Lipid metabolism and neuroinflammation in Alzheimer’s disease: a role for liver X receptors

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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The role of apolipoprotein E in Alzheimer's disease

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Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

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Activation of microglial cells by β-amyloid protein and interferon-γ

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Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies

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ApoE Promotes the Proteolytic Degradation of Aβ

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Regulation of innate immune responses in the brain

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

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Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

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Apolipoprotein E structure: insights into function

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

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The Alzheimer’s Disease Mitochondrial Cascade Hypothesis

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Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

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Cholesterol metabolism in neurons and astrocytes

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

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Central nervous system: cholesterol turnover, brain development and neurodegeneration

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Insulin resistance and Alzheimer's disease

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Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a Randomized, Controlled Trial of Naproxen and Celecoxib

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

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Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

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Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia

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Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

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Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?

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Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

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The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

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Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

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Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

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Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis

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Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

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Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

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Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

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Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

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Mechanism underlying apolipoprotein E (ApoE) isoform‐dependent lipid efflux from neural cells in culture

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Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo

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Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

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Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

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Peroxisome Proliferator-activated Receptor γ Stimulation of Adipocyte ApoE Gene Transcription Mediated by the Liver Receptor X Pathway

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Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

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APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.007 · Cited by 105 · see citing works

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

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