The effects of psychological stress on plasma interleukin-6 activity in rats
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The purpose of this study was to determine the effects of a particular psychological stress, exposure to an open-field, on plasma IL-6 activity in rats. Plasma IL-6 activity was 40.6 +/- 7.2 units/ml in control rats, 105 +/- 6.8 units/ml after 30 minutes exposure to an open-field, and 221 +/- 17 units/ml after 60 minutes of exposure (p = 0.0003). There was a positive correlation (r = .71, p = 0.043) between the change in plasma IL-6 activity and body temperature. However, we conclude, based on earlier data relating plasma IL-6 activity to body temperature changes following injection of lipopolysaccharide, that the plasma levels of IL-6 following exposure to an open-field are not high enough to account for the rise in body temperature observed in rats during this stress. In conclusion, these experiments indicate that exposure to psychological stress can elevate the plasma concentration of IL-6, a known mediator of the acute phase response.
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Psychological stress increases circulating levels of IL6 in humans and laboratory animals.
“Studies dating back to 1990 have shown that psychological stress increase circulating levels of IL6 in humans and laboratory animals (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as LeMay et al., 1990
Standard laboratory models of acute stress-including tube restraint, cage switching, and social isolation-induced high levels of circulating IL6.
“We found that standard laboratory models of acute stress—including tube restraint, cage switching, and social isolation—induced high levels of circulating IL6 (Figure 1A), consistent with previous studies demonstrating that stress alone induced IL6 (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as LeMay et al., 1990
Psychological stress has been known to induce endocrine IL6 for nearly 30 years and has been shown in multiple species, including rats, mice, and humans.
“Psychological stress has been known to induce endocrine IL6 for nearly 30 years and has been shown in multiple species, including rats, mice, and humans (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as LeMay et al., 1990
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- Authors
- LeMay, L. G., Vander, A. J., & Kluger, M. J.
- Affiliations
- University of Michigan (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 47
- Issue
- 5
- Pages
- 957-961
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2087870123
- Cited by
- 313
- References
- 21
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (5r01ns023633-02, 1r01dk038984-01, 23633)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38984)
- National Institute of Neurological Disorders and Stroke (NS 23633)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- psychological stress, interleukin-6, body temperature, acute phase response, lipopolysaccharide, rats
- MeSH terms
- Animals, Arousal, Body Temperature Regulation, Exploratory Behavior, Male, Rats, Inbred Strains, Social Environment, Interleukin-6, Rats
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