Cited by 291Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

The DOI matches its Crossref record; 220 of the 222 references it cites were found in a registry or an index.

Factors influencing the blood-brain barrier permeability

Open access

Zhao, Yibin, Gan, Lin, Ren, Li, Lin, Yubo, Ma, Congcong, Lin, Xianming·2022·Brain Research

DOI 10.1016/j.brainres.2022.147937

Open this paper in CoChat — free account Open PDF

Abstract

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment. All constituent cell types play indispensable roles in the BBB's integrity, and other structural BBB components, such as tight junction proteins, adherens junctions, and junctional proteins, can control the barrier permeability. Regarding the need to exchange nutrients and toxic materials, solute carriers, ATP-binding case families, and ion transporter, as well as transcytosis regulate the influx and efflux transport, while the difference in localisation and expression can contribute to functional differences in transport properties. Numerous chemical mediators and other factors such as non-physicochemical factors have been identified to alter BBB permeability by mediating the structural components and barrier function, because of the close relationship with inflammation. In this review, we highlight recently gained mechanistic insights into the maintenance and disruption of the BBB. A better understanding of the factors influencing BBB permeability could contribute to supporting promising potential therapeutic targets for protecting the BBB and the delivery of central nervous system drugs via BBB permeability interventions under pathological conditions.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2022.147937

Cites

220 of 220 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917
Clearance systems in the brain—implications for Alzheimer disease
Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678
Astrocytes induce blood–brain barrier properties in endothelial cells
Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,479
The human ATP-binding cassette (ABC) transporter superfamily
Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302
VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296

Flagged first, then by citations

Show all 222 references

2 of the 222 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

Agúndez, 2014, Drug and xenobiotic biotransformation in the blood-brain barrier: a neglected issue, Front Cell Neurosci, 8, 335
Goldmann, 1909, Die aussere und innere Sekretion des gesunden und kranken Organismus im Lichte der vitalen Farbung, Laupp'schen
Monteiro, A.C., Luissint, A.C., Sumagin, R., Lai, C., Vielmuth, F., Wolf, M.F., et al. (2014). Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface. Mol Biol Cell 25(10), 1574-1585. 10.1091/mbc.E14-01-0018. Yeung, D., Manias, J.L., Stewart, D.J., and Nag, S. (2008). Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol 115(6), 635-642. 10.1007/s00401-008-0364-4. · DOI
Roher, 2003, Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Molecular medicine (Cambridge, Mass.), 9, 112
Stern, 1921, Recherches sur le liquide céphalo-rachidien, Arch. Int. Physiol., 1921, 138
Stern, 1929, Le fonctionnement de la barrière hématoencéphalique chez les nouveau-nés, Soc. Biol., 1929, 231
Hamann, G.F., Burggraf, D., Martens, H.K., Liebetrau, M., Jäger, G., Wunderlich, N., et al. (2004). Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke 35(3), 764-769. 10.1161/01.str.0000116866.60794.21. · DOI

Sorted by citations

Items 101–200 of 291

Zingerone as a Neuroprotective Agent Against Cognitive Disorders: A Systematic Review of Preclinical Studies
Olasehinde, T. A., & Olaokun, O. O. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136111 · Cited by 8
Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways
Wang, D., Wang, J., Li, B., Yang, S., Guo, F., Zheng, B., & Wang, J. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01312-4 · Cited by 9
Current insights on transglutaminase 2: Exploring its functions, mechanisms, and therapeutic potential in glioblastoma
Lan, K., April, V., Jamali, F., Sabri, S., & Abdulkarim, B. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104894 · Cited by 10
Immune effector cell-associated neurotoxicity syndrome: integrative mechanisms, predictive biomarkers, and translational pathways for prevention in CAR T-cell therapy
Aziz, F., Chakraborty, A., Saha, D., & Dutta, P. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1739021 · Cited by 8
New insights of miRNA molecular mechanisms in breast cancer brain metastasis and therapeutic targets
Hussen, B. M., Abdullah, K. H., Abdullah, S. R., majeed, N. M., Mohamadtahr, S., Rasul, M. F., Dong, P., Taheri, M. N., & Samsami, M. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.09.003 · Cited by 8
S100A4 exerts neuroprotective effects by attenuating blood-brain barrier disruption and oxidative stress via the PI3K/Akt/Nrf2 axis in ischemic stroke
Ji, J., Li, X., Zhang, R., Zhang, J., Ren, J., Du, J., Zhou, S., Tian, X., Wang, Y., Fang, X., et al. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151099 · Cited by 8
Acupuncture modulates the gut microbiota in Alzheimer’s disease: current evidence, challenges, and future opportunities
Yan, L., Li, H., Qian, Y., Liu, Q., Cong, S., Dou, B., Wang, Y., Wang, M., & Yu, T. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1334735 · Cited by 8
Alzheimer's disease: Current concept and a new hope with siRNA-liposomal system
Abla, K. K., & Zahwi, M. K. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106409 · Cited by 7
CAR-T cell therapy in the treatment of relapsed or refractory primary central nervous system lymphoma: recent advances and challenges
Xiong, S., Zhang, S., Yue, N., Cao, J., & Wu, C. (2025) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2025.2458214 · Cited by 7
Natural disaster-induced dementia and cognitive decline: A meta-analysis and systematic review
Thompson, J., & Vasefi, M. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.117898 · Cited by 7
Overcoming the blood–brain barrier (BBB) in pediatric CNS tumors: immunotherapy and nanomedicine-driven strategies
Alaseem, A. M., & Alrehaili, J. A. (2025) · Medical Oncology · doi:10.1007/s12032-025-02984-y · Cited by 9
Functionalized albumin nanoparticles: A multifunctional platform for enhanced brain drug delivery
Mohammad, H., Darwish, M., Katona, G., & Csóka, I. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102616 · Cited by 7
Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK
Yang, X., Chang, Q., Wang, Y., Dong, S., & Qu, K. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102450 · Cited by 7
RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice
Ma, Y., Chen, H., Jiang, Y., Wang, D., Aschner, M., Luo, W., & Su, P. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100207 · Cited by 7
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice
Qin, X., Xie, C., Hakenjos, J. M., MacKenzie, K. R., Boyd, S. R., Barzi, M., Bissig, K., Young, D. W., & Li, F. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106358 · Cited by 7
Pro-Oxidative and Inflammatory Actions of Extracellular Hemoglobin and Heme: Molecular Events and Implications for Alzheimer's and Parkinson Disease
Campomayor, N. B., Kim, H. J., & Kim, M. (2025) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.224 · Cited by 8
Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies
Morrison, J. I., Metzendorf, N. G., Liu, J., & Hultqvist, G. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01811-1 · Cited by 7
Pirtobrutinib is an Effective Salvage Treatment After Ibrutinib in Bing–Neel Syndrome
Frustaci, A. M., Zappaterra, A., Turri, G., Rossi, V., Deodato, M., Gambacorti-Passerini, C. B., Cairoli, R., Danesi, R., & Tedeschi, A. (2025) · American Journal of Hematology · doi:10.1002/ajh.27759 · Cited by 6
Identification and exploration of sleep-enhancing peptides from goat milk casein by peptidomics and virtual screening
Mo, L., Wang, S., Wu, B., Zhao, C., Yu, Y., Li, J., & Wang, H. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117333 · Cited by 6
Pathogenic breaches: how viruses compromise blood-tissue barriers
Apoorva, & Singh, S. K. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2549020 · Cited by 9
A critical appraisal of drug transport across the blood-brain barrier: Evaluation using new-age microfluidic technique
Marathe, K., Gupta, D., Barve, K. H., & Bodas, D. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111662 · Cited by 6
Brain neurovascular unit in response to intra- and extra-central nervous system cancers: implications, mechanisms, and challenges
Mirzaahmadi, B., Salahpour‐Anarjan, F., Mousakhani, A., Haddadi, P., Nezamdoust, F. V., Rahbarghazi‬, R., & Karimipour, M. (2025) · Cancer Cell International · doi:10.1186/s12935-025-04134-w · Cited by 6
Intranasal Drug Delivery in Neuropharmacology: Advances in Brain-Targeted Therapies and Bioethical Challenges
Damian, S. I., David, S. M., Nour, M., Haliţchi, G. L., Ciurlea, S. A., Ştefanache, A., Duma, O.-O., Călin, G., & Spaiuc, D. (2026) · Biomedicines · doi:10.3390/biomedicines14030571 · Cited by 6
Cerebral endothelial cells mediated enhancement of brain pericyte number and migration in oxygen-glucose deprivation involves the HIF-1α/PDGF-β signaling
Song, S.-N., Wen-ping, D., Dong, X.-X., Guo, F., Ren, L., Li, C., & Wang, J. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148849 · Cited by 6
Self-citation
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy
Liu, Y., Qin, Y., & Zhang, Y. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09865-6 · Cited by 6
Non-Tumor Cells within the Tumor Microenvironment—The “Eminence Grise” of the Glioblastoma Pathogenesis and Potential Targets for Therapy
Bugakova, A., Chudakova, D. A., Myzina, M. S., Yanysheva, E. P., Ozerskaya, I. V., Soboleva, A. V., Baklaushev, V. P., & Yusubalieva, G. M. (2024) · Cells · doi:10.3390/cells13100808 · Cited by 6
Exercise alleviates CUS-induced depressive-like behaviors by modulating paracellular and transcellular permeability of the blood-brain barrier in the prefrontal cortex
Luo, Y., Meng, D., Tang, H., Wu, P., & Zhang, Y. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115286 · Cited by 7
Association Between Visit-to-Visit Glucose Variability and Brain Morphology and Cognitive Function in Type 2 Diabetes
Lu, W., Shen, D., & Qiu, S. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf228 · Cited by 5
Cholesterol dependent cytolysins and the brain: Revealing a potential therapeutic avenue for bacterial meningitis
Pramitasuri, T. I., Susilawathi, N. M., Tarini, N. M. A., Sudewi, A. R., & Evans, M. C. (2023) · AIMS Microbiology · doi:10.3934/microbiol.2023033 · Cited by 7
Nanomedicine breakthroughs in cancer and neurodegenerative disease therapy
Haque, A., Khan, T., Islam, R. U., & Naseem, S. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100233 · Cited by 5
Rutin alleviates lipopolysaccharide-induced neuroinflammation and blood brain barrier dysfunction
Meng, Y., Liu, X., Ding, D., Wang, J., Mao, J., Kang, L., & Cao, L. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149941 · Cited by 5
Photothermal nano-agents: an innovative trident weapon for accurate and effective treatment of alzheimer’s disease
Chen, J., Zhang, X., Sun, J., Zhi, Y., Xie, Z., Guan, Y., Zhang, Z., & Wu, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03709-z · Cited by 7
Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases
Chen, Y., Sun, X., Xi, Y., Luo, Z., Lai, H., Zhu, D., Zhang, Y., Xu, F., Li, J., Zhou, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.10.016 · Cited by 9
Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview
Cerdán-Centeno, K. T., González-Soto, A. Y., Lares-López, V., Sánchez-Vázquez, L. D., Tapia-Estrada, H. R., Túnez, I., López-Goerne, T. M., Tinkov, A. A., Aschner, M., & Santamarı́a, A. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05802-2 · Cited by 5
Medicinal chemistry strategies to breach the blood–brain barrier: structural design principles for brain-targeted therapeutics
Gupta, H. K., Jangra, J., Ramesh, V. K., Mahindru, I., & Kumar, R. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104673 · Cited by 6
Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis
Duan, Y., Deng, Y., Tang, F., & Li, J. (2024) · Aging · doi:10.18632/aging.205692 · Cited by 5
Electroacupuncture Serum Protects against Blood-brain Barrier Damage after Ischemic Stroke by Regulating Pericytes in vitro
Zhang, H., Lyv, H., Feng, Y., & Peng, Y. (2024) · Current Neurovascular Research · doi:10.2174/0115672026361204241115112340 · Cited by 5
Biological mechanisms and immunotherapy of brain metastases in non-small cell lung cancer
Jiang, S., Guo, F., & Li, L. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189320 · Cited by 6
Simultaneous determination of fenthion and its metabolites in a case of fenthion self-poisoning
Nishio, T., Toukairin, Y., Hoshi, T., Arai, T., & Nogami, M. (2023) · Legal Medicine · doi:10.1016/j.legalmed.2023.102323 · Cited by 5
Advances in modeling permeability and selectivity of the blood-brain barrier using microfluidics
Sun, J., & Song, S. (2024) · Microfluidics and Nanofluidics · doi:10.1007/s10404-024-02741-z · Cited by 5
Microglia and Systemic Immunity
Jucá, P. M., Duque, É. D. A., Covre, L. H. H., Albernaz-Mariano, K. A., & Munhoz, C. D. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_16 · Cited by 6
Pathogenic Crosstalk Between the Peripheral and Central Nervous System in Rheumatic Diseases: Emerging Evidence and Clinical Implications
Paroli, M., & Sirinian, M. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136036 · Cited by 7
Emerging anti-inflammatory nanosystems targeted to the brain
Mahanta, A. K., Gothwal, A., Chaulagain, B., Muolokwu, C. E., Tagoe, B., Lamsal, B., Belin, M. A. F., & Singh, J. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2552103 · Cited by 4
Engineering vascularized brain tumor organoids: bridging the gap between models and reality
Hariri, A., Zarepour, A., Khosravi, A., Mirian, M., Iravani, S., & Zarrabi, A. (2025) · Biomedical Microdevices · doi:10.1007/s10544-025-00773-y · Cited by 4
Perfluorocarbon nanotechnologies for blood-brain barrier modulation: Enhancing drug delivery and neuroprotection
Mahdi, E., Alalikhan, A., Salman, H., Ameen, M. A., Abbass, Z. H., Bemidinezhad, A., & Soukhtanloo, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152843 · Cited by 5
MolCL-SP: a multimodal contrastive learning framework with non-overlapping substructure perturbations for molecular property prediction
Luo, Y., & Deng, L. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf507 · Cited by 4
The elevated plasma levels of Claudin-5 are associated with peripheral inflammatory activity in patients with major depressive disorder
Wu, L., Wu, F., Li, M., Liu, Y., Wang, S., Guo, S., Liu, S. Q., Jiang, X., Zhou, Y., & Kong, L. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120988 · Cited by 4
Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis
Shi, Y., Tao, L., Shi, C., Yao, B., Xiong, B., & Zhang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1628503 · Cited by 4
Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier physiology in Friedreich’s ataxia
Smith, F. M., & Kosman, D. J. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1299201 · Cited by 4
Acute brain injury and nanomedicine: sex as a biological variable
Simmons, A., Mihalek, O., Nelson, H. A. B., Sirianni, R. W., & Stabenfeldt, S. E. (2024) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2024.1348165 · Cited by 4
Thou shalt not pass - arachnid venom peptides interacting with biological membranes
Wang, Y., Guo, S., Jee, K. F., & Herzig, V. (2024) · Frontiers in Arachnid Science · doi:10.3389/frchs.2024.1490313 · Cited by 4
Correlations between SHBG, Sex Hormones, Inflammation, and Neurocognitive Decline in Alzheimer's Disease: A Retrospective Study
Jin, J., Lü, L., Hua, K., Fang, L., Li, X., & Li, W. (2024) · Current Alzheimer Research · doi:10.2174/0115672050341904241111082935 · Cited by 5
Log BB Prediction Models Using TLC and HPLC Retention Values as Protein Affinity Data
Wanat, K., Michalak, K., & Brzezińska, E. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121534 · Cited by 4
Alfalfa (Medicago sativa) and neurodegeneration: mechanistic insights into oxidative stress, inflammation, and neuronal survival pathways
Pal, A., Bhardwaj, V., Goel, F., & Garg, V. K. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10840-5 · Cited by 4
A Pore Forming Toxin-like Protein Derived from Chinese Red Belly Toad Bombina maxima Triggers the Pyroptosis of Hippomal Neural Cells and Impairs the Cognitive Ability of Mice
Ye, Q., Wang, Q., Lee, W., Xiang, Y., Yuan, J., Zhang, Y., & Guo, X. (2023) · Toxins · doi:10.3390/toxins15030191 · Cited by 4
Unveiling the regulatory role of miRNAs in stroke pathophysiology and diagnosis
Abdel‐Reheim, M. A., Nomier, Y., Zaki, M. B., Abulsoud, A. I., Mohammed, O. A., Rashad, A. A., Oraby, M. A., Elballal, M. S., Tabaa, M. M. E., Elazazy, O. E., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155085 · Cited by 4
Endothelial Unfolded Protein Response‐Mediated Cytoskeletal Effects
Folahan, J. T., Fakir, S., & Barabutis, N. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.70007 · Cited by 4
Deubiquitinating enzymes at the crossroads of blood–brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions
Munavar-K, F., & Lenka, N. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2504738 · Cited by 5
What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease?
Brutkiewicz, R. R., Cao, W., Morgan, D., Reis, R. S. D., Suryadevara, V., Willette, A. A., Willette, S. A., Wyatt-Johnson, S. K., & Duggan, M. R. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.009 · Cited by 3
Protective Effects of Extracts from Green Leaves and Rhizomes of Posidonia oceanica (L.) Delile on an In Vitro Model of the Human Blood–Brain Barrier
Abruscato, G., Mauro, M., Boucau, M., Arizza, V., Vazzana, M., Dehouck, L., Gosselet, F., Luparello, C., & Candela, P. (2025) · Biology · doi:10.3390/biology14060699 · Cited by 3
The influence of diet, age, and obesity on hypothalamic omega-3 fatty acid transporter MFSD2a
Cunha, C. V. A., Oharomari, L. K., de Lima, J. B., de Paula, L. M., Katashima, C. K., Rios, T. D. S., Meneguelli, T. S., Pinto, A. P., Buoro, D. H. T., Carneiro, F. D. S., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116906 · Cited by 3
The Role of the human microbiome in neurodegenerative diseases: A Perspective
Mukherjea, N., Khandelwal, A., Saluja, R., & Kalra, N. (2025) · Current Genetics · doi:10.1007/s00294-025-01319-8 · Cited by 3
Key Challenges and Optimization Practices for Non-clinical Evaluation of AAV based Gene Therapy for Central Nervous System Disease
Dou, D., Lu, J., Chen, X., & Zhang, X. (2025) · Pharmaceutical Research · doi:10.1007/s11095-025-03931-2 · Cited by 4
Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice
Basu, B., Breese, N. M., Lombardi, S., Wang, H. M., Li, X., Tiburcio, D., Niemasz, Z., Beyer, S. E., Dean, L. E., Marek, R. F., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03466-x · Cited by 3
Inflammation-Associated Mechanisms of Blood–Brain Barrier Disruption and Depression Pathogenesis in People with and Without HIV
Hills, C., Hernandez, C. A., Gabbay, V., & Berman, J. W. (2026) · Cells · doi:10.3390/cells15050399 · Cited by 3
Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy
Carrillo, C., Belecky‐Adams, T. L., & Nader, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1771836 · Cited by 4
A Age Related Vascular Senescence: Mystery of Blood-brain Barrier Dysfunction in Neurodegeneration
Behl, T., Jayabalan, K., Ballal, S., Sahoo, S., Chellammal, H. S. J., Gulati, M., Anand, K., Jha, S. K., & Gasmi, A. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05984-9 · Cited by 3
Studies on the Comparative Response of Fibers Obtained from the Pastazzo of Citrus bergamia and Cladodes of Opuntia ficus-indica on In Vitro Model of Neuroinflammation
Maiuolo, J., Liuzzi, F., Spagnoletta, A., Oppedisano, F., Macrì, R., Scarano, F., Caminiti, R., Nucera, S., Serra, M. D. R., Palma, E., et al. (2024) · Plants · doi:10.3390/plants13152123 · Cited by 3
Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes
Mohammadiaria, M., Bianco, M., Balena, A., Andriani, M. S., Montinaro, C., Spagnola, B., Pisano, F., Pisanello, F., & Vittorio, M. D. (2024) · Neurophotonics · doi:10.1117/1.nph.11.s1.s11514 · Cited by 3
Pollutant distribution in vertebrates across scales: Organs, cells, and organelles
Ren, B., Zhao, Y., Wang, X., Wang, M., Wang, Y., Li, X., & Fan, W. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126680 · Cited by 3
Self-citation
The Streptococcus agalactiae LytSR two-component regulatory system promotes vaginal colonization and virulence in vivo
AlQadeeb, H., Baltazar, M., Cazares, A., Poonpanichakul, T., Kjos, M., French, N., Kadioglu, A., & O’Brien, M. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01970-24 · Cited by 3
Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit
Lavekar, S. S., Hughes, J. M., Gomes, C., Huang, K.-C., Harkin, J., Canfield, S. G., & Meyer, J. S. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00593-x · Cited by 3
IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemary methanolic extract
El-Sheikh, A. A., Abd-Almotaleb, N. A., Ahmed, M. M., & Khayal, E. E.-S. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101935 · Cited by 7
Negative Association of Cognitive Performance With Blood Serum Neurotoxicity and Its Modulation by Human Herpes Virus 5 (HHV5) Seropositivity in Healthy Women
James, L. M., Tsilibary, E.-P. C., Wanberg, E. J., & Georgopoulos, A. P. (2024) · Neuroscience Insights · doi:10.1177/26331055241258436 · Cited by 2
Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System
Sethumadhavan, V., Guleria, M., Kumar, P., Bhowmick, M., Bhowmick, P., Ashique, S., Husain, I., & Pal, R. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249305383240705045921 · Cited by 2
In silico Assessment of Phytochemicals from Selected Plants as Prospective TGF‐β1 Inhibitors for Prostate Cancer Therapy
Ishabiyi, F. O., Omotosho‐Sanni, R. Y., Baammi, S., Bourhia, M., Shazly, G. A., Ibenmoussa, S., & Umar, H. I. (2024) · ChemistrySelect · doi:10.1002/slct.202401413 · Cited by 2
Fe3O4@SiO2-NH2 Functionalized Nanoparticles as a Potential Contrast Agent in Magnetic Resonance
Betin-Bohórquez, B. S., Gaona, I. M. S., Vargas, C. A. P., Vargas-Sánchez, K., Amaya, J., Losada-Barragán, M., Rincón-Ortiz, R. J., & Pérez, D. L. (2024) · Condensed Matter · doi:10.3390/condmat9040049 · Cited by 2
Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model
Weiß, E., Pauletti, A., Egilmez, A., & Bröer, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-81925-7 · Cited by 2
Hippocampal syndrome secondary to tuberculosis: From neuroinflammation to neurodegeneration
Torres, J. C. M., Durán-Hernández, N., Choreño-Parra, J. A., Sánchez-Garibay, C., & Salinas‐Lara, C. (2025) · Tuberculosis · doi:10.1016/j.tube.2025.102653 · Cited by 3
Carbohydrate biopolymer-based nanocomposites as strategic modality in addressing brain cancer
Satapathy, B. S., Mishra, A., & Nayak, A. K. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146482 · Cited by 2
Concept of theranostic Exosomes: Potential diagnostic and therapeutic approaches for brain cancer therapy
Wagh, B., Verma, N., Setia, A., Rani, K., Randhave, N. V., Kumar, V., Vaishali, Malik, A. K., & Muthu, M. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107340 · Cited by 2
Synergistic Neuroprotection of Artesunate and Tetramethylpyrazine in Ischemic Stroke, Mechanisms of Blood–Brain Barrier Preservation
Liang, Y., Deng, S., Li, Y., Qu, S., Liu, C., Wang, L., Chen, L., Liu, T., & Li, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167979 · Cited by 2
Material considerations for delivering therapeutics across the blood–brain barrier
Zoba, A. N., & Tringides, C. M. (2025) · APL Materials · doi:10.1063/5.0284305 · Cited by 2
Research progress on the correlation between biological rhythms and the blood-brain barrier after ischemic stroke
Liao, Y., Luo, L., Ma, Q., Gao, X., Chen, Y., Yan, S., He, M., Liu, L., & Zhou, D. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1627172 · Cited by 3
Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium
Mauser, H. D., Keyzer, T. E., Surma, J. M., Alexander, N. G., Cutts, W. D., Hathcock, S. F., Lackey, K., Lam, D. W., Thornton, J. A., Vollmuth, N., et al. (2025) · Virulence · doi:10.1080/21505594.2025.2564281 · Cited by 2
Ultrasound actuated neuropeptide delivery across cerebrovascular interfaces using phase-change peptide nanoemulsions
Kim, I., Griffith, K. R., Brockway, D. F., Crowley, N. A., & Medina, S. H. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.139466 · Cited by 2
Organ transplantation in brain-dead patients: Integrating immunology, life support, case studies, legal, and ethical considerations for future therapeutics
Ciarlini, C. G., & Fischer, K. (2025) · Transplantation Reports · doi:10.1016/j.tpr.2025.100187 · Cited by 2
Immunity in Rodent Models of Stress
Hachenberg, S., Russo, S. J., & Cathomas, F. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.11.007 · Cited by 4
Imaging Neuroimmune Dysfunction: From TSPO to Emerging Positron Emission Tomography Targets
Bonomi, R. E., Raval, N. R., Hillmer, A. T., & Cosgrove, K. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.11.010 · Cited by 3
Neuroinflammation and Pediatric Chronic Pain – A Review
Rogan, H., Smith, A., Farr, G., & Lebel, A. (2026) · Current Pain and Headache Reports · doi:10.1007/s11916-025-01445-5 · Cited by 2
Breaking barriers and beyond: Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfaces
Hui, L., Qian, D., Guo, Y., Yi, Z., Guo, T., Li, A., & Wu, Y. (2026) · Virologica Sinica · doi:10.1016/j.virs.2026.03.014 · Cited by 2
Recent advances in self-assembled nanoplatforms for central nervous system disorders therapy: Design principles, multifunctional strategies, and therapeutic applications
Zhang, W., Wan, L., Chen, Y., Li, S., & Mao, Y. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103083 · Cited by 3
BDNF/TrkB Signaling in the Brain–Kidney Axis Under Functional Stress
Beknazarova, A., Kuvaeva, V., Baltin, M. E., Mutig, K., & Bobylev, A. G. (2026) · Biology · doi:10.3390/biology15090696 · Cited by 2
Global Clock Coordination by the Brain Clock in the Suprachiasmatic Nucleus Through Relay and Amplification of Diffusible and Neural Signaling
Silver, R., Yao, Y., & Myung, J. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70097 · Cited by 2
Targeting the Reticuloendothelial System for the Management of Neurological Disorders
Prakash, A., Malviya, R., & Sridhar, S. B. (2025) · Current Drug Therapy · doi:10.2174/0115748855410983250827042543 · Cited by 2
Gestational hypoxia increases brain-blood barrier permeability in the neonatal cerebral cortex of Guinea pigs
Figueroa, E. G., Paz, A. A., Jiménez, T. A., Meza-Vilches, O., Daniel Palma, C., Muños-Guzman, F., Beñaldo, F., Herrera, E. A., & González‐Candia, A. (2025) · Pediatric Research · doi:10.1038/s41390-025-04345-x · Cited by 2
Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex
Merced‐Nieves, F. M., Eitenbichler, S., Goldson, B., Zhang, X., Klein, D. N., Enlow, M. B., Curtin, P. C. P., Wright, R. O., & Wright, R. J. (2023) · Child Development · doi:10.1111/cdev.13997 · Cited by 2
Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable –implications for blood-brain barrier integrity in Friedreich’s AtaxiaPreprint
Smith, F. M., & Kosman, D. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.09.527936 · Cited by 2
Breaking through the blood-brain barrier for different kinds of drugs: challenges, solutions, and perspectives
She, P., Ao, X., Zhan, X., Zhou, W., Cheng, Y., Yang, H. J., Wu, S., Zhang, X., Peng, W., & Wang, J. (2024) · BME Horizon · doi:10.70401/bmeh.2024.124 · Cited by 2
Glioblastoma multiforme tedavisindeki birincil engel: Kan beyin bariyeri
Yazıcı, E., Gezen, A., Oylumlu, E., & Tanrιöver, G. (2025) · Ege Tıp Dergisi · doi:10.19161/etd.1621826 · Cited by 1

Authors: Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X.
Affiliations: Zhejiang Chinese Medical University (CN)
Corresponding author: Lin, Xianming
ORCID: Zhao, Yibin
Ren, Li
Lin, Yubo
Ma, Congcong
Lin, Xianming
Venue: Brain Research
Publisher: Elsevier BV
Published: 2022-08
Volume: 1788
Pages: 147937
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2022.147937
OpenAlex: W4280550830
Cited by: 291
References: 222
Citations by year: 2026: 68 · 2025: 112 · 2024: 72 · 2023: 36 · 2022: 3
FWCI: 19.57
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Brain Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (82174502)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: blood-brain barrier, blood-brain barrier permeability, tight junction proteins, adherens junctions, junctional proteins, solute carrier transporters, ABC transporters, ion transporters, transcytosis, blood-brain barrier disruption, inflammation, brain drug delivery, therapeutic target
MeSH terms: Biological Transport, Blood-Brain Barrier, Brain, Humans, Permeability, Tight Junctions, Tight Junction Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Factors influencing the blood-brain barrier permeability

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks