The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Peripheral and central proinflammatory cytokine response to a severe acute stressor
Abstract
The role of proinflammatory cytokines in the response to acute stressor exposure has received recent attention. Exposure to a single session of inescapable shock (IS) induces peripheral and central proinflammatory cytokines. Other stressors also increase expression of proinflammatory cytokine mRNA and/or protein in various tissues. However, the induction of central and peripheral proinflammatory cytokines by stressors remains controversial and the pattern of cytokine induction is not consistent across stressors. The present experiments sought to examine the pattern of the proinflammatory cytokine response to a stressor known to cause elevations of IL-1beta protein. mRNA expression for three proinflammatory cytokines, IL-1beta, TNF-alpha and IL-6, and IL-1beta protein was examined after IS. IS increases IL-1beta mRNA and/or protein in a variety of tissues, including hypothalamus, hippocampus, pituitary and spleen. Furthermore, IS concomitantly alters IL-1beta mRNA and protein in hypothalamus and spleen, while the IL-1beta mRNA increase in pituitary lags behind the increase of IL-1beta protein. Interestingly, IL-1beta mRNA is elevated in hippocampus 4 h after IS, but an increase of IL-1beta protein in hippocampus is not detected. Expression of TNF-alpha and IL-6 mRNA do not increase in response to IS. Indeed, TNF-alpha mRNA expression decreases in cortex, pituitary and liver immediately after IS. These findings suggest that alterations of proinflammatory cytokine expression by stressors, and IS in particular, are region- and cytokine-specific.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In response to a traumatic event, hypothalamic pituitary adrenal (HPA) and sympathetic nervous system (SNS) axes are activated, and proinflammatory cytokines are released in the periphery and central nervous system (CNS).(10)”
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Lee, S. W., Tsou, A.-P., Chan, H., Thomas, J., Petrie, K. J., Eugui, E. M., & ALLISON, A. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1204 · Cited by 507
Layé, S., Parnet, P., Goujon, E., & Dantzer, R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90197-x · Cited by 500
Zhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243274 · Cited by 494
Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat
Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460
Self-citationThe effects of psychological stress on plasma interleukin-6 activity in rats
LeMay, L. G., Vander, A. J., & Kluger, M. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90024-x · Cited by 313
Barrientos, R. M., Higgins, E. A., Sprunger, D. B., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00043-8 · Cited by 263
Self-citationImmobilization stress induces interleukin-1β mRNA in the rat hypothalamus
Minami, M., Kuraishi, Y., Yamaguchi, T., Nakai, S., Hirai, Y., & Satoh, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90944-o · Cited by 258
Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
Pugh, C. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00098-4 · Cited by 251
Shintani, F., Nakaki, T., Kanba, S., Sato, K., Yagi, G., Shiozawa, M., Aiso, S., Kato, R., & Asai, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01961.1995 · Cited by 246
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications
Godoy, L. D., Rossignoli, M. T., Delfino-Pereira, P., Garcia‐Cairasco, N., & Umeoka, E. H. D. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00127 · Cited by 991
The Semantics of Microglia Activation: Neuroinflammation, Homeostasis, and Stress
Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02309-6 · Cited by 783
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Calcia, M., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4218-9 · Cited by 748
Metadata
- Authors
- O'Connor, K. A., Johnson, J. D., Hansen, M. K., Wieseler Frank, J. L., Maksimova, E., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- O'Connor, Kevin A
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 991
- Issue
- 1-2
- Pages
- 123-132
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2093539486
- Cited by
- 247
- References
- 43
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 15 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 11
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh045045-12, 5r01mh055283-05)
- National Institute of Mental Health (MH 01558, MH55283, MH-00314, MH-45045)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- inflammatory cytokines, acute stress, inescapable shock, IL-1β, TNF-α, interleukin-6, hypothalamus, hippocampus, pituitary gland, spleen, stress-induced inflammation
- MeSH terms
- Animals, Brain, Electroshock, Enzyme-Linked Immunosorbent Assay, Interleukin-1, Male, RNA, Messenger, Stress, Psychological, Time Factors, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Cytokines, Rats, Sprague-Dawley, Peripheral Nervous System, Reverse Transcriptase Polymerase Chain Reaction, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
