Cited by 203Nerve injury and regenerationClinical Laboratory Practices and Quality ControlBiosimilars and Bioanalytical Methods

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Measurements of brain-derived neurotrophic factor. Methodological aspects and demographical data.

Trajkovska, Viktorija, Marcussen, Anders B., Vinberg, Maj, Hartvig, Per, Aznar, Susana, Knudsen, Gitte M.·2007·Brain Research Bulletin

DOI 10.1016/j.brainresbull.2007.03.009

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Abstract

Although numerous studies have dealt with changes in blood brain-derived neurotrophic factor (BDNF), methodological issues about BDNF measurements have only been incompletely resolved. We validated BDNF ELISA with respect to accuracy, reproducibility and the effect of storage and repeated freezing cycles on BDNF concentrations. Additionally, the effect of demographic characteristics in healthy subjects on BDNF was verified. Whole blood and serum was collected from 206 healthy subjects and a subgroup was genotyped for BDNF Val66Met polymorphism. The effect of age, gender, BDNF genotype and thrombocyte count on whole blood BDNF was assessed. The BDNF ELISA measurement was accurate, 91.6+/-3.0%, and showed high reproducibility, whereas inter-assay and intra-subject variations were modest, 8.4+/-5.2% and 17.5+/-14.1%, respectively. Storage of whole blood samples at 4 degrees C significantly decreased BDNF concentration, while repeated freezing cycles and storage at -20 degrees C was without any effect. Storage at -20 degrees C of serum, but not whole blood, was associated with a significant decrease in BDNF concentration. Women had significantly higher whole blood BDNF concentrations than men (18.6+/-1.3 ng/ml versus 16.5+/-1.4 ng/ml), and showed a right-skewed BDNF concentration distribution. No association between whole blood BDNF concentrations and thrombocyte count, age, or BDNF genotype was found. In conclusion, the BDNF ELISA assay determines whole blood BDNF accurately and with high reproducibility. Female gender is associated with higher whole blood BDNF concentrations whereas age, thrombocyte count and BDNF Val66Met polymorphism were un-associated.

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Authors: Trajkovska, V., Marcussen, A. B., Vinberg, M., Hartvig, P., Aznar, S., & Knudsen, G. M.
Affiliations: Copenhagen University Hospital (DK)
Corresponding author: Trajkovska, Viktorija
ORCID: Vinberg, Maj
Aznar, Susana
Knudsen, Gitte M.
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2007-06
Volume: 73
Issue: 1-3
Pages: 143-149
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/j.brainresbull.2007.03.009
OpenAlex: W1969534686
Cited by: 203
References: 50
Citations by year: 2026: 7 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 12 · 2018: 18 · 2017: 11 · 2016: 13 · 2015: 15 · 2014: 13 · 2013: 10 · 2012: 14
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Life Sciences › Immunology and Microbiology › Immunology › Biosimilars and Bioanalytical Methods
Keywords: brain-derived neurotrophic factor, sample storage effects, serum BDNF, BDNF Val66Met polymorphism, sex differences, healthy volunteers, platelet count, age effects
MeSH terms: Adult, Aged, Aging, DNA, Enzyme-Linked Immunosorbent Assay, Female, Freezing, Genotype, Humans, Male, Middle Aged, Platelet Count, Polymorphism, Genetic, Reference Standards, Sex Characteristics, Specimen Handling, Reproducibility of Results, Brain-Derived Neurotrophic Factor

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Measurements of brain-derived neurotrophic factor. Methodological aspects and demographical data.

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