Dietary soy supplements produce opposite effects on anxiety in intact male and female rats in the elevated plus-maze
Abstract
The effects of 2 popular, commercially available soy phytoestrogen supplements on anxiety in male, diestrus female, and proestrus female rats were examined with an elevated plus-maze. Both of the soy supplements were anxiolytic in proestrus females but anxiogenic in males as determined by time spent in the open arms. No effect of diet was seen in the diestrus females. The observed changes in anxiety were not because of altered levels of gonadal hormones, as serum estrogen and progesterone levels were unaffected by diet in the females. The results suggest that the soy supplements have sex- and cycle-specific effects on anxiety.
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Two dietary isoflavone supplements produced anxiolytic elevated plus maze behavior in proestrus female rats, but anxiogenic responses in gonadally intact males.
“My lab has also shown that two dietary isoflavone supplements produced anxiolytic elevated plus maze behavior in proestrus female rats, but anxiogenic responses in gonadally intact males (118).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [118]
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- Authors
- Patisaul, H. B., Blum, A., Luskin, J. R., & Wilson, M. E.
- Affiliations
- Emory University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2005
- Volume
- 119
- Issue
- 2
- Pages
- 587-594
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1999993860
- Cited by
- 35
- References
- 70
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2012: 3
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR-00 165, P51RR000165)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD038917, HD38917)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- soy phytoestrogens, anxiety, sex differences, menstrual cycle, proestrus, diestrus, gonadal hormones, serum estrogen, serum progesterone, anxiolytic effects, anxiogenic effects, elevated plus maze
- MeSH terms
- Animals, Anxiety, Estrus, Female, Male, Sex Factors, Maze Learning, Dietary Supplements, Rats, Long-Evans, Soybean Proteins, Phytoestrogens, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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