Prebiotics from marine macroalgae for human and animal health applications
Open accessAbstract
The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health applications. Prebiotics are non-digestible, selectively fermented compounds that stimulate the growth and/or activity of beneficial gut microbiota which, in turn, confer health benefits on the host. This review will introduce the concept and potential applications of prebiotics, followed by an outline of the chemistry of seaweed polysaccharides. Their potential for use as prebiotics for both humans and animals will be highlighted by reviewing data from both in vitro and in vivo studies conducted to date.
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Agarose hydrolysates (NAOS) increase bifidobacteria and lactobacilli in mice and lower Bacteroides compared to FOS controls.
“Similar increases were observed by [138] in mice fed with diets supplemented with agarose hydrolysates (NAOS). Moreover, a lower number of Bacteroides compared to the controls fed with FOS, were observed [135].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [135]
Molecular methods such as FISH, PCR, DGGE and 16S rRNA gene sequencing provide a complete representation of the in vitro effect of prebiotic candidates from seaweeds on modulation of intestinal microbiota by increasing beneficial bacteria and decreasing prejudicial microorganisms.
“Using molecular methods such as fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE) and 16S rRNA gene sequencing provides a complete representation of the in vitro effect of prebiotic candidates from seaweeds on the modulation of intestinal microbiota by increasing the amount of beneficial bacteria and decreasing prejudicial”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [135]
Laminarin is uncharged at neutral pH, stabilized by inter-chain hydrogen bonds, resistant to hydrolysis in the upper gastrointestinal tract, and classified as dietary fiber.
“They are uncharged molecules at neutral pH which are stabilized by inter-chain hydrogen bonds, thus unable to hydrolyse in the upper gastrointestinal tract and are classified as dietary fibers”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as O'Sullivan et al., 2010
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Vidanarachchi, J. K., Kurukulasuriya, M. S., Malshani Samaraweera, A., & Silva, K. F. S. T. (2012) · Advances in food and nutrition research · doi:10.1016/b978-0-12-416003-3.00030-5 · Cited by 24 · see citing works
Seaweed aquaculture for human foods in land-based and IMTA systems
Pereira, R., Yarish, C., & Critchley, A. T. (2013) · Sustainable Food Production · doi:10.1007/978-1-4614-5797-8_189 · Cited by 14 · see citing works
- Authors
- O’Sullivan, L., Murphy, B., McLoughlin, P., Duggan, P., Lawlor, P. G., Hughes, H., & Gardiner, G. E.
- Affiliations
- Waterford Institute of Technology (IE)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Corresponding author
- O’Sullivan, Laurie
- Hughes, Helen
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2010-07-01
- Volume
- 8
- Issue
- 7
- Pages
- 2038-2064
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC2920542
- OpenAlex
- W2083982708
- Cited by
- 421
- References
- 87
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 26 · 2023: 29 · 2022: 33 · 2021: 32 · 2020: 18 · 2019: 34 · 2018: 33 · 2017: 28 · 2016: 33 · 2015: 35 · 2014: 21 · 2013: 17 · 2012: 20
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- prebiotics, seaweed, seaweed polysaccharides, gut microbiota, human health, animal health, functional food ingredients, prebiotic chemistry, bioactive compounds
- MeSH terms
- Animals, Fermentation, Humans, Polysaccharides, Seaweed, Gastrointestinal Tract, Prebiotics
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