Pathology and physiopathology of adenomyosis
Abstract
Adenomyosis is defined by the presence of endometrial mucosa within the myometrium. This probably occurs by invagination of the basalis endometrium into the myometrium. The process of invagination and intramyometrial spreading may be facilitated by the non-cyclic, anti-apoptotic activity of the basalis associated with relative hyper-oestrogenic states. Most cases of adenomyosis are discovered in multiparous women during the 'transitional' years (40-50 years), and the condition is associated with menorrhagia, dysmenorrhoea, endometrial polyps and leiomyomata uteri. Endometrioid adenocarcinoma is often associated with adenomyosis, is frequently of early stage and low histological grade, is hormone-sensitive, and has an excellent prognosis. Extension of malignant growth into foci of adenomyosis has no adverse effect on prognosis. Definite diagnosis and treatment of adenomyosis are obtained by hysterectomy. Although adenomyotic endometrial glands are hormone-sensitive, exogenous progestogenic agents are ineffective for the treatment of adenomyosis. Anti-oestrogenic danazol and gonadotrophin-releasing hormone (GnRH) analogues induce suppression of adenomyosis, but their use must be of short duration. Surgical extirpation, therefore, is the best therapeutic option.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adenomyosis is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology.
“Adenomyosis, defined as the presence of endometrial glands and stroma infiltrated deep and haphazardly into the myometrium [1], is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology [2,3,4].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [2]
Cites
Amant, F. C., Moerman, P., Neven, P., Timmerman, D., Limbergen, E. V., & Vergote, I. B. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67063-8 · Cited by 1,613 · see citing works
The elusive adenomyosis of the uterus—revisited
Bird, C. C., McElin, T. W., & Manalo-Estrella, P. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90781-8 · Cited by 531 · see citing works
Pathophysiology of adenomyosis
Ferenczy, A. S. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.312 · Cited by 512 · see citing works
Bazot, M., Cortez, A., Daraï, É., Rouger, J., Chopier, J., Antoine, J.-M., & Uzan, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2427 · Cited by 501 · see citing works
Azziz, R. (1989) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00148-0 · Cited by 316 · see citing works
Cytokeratins of normal epithelia and some neoplasms of the female genital tract.
Moll, R., Levy, R., Czernobilsky, B., Hohlweg-Majert, P., Dallenbach-Hellweg, G., & Franke, W. W. (1983) · PubMed · Cited by 229 · see citing works
Adenomyosis: symptoms, histology, and pregnancy terminations
Levgur, M. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00659-6 · Cited by 209 · see citing works
Uterine adenomyosis in the infertility clinic
Devlieger, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg010 · Cited by 206 · see citing works
Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle
OTSUKI, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91051-0 · Cited by 187 · see citing works
Confirmation of the preoperative diagnoses for hysterectomy
Lee, N. C., Dicker, R. C., RUBIN, G. L., & Ory, H. W. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(84)90366-1 · Cited by 172 · see citing works
Invasiveness of endometriotic cells in vitro
Gaetje, R., BAUMANN, R., Herrmann, G., Kotzian, S., & Starzinski‐Powitz, A. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92474-4 · Cited by 156 · see citing works
Adenomyosis: A reappraisal of symptomatology
Benson, R. C., & Sneeden, V. D. (1958) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(58)90186-8 · Cited by 150 · see citing works
The elusive adenomyosis of the uterus
Emge, L. A. (1962) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(62)90170-9 · Cited by 140 · see citing works
Adenomyosis: US Features with Histologic Correlation in an in Vitro Study
Atri, M., Reinhold, C., Mehio, A. R., Chapman, W. B., & Bret, P. M. (2000) · Radiology · doi:10.1148/radiology.215.3.r00jn06783 · Cited by 140 · see citing works
Is adenomyosis an immune disease?
Ota, H. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.360 · Cited by 130 · see citing works
Gilks, C. B., Clement, P. B., Hart, W. R., & Young, R. H. (2000) · International Journal of Gynecological Pathology · doi:10.1097/00004347-200007000-00001 · Cited by 128 · see citing works
Endometrial-Myometrial Interface: Relationship to Adenomyosis and Changes in Pregnancy
Uduwela, A. S., Perera, M. A. K., Li, A., & Fraser, I. S. (2000) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200006000-00025 · Cited by 126 · see citing works
Seidman, J. D., & Kjerulff, K. H. (1996) · International Journal of Gynecological Pathology · doi:10.1097/00004347-199607000-00005 · Cited by 101 · see citing works
Adenomyosis: a neglected diagnosis.
To, O., & Rc, S. (1977) · PubMed · Cited by 100 · see citing works
Adenocarcinomas Arising from Uterine Adenomyosis: A Report of Four Cases
Koshiyama, M., Suzuki, A., Ozawa, M., Fujita, K., Sakakibara, A., Kawamura, M., Takahashi, S., Fujii, H., Hirano, T., Okagaki, A., et al. (2002) · International Journal of Gynecological Pathology · doi:10.1097/00004347-200207000-00006 · Cited by 88 · see citing works
Accuracy of Intraoperative Frozen-Section Diagnosis in Stage I Endometrial Adenocarcinoma
Kučera, E., Kainz, C., Reinthaller, A., Sliutz, G., Leodolter, S., Kucera, H., & Breitenecker, G. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000010215 · Cited by 81 · see citing works
Relationship between the onset of dysmenorrhea and histologic findings in adenomyosis
Nishida, M. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90257-r · Cited by 76 · see citing works
Adenomyosis in Postmenopausal Breast Cancer Patients Treated with Tamoxifen: A New Entity?
Cohen, I., Beyth, Y., Tepper, R., Figer, A., Shapira, J., Cordoba, M., Yigael, D., & Altaras, M. M. (1995) · Gynecologic Oncology · doi:10.1006/gyno.1995.1188 · Cited by 69 · see citing works
Clinical Value of Intraoperative Gross Examination in Endometrial Cancer
Franchi, M. P., Ghezzi, F., Melpignano, M., Cherchi, P. L., Scarabelli, C., Apolloni, C., & Zanaboni, F. (2000) · Gynecologic Oncology · doi:10.1006/gyno.1999.5694 · Cited by 68 · see citing works
Mittal, K., & Barwick, K. W. (1993) · Gynecologic Oncology · doi:10.1006/gyno.1993.1107 · Cited by 64 · see citing works
Radiographic imaging techniques for the diagnosis of abnormal uterine bleeding
Bradley, L. D., Falcone, T., & Magen, A. B. (2000) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(00)80019-4 · Cited by 59 · see citing works
The prognostic significance of adenomyosis in endometrial carcinoma
Hall, J. B., Young, R. H., & Nelson, J. H. (1984) · Gynecologic Oncology · doi:10.1016/0090-8258(84)90057-x · Cited by 57 · see citing works
Adenomyosis With Sparse Glands:A Potential Mimic of Low-Grade Endometrial Stromal Sarcoma
Goldblum, J. R., Clement, P. B., & Hart, W. R. (1995) · American Journal of Clinical Pathology · doi:10.1093/ajcp/103.2.218 · Cited by 56 · see citing works
Endometrial Tissue in Myometrial Vessels not Associated with Menstruation
Sahin, A. A., Silva, E. G., Landon, G., Ordoñez, N. G., & Gershenson, D. M. (1989) · International Journal of Gynecological Pathology · doi:10.1097/00004347-198906000-00007 · Cited by 55 · see citing works
Jacques, S. M., & Lawrence, W. D. (1990) · Gynecologic Oncology · doi:10.1016/0090-8258(90)90376-v · Cited by 54 · see citing works
Relationship of adenomyosis uteri to endometrial hyperplasia and endometrial carcinoma
Marcus, C. C. (1961) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(61)90082-5 · Cited by 53 · see citing works
Endometrial adenocarcinoma arising in adenomyosis
Hernández, E., & Woodruff, J. D. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32744-2 · Cited by 52 · see citing works
Koshiyama, M., Okamoto, T., & Ueta, M. (2004) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2003.12.008 · Cited by 51 · see citing works
McCluggage, W. G., Desai, V., & Manek, S. (2000) · Histopathology · doi:10.1046/j.1365-2559.2000.01001.x · Cited by 50 · see citing works
Nascimento, A. F., Hirsch, M. S., Čviko, A., Quade, B. J., & Nucci, M. R. (2003) · Modern Pathology · doi:10.1097/01.mp.0000043523.03519.fc · Cited by 49 · see citing works
Five-year cure of a primary malignant melanoma of the vagina by local radioactive isotope therapy
Ariel, I. M. (1961) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(61)90081-3 · Cited by 47 · see citing works
Teefey, S. A., Stahl, J., Middleton, W. D., Huettner, P. C., Bernhard, L. M., Brown, J. J., Hildebolt, C. F., & Mutch, D. G. (1996) · American Journal of Roentgenology · doi:10.2214/ajr.166.3.8623626 · Cited by 46 · see citing works
Fong, K. W., Causer, P. A., Atri, M., Lytwyn, A., & Kung, R. (2003) · Radiographics · doi:10.1148/rg.231025048 · Cited by 41 · see citing works
Srodon, M., Klein, W. M., & Kurman, R. J. (2003) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200306000-00009 · Cited by 39 · see citing works
Non‐Specificity of Symptoms Related to Adenomyosis
Kilkku, P., Erkkola, R., & Grönroos, M. A. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409155502 · Cited by 37 · see citing works
Adenomyosis; a neglected diagnosis.
Israel, S. L., & Woutersz, T. B. (1959) · PubMed · Cited by 37 · see citing works
Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp
Ugwumadu, A. H. N., Bower, D., & Ho, P. (1993) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1993.tb12986.x · Cited by 36 · see citing works
Clinical significance of adenomyosis.
Nikkanen, V., & Punnonen, R. (1980) · PubMed · Cited by 33 · see citing works
Expression of Apoptosis-Related Proteins in Adenomyotic Uteri Treated with Danazol and GnRH Agonists
Ueki, K., Kumagai, K., Yamashita, H., Li, Z., Ueki, M., & Otsuki, Y. (2004) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000130109.80359.57 · Cited by 30 · see citing works
Mathur, B. B. L., Shah, B. S., & Bhende, Y. M. (1962) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(62)90467-2 · Cited by 29 · see citing works
P53 Expression in Adenomyosis in Endometrial Carcinoma Patients
Taskin, M., Lallas, T. A., Shevchuk, M., & Barber, H. R. K. (1996) · Gynecologic Oncology · doi:10.1006/gyno.1996.0222 · Cited by 27 · see citing works
Prior cesarean section. A risk factor for adenomyosis?
Harris, W. J., Daniell, J. F., & Baxter, J. (1985) · PubMed · Cited by 23 · see citing works
Endometrioid Adenocarcinoma Arising from Adenomyosis
Takai, N., Akizuki, S., Nasu, K., Etoh, Y., & Miyakawa, I. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000010139 · Cited by 20 · see citing works
Invasive adenocarcinoma arising from uterine adenomyosis involving the rectosigmoid colon
Takeuchi, K., Yamanaka, Y., Hamana, S., Ohara, N., & Maruo, T. (2004) · International Journal of Gynecological Cancer · doi:10.1111/j.1048-891x.2004.14541.x · Cited by 20 · see citing works
Kır, G., Kir, M., Çetiner, H., Karateke, A., & Gürbüz, A. (2004) · PubMed · Cited by 20 · see citing works
Adenocarcinoma arising in adenomyosis: report of an unusual case
Couto, D. D. R., Mota, F. L., Silva, T., & de Oliveira, C. A. F. (2004) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.0001-6349.2004.00025b.x · Cited by 17 · see citing works
Location of Adenomyosis in Total Hysterectomy Specimens
Ascher‐Walsh, C., Tu, J. L., Du, Y., & Blanco, J. S. (2003) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60262-9 · Cited by 16 · see citing works
Successful microwave endometrial ablation in a uterus enlarged by adenomyosis.
Kanaoka, Y., Hirai, K., & Ishiko, O. (2004) · PubMed · Cited by 12 · see citing works
Adenocarcinoma arising in adenomyosis: report of an unusual case
Couto, D., Mota, F., Silva, T., & de Oliveira, C. (2004) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/j.0001-6349.2004.00025b.x · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Physiology of the Endometrium and Regulation of Menstruation
Critchley, H., Maybin, J. A., Armstrong, G. M., & Williams, A. R. W. (2020) · Physiological Reviews · doi:10.1152/physrev.00031.2019 · Cited by 552 · see citing works
Diagnosing adenomyosis: an integrated clinical and imaging approach
Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S., Just, P., Noël, J., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz049 · Cited by 439 · see citing works
Pathogenesis of uterine adenomyosis, invagination or metaplasia?
García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.030 · Cited by 339 · see citing works
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326 · see citing works
Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition
Struble, J., Reid, S., & Bedaiwy, M. A. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.09.018 · Cited by 323 · see citing works
Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification
Kishi, Y., Suginami, H., 蔵盛, 理., Yabuta, M., Suginami, R., & Taniguchi, F. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.027 · Cited by 301 · see citing works
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331 · see citing works
Chapron, C., Tosti, C., Marcellin, L., Bourdon, M., Lafay-Pillet, M.-C., Millischer, A.-E., Streuli, I., Borghese, B., Petraglia, F., & Santulli, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex088 · Cited by 294 · see citing works
The Impact of Adenomyosis on Women's Fertility
Harada, T., Khine, Y. M., Kaponis, A. I., Nikellis, T., Decavalas, G., & Taniguchi, F. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000346 · Cited by 258 · see citing works
Uterus-sparing operative treatment for adenomyosis
Grimbizis, G., Mikos, T., & Tarlatzis, B. C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.10.025 · Cited by 224 · see citing works
Uterine adenomyosis and adenomyoma: the surgical approach
Osada, H. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.032 · Cited by 219 · see citing works
Adenomyosis: Review of the Literature
Garcia, L., & Isaacson, K. (2011) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2011.04.004 · Cited by 203 · see citing works
Adenomyosis pathogenesis: insights from next-generation sequencing
Bulun, S. E., Yıldız, Ş., Adli, M., & Wei, J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab017 · Cited by 211 · see citing works
Liu, X., Shen, M., Qi, Q., Zhang, H., & Guo, S.-W. (2016) · Human Reproduction · doi:10.1093/humrep/dew018 · Cited by 190 · see citing works
Transvaginal Ultrasound for the Diagnosis of Adenomyosis: Systematic Review and Meta-Analysis
Andres, M. P., Borrelli, G. M., Ribeiro, J., Baracat, E. C., Abrão, M. S., & Kho, R. M. (2017) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.08.653 · Cited by 187 · see citing works
Immunological changes associated with adenomyosis: a systematic review
Bourdon, M., Santulli, P., Jeljeli, M. M., Vannuccini, S., Marcellin, L., Doridot, L., Petraglia, F., Batteux, F., & Chapron, C. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa038 · Cited by 189 · see citing works
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165 · see citing works
Campo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158 · see citing works
Harmsen, M. J., Wong, C. F. C., Mijatovic, V., Griffioen, A. W., Groenman, F. A., Hehenkamp, W. J. K., & Huirne, J. A. F. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz024 · Cited by 142 · see citing works
Park, C. W., Choi, M. H., Yang, K. M., & Song, I. O. (2016) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2016.43.3.169 · Cited by 137 · see citing works
Exacoustós, C., Morosetti, G., Conway, F., Camilli, S., Martire, F. G., Lazzeri, L., Piccione, E., & Zupi, E. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.09.788 · Cited by 135 · see citing works
Guo, S.-W., Mao, X., Ma, Q., & Liu, X. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.038 · Cited by 131 · see citing works
Shen, M., Liu, X., Zhang, H., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev314 · Cited by 124 · see citing works
Nie, J., Liu, X., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110377118 · Cited by 120 · see citing works
Conservative Surgery for Adenomyosis and Results: A Systematic Review
Younes, G., & Tulandi, T. (2017) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.07.014 · Cited by 116 · see citing works
Adenomyosis: An update regarding its diagnosis and clinical features
Bourdon, M., Santulli, P., Marcellin, L., Maignien, C., Maitrot‐Mantelet, L., Bordonné, C., Plu‐Bureau, G., & Chapron, C. (2021) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2021.102228 · Cited by 119 · see citing works
Association between ultrasound features of adenomyosis and severity of menstrual pain
Naftalin, J., Hoo, W., Nunes, N., Holland, T., Mavrelos, D., & Jurkovic, D. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15798 · Cited by 113 · see citing works
Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy
Li, X., Liu, X., & Guo, S. (2013) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12211 · Cited by 103 · see citing works
The Role of Hysteroscopy in the Diagnosis and Treatment of Adenomyosis
Sardo, A. D. S., Calagna, G., Santangelo, F., Zizolfi, B., Tanos, V., Perino, A., & Wilde, R. L. D. (2017) · BioMed Research International · doi:10.1155/2017/2518396 · Cited by 102 · see citing works
Pathophysiology of Heavy Menstrual Bleeding
Hapangama, D. K., & Bulmer, J. N. (2015) · Women s Health · doi:10.2217/whe.15.81 · Cited by 108 · see citing works
Adenomyosis and Infertility—Review of Medical and Surgical Approaches
Szubert, M., Koziróg, E., Olszak, O., Krygier-Kurz, K., Kaźmierczak, J., & Wilczyński, J. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031235 · Cited by 99 · see citing works
Effective ablation therapy of adenomyosis with ultrasound‐guided high‐intensity focused ultrasound
Zhang, X., Li, K., Xie, B., He, M., He, J., & Zhang, L. (2013) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2013.08.022 · Cited by 97 · see citing works
High-intensity focused ultrasound (HIFU) for adenomyosis: Two-year follow-up results
Shui, L., Mao, S., Wu, Q., Huang, G., Wang, J., Zhang, R., Li, K., He, J., & Zhang, L. (2015) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2015.05.024 · Cited by 95 · see citing works
Diagnostic findings in adenomyosis: a pictorial review on the major concerns.
Graziano, A., Monte, G. L., Piva, I., Caserta, D., Kärner, M., Engl, B., & Marci, R. (2015) · PubMed · Cited by 87 · see citing works
A pilot study on the off-label use of valproic acid to treat adenomyosis
Liu, X., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.009 · Cited by 84 · see citing works
Campo, S., Campo, V., & Benagiano, G. (2011) · Obstetrics and Gynecology International · doi:10.1155/2012/786132 · Cited by 83 · see citing works
Immunoreactivity of progesterone receptor isoform B, nuclear factor κB, and IκBα in adenomyosis
Nie, J., Lü, Y., Liu, X., & Guo, S. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.084 · Cited by 82 · see citing works
Medical treatment for adenomyosis and/or adenomyoma
Tsui, K., Lee, W.-L., Chen, C.-Y., Sheu, B., Yen, M., Chang, T., & Wang, P. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2014.04.024 · Cited by 78 · see citing works
A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment
Chen, L.-H., Lo, W.-C., Huang, H.-Y., & Wu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087503 · Cited by 85 · see citing works
Nie, J., Liu, X., & Guo, S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.11.035 · Cited by 77 · see citing works
Dessouky, R., Gamil, S. A., Nada, M. G., Mousa, R., & Libda, Y. I. (2019) · Insights into Imaging · doi:10.1186/s13244-019-0732-8 · Cited by 76 · see citing works
An update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75 · see citing works
Li, B., Chen, M., Liu, X., & Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.028 · Cited by 78 · see citing works
Transvaginal Elastosonography as an Imaging Technique for Diagnosing Adenomyosis
Liu, X., Ding, D., Ren, Y., & Guo, S. (2018) · Reproductive Sciences · doi:10.1177/1933719117750752 · Cited by 78 · see citing works
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility
Khan, K. N., Fujishita, A., & Mori, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144057 · Cited by 74 · see citing works
Khan, K. N., Fujishita, A., Koshiba, A., Kuroboshi, H., Mori, T., Ogi, H., Itoh, K., Nakashima, M., & Kitawaki, J. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.03.210 · Cited by 71 · see citing works
Khan, K. N., Kitajima, M., Hiraki, K., Fujishita, A., Nakashima, M., & Masuzaki, H. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.124891 · Cited by 68 · see citing works
Liu, X., Nie, J., & Guo, S. (2010) · Human Reproduction · doi:10.1093/humrep/deq311 · Cited by 68 · see citing works
Complications and outcomes of pregnant women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12050 · Cited by 69 · see citing works
Tellum, T., Matic, G. V., Dormagen, J. B., Nygaard, S., Viktil, E., Qvigstad, E., & Lieng, M. (2019) · European Radiology · doi:10.1007/s00330-019-06308-3 · Cited by 66 · see citing works
Valproic Acid as a Therapy for Adenomyosis: A Comparative Case Series
Liu, X., Yuan, L., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110373807 · Cited by 64 · see citing works
Mao, X., Wang, Y., Carter, A. V., Zhen, X., & Guo, S. (2011) · Reproductive Sciences · doi:10.1177/1933719111404610 · Cited by 63 · see citing works
Mesenchymal Tumors of the Uterus
Zaloudek, C. J., Hendrickson, M. R., & Soslow, R. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0489-8_10 · Cited by 59 · see citing works
Yen, C., Huang, S.-T. J., Lee, C., Wang, H., & Liao, S. (2017) · Reproductive Sciences · doi:10.1177/1933719117691141 · Cited by 57 · see citing works
Decreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization
Jiang, Y., Jiang, R., Cheng, X., Zhang, Q., Hu, Y., Zhang, H., Cao, Y., Zhang, M., Wang, J., Ding, L., et al. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw042 · Cited by 53 · see citing works
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
Liu, X., & Guo, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01655.x · Cited by 52 · see citing works
Hormonal treatments for adenomyosis
Fedele, L., Bianchi, S., & Frontino, G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.07.006 · Cited by 50 · see citing works
Tsui, K.-H., Lee, F.-K., Seow, K., Chang, W.-C., Wang, J.-W., Chen, S., Chao, H., Yen, M.-S., & Wang, P. (2015) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2015.05.003 · Cited by 49 · see citing works
Molecular characterization of human adenomyosis
Hevér, A., Roth, R. B., Hevezi, P. A., Lee, J., Willhite, D., White, E. C., Marin, E. M., Herrera, R. M. B., Acosta, H., Acosta, A. J., et al. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal076 · Cited by 49 · see citing works
Focal adenomyosis of the outer myometrium and deep infiltrating endometriosis severity
Marcellin, L., Santulli, P., Bourdon, M., Maignien, C., Campin, L., Lafay-Pillet, M.-C., Millischer, A., Bordonné, C., Borghese, B., Dousset, B. E., et al. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.05.003 · Cited by 52 · see citing works
Implantation Failure in Endometriosis Patients: Etiopathogenesis
Boucher, A., Brichant, G., Gridelet, V., Nisolle, M., Ravet, S., Timmermans, M., & Henry, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185366 · Cited by 46 · see citing works
Feng, Y., Hu, L., Chen, W., Zhang, R., Wang, X., & Chen, J. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.11.022 · Cited by 46 · see citing works
Yang, Z., Cao, Y., Hu, L., & Wang, Z. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.017 · Cited by 46 · see citing works
Prevalence of adenomyosis in endometrial cancer patients: a systematic review and meta-analysis
Raffone, A., Seracchioli, R., Raimondo, D., Maletta, M., Travaglino, A., Raimondo, I., Giaquinto, I., Orsini, B., Insabato, L., Pellicano, M., et al. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05840-8 · Cited by 44 · see citing works
Streuli, I., Santulli, P., Chouzenoux, S., Chapron, C., & Batteux, F. (2015) · Reproductive Sciences · doi:10.1177/1933719115589410 · Cited by 43 · see citing works
Adenomyosis: What the Patient Needs
Alabiso, G., ALIO, L., Arena, S., di Prun, A. B., Bergamini, V., Berlanda, N., Busacca, M., Candiani, M., Centini, G., Cello, A. D., et al. (2016) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.12.017 · Cited by 43 · see citing works
Valentini, A. L., Speca, S., Gui, B., Soglia, B. G., Miccò, M., & Bonomo, L. (2011) · La radiologia medica · doi:10.1007/s11547-011-0714-5 · Cited by 43 · see citing works
An update on uterine artery embolization for uterine leiomyomata and adenomyosis of the uterus
Kröncke, T. J. (2022) · British Journal of Radiology · doi:10.1259/bjr.20220121 · Cited by 43 · see citing works
The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis
Harada, T., Taniguchi, F., Guo, S., Choi, Y. M., Biberoglu, K. O., Tsai, S. S., Alborzi, S., Al‐Jefout, M., Chalermchockcharoenkit, A., Sison-Aguilar, A. G., et al. (2023) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12535 · Cited by 44 · see citing works
Adenomyosis and accompanying gynecological pathologies
Genç, M., Genç, B., & Cengiz, H. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3498-8 · Cited by 43 · see citing works
Question Mark Sign and Transvaginal Ultrasound Uterine Tenderness for the Diagnosis of Adenomyosis
Zannoni, L., Ambrosio, M., Raimondo, D., Arena, A., Forno, S. D., Borghese, G., Paradisi, R., & Seracchioli, R. (2020) · Journal of Ultrasound in Medicine · doi:10.1002/jum.15237 · Cited by 42 · see citing works
Froeling, V., Scheurig‐Muenkler, C., Hamm, B., & Kröncke, T. J. (2011) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-011-0254-3 · Cited by 42 · see citing works
Tan, J., Yong, P. J., & Bedaiwy, M. A. (2019) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000555 · Cited by 42 · see citing works
Aberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis
Liu, X., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337718 · Cited by 41 · see citing works
Elevated Immunoreactivity against Class I Histone Deacetylases in Adenomyosis
Liu, X., Nie, J., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000336409 · Cited by 41 · see citing works
Uterine-sparing surgery for adenomyosis and/or adenomyoma
Horng, H., Chen, C.-H., Chen, C.-Y., Tsui, K.-H., Liu, W., Wang, P., Chang, W.-H., Huang, B., Sun, H., Chang, T.-C., et al. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2014.01.001 · Cited by 40 · see citing works
Stephens, V. R., Rumph, J. T., Ameli, S., Bruner‐Tran, K. L., & Osteen, K. G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.807685 · Cited by 42 · see citing works
The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease
Popli, P., Sun, A. J., & Kommagani, R. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00587-2 · Cited by 45 · see citing works
Clinical outcomes of infertility treatment for women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12036 · Cited by 41 · see citing works
Hao, M., Liu, X., & Guo, S. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.07.023 · Cited by 40 · see citing works
Meenakshi, M., & McCluggage, W. G. (2010) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e3181b7018d · Cited by 39 · see citing works
Adenomyosis and Adolescence: A Challenging Diagnosis and Complex Management
Martire, F. G., d’Abate, C., Schettini, G., Cimino, G., Ginetti, A., Colombi, I., Cannoni, A., Centini, G., Zupi, E., & Lazzeri, L. (2024) · Diagnostics · doi:10.3390/diagnostics14212344 · Cited by 38 · see citing works
Expression of GRIM-19 in adenomyosis and its possible role in pathogenesis
Wang, J., Deng, X., Yang, Y., Yang, X., Kong, B., & Lan, C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.019 · Cited by 38 · see citing works
Accuracy of findings in the diagnosis of uterine adenomyosis on ultrasound
Sam, M., Raubenheimer, M., Manolea, F., Aguilar, H. N., Mathew, R. P., Patel, V. H., & Low, G. (2019) · Abdominal Radiology · doi:10.1007/s00261-019-02231-9 · Cited by 37 · see citing works
The prevalence of adenomyosis in an infertile population: a cross-sectional study
Hashim, H. A., Elaraby, S., Foda, A. A., & Rakhawy, M. E. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.02.011 · Cited by 37 · see citing works
Adenomyosis and infertility: the role of the junctional zone
Barbanti, C., Centini, G., Lazzeri, L., Habib, N., Labanca, L., Zupi, E., Afors, K., & Starace, A. C. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1878131 · Cited by 38 · see citing works
Senturk, L. M., & İmamoğlu, M. (2015) · Women s Health · doi:10.2217/whe.15.60 · Cited by 37 · see citing works
Influences of Uterine Adenomyosis on Muscle Invasion and Prognosis of Endometrioid Adenocarcinoma
Taneichi, A., Fujiwara, H., Takahashi, Y., Takei, Y., 町田, 静., Saga, Y., Takahashi, S., & Suzuki, M. (2014) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000243 · Cited by 35 · see citing works
The disturbance of TH17-Treg cell balance in adenomyosis
Gui, T., Chen, C., Zhang, Z., Tang, W., Qian, R., Ma, X., Cao, P., & Wan, G. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.10.050 · Cited by 36 · see citing works
The impact of adenomyosis on IVF outcomes: a prospective cohort study
Higgins, C., Fernandes, H., Costa, F. D. S., Martins, W. P., Vollenhoven, B. J., & Healey, M. (2021) · Human Reproduction Open · doi:10.1093/hropen/hoab015 · Cited by 35 · see citing works
Occurrence of chronic endometritis in different types of human adenomyosis
Khan, K. N., Fujishita, A., Ogawa, K., Koshiba, A., Mori, T., Itoh, K., Nakashima, M., & Kitawaki, J. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12421 · Cited by 34 · see citing works
Laparoscopic excision of uterine adenomyomas
Grimbizis, G., Mikos, T., Zepiridis, L. I., Theodoridis, T., Miliaras, D., Tarlatzis, B. C., & Bontis, J. N. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.063 · Cited by 35 · see citing works
Pharmacological Treatment for Symptomatic Adenomyosis: A Systematic Review
Benetti‐Pinto, C. L., de Mira, T. A. A., Yela, D. A., Juliato, C. R. T., & Brito, L. G. O. (2019) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0039-1695737 · Cited by 34 · see citing works
Role of Hormones in Common Benign Uterine Lesions: Endometrial Polyps, Leiomyomas, and Adenomyosis
Kossaï, M., & Penault-Llorca, F. M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38474-6_3 · Cited by 37 · see citing works
Wu, H., Chang, H., & Leung, P. C. K. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100876 · Cited by 36 · see citing works
Gizzo, S., Patrelli, T. S., Dall’Asta, A., Gangi, S. D., Giordano, G., Migliavacca, C., Monica, M., Merisio, C., Nardelli, G. B., Quaranta, M., et al. (2015) · Oncology Letters · doi:10.3892/ol.2015.4032 · Cited by 33 · see citing works
Treatment options and reproductive outcome for adenomyosis-associated infertility
Soave, I., Wenger, J., Pluchino, N., & Marci, R. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1393404 · Cited by 33 · see citing works
Sztachelska, M., Ponikwicka‐Tyszko, D., Martínez-Rodrigo, L., Bernaczyk, P., Palak, E., Półchłopek, W., Bielawski, T., & Wołczyński, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154407 · Cited by 36 · see citing works
Chen, Y., Zhu, B., Zhang, H., Liu, X., & Guo, S. (2013) · Reproductive Sciences · doi:10.1177/1933719113488455 · Cited by 32 · see citing works
Adenomyosis and its impact on women fertility.
Garavaglia, E., Serafini, A., Inversetti, A., Stefano, F., Tandoi, I., Corti, L., & Candiani, M. (2015) · PubMed Central · Cited by 32 · see citing works
- Authors
- Bergeron, C., Amant, F., & Ferenczy, A.
- Affiliations
- Processus d'Activation Sélective par Transfert d'Énergie Uni-électronique ou Radiatif (FR)
- Jewish General Hospital (CA)
- Corresponding author
- Bergeron, Christine
- ORCID
- Bergeron, Christine
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 20
- Issue
- 4
- Pages
- 511-521
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2038354928
- Cited by
- 359
- References
- 54
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 19 · 2023: 33 · 2022: 25 · 2021: 36 · 2020: 35 · 2019: 26 · 2018: 19 · 2017: 20 · 2016: 19 · 2015: 27 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- adenomyosis, anti-apoptotic effects, hyperoestrogenism, menorrhagia, dysmenorrhea, endometrial polyps, uterine fibroids, endometrioid carcinoma, hysterectomy, danazol, GnRH analogues, progestogens, surgical treatment
- MeSH terms
- Adult, Danazol, Endometrial Hyperplasia, Endometriosis, Estrogen Antagonists, Female, Humans, Hysterectomy, Leiomyoma, Gonadotropin-Releasing Hormone, Middle Aged, Polyps, Uterine Diseases, Uterine Neoplasms, Endometrial Neoplasms, Carcinoma, Endometrioid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
