CoChat
Sign Up
Cited by 27Phytoestrogen effects and researchNeuroendocrine regulation and behaviorEstrogen and related hormone effects

The neurobehavioral effects of phytoestrogens in male Syrian hamsters

Moore, Tim O., Karom, Mary, O'Farrell, Laura·2004·Brain Research
DOI 10.1016/j.brainres.2004.04.073
Open this paper in CoChat — free account

Abstract

We used a phytoestrogen (PE) and a phytoestrogen-free (PE-Free) diet to determine whether or not diet can have neurobehavioral effects on intermale aggression in Syrian hamsters (Mesocricetus auratus). In Experiment 1, 20 adult male hamsters were pre-tested for aggression and then placed on a PE (n=10) or a PE-Free diet (n=10) for 4 weeks in isolation. During week 5, experimental hamsters were exposed to a group-housed, nonaggressive opponent (NAO) for 5 min in a neutral cage arena. PE-fed hamsters exhibited more attacks (33.4+/-6.1) toward the NAO compared to the PE-Free-fed hamsters (18.1+/-4) (p<0.05). Interestingly, testosterone in the blood serum was higher in the PE-fed group (11.01+/-1.48 ng/ml) compared to the PE-Free group (6.5+/-0.87 ng/ml). In Experiment 2, 16 juvenile hamsters were weaned onto a PE (n=8) or a PE-Free diet (n=8). After 7 weeks on the diet, experimental hamsters were exposed to a NAO for 5 min in a neutral cage arena. Although the PE group exhibited higher levels of aggressive behavior, there were no statistically significant differences between groups. However, the PE group had higher levels of testosterone (9.0+/-0.95 ng/ml) compared to the PE-Free group (4.6+/-0.98 ng/ml) (p<0.05). In addition, analysis of the brains from both experiments revealed differences in binding for vasopressin 1A (V1A) receptors. Optical densities were converted to disintegrating units per min/mg. The PE-Free group had higher levels of V1A receptor binding (2689.93+/-254…

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2004.04.073

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • GEN alters AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species, and is anxiogenic in males of multiple species.

    “Altered AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species; anxiogenic in males of multiple species”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [72]

  • Long-term consumption of soy-rich diets enhances aggression in Syrian hamsters, which also had lower AVP1A expression in the LS but higher AVP1A expression in lateral hypothalamus.

    “and Syrian hamsters (72), the latter of which also had lower AVP1A expression in the LS but higher AVP1A expression in lateral hypothalamus.”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [72]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Moore, T. O., Karom, M., & O'Farrell, L.
Affiliations
  • Morehouse School of Medicine (US)
  • Georgia State University (US)
Corresponding author
Moore, Tim O.
Venue
Brain Research
Publisher
Elsevier BV
Published
2004-07
Volume
1016
Issue
1
Pages
102-110
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2004.04.073
OpenAlex
W2072276309
Cited by
27
References
22
Citations by year
2025: 1 · 2018: 2 · 2017: 2 · 2014: 2 · 2012: 2
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5s11ns037232-05)
  • National Institute of Neurological Disorders and Stroke (NS37232)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
male-male aggression, golden hamster, testosterone, vasopressin V1a receptor, lateral septum, lateral hypothalamus, neurobehavioral effects, diet, aggression development, brain receptor binding, social behavior, neuroendocrinology
MeSH terms
Aggression, Animals, Autoradiography, Behavior, Animal, Binding Sites, Brain, Cricetinae, Isoflavones, Male, Mesocricetus, Radioimmunoassay, Reaction Time, Testosterone, Receptors, Vasopressin, Plant Preparations, Phytoestrogens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review