Prebiotics
Abstract
In nutritional sciences there is much interest in dietary modulation of the human gut. The gastrointestinal tract, particularly the colon, is very heavily populated with bacteria. Most bacteria are benign; however, certain gut species are pathogenic and may be involved in the onset of acute and chronic disorders. Bifidobacteria and lactobacilli are thought to be beneficial and are common targets for dietary intervention. Prebiotic is a non-viable food ingredient selectively metabolized by beneficial intestinal bacteria. Dietary modulation of the gut microflora by prebiotics is designed to improve health by stimulating numbers and/or activities of the bifidobacteria and lactobacilli. Having an 'optimal' gut microflora can increase resistance to pathogenic bacteria, lower blood ammonia, increase stimulation of the immune response and reduce the risk of cancer. This chapter examines how prebiotics are being applied to the improvement of human health and reviews the scientific evidence behind their use.
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The prebiotic effects of NSPs, fructans, lactulose, and gluco-oligosaccharides in promoting SCFA-producing bacteria are now reasonably well accepted.
“The prebiotic effects of NSPs, fructans, lactulose, and gluco-oligosaccharides in promoting the populations of bacteria that produce SCFAs (notably) Bifidobacteria and Lactobacilli (Manning and Gibson, 2004) are now reasonably well accepted.”
From Role of polysaccharides in food, digestion, and health (2017) · cites this paper as Manning and Gibson, 2004
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“The prebiotic effects of NSPs, fructans, lactulose, and gluco-oligosaccharides in promoting the populations of bacteria that produce SCFAs (notably) Bifidobacteria and Lactobacilli (Manning and Gibson, 2004) are now reasonably well accepted.”
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- Authors
- Manning, T. S., & Gibson, G. R.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Manning, Thea Scantlebury
- ORCID
- Gibson, Glenn R
- Venue
- Best Practice & Research Clinical Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 18
- Issue
- 2
- Pages
- 287-298
- ISSN
- 1521-6918 (ISSN-L)
- OpenAlex
- W2434941261
- Cited by
- 480
- References
- 0
- Citations by year
- 2026: 6 · 2025: 26 · 2024: 20 · 2023: 17 · 2022: 27 · 2021: 40 · 2020: 21 · 2019: 32 · 2018: 29 · 2017: 19 · 2016: 29 · 2015: 30 · 2014: 30 · 2013: 20 · 2012: 25
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- prebiotics, gut microbiota, Bifidobacterium, lactobacilli, colonic microbiota, pathogenic bacteria, immune response, blood ammonia, cancer risk
- MeSH terms
- Bifidobacterium, Humans, Intestines, Lactobacillus, Dietary Supplements
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