Cited by 225Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Cognitive correlates of Aβ deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Howlett, David R, Richardson, Jill C, Austin, Angela, Parsons, Andrew A, Bate, Simon T, Davies, D.Ceri, Gonzalez, M.Isabel·2004·Brain Research

DOI 10.1016/j.brainres.2004.05.029

Open this paper in CoChat — free account

Abstract

Several transgenic mouse models of Alzheimer's disease (AD) have been developed that exhibit beta-amyloid (Abeta) neuropathology and behavioural deficits. However, not all studies have investigated the relationship between the development of cognitive impairment and neuropathology. Therefore, temporal changes in cognition were investigated in male and female double-mutant APPswexPS1.M146V (TASTPM) transgenic mice using an object recognition test and correlated with the development of cerebral Abeta neuropathology. Both male and female TASTPM mice exhibited similar significant cognitive impairment at 6, 8 and 10 months of age in the object recognition test, compared to wild-type littermates. There was no such cognitive impairment at 3 or 4 months of age. Quantitative immunohistochemistry using a battery of Abeta antibodies demonstrated that cerebral Abeta deposition was first apparent in 3-month-old mice, and it increased with age. The early appearance of cerebral Abeta deposits in the double-transgenic TASTPM mice supports the evidence that mutations in the PS1 gene accelerate Abeta deposition. The cerebral Abeta load was greater in female than in male TASTPM mice at all ages investigated. In the electron microscope, mature Abeta plaques comprising a fibrillar core surrounded by degenerating neurites and reactive glia were first observed in the cortex of TASTPM mice at 6 months of age, the same age at which cognitive impairment became apparent. These results suggest that the cognitive impairment in TASTPM mice is related to the disruption of neural connectivity and not simply Abeta deposition, which first occurs 3 months earlier.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2004.05.029

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
Chishti, M. A., Yang, D.-S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100710200 · Cited by 955
Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys
Meunier, M., Bachevalier, J., Mishkin, M., & Murray, E. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05418.1993 · Cited by 900
A Modified Method for Lead Staining of Thin Sections
Sato, T. (1968) · Journal of Electron Microscopy · doi:10.1093/oxfordjournals.jmicro.a049610 · Cited by 809

Show all 41 references

Research works printed but not linked: 1

Moechars, 1995, Molecular and behavioral characterization of transgenic mice expressing mutant app in the brain, Behav. Genet., 25, 280

Sorted by citations

Alzheimer disease models and human neuropathology: similarities and differences
Duyckaerts, C., Potier, M.-C., & Delatour, B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 375
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Kinsey, A., Güntert, A., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.78 · Cited by 405
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults
Buckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., Jacobs, H. I. L., Papp, K. V., Amariglio, R. E., Properzi, M. J., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.4693 · Cited by 373
Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses
Lee, J. K., Jin, H. K., Endo, S., Schuchman, E. H., Carter, J., & Bae, J.-S. (2009) · Stem Cells · doi:10.1002/stem.277 · Cited by 308
GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer’s Disease Brain and Improves Cognitive Performance in Preclinical Models
Medhurst, A. D., Atkins, A. R., Beresford, I. J. M., Brackenborough, K. T., Briggs, M. A., Calver, A. R., Cilia, J., Cluderay, J. E., Crook, B., Davis, J. B., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120311 · Cited by 302
Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts
Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., Lim, Y. Y., Papp, K. V., Jacobs, H. I. L., Burnham, S., Hanseeuw, B. J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.010 · Cited by 276
Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents
Grayson, B., Léger, M., Piercy, C., Adamson, L., Harte, M., & Neill, J. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.025 · Cited by 264
Role of Copper in the Onset of Alzheimer’s Disease Compared to Other Metals
Bagheri, S., Squitti, R., Haertlé, T., Siotto, M., & Saboury, A. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00446 · Cited by 235
Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo
Hussain, I., Hawkins, J., Harrison, D. C., Hille, C. J., Wayne, G. J., Cutler, L., Buck, T., Walter, D. S., Demont, E. H., Howes, C., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04260.x · Cited by 197
Imaging and spatial distribution of β-amyloid peptide and metal ions in Alzheimer’s plaques by laser ablation–inductively coupled plasma–mass spectrometry
Hutchinson, R. W., Cox, A. G., McLeod, C. W., Marshall, P. S., Harper, A. J., Dawson, E. L., & Howlett, D. R. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.08.024 · Cited by 189
β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death
Abeti, R., Abramov, A. Y., & Duchen, M. R. (2011) · Brain · doi:10.1093/brain/awr104 · Cited by 172
MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity
Culbert, A. A., Skaper, S. D., Howlett, D. R., Evans, N. A., Facci, L., Soden, P. E., Seymour, Z. M., Guillot, F., Gaestel, M., & Richardson, J. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513646200 · Cited by 172
Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression
Cole, A. R., Noble, W. J., van Aalten, L., Plattner, F., Meimaridou, R., Hogan, D., Taylor, M., LaFrancois, J. J., Gunn‐Moore, F. J., Verkhratsky, A., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04829.x · Cited by 169
NMDA-Mediated Ca2+Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice
Goussakov, I. V., Miller, M. B., & Stutzmann, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2474-10.2010 · Cited by 168
Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology
Kosel, F., Pelley, J. M. S., & Franklin, T. B. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.012 · Cited by 173
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158
Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis
Zhu, L., Zhong, M., Elder, G. A., Sano, M., Holtzman, D. M., Gandy, S., Cardozo, C., Haroutunian, V., Robakis, N. K., & Cai, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510011112 · Cited by 160
Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease
Searcy, J. L., Phelps, J. T., Pancani, T., Kadish, I., Popovic, J., Anderson, K. L., Beckett, T. L., Murphy, M. P., Chen, K.-C., Blalock, E. M., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111661 · Cited by 154
Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease
Lau, J. C., Lerch, J. P., Sled, J. G., Henkelman, R. M., Evans, A. C., & Bedell, B. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.252 · Cited by 152
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease
Lee, J. K., Jin, H. K., Park, M. H., Kim, B.-R., Lee, P. H., Nakauchi, H., Carter, J., He, X., Schuchman, E. H., & Bae, J. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20132451 · Cited by 149
Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)
Filali, M., Lalonde, R., Thériault, P., Julien, C., Calon, F., & Planel, E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.004 · Cited by 139
Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease
Chakroborty, S., Briggs, C. A., Miller, M. B., Goussakov, I. V., Schneider, C., Kim, J. S., Wicks, J. M., Richardson, J. C., Conklin, V., Cameransi, B. G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052056 · Cited by 136
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease
Pugh, P. L., Richardson, J. C., Bate, S. T., Upton, N., & Sunter, D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.044 · Cited by 140
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits
Jardanhazi‐Kurutz, D., Kummer, M. P., Terwel, D., Vogel, K., Dyrks, T., Thiele, A., & Heneka, M. T. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.001 · Cited by 135
Non-invasive infra-red therapy (1072 nm) reduces β-amyloid protein levels in the brain of an Alzheimer’s disease mouse model, TASTPM
Grillo, S. L., Duggett, N. A., Ennaceur, A., & Chazot, P. L. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.02.015 · Cited by 114
Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders
Ullah, M. F., Ahmad, A., Bhat, S. H., Abuduhier, F. M., Barreto, G. E., & Ashraf, G. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.003 · Cited by 113
Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model
Sil, A., Erfani, A., Lamb, N., Copland, R., Riedel, G., & Platt, B. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-210523 · Cited by 109
Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease
Александровна, П. Е., & Борисович, Б. И. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00029 · Cited by 110
Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI
Maheswaran, S., Barjat, H., Rueckert, D., Bate, S. T., Howlett, D. R., Tilling, L. C., Smart, S., Pohlmann, A., Richardson, J. C., Hartkens, T., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.045 · Cited by 109
Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research
Dennison, J. L., Ricciardi, N. R., Lohse, I., Volmar, C., & Wahlestedt, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201014 · Cited by 107
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
Lee, J. Y., Han, S. H., Park, M. H., Baek, B., Song, I., Choi, M.-K., Takuwa, Y., Ryu, H., Kim, S. H., He, X., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03674-2 · Cited by 98
Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy
Nisticò, R., Pignatelli, M., Piccinin, S., Mercuri, N. B., & Collingridge, G. L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8324-3 · Cited by 102
The role of positive selection in determining the molecular cause of species differences in disease
Vamathevan, J. J., Hasan, S., Emes, R. D., Amrine‐Madsen, H., Rajagopalan, D., Topp, S. D., Kumar, V. D., Word, M., Simmons, M. D., Foord, S. M., et al. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-273 · Cited by 98
Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis
Mattana, S., Caponi, S., Tamagnini, F., Fioretto, D., & Palombo, F. (2017) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545817420019 · Cited by 92
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models
Huang, Y., Skwarek‐Maruszewska, A., Horré, K., Vandewyer, E., Wolfs, L., Snellinx, A., Saito, T., Radaelli, E., Corthout, N., Colombelli, J., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3492 · Cited by 92
Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease
Placanica, L., Zhu, L., & Li, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005088 · Cited by 88
Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T., & Williams, R. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.032 · Cited by 89
Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Scott, L., Feng, J., Kiss, T., Needle, E., Atchison, K. P., Kawabe, T. T., Milici, A. J., Hajós‐Korcsok, É., Riddell, D. R., & Hajós, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.010 · Cited by 93
Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice
Sierksma, A. S. R., Prickaerts, J., Chouliaras, L., Rostamian, S., Delbroek, L., Rutten, B. P. F., Steinbusch, H. W. M., & van den Hove, D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.012 · Cited by 88
Locus coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease
Ross, J. A., McGonigle, P., & Bockstaele, E. J. V. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.09.002 · Cited by 86
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease
Bonham, L. W., Sirkis, D. W., & Yokoyama, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01170 · Cited by 83
Impairment of hippocampal gamma (γ)‐frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)
Driver, J. E., Racca, C., Cunningham, M. O., Towers, S. K., Davies, C. H., Whittington, M. A., & LeBeau, F. E. N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05705.x · Cited by 83
First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression
Cummings, D. M., Liu, W., Portelius, E., Bayram, S., Yasvoina, M. V., Ho, H., Smits, H., Ali, S. S., Steinberg, R., Pegasiou, C.-M., et al. (2015) · Brain · doi:10.1093/brain/awv127 · Cited by 84
Gender-specificities in Alzheimer's disease and mild cognitive impairment
Beinhoff, U., Tumani, H., Brettschneider, J., Bittner, D., & Riepe, M. W. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0726-9 · Cited by 79
MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
Cao, J., Huang, M., Guo, L., Zhu, L., Hou, J., Zhang, L., Pero, A., Ng, S., Gaamouch, F. E., Elder, G. A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0824-3 · Cited by 82
Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljković, M., Kelley, C., Stutz, B., Horváth, T. L., & Hajós, M. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy140 · Cited by 72
Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?
Franco, S., Blasco, M. A., Siedlak, S. L., Harris, P. L. R., Moreira, P. I., Perry, G. L., & Smith, M. A. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.03.001 · Cited by 77
APP transgenic mice: their use and limitations
Balducci, C., & Forloni, G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8141-7 · Cited by 79
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration
Chai, Y. L., Chong, J. R., Weng, J., Howlett, D., Halsey, A., Lee, J. H., Attems, J., Aarsland, D., Francis, P. T., Chen, C. P., et al. (2019) · Brain Pathology · doi:10.1111/bpa.12631 · Cited by 73
PET Imaging of Copper Trafficking in a Mouse Model of Alzheimer Disease
Torres, J. B., Andreozzi, E. M., Dunn, J., Siddique, M., Szanda, I., Howlett, D. R., Sunassee, K., & Blower, P. J. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.162370 · Cited by 67
Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model
Zhu, L., Zhong, M., Zhao, J., Rhee, H., Caesar, I., Knight, E. M., Volpicelli-Daley, L., Bustos, V., Netzer, W., Liu, L., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.504365 · Cited by 70
What do we know about the long-term consequences of stress on ageing and the progression of age-related neurodegenerative disorders?
Pardon, M., & Rattray, I. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.005 · Cited by 70
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
Howlett (2008) · PubMed · doi:10.14670/hh-23.67 · Cited by 65
Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action
Luo, Y., Sun, Y., Tian, X., Zheng, X., Wang, X., Li, W., Wu, X., Shu, B., & Hou, W. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.619543 · Cited by 69
CRMP2 Hyperphosphorylation is Characteristic of Alzheimer's Disease and not a Feature Common to Other Neurodegenerative Diseases
Williamson, R., van Aalten, L., Mann, D. M. A., Platt, B., Plattner, F., Bedford, L., Mayer, J., Howlett, D. R., Usardi, A., Sutherland, C. D., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110617 · Cited by 68
Sex and Gender Differences in Alzheimer’s Disease: Genetic, Hormonal, and Inflammation Impacts
Kolahchi, Z., Henkel, N., Eladawi, M. A., Villarreal, E. C., Kandimalla, P., Lundh, A., McCullumsmith, R. E., & Cuevas, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158485 · Cited by 66
Clusterin Associates Specifically with A β40 in Alzheimer's Disease Brain Tissue
Howlett, D. R., Hortobágyi, T., & Francis, P. T. (2013) · Brain Pathology · doi:10.1111/bpa.12057 · Cited by 51
APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
Lalonde, R., Fukuchi, K., & Strazielle, C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.011 · Cited by 66
Modeling Alzheimer’s disease: from past to future
Saraceno, C., Musardo, S., Marcello, E. E., Pelucchi, S., & Luca, M. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00077 · Cited by 62
Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease
Willuweit, A., Velden, J., Godemann, R., Manook, A., Jetzek, F., Tintrup, H., Kauselmann, G., Zevnik, B., Henriksen, G., Drzezga, A. E., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007931 · Cited by 60
A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease
Bonardi, C., de Pulford, F., Jennings, D. J., & Pardon, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.041 · Cited by 62
Metabonomic Profiling of TASTPM Transgenic Alzheimer’s Disease Mouse Model
Hu, Z., Browne, E. R., Liu, T., Angel, T. E., Ho, P. C., & Chan, E. C. Y. (2012) · Journal of Proteome Research · doi:10.1021/pr300666p · Cited by 58
Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice
Rauch, S. M., Huen, K. H. Y., Miller, M. C., Chaudry, H., Lau, M., Sanes, J. R., Johanson, C. E., Stopa, E. G., & Burgess, R. W. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31823b0b12 · Cited by 59
Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over‐expressing TASTPM mice
Medhurst, A. D., Roberts, J., Lee, J., Chen, C., Brown, S., Roman, S. A., & Lai, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00075.x · Cited by 57
Anesthesia in presymptomatic Alzheimer's disease: A study using the triple‐transgenic mouse model
Tang, J. X., Mardini, F., Caltagarone, B. M., Garrity, S. T., Li, R. Q., Bianchi, S. L., Gomes, O., LaFerla, F. M., Eckenhoff, R. G., & Eckenhoff, M. F. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.10.003 · Cited by 57
Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice
Park, M. H., Lee, J. K., Choi, S., Ahn, J., Jin, H. K., Park, J., & Bae, J. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.045 · Cited by 59
Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
Dubal, D. B., Broestl, L., & Worden, K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-24 · Cited by 62
Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium‐derived factor: Two novel biomarkers of Alzheimer's disease in human plasma
Cutler, P., Akuffo, E. L., Bodnar, W. M., Briggs, D. M., Davis, J. B., Debouck, C. M., Fox, S. M., Gibson, R. A., Gormley, D. A., Holbrook, J. D., et al. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200780101 · Cited by 55
Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer’s disease
Yang, J., Kou, J., Lalonde, R., & Fukuchi, K.-I. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.012 · Cited by 57
18F-FDG-PET in Mouse Models of Alzheimer's Disease
Bouter, C., & Bouter, Y. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00071 · Cited by 52
N , N ′-Diacetyl- p -phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
Park, M. H., Lee, M., Nam, G., Kim, M., Kang, J., Choi, B. J., Jeong, M. S., Park, K. H., Han, W. H., Tak, E., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916318116 · Cited by 54
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
Lee, J. Y., Han, S. H., Park, M. H., Song, I., Choi, M., Yu, E., Park, C., Kim, H.-J., Kim, S. H., Schuchman, E. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16080-4 · Cited by 53
Prenatal exposure to chronic mild stress increases corticosterone levels in the amniotic fluid and induces cognitive deficits in female offspring, improved by treatment with the antidepressant drug amitriptyline
Aziz, N. H. K. A., Kendall, D. A., & Pardon, M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.02.040 · Cited by 52
Sex specific molecular networks and key drivers of Alzheimer’s disease
Guo, L., Cao, J., Hou, J., Li, Y., Huang, M., Zhu, L., Zhang, L., Lee, Y., Duarte, M. L., Zhou, X., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00624-5 · Cited by 49
Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-β cascade
Belkacemi, A., & Ramassamy, C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.020 · Cited by 51
Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age
Yuan, Y., Li, J., Zhang, N., Fu, P., Jing, Z., Yu, C., Zhao, D., Hao, W., & Zhou, C. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03059-8 · Cited by 46
Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia
Micale, V., Leggio, G. M., Mazzola, C., & Drago, F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.108 · Cited by 46
Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon
Baño‐Otálora, B., Popovic, N., Gambini, J., Popović, M., Viña, J., Bonet-Costa, V., Reiter, R. J., Camello, P. J., Rol, M. A., & Madrid, J. A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699119 · Cited by 46
Regional metabolic alteration of Alzheimer's disease in mouse brain expressing mutant human APP-PS1 by 1H HR-MAS☆
Woo, D., Lee, S., Lee, D., Kim, S.-Y., Kim, G., Rhim, H., Choi, C., Kim, H., Lee, C., & Choe, B. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.026 · Cited by 45
Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis
Scullion, G. A., Kendall, D. A., Marsden, C. A., Sunter, D., & Pardon, M. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.002 · Cited by 44
Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease (Erratum)
Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/356862 · Cited by 44
Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice
Choudhry, F., Howlett, D. R., Richardson, J. C., Francis, P. T., & Williams, R. J. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.008 · Cited by 43
Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease
Spencer, J. P., Brown, J. T., Richardson, J. C., Medhurst, A. D., Sehmi, S. S., Calver, A. R., & Randall, A. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.070 · Cited by 43
Detection of Aβ plaque-associated astrogliosis in Alzheimer's disease brain by spectroscopic imaging and immunohistochemistry
Palombo, F., Tamagnini, F., Jeynes, J. C. G., Mattana, S., Swift, I. J., Nallala, J., Hancock, J. M., Brown, J. T., Randall, A. D., & Stone, N. (2017) · The Analyst · doi:10.1039/c7an01747b · Cited by 41
Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease
Lok, K., Hong, Z., Zhang, C. M., He, N., Shen, H., Wang, Z., Zhao, W., & Yin, M. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.09.018 · Cited by 40
Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels
Pardon, M., Sarmad, S., Rattray, I., Bates, T. E., Scullion, G. A., Marsden, C. A., Barrett, D. A., Lowe, J. S., & Kendall, D. A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.002 · Cited by 39
Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer's Disease
Campbell, S. N., Zhang, C., Roe, A. D., Lee, N., Lao, K., Monte, L., Donohue, M., & Rissman, R. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142844 · Cited by 39
The Continuing Failure of Bexarotene in Alzheimer’s Disease Mice
Balducci, C., Paladini, A., Micotti, E., Tolomeo, D., Vitola, P. L., Grigoli, E., Richardson, J. C., & Forloni, G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150029 · Cited by 37
Early development of social deficits in APP and APP-PS1 mice
Pietropaolo, S., Delage, P., Lebreton, F., Crusio, W. E., & Cho, Y. H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.012 · Cited by 36
Transgenic mice over-expressing human β-amyloid have functional nicotinic alpha 7 receptors
Spencer, J. P., Weil, A., Hill, K., Hussain, I., Richardson, J. C., Cusdin, F. S., Chen, Y. H., & Randall, A. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.007 · Cited by 35
Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic mice
Medawar, E., Benway, T. A., Liu, W., Hanan, T. A., Haslehurst, P., James, O. T., Yap, K., Muessig, L., Moroni, F., Nahaboo Solim, M. A., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.006 · Cited by 26
Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease
Aman, Y., Pitcher, T., Simeoli, R., Ballard, C. G., & Malcangio, M. (2016) · Pain · doi:10.1097/j.pain.0000000000000644 · Cited by 33
Gene Therapy Models of Alzheimer’s Disease and Other Dementias
Combs, B., Kneynsberg, A., & Kanaan, N. M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3271-9_25 · Cited by 33
Sex difference in biological change and mechanism of Alzheimer’s disease: From macro- to micro-landscape
Cui, S., Jiang, Q., & Chen, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101918 · Cited by 31
Exercise preconditioning improves behavioral functions following transient cerebral ischemia induced by 4-vessel occlusion (4-VO) in rats.
Tahamtan, M., Allahtavakoli, M., Abbasnejad, M., Roohbakhsh, A., Taghipour, Z., Taghavi, M., Khodadadi, H., & Shamsizadeh, A. (2013) · PubMed · Cited by 31
One‐year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice
Cudennec, C. L., Faure, A., Ly, M., & Delatour, B. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00374.x · Cited by 32
Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/859101 · Cited by 30
F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice
Hafez, D. M., Huang, J., Richardson, J. C., Masliah, E., Peterson, D. A., & Marr, R. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.07.038 · Cited by 31
Analysis of serial magnetic resonance images of mouse brains using image registration
Maheswaran, S., Barjat, H., Bate, S. T., Aljabar, P., Hill, D., Tilling, L. C., Upton, N., James, M. F., Hajnal, J. V., & Rueckert, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.016 · Cited by 30
Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain
Yue, X., Zhou, Y., Qiao, M., Zhao, X., Huang, X. H., Zhao, T., Cheng, X., Fan, M., Zhao, Y., Chen, R., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00935-z · Cited by 30

Authors: Howlett, D. R., Richardson, J. C., Austin, A., Parsons, A. A., Bate, S. T., Davies, D. C., & Gonzalez, M. I.
Affiliations: GlaxoSmithKline (United Kingdom) (GB)
St George's Hospital (GB)
Corresponding author: Howlett, David R
ORCID: Howlett, David R
Richardson, Jill C
Bate, Simon T
Venue: Brain Research
Publisher: Elsevier BV
Published: 2004-08
Volume: 1017
Issue: 1-2
Pages: 130-136
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2004.05.029
OpenAlex: W2048622057
Cited by: 212
References: 41
Citations by year: 2026: 2 · 2025: 1 · 2024: 21 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 6 · 2018: 17 · 2017: 5 · 2016: 6 · 2015: 13 · 2014: 6 · 2013: 14 · 2012: 15
FWCI: 3.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, amyloid-beta deposition, presenilin 1 mutations, amyloid precursor protein mutations, cognitive impairment, object recognition, sex differences, amyloid plaques, neuronal connectivity
MeSH terms: Age Factors, Alzheimer Disease, Analysis of Variance, Animals, Behavior, Animal, Cerebral Cortex, Disease Models, Animal, Female, Immunohistochemistry, Male, Membrane Proteins, Mice, Transgenic, Microscopy, Electron, Mutation, Neuropsychological Tests, Sex Characteristics, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice, Presenilin-1, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cognitive correlates of Aβ deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks