TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516 · see citing works

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works

Microenvironmental regulation of metastasis

Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works

Metastasis to bone: causes, consequences and therapeutic opportunities

Mundy, G. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc867 · Cited by 2,787 · see citing works

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,693 · see citing works

Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267 · see citing works

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R. L., Itoh, S., Kawabata, M., Heldin, N., Heldin, C., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,796 · see citing works

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,754 · see citing works

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

Nakamura, K., Kitani, A., & Strober, W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.629 · Cited by 1,596 · see citing works

TH-17 cells in the circle of immunity and autoimmunity

Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007) · Nature Immunology · doi:10.1038/ni0407-345 · Cited by 1,503 · see citing works

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355 · see citing works

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,322 · see citing works

TGFβ: the molecular Jekyll and Hyde of cancer

Bierie, B., & Moses, H. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1926 · Cited by 1,262 · see citing works

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

Yanaba, K., Bouaziz, J., Haas, K. M., Poe, J. C., Fujimoto, M., & Tedder, T. F. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.017 · Cited by 1,239 · see citing works

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

Movahedi, K., Guilliams, M., den Bossche, J. V., den Bergh, R. V., Gysemans, C. A., Beschin, A., BAETSELIER, P. D., & Ginderachter, J. A. V. (2008) · Blood · doi:10.1182/blood-2007-07-099226 · Cited by 1,234 · see citing works

Trophic macrophages in development and disease

Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178 · see citing works

Hypoxia, DNA repair and genetic instability

Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140 · see citing works

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

Yang, L., DeBusk, L. M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. M., Carbone, D. P., & Lin, P. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.031 · Cited by 1,140 · see citing works

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

Hiratsuka, S., Watanabe, A., Aburatani, H., & Maru, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1507 · Cited by 1,016 · see citing works

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taı̈eb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B. J., Vivier, É., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 948 · see citing works

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 947 · see citing works

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., Carbone, D. P., Matrisian, L. M., Richmond, A., Lin, P. C., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.004 · Cited by 918 · see citing works

TGF-β: A Master of All T Cell Trades

Li, M. O., & Flavell, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.07.025 · Cited by 888 · see citing works

Molecular Predictors of Survival after Adjuvant Chemotherapy for Colon Cancer

Watanabe, T., Wu, T., Catalano, P. J., Ueki, T., Satriano, R., Haller, D. G., Benson, A. B., & Hamilton, S. R. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104193441603 · Cited by 886 · see citing works

Role of tumor-associated macrophages in tumor progression and invasion

Mantovani, A., Schioppa, T., Porta, C., Allavena, P., & Sica, A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9001-7 · Cited by 885 · see citing works

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment

Budhu, A., Forgues, M., Ye, Q.-H., Jia, H.-L., He, P., Zanetti, K. A., Kammula, U. S., Chen, Y., Qin, L., Tang, Z., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.016 · Cited by 843 · see citing works

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 826 · see citing works

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806 · see citing works

Transforming growth factor-β in T-cell biology

Gorelik, L., & Flavell, R. A. (2002) · Nature Reviews Immunology · doi:10.1038/nri704 · Cited by 792 · see citing works

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 783 · see citing works

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine · doi:10.1038/nm1001-1118 · Cited by 770 · see citing works

TGF- β signaling in cancer – a double-edged sword

Akhurst, R. J., & Derynck, R. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02130-4 · Cited by 756 · see citing works

The two faces of transforming growth factor β in carcinogenesis

Roberts, A. B., & Wakefield, L. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633291100 · Cited by 747 · see citing works

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Castriconi, R., Cantoni, C., Chiesa, M. D., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 727 · see citing works

Clinical significance of defective dendritic cell differentiation in cancer.

Almand, B., Resser, J. R., Lindman, B. R., Nadaf, S., Clark, J. I., Kwon, E. D., Carbone, D. P., & Gabrilovich, D. I. (2000) · PubMed · Cited by 699 · see citing works

A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)

Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 693 · see citing works

An inflammatory link

Balkwill, F. R., & Coussens, L. M. (2004) · Nature · doi:10.1038/431405a · Cited by 627 · see citing works

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

Lee, J.-C., Lee, K., Kim, D., & Heo, D. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7335 · Cited by 549 · see citing works

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

Terabe, M., Matsui, S., Park, J.-M., Mamura, M., Noben-Trauth, N., Donaldson, D. D., Chen, W., Wahl, S. M., Ledbetter, S. R., Pratt, B. M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022227 · Cited by 539 · see citing works

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L., Adorno, M., Martello, G., Stinchfield, M. J., Soligo, S., Morsut, L., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.051 · Cited by 494 · see citing works

Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity

Kopp, H., Placke, T., & Salih, H. R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2123 · Cited by 473 · see citing works

High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene

Bruna, A., Darken, R. S., Rojo, F., Ocaña, A., Peñuelas, S., Arias, A., Parı́s, R., Tortosa, A., Mora, J., Baselga, J. M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.023 · Cited by 472 · see citing works

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

Laouar, Y., Sutterwala, F. S., Gorelik, L., & Flavell, R. A. (2005) · Nature Immunology · doi:10.1038/ni1197 · Cited by 452 · see citing works

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

Cazac, B. B., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00044-3 · Cited by 430 · see citing works

Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Biswas, S., Guix, M., Rinehart, C., Dugger, T. C., Chytil, A. M., Moses, H. L., Freeman, M. L., & Arteaga, C. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30740 · Cited by 346 · see citing works

Inhibitory Effects of B Cells on Antitumor Immunity

Inoue, S., Leitner, W. W., Golding, B., & Scott, D. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3766 · Cited by 338 · see citing works

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

Kim, B., Li, C., Qiao, W., Mamura, M., Kasperczak, B., Anver, M. R., Wolfraim, L. A., Hong, S., Mushinski, E. B., Potter, M., et al. (2006) · Nature · doi:10.1038/nature04846 · Cited by 320 · see citing works

RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates Tumorigenicity In vivo

Friese, M. A., Wischhusen, J., Wick, W., Weiler, M., Eisele, G., Steinle, A., & Weller, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1627 · Cited by 305 · see citing works

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., et al. (2007) · Nature Genetics · doi:10.1038/ng1997 · Cited by 282 · see citing works

The ‘short’ history of regulatory B cells

Mauri, C., & Ehrenstein, M. R. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.10.004 · Cited by 281 · see citing works

Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia

Guasch, G., Schöber, M., Pasolli, H. A., Conn, E. B., Polak, L., & Fuchs, E. V. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.020 · Cited by 267 · see citing works

Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

Nam, J., Terabe, M., Kang, M., Chae, H., Voong, N., Yang, Y.-A., Laurence, A. D. J., Michalowska, A. M., Mamura, M., Lonning, S. M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0206 · Cited by 250 · see citing works

An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

Nam, J., Terabe, M., Mamura, M., Kang, M., Chae, H., Stuelten, C. H., Kohn, E. A., Tang, B., Sabzevari, H., Anver, M. R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0215 · Cited by 233 · see citing works

TGF‐β: a mobile purveyor of immune privilege

Wahl, S. M., Wen, J., & Moutsopoulos, N. M. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00437.x · Cited by 228 · see citing works

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

Xie, W. Q., Mertens, J. C., Reiss, D. J., Rimm, D. L., Camp, R. L., Haffty, B. G., & Reiß, M. (2002) · PubMed · Cited by 217 · see citing works

Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice

Pangas, S. A., Li, X., Umans, L., Zwijsen, A., Huylebroeck, D., Gutiérrez, C., Wang, D., Martin, J. F., Jamin, S. P., Behringer, R. R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01404-07 · Cited by 210 · see citing works

Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice

Maggio‐Price, L., Treuting, P. M., Zeng, W., Tsang, M., Bielefeldt‐Ohmann, H., & Iritani, B. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2448 · Cited by 209 · see citing works

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinomaPreprint

Lu, S., Herrington, H. C., Reh, D. D., Weber, S. M., Bornstein, S., Wang, D., Li, A. G., Tang, C.-F., Siddiqui, Y., Nord, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1413306 · Cited by 204 · see citing works

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.

Engle, S. J., Ormsby, I., Pawlowski, S. A., Boivin, G. P., Croft, J., Balish, E., & Doetschman, T. C. (2002) · PubMed · Cited by 199 · see citing works

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

Lu, S., Reh, D. D., Li, A. G., Woods, J., Corless, C. L., Kulesz-Martin, M. F., & Wang, X. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1032 · Cited by 197 · see citing works

TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch

Liu, I. M., Schilling, S. H., Knouse, K. A., Choy, L., Derynck, R., & Wang, X. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.266 · Cited by 174 · see citing works

Transforming Growth Factor β: Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

Yang, L., & Moses, H. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2556 · Cited by 151 · see citing works

The Yin-Yang of Tumor-Associated Neutrophils

Mantovani, A. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.08.014 · Cited by 148 · see citing works

A Failure of Transforming Growth Factor-β1 Negative Regulation Maintains Sustained NF-κB Activation in Gut Inflammation

Monteleone, G., Mann, J., Monteleone, I., Vavassori, P., Bremner, R., Fantini, M. C., Blanco, G. D. V., Tersigni, R., Alessandroni, L., Mann, D. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m303654200 · Cited by 148 · see citing works

Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone Metastases

Guise, T. A., & Chirgwin, J. M. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000093055.96273.69 · Cited by 134 · see citing works

Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer

Bierie, B., Chung, C. H., Parker, J. S., Stover, D. G., Cheng, N., Chytil, A. M., Aakre, M. E., Shyr, Y., & Moses, H. L. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37480 · Cited by 134 · see citing works

Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA

Kehrl, J. H., Thévenin, C., Rieckmann, P., & Fauci, A. S. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.11.4016 · Cited by 125 · see citing works

Transforming Growth Factor–β Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment

Bierie, B., Stover, D. G., Abel, T. W., Chytil, A. M., Gorska, A. E., Aakre, M. E., Forrester, E., Yang, H. H., Wagner, K., & Moses, H. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5597 · Cited by 124 · see citing works

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M., & Stark, G. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700118104 · Cited by 113 · see citing works

Synergistic Enhancement of CD8+ T Cell–Mediated Tumor Vaccine Efficacy by an Anti–Transforming Growth Factor-β Monoclonal Antibody

Terabe, M., Ambrosino, E., Takaku, S., O’Konek, J. J., Venzon, D. J., Lonning, S. M., McPherson, J. M., & Berzofsky, J. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1066 · Cited by 112 · see citing works

Inhibition of TGFβ signaling in cancer therapy

Arteaga, C. L. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.009 · Cited by 105 · see citing works

Systemic Blockade of Transforming Growth Factor-β Signaling Augments the Efficacy of Immunogene Therapy

Kim, S., Buchlis, G., Fridlender, Z. G., Sun, J., Kapoor, V., Cheng, G., Haas, A. R., Cheung, H. K., Zhang, X., Corbley, M. J., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1494 · Cited by 84 · see citing works

The dual adverse effects of TGF-β secretion on tumor progression

Trapani, J. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.018 · Cited by 77 · see citing works

Gain or loss of TGF-β signaling in mammary carcinoma cells can promote metastasis

Bierie, B., & Moses, H. L. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9727 · Cited by 60 · see citing works

Inhibition of Transforming Growth Factor-β–Mediated Immunosuppression in Tumor-Draining Lymph Nodes Augments Antitumor Responses by Various Immunologic Cell Types

Fujita, T., Teramoto, K., Ozaki, Y., Hanaoka, J., Tezuka, N., Itoh, Y., Asai, T., Fujino, S., Kontani, K., & Ogasawara, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2499 · Cited by 35 · see citing works

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

TGFβ signalling in context

Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,130 · see citing works

Inflammation and tumor progression: signaling pathways and targeted intervention

Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 2,907 · see citing works

Hypoalbuminemia: Pathogenesis and Clinical Significance

Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448 · see citing works

Oncolytic virotherapy

Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428 · see citing works

TGF-β signaling in fibrosis

Biernacka, A., Dobaczewski, M. P., & Frangogiannis, N. G. (2011) · Growth Factors · doi:10.3109/08977194.2011.595714 · Cited by 1,175 · see citing works

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

Hao, Y., Baker, D. A., & ten Dijke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112767 · Cited by 1,155 · see citing works

Role of Extracellular Matrix in Development and Cancer Progression

Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,102 · see citing works

Prospects for combining targeted and conventional cancer therapy with immunotherapy

Gotwals, P. J., Cameron, S. B., Cipolletta, D., Cremasco, V., Crystal, A., Hewes, B., Mueller, B., Quaratino, S., Sabatos-Peyton, C. A., Petruzzelli, L., et al. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.17 · Cited by 948 · see citing works

Mechanisms of hepatic fibrogenesis

Lee, U. E., & Friedman, S. L. (2011) · Best Practice &amp; Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.02.005 · Cited by 923 · see citing works

Initial steps of metastasis: Cell invasion and endothelial transmigration

van Zijl, F., Krupitza, G., & Mikulits, W. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.05.002 · Cited by 884 · see citing works

Immunity, inflammation, and cancer: an eternal fight between good and evil.

Shalapour, S., & Karin, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80007 · Cited by 641 · see citing works

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

Mamessier, É., Sylvain, A., Thibult, M., Houvenaeghel, G. F., Jacquemier, J. D., Castellano, R., Gonçalvès, A., André, P., Romagné, F., Thibault, G., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45816 · Cited by 682 · see citing works

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Gao, Y., Souza-Fonseca-Guimarães, F., Bald, T., Ng, S. S., Young, A., Ngiow, S. F., Rautela, J., Straube, J., Waddell, N., Blake, S. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3800 · Cited by 654 · see citing works

Targeting the TGFβ pathway for cancer therapy

Neuzillet, C., Tijeras‐Raballand, A., Cohen, R., Cros, J. F., Faivre, S. J., Raymond, É., & Gramont, A. D. E. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.001 · Cited by 610 · see citing works

TGF-β – an excellent servant but a bad master

Kubiczkova, L., Sedlarikova, L., Hajek, R., & Sevcikova, S. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-183 · Cited by 511 · see citing works

Targeting the microenvironment in solid tumors

Belli, C., Trapani, D., Viale, G., D’Amico, P., Duso, B. A., Vigna, P. D., Orsi, F., & Curigliano, G. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.02.004 · Cited by 506 · see citing works

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Lan, Y., Zhang, D., Xu, C., Hance, K. W., Marelli, B., Qi, J., Yu, H., Qin, G., Sircar, A., Hernández, V. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5488 · Cited by 494 · see citing works

Novel therapies emerging in oncology to target the TGF‐β pathway

Kim, B.-G., Malek, E., Choi, S. H., Ignatz-Hoover, J. J., & Driscoll, J. J. (2021) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-021-01053-x · Cited by 453 · see citing works

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

Maekawa, T., Krauss, J. L., Abe, T., Jotwani, R., Triantafilou, M., Triantafilou, K., Hashim, A., Hoch, S., Curtis, M. A., Nussbaum, G., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.05.012 · Cited by 430 · see citing works

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

Szczepański, M. J., Szajnik, M. E., Welsh, A., Whiteside, T. L., & Boyiadzis, M. M. (2011) · Haematologica · doi:10.3324/haematol.2010.039743 · Cited by 421 · see citing works

TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors

Tang, N., Cheng, C. Y., Zhang, X., Qiao, M., Li, N., Mu, W., Wei, X., Han, W., & Wang, H. (2020) · JCI Insight · doi:10.1172/jci.insight.133977 · Cited by 418 · see citing works

Molecular Link Mechanisms between Inflammation and Cancer

Costa, D. B. V., & de Carvalho, J. E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802083707 · Cited by 416 · see citing works

The dynamic roles of TGF‐β in cancer

Meulmeester, E., & ten Dijke, P. (2010) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 391 · see citing works

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Tufail, M., Jiang, C., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 424 · see citing works

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

Elpek, G. Ö. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7260 · Cited by 384 · see citing works

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., Acevedo, L. M., Manglicmot, J. R. E., Song, X., Wrasidlo, W., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.016 · Cited by 378 · see citing works

Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions

Wang, Y., Deng, W., Li, N., Neri, S., Sharma, A., Jiang, W., & Lin, S. H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00185 · Cited by 376 · see citing works

Ontogeny of early life immunity

Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 365 · see citing works

Tumor-induced perturbations of cytokines and immune cell networks

Burkholder, B., Huang, R.-Y., Burgess, R., Luo, S., Jones, V. S., Zhang, W., Lv, Z., Gao, C., Wang, B.-L., Zhang, Y., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.01.004 · Cited by 354 · see citing works

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis

Fabregat, I., & Caballero‐Díaz, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00357 · Cited by 352 · see citing works

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Baglieri, J., Brenner, D. A., & Kisseleva, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071723 · Cited by 341 · see citing works

TGF-beta in CAF-mediated tumor growth and metastasis

Calon, A., Tauriello, D. V. F., & Batlle, E. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.008 · Cited by 342 · see citing works

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease

Murphy-Ullrich, J. E., & Suto, M. J. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.12.009 · Cited by 336 · see citing works

Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?

Hasselbalch, H. C. (2012) · Blood · doi:10.1182/blood-2011-11-394775 · Cited by 328 · see citing works

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Goodson, W. H., Lowe, L. J., Carpenter, D. O., Gilbertson, M., Ali, A. M., Salsamendi, A. L. D. C., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv039 · Cited by 324 · see citing works

Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer

Zhao, S., Ren, S., Jiang, T., Zhu, B., Li, X., Zhao, C., Jia, Y., Shi, J., Zhang, L., Liu, X., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0640 · Cited by 320 · see citing works

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix MetalloproteinasesPreprint

Nisticò, P., Bissell, M. J., & Radisky, D. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011908 · Cited by 311 · see citing works

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Qing, S., Lyu, C., Zhu, L., Pan, C., Wang, S., Li, F., Wang, J., Yue, H., Gao, X., Jia, R., et al. (2020) · Advanced Materials · doi:10.1002/adma.202002085 · Cited by 309 · see citing works

Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents

Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.001 · Cited by 358 · see citing works

The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis

Nishida, A., & Andoh, A. (2025) · Cells · doi:10.3390/cells14070488 · Cited by 282 · see citing works

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

Liu, Y., Lai, L., Chen, Q., Song, Y., Xu, S., Ma, F., Wang, X., Wang, J., Yu, H. C., Cao, X., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103505 · Cited by 272 · see citing works

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

Cheng, J.-T., Deng, Y.-N., Yi, H.-M., Wang, G.-S., Fu, B.-S., Chen, W., Liu, W., Tai, Y., Peng, Y.-W., & Zhang, Q. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.7 · Cited by 268 · see citing works

Determinants of metastatic competency in colorectal cancer

Tauriello, D. V. F., Calon, A., Lonardo, E., & Batlle, E. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12018 · Cited by 259 · see citing works

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., & Hinz, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.11.037 · Cited by 257 · see citing works

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

Huang, K., Hsu, F., Qiu, J. T., Chern, G., Lee, Y.-A., Chang, C., Huang, Y., Sung, Y., Chiang, C.-C., Huang, R.-L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax5032 · Cited by 258 · see citing works

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

Lind, H., Gameiro, S. R., Jochems, C., Donahue, R. N., Strauss, J., Gulley, J. L., Palena, C., & Schlom, J. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000433 · Cited by 247 · see citing works

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

Shi, X., Young, C. D., Zhou, H., & Wang, X. (2020) · Biomolecules · doi:10.3390/biom10121666 · Cited by 256 · see citing works

Transforming growth factor β as regulator of cancer stemness and metastasis

Bellomo, C., Caja, L., & Moustakas, A. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.255 · Cited by 235 · see citing works

Engineering universal cells that evade immune detection

Lanza, R., Russell, D. W., & Nagy, A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0200-1 · Cited by 230 · see citing works

Cancer drug resistance induced by EMT: novel therapeutic strategies

Rivas, J. D. L., Brozović, A., Izraely, S., Casas-Pais, A., Witz, I. P., & Figueroa, A. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03063-7 · Cited by 231 · see citing works

Mechanical Aspects of Lung Fibrosis: A Spotlight on the Myofibroblast

Hinz, B. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201202-017aw · Cited by 226 · see citing works

TGF-β in T Cell Biology: Implications for Cancer Immunotherapy

Dahmani, A., & Delisle, J. (2018) · Cancers · doi:10.3390/cancers10060194 · Cited by 216 · see citing works

Two Faces of TGF-Beta1 in Breast Cancer

Zarzynska, J. M. (2014) · Mediators of Inflammation · doi:10.1155/2014/141747 · Cited by 214 · see citing works

Trends in vaccine adjuvants

Schijns, V. E. C. J., & Lavelle, E. C. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.21 · Cited by 211 · see citing works

On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?

Teixeira, A. F., ten Dijke, P., & Zhu, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00605 · Cited by 210 · see citing works

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

Yan, X., & Chen, Y. (2011) · Biochemical Journal · doi:10.1042/bj20101827 · Cited by 208 · see citing works

Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy

Gao, S., Yang, D., Fang, Y., Lin, X., Jin, X., Wang, Q., Wang, X., Ke, L., & Shi, K. (2018) · Theranostics · doi:10.7150/thno.29431 · Cited by 201 · see citing works

TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation

Fuxe, J., & Karlsson, M. C. I. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.05.004 · Cited by 197 · see citing works

Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment

Achyut, B. R., & Yang, H. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.048 · Cited by 200 · see citing works

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

Wang, H., Tang, Y., Fang, Y., Zhang, M., Wang, H., He, Z., Wang, B., Xu, Q., & Huang, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00021 · Cited by 195 · see citing works

Molecular Pathways: Targeting the TGF-β Pathway for Cancer Therapy

Smith, A., Robin, T. P., & Ford, H. L. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3224 · Cited by 192 · see citing works

TGF-β Signaling and Resistance to Cancer Therapy

Zhang, M., Zhang, Y. Y., Chen, Y., Wang, J., Wang, Q., & Lu, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.786728 · Cited by 194 · see citing works

The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer

Sun, Q., Zhang, B., Hu, Q., Qin, Y., Xu, W., Liu, W., Yu, X., & Xu, J. (2018) · Theranostics · doi:10.7150/thno.26546 · Cited by 193 · see citing works

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Park, S. L., Gebhardt, T., & Mackay, L. K. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.002 · Cited by 190 · see citing works

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

Tang, P. M., Zhou, S., Meng, X., Wang, Q.-M., Li, C., Lian, G., Huang, X.-R., Tang, Y.-J., Guan, X., Yan, B. P.-Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14677 · Cited by 191 · see citing works

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189 · see citing works

On the cytokines produced by human neutrophils in tumors

Tecchio, C., Scapini, P., Pizzolo, G., & Cassatella, M. A. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.02.004 · Cited by 187 · see citing works

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Xu, Y., Xiong, J., Sun, X., & Gao, H. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.001 · Cited by 187 · see citing works

A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis

Bruno, A., Ferlazzo, G., Albini, A., & Noonan, D. M. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju200 · Cited by 184 · see citing works

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

Beury, D. W., Parker, K. H., Nyandjo, M., Sinha, P., Carter, K. A., & Ostrand‐Rosenberg, S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0414-210r · Cited by 183 · see citing works

Predictive clinical outcome of the intratumoral CD66b‐positive neutrophil‐to‐CD8‐positive T‐cell ratio in patients with resectable nonsmall cell lung cancer

Ilié, M., Hofman, V., Ortholan, C., Bonnetaud, C., Coëlle, C., Mouroux, J., & Hofman, P. M. (2011) · Cancer · doi:10.1002/cncr.26456 · Cited by 179 · see citing works

Immune Priming of the Tumor Microenvironment by Radiation

Jiang, W., Chan, C. K. F., Weissman, I. L., Kim, B. Y. S., & Hahn, S. M. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.007 · Cited by 179 · see citing works

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Gu, Z., Silva, C. G. D., van der Maaden, K., OSSENDORP, F. A., & Cruz, L. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111054 · Cited by 177 · see citing works

Involvement of cystatin C in immunity and apoptosis

Zi, M., & Xu, Y. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.006 · Cited by 170 · see citing works

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

Zhang, N., & Bevan, M. J. (2012) · Nature Immunology · doi:10.1038/ni.2319 · Cited by 175 · see citing works

CTLA-4 Is Expressed by Activated Mouse NK Cells and Inhibits NK Cell IFN-γ Production in Response to Mature Dendritic Cells

Stojanovic, A., Fiegler, N., Brunner-Weinzierl, M. C., & Cerwenka, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302091 · Cited by 175 · see citing works

Human Tumour Immune Evasion via TGF-β Blocks NK Cell Activation but Not Survival Allowing Therapeutic Restoration of Anti-Tumour Activity

Wilson, E., El‐Jawhari, J. J., Neilson, A. L., Hall, G. D., Melcher, A. A., Meade, J. L., & Cook, G. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022842 · Cited by 174 · see citing works

TGF-beta signal transduction: biology, function and therapy for diseases

Tie, Y., Tang, F., Peng, D., Zhang, Y., & Shi, H. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00109-9 · Cited by 178 · see citing works

Cancer-associated fibroblasts in hepatocellular carcinoma

Kubo, N., Araki, K., Kuwano, H., & Shirabe, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i30.6841 · Cited by 173 · see citing works

Hepatoprotective effect of plant polysaccharides from natural resources: A review of the mechanisms and structure-activity relationship

Qu, J., Huang, P., Zhang, L., Qiu, Y., Qi, H., Leng, A., & Shang, D. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.196 · Cited by 167 · see citing works

Activation of immune signals during organ transplantation

Li, Q., & Lan, P. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01377-9 · Cited by 173 · see citing works

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

Bian, Y., Hall, B., Sun, Z.-J., Molinolo, A., Chen, W., Gutkind, J. S., Waes, C. V., & Ab, K. (2011) · Oncogene · doi:10.1038/onc.2011.494 · Cited by 160 · see citing works

TGF-β signaling: critical nexus of fibrogenesis and cancer

Giarratana, A. O., Prendergast, C. M., Salvatore, M. M., & Capaccione, K. M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05411-4 · Cited by 170 · see citing works

Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells

Castriconi, R., Dondero, A., Bellora, F., Moretta, L., Castellano, A., Locatelli, F., Corrias, M. V., Moretta, A., & Bottino, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202693 · Cited by 159 · see citing works

Modulation of angiotensin II signaling in the prevention of fibrosis

Murphy, A. M., Wong, A. L., & Bezuhly, M. (2015) · Fibrogenesis & Tissue Repair · doi:10.1186/s13069-015-0023-z · Cited by 159 · see citing works

TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis

Pang, Y., Gara, S. K., Achyut, B. R., Li, Z., Yan, H. H., Day, C., Weiss, J. M., Trinchieri, G., Morris, J. C., & Li, Y. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0527 · Cited by 155 · see citing works

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

Roy, N., Malik, S., Villanueva, K. E., Urano, A., Lu, X., Von Figura, G., Seeley, E. S., Dawson, D. W., Collisson, E. A., & Hebrok, M. (2015) · Genes &amp; Development · doi:10.1101/gad.256628.114 · Cited by 155 · see citing works

Therapeutic Efficacy of Bifunctional siRNA Combining TGF-β1 Silencing with RIG-I Activation in Pancreatic Cancer

Ellermeier, J., Wei, J., Duewell, P., Hoves, S., Stieg, M. R., Adunka, T., Noerenberg, D., Anders, H., Mayr, D. C., Poeck, H., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-11-3850 · Cited by 155 · see citing works

&lt;p&gt;Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor&lt;/p&gt;

Bai, X., Yi, M., Jiao, Y., Chu, Q., & Wu, K. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s224013 · Cited by 153 · see citing works

Nanomedicine and macroscale materials in immuno-oncology

Sun, Q., Barz, M., Geest, B. G. D., Diken, M., Hennink, W. E., Kiessling, F. M., Lammers, T., & Shi, Y. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00473k · Cited by 153 · see citing works

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Slattery, K., Woods, E., Zaiatz-Bittencourt, V., Marks, S. J., Chew, S. M., Conroy, M. R., Goggin, C., Eochagáin, C. M., Kennedy, J., Lucas, S., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002044 · Cited by 153 · see citing works

From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation

Servais, C., & Erez, N. (2012) · The Journal of Pathology · doi:10.1002/path.4103 · Cited by 152 · see citing works

The role of cytokines in the initiation and progression of myelofibrosis

Hasselbalch, H. C. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.01.004 · Cited by 152 · see citing works

Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies

Huck, B. R., Kötzner, L., & Urbahns, K. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707816 · Cited by 149 · see citing works

Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment

McQuitty, C. E., Williams, R., Chokshi, S., & Urbani, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574276 · Cited by 146 · see citing works

TGF-beta signalling in colon carcinogenesis

Lampropoulos, P., Zizi-Sermpetzoglou, A., Rizos, S., Kostakis, A. I., Nikiteas, N. I., & Papavassiliou, A. G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.09.041 · Cited by 146 · see citing works

TGF-β signaling in liver and gastrointestinal cancers

Katz, L. H., Likhter, M., Jogunoori, W. S., Belkin, M. D., Ohshiro, K., & Mishra, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.033 · Cited by 145 · see citing works

Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors

Zheng, Y., Tang, L., Mabardi, L., Kumari, S., & Irvine, D. J. (2017) · ACS Nano · doi:10.1021/acsnano.7b00078 · Cited by 145 · see citing works

Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment

Xie, Q., Ding, J. P., & Chen, Y. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.027 · Cited by 148 · see citing works

TGFß, a Potent Regulator of Tumor Microenvironment and Host Immune Response, Implication for Therapy

Yang, H. H. (2010) · Current Molecular Medicine · doi:10.2174/156652410791317039 · Cited by 46 · see citing works

REVIEW ARTICLE Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-β

Park, H.-Y., Wakefield, L. M., & Mamura, M. (2013)

Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-β

Park, H., Wakefield, L. M., & Mamura, M. (2009) · Immune Network · doi:10.4110/in.2009.9.4.122 · Cited by 24 · see citing works

TGF-β and tumors — an ill-fated alliance

Moutsopoulos, N. M., Wen, J., & Wahl, S. M. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.04.003 · Cited by 57 · see citing works

TGF-beta: a master switch in tumor immunity

Gigante, M., Gesualdo, L., & Ranieri, E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802430378 · Cited by 45 · see citing works