Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis
Open accessAbstract
Objective To evaluate uterine contractility, oxytocin receptor (OTR) expression in myometrial smooth muscle cells (MSMCs) derived from uterine tissues from women with and without adenomyosis correlate OTR expression with uterine contractility and dysmenorrhea severity, and see whether trichostatin A (TSA) and andrographolide inhibit OTR expression.Design Laboratory study using human tissues.Setting Academic hospital.Patient(s) Twenty patients (cases) with histologically confirmed adenomyosis and 10 (controls) with leiomyomas, cervical dysplasia, and cancer but no adenomyosis or endometriosis.Intervention(s) Dysmenorrhea severity was scored by Visual Analog Scale. Uterine tissue samples were collected during hysterectomy. Myometrial smooth muscle cells derived from tissue samples were cultured and OTR protein levels were measured. The effect of TSA (0.5 or 1 μM) and andrographolide (15 or 30 μM) on OTR expression was evaluated.Main outcome measure(s) Visual Analog Scale scores, and contractile amplitude and frequency. The OTR protein levels in MSMCs were quantified by Western blot analysis.Result(s) The contractile amplitude and OTR expression levels were significantly higher in cases than in controls. Dysmenorrhea Visual Analog Scale scores correlated positively with contractile amplitude and OTR expression level. Both TSA and andrographolide dose-dependently inhibit OTR expression in MSMC.Conclusion(s) Oxytocin receptor overexpression in MSMCs may be responsible for increased uterine contractility and adenomyosis-associated dysmenorrhea. Both histone deacetylase inhibitors and andrographolide are therapeutically promising.
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In adenomyosis, OTR overexpression in myometrium with uterine hyperactivity correlates with severity of dysmenorrhea.
“In adenomyosis, OTR overexpression in myometrium, concomitant with uterine hyperactivity, has been reported and is found to correlate to the severity of dysmenorrhea [46].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [46]
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- Authors
- Guo, S.-W., Mao, X., Ma, Q., & Liu, X.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Guo, Sun-Wei
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 99
- Issue
- 1
- Pages
- 231-240
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2094195931
- Cited by
- 131
- References
- 68
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 9 · 2023: 21 · 2022: 11 · 2021: 3 · 2020: 16 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 4
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanghai Science and Technology Commission (09PJD015, 10410700200)
- State Key Laboratory of Medical Neurobiology of Fudan University (09-11)
- Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases
- Key Specialty Project of the Ministry of Health, People's Republic of China
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- adenomyosis, dysmenorrhea, uterine contractility, oxytocin receptor, myometrial smooth muscle cells, trichostatin A, andrographolide, histone deacetylase inhibitors, dysmenorrhea severity
- MeSH terms
- Adult, Cells, Cultured, Uterine Cervical Dysplasia, Cross-Sectional Studies, Diterpenes, Dose-Response Relationship, Drug, Dysmenorrhea, Female, Gene Expression Regulation, Humans, Hydroxamic Acids, Leiomyoma, Middle Aged, Myometrium, Severity of Illness Index, Uterine Contraction, Uterine Neoplasms, Case-Control Studies, Receptors, Oxytocin, Myocytes, Smooth Muscle, Adenomyosis, In Vitro Techniques
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