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Cited by 132Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Interlaminar astroglia of the cerebral cortex: a marker of the primate brain

Colombo, Jorge A., Reisin, Hernán D.·2004·Brain Research
DOI 10.1016/j.brainres.2004.02.003
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Abstract

Evidence for "cable-like" processes stemming from astroglial cells in the supragranular cerebral cortex has been recently presented. In addition to what could be called the "general mammalian-like" astroglial architecture (the so-called "panglial syncytium") of the cerebral cortex, composed of typical stellate astrocytes (intralaminar astrocytes), the anthropoid species, mostly catarrhines, show a manifest vertical, radial distribution of long (interlaminar) astroglial processes. It can be tentatively proposed that evolutionary pressures resulted in the progressive appearance, in primates, of a new type of glial cell. Its soma has a superficial location and unusually long cellular processes that invade, in a predominant radial fashion, the supragranular region of the cerebral cortex. Their existence has been ignored for more than a century. On the neuronal side, modular (columnar) organization of the cerebral cortex may represent an evolutionary acquisition that could optimize communication and information processing, with the least volume compromise in terms of wiring. Yet, for such columns to be functionally operative, adequate isolation from neighboring units would be required. A "mass" operation of the astroglial architecture would tend to compromise spatial definition and the degrees of freedom of such columnar modules. It is proposed that the presence of a "palisade" of interlaminar glial processes represents a relatively recent evolutionary event, instrumental for the…

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  • The formation of fascicules in a honeycomb pattern in tangential sections of the human brain suggests a role for ILAs in the columnization of Ca2+ waves around granular neurons, leading to cylindrical-like waves that follow the morphology of ILAs long processes.

    “The formation of fascicules in a honeycomb pattern, visualized in tangential sections of the human brain (Colombo et al., 1998), suggests a role in the “columnization” of Ca2+ waves around granular neurons, leading to cylindrical-like waves that follow the morphology of ILAs long processes (Colombo and Reisin, 2004; Hern’ et al., 2002).”

    From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo and Reisin, 2004

  • In Down's syndrome, no differences are observed between DS and healthy patients at birth; by 6 months of age, there is a general alteration of the tortuosity and parallelism typical of ILA long processes, becoming particularly visible by the end of the first year of life.

    “While no differences are observed between DS and healthy patients at birth, by 6 months of age, there is a general alteration of the tortuosity and parallelism typical of ILA long processes. These changes become particularly visible by the end of the first year of life (Colombo et al., 2005; Colombo and Reisin, 2004).”

    From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo and Reisin, 2004

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Authors
Colombo, J. A., & Reisin, H. D.
Affiliations
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
Colombo, Jorge A.
ORCID
Colombo, Jorge A.
Venue
Brain Research
Publisher
Elsevier BV
Published
2004-04
Volume
1006
Issue
1
Pages
126-131
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2004.02.003
OpenAlex
W1988216749
Cited by
132
References
2
Citations by year
2026: 4 · 2025: 10 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 2
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
cerebral cortex, primate brain evolution, astrocytes, columnar organization, glial processes, stellate astrocytes, cortico-cortical interactions, catarrhines
MeSH terms
Animals, Astrocytes, Cerebral Cortex, Biological Evolution, Glial Fibrillary Acidic Protein, Primates, Biomarkers

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