., Pianetta, P., Globus, R. K., Burns, B. P., & Almeida, E. A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061372 · Cited by 196 · see citing works

PGE2 Is Essential for Gap Junction-Mediated Intercellular Communication between Osteocyte-Like MLO-Y4 Cells in Response to Mechanical Strain

Cheng, B., Kato, Y., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Endocrinology · doi:10.1210/endo.142.8.8338 · Cited by 186 · see citing works

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

Joeng, K. S., Lee, Y., Lim, J., Chen, Y., Jiang, M., Munivez, E. M., Ambrose, C. G., & Lee, B. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92617 · Cited by 181 · see citing works

Degeneration of the osteocyte network in the C57BL/6 mouse model of aging

Tiede-Lewis, L. M., Xie, Y., Hulbert, M. A., Campos, R., Dallas, M. R., Dusevich, V., Bonewald, L. F., & Dallas, S. L. (2017) · Aging · doi:10.18632/aging.101308 · Cited by 176 · see citing works

Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading

Siller-Jackson, A. J., Burra, S., Gu, S., Xia, X., Bonewald, L. F., Sprague, E. A., & Jiang, J. X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803136200 · Cited by 174 · see citing works

Tissue strain amplification at the osteocyte lacuna: A microstructural finite element analysis

Bonivtch, A. R., Bonewald, L. F., & Nicolella, D. P. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2006.10.040 · Cited by 166 · see citing works

T he W rickkened P athways of FGF23, MEPE and PHEX

Rowe, P. S. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500503 · Cited by 154 · see citing works

Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2

Kogawa, M., Wijenayaka, A. R., Ormsby, R. T., Thomas, G. P., Anderson, P., Bonewald, L. F., Findlay, D. M., & Atkins, G. J. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2003 · Cited by 153 · see citing works

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

Rowe, P. S. N., Garrett, I. R., Schwarz, P. M., Carnes, D. L., Lafer, E. M., Mundy, G. R., & Gutierrez, G. E. (2005) · Bone · doi:10.1016/j.bone.2004.09.015 · Cited by 149 · see citing works

Calculating the probability that microcracks initiate resorption spaces

Burr, D. B., & Martin, R. B. (1993) · Journal of Biomechanics · doi:10.1016/0021-9290(93)90023-8 · Cited by 149 · see citing works

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

Kamel, M. A., Picconi, J. L., Lara-Castillo, N., & Johnson, M. L. (2010) · Bone · doi:10.1016/j.bone.2010.08.007 · Cited by 147 · see citing works

RANK‐Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

O’Brien, W. M., Fissel, B. M., MAEDA, Y. Y., Yan, J., Ge, X., Gravallese, E. M., Aliprantis, A. O., & Charles, J. F. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39837 · Cited by 147 · see citing works

Matrix mineralization and the differentiation of osteocyte-like cells in culture

Mikuni-Takagaki, Y., Kakai, Y., Satoyoshi, M., Kawano, E., Suzuki, Y., Kawase, T., & Saito, S. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100209 · Cited by 144 · see citing works

Mechanism by which MLO-A5 Late Osteoblasts/Early Osteocytes Mineralize in Culture: Similarities with Mineralization of Lamellar Bone

Barragan‐Adjemian, C., Nicolella, D. P., Dusevich, V., Dallas, M. R., Eick, J. D., & Bonewald, L. F. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0107-2 · Cited by 142 · see citing works

Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow

Lu, X. L., Huo, B., Chiang, V., & Guo, X.-D. E. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1474 · Cited by 142 · see citing works

The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts

McGarry, J. G., Klein‐Nulend, J., & Prendergast, P. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.175 · Cited by 139 · see citing works

Distinct responses of different populations of bone cells to mechanical stress

Mikuni‐Takagaki, Y., Suzuki, Y., Kawase, T., & Saito, S. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612544 · Cited by 138 · see citing works

Characteristics and properties of osteocytes in culture

van der Plas, A., Aarden, E. M., Feijen, J., BOER, A. H. D., Wiltink, A., Alblas, M. J., de Leij, L., & Nijweide, P. J. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650091105 · Cited by 138 · see citing works

Effects of sclerostin antibodies in animal models of osteoporosis

Ominsky, M. S., Boyce, R. W., Li, X., & Ke, H. Z. (2016) · Bone · doi:10.1016/j.bone.2016.10.019 · Cited by 137 · see citing works

The Role of Osteocytes in Age-Related Bone Loss

Jilka, R. L., & O’Brien, C. A. (2016) · Current Osteoporosis Reports · doi:10.1007/s11914-016-0297-0 · Cited by 136 · see citing works

Calcium response in single osteocytes to locally applied mechanical stimulus: Differences in cell process and cell body

ADACHI, T., Aonuma, Y., TANAKA, M., Hojo, M., Takano‐Yamamoto, T., & Kamioka, H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.04.034 · Cited by 134 · see citing works

FGF23 production by osteocytes

Bonewald, L. F., & Wacker, M. (2012) · Pediatric Nephrology · doi:10.1007/s00467-012-2309-3 · Cited by 128 · see citing works

Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies

Maurel, D. B., Jähn, K., & Lara-Castillo, N. (2017) · Biomedicines · doi:10.3390/biomedicines5040062 · Cited by 123 · see citing works

Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity

Igwe, J. C., Jiang, X., Paić, F., Ma, L., Adams, D. J., Baldock, P. A. J., Pilbeam, C. C., & Kalajzić, I. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22294 · Cited by 122 · see citing works

Mechanotransduction activates α5β1 integrin and PI3K/Akt signaling pathways in mandibular osteoblasts

Watabe, H., Furuhama, T., Tani‐Ishii, N., & Mikuni‐Takagaki, Y. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.07.015 · Cited by 120 · see citing works

Transient receptor potential vanilloid 4 deficiency suppresses unloading‐induced bone loss

Mizoguchi, F., Mizuno, A., Hayata, T., Nakashima, K., Heller, S., Ushida, T., Sokabe, M., Miyasaka, N., Suzuki, M., Ezura, Y., et al. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21374 · Cited by 120 · see citing works

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

Javaheri, B., Stern, A. R., Lara, N., Dallas, M., Zhao, H. L., Liu, Y., Bonewald, L. F., & Johnson, M. L. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2064 · Cited by 119 · see citing works

Sclerostin: A gem from the genome leads to bone-building antibodies

Pászty, C., Turner, C. H., & Robinson, M. K. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.161 · Cited by 118 · see citing works

Update on the Biology of Osteocalcin

Karsenty, G. (2017) · Endocrine Practice · doi:10.4158/ep171966.ra · Cited by 118 · see citing works

Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects

Harris, S. E., MacDougall, M., Horn, D., Woodruff, K., Zimmer, S. N., Rebel, V. I., Fajardo, R., Feng, J. Q., Gluhak-Heinrich, J., Harris, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2011.09.038 · Cited by 116 · see citing works

Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo

Jähn, K., Kelkar, S., Zhao, H., Xie, Y., Tiede-Lewis, L. M., Dusevich, V., Dallas, S. L., & Bonewald, L. F. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3167 · Cited by 116 · cited 1× · see citing works

Physiological and pathological osteocytic osteolysis.

Tsourdi, E. A., Jähn, K., Rauner, M., Busse, B., & Bonewald, L. F. (2018) · Europe PMC (PubMed Central) · Cited by 115 · see citing works

Paracrine Effects of FGF23 on the Heart

Leifheit‐Nestler, M., & Haffner, D. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00278 · Cited by 109 · see citing works

Crosstalk Between MLO‐Y4 Osteocytes and C2C12 Muscle Cells Is Mediated by the Wnt/β‐Catenin Pathway

Huang, J. M., Romero‐Suarez, S., Lara, N., Mo, C., Kaja, S., Brotto, L. S., Dallas, S. L., Johnson, M. L., Jähn, K., Bonewald, L. F., et al. (2017) · JBMR Plus · doi:10.1002/jbm4.10015 · Cited by 107 · see citing works

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Taylor, S., Ominsky, M. S., Hu, R., Pacheco, E., He, Y. D., Brown, D. L., Aguirre, J. I., Wronski, T. J., Buntich, S., Afshari, C. A., et al. (2016) · Bone · doi:10.1016/j.bone.2015.12.013 · Cited by 106 · see citing works

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

Lyons, J. S., Joca, H. C., Law, R. A., Williams, K. M., Kerr, J. P., Shi, G., Khairallah, R. J., Martin, S. S., Konstantopoulos, K., Ward, C. W., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan5748 · Cited by 106 · see citing works

β1 Integrins Mediate Mechanosensitive Signaling Pathways in Osteocytes

Litzenberger, J. B., Kim, J., Tummala, P., & Jacobs, C. R. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9343-6 · Cited by 105 · see citing works

Molecular analyses of dinosaur osteocytes support the presence of endogenous molecules

Schweitzer, M. H., Zheng, W., Cleland, T. P., & Bern, M. W. (2012) · Bone · doi:10.1016/j.bone.2012.10.010 · Cited by 104 · see citing works

Osteocytes remove and replace perilacunar mineral during reproductive cycles

Wysolmerski, J. J. (2013) · Bone · doi:10.1016/j.bone.2013.01.025 · Cited by 102 · see citing works

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

Kobayashi, K., Nojiri, H., Saita, Y., Morikawa, D., Ozawa, Y., Watanabe, K., Koike, M., Asou, Y., Shirasawa, T., Yokote, K., et al. (2015) · Scientific Reports · doi:10.1038/srep09148 · Cited by 101 · see citing works

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

Honma, M., Ikebuchi, Y., Kariya, Y., Hayashi, M., Hayashi, N., Aoki, S., & Suzuki, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1941 · Cited by 98 · see citing works

Nitric oxide signaling in mechanical adaptation of bone

Klein‐Nulend, J., van Oers, R. F. M., Bakker, A. D., & Bacabac, R. G. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2590-4 · Cited by 95 · see citing works

Tumor necrosis factor α and interleukin‐1β modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes

Bakker, A. D., da Silva, V. C., Krishnan, R. G., Bacabac, R. G., Blaauboer, M. E., Lin, Y.-C., Marcantonio, R. A. C., Cirelli, J. A., & Klein‐Nulend, J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24920 · Cited by 92 · see citing works

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

Cheung, W. Y., Fritton, J. C., Morgan, S. A., Seref-Ferlengez, Z., Basta-Pljakic, J., Thi, M. M., Suadicani, S. O., Spray, D. C., Majeska, R. J., & Schaffler, M. B. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2740 · Cited by 89 · see citing works

Novel approaches for two and three dimensional multiplexed imaging of osteocytes

Kamel-ElSayed, S. A., Tiede-Lewis, L. M., Lu, Y., Veno, P. A., & Dallas, S. L. (2015) · Bone · doi:10.1016/j.bone.2015.02.011 · Cited by 87 · see citing works

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

Saxon, L., Jackson, B. F., Sugiyama, T., Lanyon, L. E., & Price, J. S. (2011) · Bone · doi:10.1016/j.bone.2011.03.683 · Cited by 84 · see citing works

Glucocorticoids and osteocyte autophagy

Yao, W., Dai, W., Jiang, J. X., & Lane, N. E. (2013) · Bone · doi:10.1016/j.bone.2013.01.034 · Cited by 82 · see citing works

Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice

Grimston, S. K., Watkins, M. P., Brodt, M. D., Silva, M. J., & Civitelli, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044222 · Cited by 81 · see citing works

Pro-inflammatory Cytokines and Osteocytes

Zhou, M., Li, S., & Pathak, J. L. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00507-z · Cited by 80 · see citing works

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

Pathak, J. L., Bakker, A. D., Luyten, F. P., Verschueren, P., Lems, W. F., Klein‐Nulend, J., & Bravenboer, N. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0116-8 · Cited by 78 · see citing works

Label-free imaging of bone multiscale porosity and interfaces using third-harmonic generation microscopy

Genthial, R., Beaurepaire, E., Schanne‐Klein, M., Peyrin, F., Farlay, D., Olivier, C., Bala, Y., Boivin, G., Vial, J., Débarre, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03548-5 · Cited by 78 · see citing works

Romosozumab for the treatment of osteoporosis

McClung, M. R. (2018) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2018.03.002 · Cited by 78 · see citing works

Establishment and hormonal regulation of a conditionally transformed preosteocytic cell line from adult human bone.

Bodine, P. V. N., Vernon, S. K., & Komm, B. S. (1996) · Endocrinology · doi:10.1210/endo.137.11.8895322 · Cited by 75 · see citing works

Hypophosphatemic osteomalacia and bone sclerosis caused by a novel homozygous mutation of the FAM20C gene in an elderly man with a mild variant of Raine syndrome

Takeyari, S., Yamamoto, T., Kinoshita, Y., Fukumoto, S., Glorieux, F. H., Michigami, T., Hasegawa, K., Kitaoka, T., Kubota, T., Imanishi, Y., et al. (2014) · Bone · doi:10.1016/j.bone.2014.06.026 · Cited by 74 · see citing works

Prostaglandin E2 Signals Through PTGER2 to Regulate Sclerostin Expression

Genetos, D. C., Yellowley, C. E., & Loots, G. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017772 · Cited by 74 · see citing works

A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis

Miller, P. D. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x11424220 · Cited by 74 · see citing works

Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis

Verbruggen, S. W., Garrigle, M. J. M., Haugh, M. G., Voisin, M. C., & McNamara, L. M. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.02.031 · Cited by 73 · see citing works

Osteocyte dendrogenesis in static and dynamic bone formation: An ultrastructural study

Palumbo, C., Ferretti, M., & Marotti, G. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20032 · Cited by 72 · see citing works

Extracellular NO signalling from a mechanically stimulated osteocyte

Vatsa, A., Smit, T. H., & Klein‐Nulend, J. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2007.02.015 · Cited by 69 · see citing works

Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading

Zhao, L., Shim, J. W., Dodge, T., Robling, A. G., & Yokota, H. (2013) · Bone · doi:10.1016/j.bone.2013.01.033 · Cited by 67 · see citing works

IGF‐1 signaling mediated cell‐specific skeletal mechano‐transduction

Tian, F., Wang, Y., & Bikle, D. D. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23767 · Cited by 67 · see citing works

Forceful mastication activates osteocytes and builds a stout jawbone

Inoue, M., Ono, T., KAMEO, Y., Sasaki, F., Ono, T., ADACHI, T., & Nakashima, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-40463-3 · Cited by 66 · see citing works

Studying osteocytes within their environment

Webster, D. J., Schneider, P., Dallas, S. L., & Müller, R. (2013) · Bone · doi:10.1016/j.bone.2013.01.004 · Cited by 63 · see citing works

Osteocyte regulation of bone and blood

Pajevic, P. D., & Krause, D. S. (2018) · Bone · doi:10.1016/j.bone.2018.02.012 · Cited by 61 · see citing works

Role for β1 integrins in cortical osteocytes during acute musculoskeletal disuse

Phillips, J. A., Almeida, E. A. C., HILL, E., Aguirre, J. I., Rivera, M. F., NACHBANDI, I., Wronski, T. J., van der Meulen, M. C. H., & Globus, R. K. (2008) · Matrix Biology · doi:10.1016/j.matbio.2008.05.003 · Cited by 58 · see citing works

The Emerging Role of Osteocytes in Cancer in Bone

Atkinson, E. G., & Delgado‐Calle, J. (2019) · JBMR Plus · doi:10.1002/jbm4.10186 · Cited by 56 · see citing works

Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia

Tokarz, D., Martins, J. D. S., Petit, E. T., Lin, C. P., Demay, M. B., & Liu, E. S. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3327 · Cited by 54 · see citing works

Ultrastructural changes in osteocytes in microgravity conditions

Родионова, Н. В., Oganov, V. S., & Zolotova, N. V. (2002) · Advances in Space Research · doi:10.1016/s0273-1177(02)00393-9 · Cited by 53 · see citing works

Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis

Aoki, S., Honma, M., Kariya, Y., Nakamichi, Y., Ninomiya, T., Takahashi, N., Udagawa, N., & Suzuki, H. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.89 · Cited by 51 · see citing works

Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction

Kringelbach, T. M., Aslan, D., Novak, I., Ellegaard, M., Syberg, S., Andersen, C. K. B., Kristiansen, K. A., Vang, O., Schwarz, P., & Jørgensen, N. R. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.08.016 · Cited by 49 · see citing works

Mechanotransduction in Bone Cells: Induction of Nitric Oxide and Prostaglandin Synthesis by Fluid Shear Stress, but Not by Mechanical Strain

Smalt, R., Mitchell, F. T., Howard, R. L., & Chambers, T. J. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1810-9_66 · Cited by 45 · see citing works

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

van Bezooijen, R. L., DeRuiter, M. C., Vilain, N., Monteiro, R. M., Visser, A., van der Wee-Pals, L. J. A., van Munsteren, C. J., Hogendoorn, P. C. W., Aguet, M., Mummery, C. L., et al. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21054 · Cited by 45 · see citing works

Measurement of osteocytes per unit volume and volume components of osteocytes and canaliculae in man.

Hm, F. (1960) · PubMed · Cited by 43 · see citing works

A Novel Osteogenic Cell Line That Differentiates Into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Like Lacunocanalicular Structure

Wang, K., Le, L., Chun, B. M., Tiede-Lewis, L. M., Shiflett, L. A., Prideaux, M., Campos, R., Veno, P. A., Xie, Y., Dusevich, V., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3720 · Cited by 43 · see citing works

Role of Connexin43 in Osteoblast Response to Physical Load

Grimston, S. K., Screen, J., HASKELL, J. H., Chung, D. J., Brodt, M. D., Silva, M. J., & Civitelli, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.023 · Cited by 42 · see citing works

Time Lapse Imaging Techniques for Comparison of Mineralization Dynamics in Primary Murine Osteoblasts and the Late Osteoblast/Early Osteocyte-Like Cell Line MLO-A5

Dallas, S. L., Veno, P. A., Rosser, J. L., Barragan‐Adjemian, C., Rowe, D. W., Kalajzić, I., & Bonewald, L. F. (2008) · Cells Tissues Organs · doi:10.1159/000151745 · Cited by 42 · see citing works

Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells

Huang, J. M., Wang, K., Shiflett, L. A., Brotto, L. S., Bonewald, L. F., Wacker, M., Dallas, S. L., & Brotto, M. A. P. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1691796 · Cited by 42 · see citing works

Isolated chick osteocytes stimulate formation and bone-resorbing activity of osteoclast-like cells

Tanaka, K., Yamaguchi, Y., & Hakeda, Y. (1995) · Journal of Bone and Mineral Metabolism · doi:10.1007/bf01771319 · Cited by 41 · see citing works

The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction

Zhang, J., Zhao, Y., Liu, C., Han, E. S., Xue, Y., Lidington, D., Bolz, S., & You, L. (2015) · Bone · doi:10.1016/j.bone.2015.05.017 · Cited by 40 · see citing works

In situ imaging of the autonomous intracellular Ca2+ oscillations of osteoblasts and osteocytes in bone

Ishihara, Y., Sugawara, Y., Kamioka, H., Kawanabe, N., Kurosaka, H., Naruse, K., & Yamashiro, T. (2012) · Bone · doi:10.1016/j.bone.2012.01.021 · Cited by 39 · see citing works

Irradiation‐induced osteocyte damage promotes HMGB1‐mediated osteoclastogenesis in vitro

He, F., Bai, J., Wang, J., Zhai, J., Tong, L., & Zhu, G. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28351 · Cited by 37 · see citing works

Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation

Kang, K. S., Hong, J. M., & Robling, A. G. (2016) · Bone · doi:10.1016/j.bone.2016.04.028 · Cited by 36 · see citing works

Mature osteocytes behaviour in a repletion period: the occurrence of osteoplastic activity.

Zallone, A. Z., Teti, A. M., Primavera, M. V., & Pace, G. (1983) · PubMed · Cited by 34 · see citing works

Pharmacological management of X‐linked hypophosphataemia

Imel, E. A., & White, K. E. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13763 · Cited by 29 · see citing works

Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes

Maurel, D. B., Matsumoto, T., Vallejo, J. A., Johnson, M. L., Dallas, S. L., Kitase, Y., Brotto, M. A. P., Wacker, M., Harris, M. A., Harris, S. E., et al. (2019) · Bone Research · doi:10.1038/s41413-018-0037-4 · Cited by 29 · see citing works

Live Imaging of Bone Cell and Organ Cultures

Dallas, S. L., & Veno, P. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-415-5_26 · Cited by 27 · see citing works

Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin

Nakano, M., Ikegame, M., Igarashi-Migitaka, J., Maruyama, Y., Suzuki, N., & Hattori, A. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0707 · Cited by 26 · see citing works

Analysis of Ca2+ response of osteocyte network by three-dimensional time-lapse imaging in living bone

Tanaka, T., Hoshijima, M., Sunaga, J., Nishida, T., Hashimoto, M., Odagaki, N., Osumi, R., Aadachi, T., & Kamioka, H. (2017) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-017-0868-x · Cited by 19 · see citing works

Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor.

Broudy, V. C., Kaushansky, K., Shoemaker, S. G., Aggarwal, B. B., & Adamson, J. W. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.10.3789 · Cited by 17 · see citing works

Studies of the fossil dinosaur bone in the scanning electron microscope.

Pawlicki, R. (1975) · PubMed · Cited by 9 · see citing works

Advances in pathogenesis and therapeutic strategies for osteoporosis

Song, S., Guo, Y., Yang, Y., & Fu, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108168 · Cited by 476 · see citing works

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

Kitaura, H., Marahleh, A., Ohori, F., Noguchi, T., Shen, W.-R., Qi, J., Nara, Y., Pramusita, A., Kinjo, R., & Mizoguchi, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145169 · Cited by 383 · see citing works

Oxidative Stress and Inflammation in Osteoporosis: Molecular Mechanisms Involved and the Relationship with microRNAs

Iantomasi, T., Romagnoli, C., Palmini, G., Donati, S., Falsetti, I., Miglietta, F., Aurilia, C., Marini, F., Giusti, F., & Brandi, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043772 · Cited by 392 · see citing works

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 353 · see citing works

The role of autophagy in bone metabolism and clinical significance

Wang, J., Zhang, Y., Cao, J., Wang, Y., Anwar, N., Zhang, Z., Zhang, D., Ma, Y., Xiao, Y., Xiao, L., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2186112 · Cited by 327 · see citing works

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis

Zhu, X., Chan, Y.-T., Yung, P. S., Tuan, R. S., & Jiang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607764 · Cited by 200 · see citing works

Osteocytes in bone aging: Advances, challenges, and future perspectives

Cui, J., Shibata, Y., Zhu, T., Zhou, J. M., & Zhang, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101608 · Cited by 181 · see citing works

Temporomandibular Joint Osteoarthritis: Pathogenic Mechanisms Involving the Cartilage and Subchondral Bone, and Potential Therapeutic Strategies for Joint Regeneration

Cardoneanu, A., Macovei, L., Burlui, A., Mihai, I., Bratoiu, I., Rezus, I., Richter, P., Tamba, B., & Rezuș, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010171 · Cited by 168 · see citing works

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165 · see citing works

Targeting strategies for bone diseases: signaling pathways and clinical studies

Xu, H., Wang, W., Liu, X., Huang, W. H., Chen, Z., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01467-8 · Cited by 173 · see citing works

Autophagy in Bone Remodeling: A Regulator of Oxidative Stress

Zhu, C., Shen, S., Zhang, S., Huang, M., Zhang, L., & Chen, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.898634 · Cited by 166 · see citing works

Insights and implications of sexual dimorphism in osteoporosis

Zhang, Y., Xie, N., Sun, X., Nice, E. C., Liou, Y., Huang, C., Zhu, H., & Shen, Z. (2024) · Bone Research · doi:10.1038/s41413-023-00306-4 · Cited by 159 · see citing works

The basics of phosphate metabolism

Wagner, C. A. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad188 · Cited by 157 · see citing works

New developments in the biology of fibroblast growth factors

Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works

Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments

Maeda, K., Yoshida, K., Nishizawa, T., Otani, K., Yamashita, Y., Okabe, H., Hadano, Y., Kayama, T., Kurosaka, D., & Saito, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052871 · Cited by 151 · see citing works

Metabolic regulation of skeletal cell fate and function

Stegen, S., & Carmeliet, G. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00969-x · Cited by 151 · see citing works

Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Gao, Q., Wang, L., Wang, S., Huang, B., Jing, Y., & Su, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787118 · Cited by 141 · see citing works

Advance in bone destruction participated by JAK/STAT in rheumatoid arthritis and therapeutic effect of JAK/STAT inhibitors

Hu, L., Liu, R., & Zhang, L. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109095 · Cited by 137 · see citing works

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Sun, Y., Wan, B., Wang, R., Zhang, B., Luo, P., Diaodiao, W., Nie, J., Chen, D., & Wu, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.808303 · Cited by 122 · see citing works

Ion Pathways in Biomineralization: Perspectives on Uptake, Transport, and Deposition of Calcium, Carbonate, and Phosphate

Kahil, K., Weiner, S., Addadi, L., & Gal, A. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c09174 · Cited by 118 · see citing works

Osteoimmunology in Periodontitis and Orthodontic Tooth Movement

Alghamdi, B., Jeon, H. H., Ni, J., Qiu, D., Liu, A., Hong, J. J., Ali, M., Wang, A., Troka, M. E., & Graves, D. T. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00774-x · Cited by 129 · see citing works

The roles of osteocytes in alveolar bone destruction in periodontitis

Huang, X., Xie, M.-R., Xie, Y.-L., Mei, F., Lu, X., Li, X.-S., & Chen, L.-L. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02664-7 · Cited by 110 · see citing works

Impact of the host response and osteoblast lineage cells on periodontal disease

Zhou, M., & Graves, D. T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.998244 · Cited by 114 · see citing works

Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y

Zhang, Y., Chen, C., Liu, Y., Rao, S., Tan, Y., Qian, Y., Xia, K., Huang, J., Liu, X., Hong, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202100808 · Cited by 109 · see citing works

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Wu, Z., Li, W., Jiang, K., Lin, Z., Qian, C., Wu, M., Xia, Y., Li, N., Zhang, H., Xiao, H.-X., et al. (2024) · MedComm · doi:10.1002/mco2.657 · Cited by 115 · see citing works

Noncancerous disease-targeting AIEgens

Duo, Y., Luo, G., Zhang, W., Wang, R., Xiao, G. G., Li, Z., Li, X., Chen, M., Yoon, J., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00610c · Cited by 106 · see citing works

Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis

Jiang, Z., Qi, G., He, X., Yu, Y., Cao, Y., Zhang, C., Zou, W., & Yuan, H. (2024) · Advanced Science · doi:10.1002/advs.202307388 · Cited by 108 · see citing works

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Wang, J. S., Kamath, T., Mazur, C. M., Mirzamohammadi, F., Rotter, D., Hojo, H., Castro, C. D., Tokavanich, N., Patel, R., Govea, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26571-7 · Cited by 103 · see citing works

Role of the Interaction of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors 1 and 2 in Bone-Related Cells

Kitaura, H., Marahleh, A., Ohori, F., Noguchi, T., Nara, Y., Pramusita, A., Kinjo, R., Ma, J., Kanou, K., & Mizoguchi, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031481 · Cited by 101 · see citing works

The origins and formation of bone-resorbing osteoclasts

Elson, A., Anuj, A., Barnea-Zohar, M., & Reuven, N. (2022) · Bone · doi:10.1016/j.bone.2022.116538 · Cited by 95 · see citing works

The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging

Jiang, Y., Wang, Z., Liu, X., Wan, M., Liu, Y., Jiao, B., Liao, X., Luo, Z., Wang, Y., Hong, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202105316 · Cited by 87 · see citing works

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162519 · Cited by 81 · see citing works

Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

Liu, H., Chen, J., Qiao, S., & Zhang, W. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00759 · Cited by 76 · see citing works

Bone-to-Brain: A Round Trip in the Adaptation to Mechanical Stimuli

Gerosa, L., & Lombardi, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.623893 · Cited by 77 · see citing works

Bone marrow niches in the regulation of bone metastasis

Chen, F., Han, Y., & Kang, Y. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01329-6 · Cited by 75 · see citing works

Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

Yoshimoto, T., Kittaka, M., Doan, A. A. P., Urata, R., Prideaux, M., Rojas, R. E., Harding, C. V., Boom, W. H., Bonewald, L. F., Greenfield, E. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34352-z · Cited by 75 · see citing works

Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis

Yang, J., Ueharu, H., & Mishina, Y. M. (2020) · Bone · doi:10.1016/j.bone.2020.115467 · Cited by 74 · see citing works

Osteometabolism: Metabolic Alterations in Bone Pathologies

Srivastava, R. K., Sapra, L., & Mishra, P. K. (2022) · Cells · doi:10.3390/cells11233943 · Cited by 72 · see citing works

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu, S., Zhang, L., Li, Z., Gao, F., Zhang, Q., Bianco, A., Liu, H., Ge, S., & Ma, B. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202306534 · Cited by 72 · see citing works

Metabolic reprogramming in skeletal cell differentiation

Bertels, J., He, G., & Long, F. (2024) · Bone Research · doi:10.1038/s41413-024-00374-0 · Cited by 78 · see citing works

Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

Long, J. T., Leinroth, A. P., Liao, Y., Ren, Y., Mirando, A. J., Nguyen, T., Guo, W., Sharma, D., Rouse, D., Wu, C., et al. (2022) · eLife · doi:10.7554/elife.76932 · Cited by 70 · see citing works

Control of Bone Matrix Properties by Osteocytes

Creecy, A., Damrath, J. G., & Wallace, J. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.578477 · Cited by 68 · see citing works

Crosstalk Between the Neuroendocrine System and Bone Homeostasis

Zhao, Y., Peng, X., Wang, Q., Zhang, Z., Wang, L., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad025 · Cited by 69 · see citing works

Bone Hierarchical Structure: Heterogeneity and Uniformity

Rodríguez-Palomo, A., Østergaard, M., & Birkedal, H. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202307026 · Cited by 68 · see citing works

Osteocytes and Bone Metastasis

Riquelme, M. A., Cardenas, E. R., & Jiang, J. X. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.567844 · Cited by 65 · see citing works

A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

Gadomski, S., Fielding, C., García-García, A., Korn, C., Kapeni, C., Ashraf, S., Villadiego, J., Toro, R. D., Domingues, O., Skepper, J. N., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.02.008 · Cited by 65 · see citing works

Osteocyte Cellular Senescence

Farr, J. N., Kaur, J., Doolittle, M. L., & Khosla, S. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00619-x · Cited by 60 · see citing works

Bone metabolism – an underappreciated player

Choi, I. A., Umemoto, A., Mizuno, M., & Park‐Min, K. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00010-9 · Cited by 63 · see citing works

Role and Regulation of Transcription Factors in Osteoclastogenesis

Jiang, T., Xia, T., Qiao, F., Wang, N., Jiang, Y., & Xin, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216175 · Cited by 60 · see citing works

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00328-y · Cited by 60 · see citing works

Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review

Sadek, K. M., Moshy, S. E., Radwan, I., Rady, D., Abbass, M., El-Rashidy, A. A., Dörfer, C., & El-Sayed, K. F. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054599 · Cited by 56 · see citing works

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Fărcaș, A., Miere, F. G., Filip, G. A., Clichici, S. V., Fritea, L., Vicaș, L. G., Marian, E., Pallag, A., Jurca, T., Filip, S. M., et al. (2023) · Plants · doi:10.3390/plants12102055 · Cited by 55 · see citing works

Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption

Nakai, Y., Praneetpong, N., Ono, W., & Ono, N. (2023) · Journal of Bone Metabolism · doi:10.11005/jbm.2023.30.4.297 · Cited by 59 · see citing works

Iron Overload-Induced Osteocyte Apoptosis Stimulates Osteoclast Differentiation Through Increasing Osteocytic RANKL Production In Vitro

Yang, J., Dong, D., Luo, X., Zhou, J., Shang, P., & Zhang, H. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00735-x · Cited by 55 · see citing works

Amino acid metabolism in skeletal cells

Devignes, C.-S., Carmeliet, G., & Stegen, S. (2022) · Bone Reports · doi:10.1016/j.bonr.2022.101620 · Cited by 53 · see citing works

Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin−/− mice through increasing sclerostin and RANKL/OPG

Ma, J., Wang, A., Zhang, H., Liu, B., Geng, Y., Xu, Y., Zuo, G., & Peng, J. (2022) · Bone · doi:10.1016/j.bone.2022.116511 · Cited by 52 · see citing works

Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics

Mathavan, N., Singh, A., Marques, F. C., Günther, D., Kuhn, G. A., Wehrle, E., & Müller, R. (2025) · Science Advances · doi:10.1126/sciadv.adp8496 · Cited by 52 · see citing works

Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

Che, H., Gao, Y., Xu, Y., Xu, H., Eils, R., & Tian, M. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02329-1 · Cited by 55 · see citing works

New Advances in Osteocyte Mechanotransduction

Li, X., Kordsmeier, J., & Xiong, J. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00650-y · Cited by 55 · see citing works

Endocrine Regulation on Bone by Thyroid

Zhu, S., Pang, Y., Xu, J., Chen, X., Zhang, C., Wu, B. Y., & Gao, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873820 · Cited by 53 · see citing works

The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology

Wang, J., Sun, Y., & Li, J. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.11.002 · Cited by 49 · see citing works

Convergence of scaffold-guided bone regeneration principles and microvascular tissue transfer surgery

Sparks, D. S., Savi, F. M., Dlaska, C. E., Saifzadeh, S., Brierly, G. I., Ren, E., Cipitria, A., Reichert, J. C., Wille, M., Schuetz, M., et al. (2023) · Science Advances · doi:10.1126/sciadv.add6071 · Cited by 51 · see citing works

Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity

Zhou, H., Zhang, W., Li, H., Xu, F., Yinwang, E., Xue, Y., Chen, T., Wang, S., Wang, Z., Sun, H., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi4298 · Cited by 51 · see citing works

Consequences of Aging on Bone

Zhang, L., Guan, Q., Wang, Z., Feng, J., Zou, J., & Gao, B. (2023) · Aging and Disease · doi:10.14336/ad.2023.1115 · Cited by 49 · see citing works

Is There a Governing Role of Osteocytes in Bone Tissue Regeneration?

Cao, W., Helder, M. N., Bravenboer, N., Wu, G., Jin, J., Bruggenkate, C. M. T., Klein‐Nulend, J., & Schulten, E. A. J. M. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00610-6 · Cited by 47 · see citing works

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

Wang, X., Ma, Y., Chen, J., Liu, Y., Liu, G., Wang, P., Wang, B., Taketo, M. M., Bellido, T., & Tu, X. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.017 · Cited by 46 · see citing works

Using confocal imaging approaches to understand the structure and function of osteocytes and the lacunocanalicular network

Dallas, S. L., & Moore, D. S. (2020) · Bone · doi:10.1016/j.bone.2020.115463 · Cited by 43 · see citing works

Connexin Gap Junctions and Hemichannels Link Oxidative Stress to Skeletal Physiology and Pathology

Hua, R., Zhang, J., Riquelme, M. A., & Jiang, J. X. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00645-9 · Cited by 43 · see citing works

New Emerging Biomarkers for Bone Disease: Sclerostin and Dickkopf-1 (DKK1)

Dinçel, A. S., & Jørgensen, N. R. (2022) · Calcified Tissue International · doi:10.1007/s00223-022-01020-9 · Cited by 43 · see citing works

Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review

Hu, Y., Huang, J., Chen, C., Wang, Y., Hao, Z., Chen, T., Wang, J., & Li, J. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb14010018 · Cited by 44 · see citing works

Circadian Regulation of Bone Remodeling

Kikyo, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094717 · Cited by 42 · see citing works

An Acid‐Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities

Hashimoto, R., Minoshima, M., Kikuta, J., Yari, S., Bull, S. D., Ishii, M., & Kikuchi, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202006388 · Cited by 41 · see citing works

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Yang, J., Wu, J., Guo, Z., Zhang, G., & Zhang, H. (2022) · Cells · doi:10.3390/cells11203298 · Cited by 40 · see citing works

Inflammation and mechanical force‐induced bone remodeling

Jeon, H. H., Huang, X., Rojas, L., Sripinun, P., Lee, J., Hong, J. J., & Graves, D. T. (2024) · Periodontology 2000 · doi:10.1111/prd.12619 · Cited by 43 · see citing works

Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture

Kim, J., & ADACHI, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-92607-z · Cited by 40 · see citing works

Control of osteoblast arrangement by osteocyte mechanoresponse through prostaglandin E2 signaling under oscillatory fluid flow stimuli

Matsuzaka, T., Matsugaki, A., & Nakano, T. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121203 · Cited by 40 · see citing works

Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes

Jin, H., Jiang, N., Xu, W., Zhang, Z., Yang, Y., Zhang, J., & Xu, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113379 · Cited by 40 · see citing works

SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis

Jiao, Z., Chai, H., Wang, S., Sun, C., Huang, Q., & Xu, W. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02319-2 · Cited by 39 · see citing works

Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms

Garcia-Moreno, M., Jordan, P. M., Günther, K., Dau, T., Fritzsch, C., Vermes, M., Schoppa, A., Ignatius, A. A., Wildemann, B., Werz, O., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.937466 · Cited by 38 · see citing works

Metabolic Health and Disease: A Role of Osteokines?

Shimonty, A., Bonewald, L. F., & Huot, J. R. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01093-0 · Cited by 38 · see citing works

The pathogenesis of bone metastasis in solid tumors: a review

Vičić, I., & Belev, B. (2021) · Croatian Medical Journal · doi:10.3325/cmj.2021.62.270 · Cited by 38 · see citing works

Early-Onset Osteoporosis: Rare Monogenic Forms Elucidate the Complexity of Disease Pathogenesis Beyond Type I Collagen

Costantini, A., Mäkitie, R. E., Hartmann, M. A., Fratzl‐Zelman, N., Zillikens, M. C., Kornak, U., Søe, K., & Mäkitie, O. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4668 · Cited by 38 · see citing works

Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro

Wang, Y., Xu, L., Wang, J., Bai, J., Zhai, J., & Zhu, G. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4909 · Cited by 39 · see citing works

Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology

Li, S., Liu, G., & Hu, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1396122 · Cited by 41 · see citing works

PTH1R translocation to primary cilia in mechanically‐stimulated ostecytes prevents osteoclast formation via regulation of CXCL5 and IL‐6 secretion

Tirado‐Cabrera, I., Martín‐Guerrero, E., Heredero‐Jiménez, S., Ardura, J. A., & Gortázar, A. R. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30849 · Cited by 36 · see citing works

An update on the role of ferroptosis in the pathogenesis of osteoporosis

Wu, X., Fang, X., Lu, F., Chen, Q., Liu, J., & Zheng, L. (2024) · EFORT Open Reviews · doi:10.1530/eor-23-0148 · Cited by 37 · see citing works

Non-bone metastatic cancers promote osteocyte-induced bone destruction

Pin, F., Prideaux, M., Huot, J. R., Essex, A. L., Plotkin, L. I., Bonetto, A., & Bonewald, L. F. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.030 · Cited by 36 · see citing works

Osteocyte RANKL Drives Bone Resorption in Mouse Ligature-Induced Periodontitis

Kittaka, M., Yoshimoto, T., Levitan, M. E., Urata, R., Choi, R. B., Teno, Y., Xie, Y., Kitase, Y., Prideaux, M., Dallas, S. L., et al. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4897 · Cited by 35 · see citing works

Breaking Osteoclast‐Acid Vicious Cycle to Rescue Osteoporosis via an Acid Responsive Organic Framework‐Based Neutralizing and Gene Editing Platform

Lin, W., Hu, S., Li, K., Shi, Y., Pan, C., Xu, Z., Li, D., Wang, H. H., Li, B., & Chen, H. (2023) · Small · doi:10.1002/smll.202307595 · Cited by 35 · see citing works

Redox signaling and antioxidant defense in osteoclasts

Tao, H., Li, X., Wang, Q., Yu, L., Peng, Y., Chen, W., Yang, X., Zhou, J., & Geng, D. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.043 · Cited by 35 · see citing works

Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1

Wang, Z., Lin, X., Cao, J., Liu, Y.-W., Luo, Z.-W., Rao, S.-S., Wang, Y., Wang, Y.-Y., Chen, C., Zhu, G., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02367-x · Cited by 35 · see citing works

Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles

Liu, X., Shen, L., Wan, M., Xie, H., & Wang, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02428-1 · Cited by 33 · see citing works

Sclerostin: From Molecule to Clinical Biomarker

Omran, A. S., Atanasova, D., Landgren, F., & Magnusson, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094751 · Cited by 39 · see citing works

Journey of Mineral Precursors in Bone Mineralization: Evolution and Inspiration for Biomimetic Design

Zhang, Y., Ma, S., Nie, J., Liu, Z., Chen, F., Li, A., & Pei, D. (2023) · Small · doi:10.1002/smll.202207951 · Cited by 35 · see citing works

Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues

Chen, W., Wang, Q., Tao, H., Lu, L., Zhou, J., Wang, Q., Huang, W., & Yang, X. H. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024017 · Cited by 35 · see citing works

Unraveling ferroptosis in osteogenic lineages: implications for dysregulated bone remodeling during periodontitis progression

Tang, Y., Su, S., Yu, R., Liao, C., Dong, Z., Jia, C., Yau, V., Wu, L., Guo, W., & Zheng, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01969-6 · Cited by 35 · see citing works

The Potential Roles of T Cells in Periapical Lesions

Wang, L., Yang, F., Qiu, Y., Ye, L., Song, D., & Huang, D. (2021) · Journal of Endodontics · doi:10.1016/j.joen.2021.09.016 · Cited by 34 · see citing works

Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways

Zhong, X., Zhang, F., Yin, X., Cao, H., Wang, X., Liu, D., Chen, J., & Chen, X. (2021) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2104.04016 · Cited by 34 · see citing works

Subcanalicular Nanochannel Volume Is Inversely Correlated With Calcium Content in Human Cortical Bone

Tang, T., Landis, W. J., Blouin, S., Bertinetti, L., Hartmann, M. A., Berzlanovich, A. M., Weinkamer, R., Wagermaier, W., & Fratzl, P. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4753 · Cited by 34 · see citing works

Pathological progression of osteoarthritis: a perspective on subchondral bone

Li, X., Chen, W., Liu, D., Chen, P., Wang, S., Li, F., Chen, Q., Lv, S., Li, F., Chen, C., et al. (2024) · Frontiers of Medicine · doi:10.1007/s11684-024-1061-y · Cited by 34 · see citing works

Osteocytes: master orchestrators of bone

Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514 · see citing works

The Osteocyte: From “Prisoner” to “Orchestrator”

Palumbo, C., & Ferretti, M. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6010028 · Cited by 49 · see citing works

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works

Osteocyte Biology

Bonewald, L. F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00010-8 · Cited by 10 · see citing works

Osteocytes as Dynamic Multifunctional Cells

Bonewald, L. F. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.018 · Cited by 414 · see citing works