Cited by 35Phytoestrogen effects and researchEstrogen and related hormone effectsMedicinal Plant Extracts Effects

Dietary soy supplements produce opposite effects on anxiety in intact male and female rats in the elevated plus-maze

Patisaul, Heather B., Blum, Adele, Luskin, Jordan R., Wilson, Mark E.·2005·Behavioral Neuroscience

Abstract

The effects of 2 popular, commercially available soy phytoestrogen supplements on anxiety in male, diestrus female, and proestrus female rats were examined with an elevated plus-maze. Both of the soy supplements were anxiolytic in proestrus females but anxiogenic in males as determined by time spent in the open arms. No effect of diet was seen in the diestrus females. The observed changes in anxiety were not because of altered levels of gonadal hormones, as serum estrogen and progesterone levels were unaffected by diet in the females. The results suggest that the soy supplements have sex- and cycle-specific effects on anxiety.

Integrity signals

Registry

Crossref · 10.1037/0735-7044.119.2.587

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Two dietary isoflavone supplements produced anxiolytic elevated plus maze behavior in proestrus female rats, but anxiogenic responses in gonadally intact males.

    “My lab has also shown that two dietary isoflavone supplements produced anxiolytic elevated plus maze behavior in proestrus female rats, but anxiogenic responses in gonadally intact males (118).”

Cites

Flagged first, then by citations

1 of the 70 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Patisaul, H. B., Blum, A., Luskin, J. R., & Wilson, M. E.
Affiliations
Emory University (US)
Venue
Behavioral Neuroscience
Published
2005
Volume
119
Issue
2
Pages
587-594
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W1999993860
Cited by
35
References
70
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2012: 3
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (RR-00 165, P51RR000165)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD038917, HD38917)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Keywords
soy phytoestrogens, anxiety, sex differences, menstrual cycle, proestrus, diestrus, gonadal hormones, serum estrogen, serum progesterone, anxiolytic effects, anxiogenic effects, elevated plus maze
MeSH terms
Animals, Anxiety, Estrus, Female, Male, Sex Factors, Maze Learning, Dietary Supplements, Rats, Long-Evans, Soybean Proteins, Phytoestrogens, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review