The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
Abstract
MicroRNAs (miRNAs) are short noncoding regulatory RNA molecules that modulate protein expression by inhibiting mRNA translation or promoting mRNA degradation. However, little is understood about the roles of miRNAs in Alzheimer's disease. During a research for miRNAs that are differentially expressed in cerebral cortex of APPswe/PSDeltaE9 mice (a model for Alzheimer's disease) and age-matched controls, one candidate miRNA that is relatively highly expressed, miR-34a, was studied further because sequence analysis suggested a likely interaction with the 3'-untranslated region of bcl2 mRNA. We show that the expression of miR-34a is inversely correlated with the protein level of bcl2 in APPswe/PSDeltaE9 mice and age-matched controls, and miR-34a expression directly inhibits bcl2 translation in SH-SY5Y cells. No effect on bcl2 mRNA level was observed. Western blot analysis of active caspase-3 showed higher levels in APPswe/PSDeltaE9 mice and stable transfecant cell line of miR-34a than in controls. Consistently, miR-34a knockdown through antisense LNA oligonucleotides increased the level of bcl2 protein in SH-SY5Y cells, which was accompanied by a decrease of active caspase-3. These findings suggested that bcl2 is an important functional target for miR-34a, and the abnormal expression of miR-34a may contribute to the pathogenesis of Alzheimer's disease, at least in part by affecting the expression of bcl2.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, miR-106b levels were significantly decreased in brains of AD cases and AD mouse model (Hebert et al., 2009; Wang et al., 2011; Wang et al., 2009).”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Wang et al., 2009
Citations
Cites
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,365
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Bommer, G. T., Gerin, I., Feng, Y., Kaczorowski, A. J., Kuick, R. D., Love, R. E., Zhai, Y., Giordano, T. J., Qin, Z. S., Moore, B. B., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.068 · Cited by 1,135
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040
Kosik, K. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2037 · Cited by 834
Short RNAs Repress Translation after Initiation in Mammalian Cells
Petersen, C. P., Bordeleau, M.-È., Pelletier, J., & Sharp, P. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.031 · Cited by 824
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
Welch, C., Chen, Y., & Stallings, R. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210293 · Cited by 805
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
Lodygin, D., Tarasov, V., Epanchintsev, A., Berking, C., Knyazeva, T., Koerner, H., Knyazev, P. G., Diebold, J., & Hermeking, H. (2008) · Cell Cycle · doi:10.4161/cc.7.16.6533 · Cited by 795
Cited by
Sorted by citations
Items 101–200 of 271
Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Meffre, D., Grenier, J., Bernard, S., Courtin, F., Dudev, T., Shackleford, G., Jafarian-Tehrani, M., & Massaad, C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1378-1 · Cited by 66
The regulation of exosome function in the CNS: implications for neurodegeneration
Properzi, F., Ferroni, E., Poleggi, A., & Vinci, R. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14204 · Cited by 62
Decoding the non-coding RNAs in Alzheimer’s disease
Schönrock, N., & Götz, J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1125-z · Cited by 61
Tuna, M., Machado, A. S., & Călin, G. A. (2015) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22332 · Cited by 61
MiR-7 Promotes Epithelial Cell Transformation by Targeting the Tumor Suppressor KLF4
Meza‐Sosa, K. F., Pérez-García, E. I., Camacho‐Concha, N., López-Gutiérrez, O., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103987 · Cited by 60
Zhang, W., Zhang, W., Li, Z., Hao, J., Zhang, Z., Liu, L., Mao, N., Miao, J., & Zhang, L. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.012 · Cited by 60
Self-citationDysregulation of energy metabolism in Alzheimer's disease
Yuan, Y., Zhao, G., & Zhao, Y. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12800-8 · Cited by 74
The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease
Zhao, J., Yue, D., Zhou, Y., Li, J., Wang, H., Guo, M., Xu, H., Chen, C., Zhang, J., & Xu, L. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00342 · Cited by 59
Giuliani, A., Cirilli, I., Prattichizzo, F., Mensa’, E., Fulgenzi, G., Sabbatinelli, J., Graciotti, L., Olivieri, F., Procopio, A. D., Tiano, L., et al. (2018) · Aging · doi:10.18632/aging.101591 · Cited by 58
Mollinari, C., Racaniello, M., Berry, A., Pieri, M., de Stefano, M. C., Cardinale, A., Zona, C., Cirulli, F., Garaci, E., & Merlo, D. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.589 · Cited by 56
miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models
Sun, X., Wu, Y., Gu, M., & Zhang, Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.028 · Cited by 56
Caria, A. C. I., Nonaka, C. K. V., Cavalcante, B. R. R., Sousa, R. A. L. D., Aras, R., & Souza, B. S. D. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144977 · Cited by 57
Wang, Q., Ge, X., Zhang, J., & Chen, L. (2020) · Aging · doi:10.18632/aging.104079 · Cited by 55
Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00133 · Cited by 53
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders
Chan, A. W. S., & Kocerha, J. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00082 · Cited by 54
Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease.
Liu, Q. Y., Vera-Chang, M. N., Lei, J. X., Koukiekolo, R., Smith, B., Zhang, D., & Ghribi, O. (2014) · Europe PMC (PubMed Central) · Cited by 53
MicroRNAs dysregulation in epilepsy
Li, M., Li, X., Zheng, X., Yu, J., & Tan, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.049 · Cited by 51
Leng, Y., Fessler, E. B., & Chuang, D. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000429 · Cited by 51
Zhu, L., Lin, M., Ma, J., Liu, W., Gao, L., Wei, S., Xue, Y., & Shang, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14214 · Cited by 52
Biomarkers in Alzheimer’s Disease Analysis by Mass Spectrometry-Based Proteomics
Liu, Y., Qing, H., & Deng, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15057865 · Cited by 51
Self-citationMiR-9-5p inhibits mitochondrial damage and oxidative stress in AD cell models by targeting GSK-3β
Liu, J., Zuo, X., Han, J., Dai, Q., Xu, H., Liu, Y., & Cui, S. (2020) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2020.1797469 · Cited by 50
Self-citationRole of miR‐34c in ketamine‐induced neurotoxicity in neonatal mice hippocampus
Cao, S., Tian, J., Chen, S., Zhang, X., & Zhang, Y. (2014) · Cell Biology International · doi:10.1002/cbin.10349 · Cited by 48
Hunsberger, J. G., Fessler, E. B., Chibane, F. L., Leng, Y., Maric, D., ELKAHLOUN, A. G., & Chuang, D. (2013) · Europe PMC (PubMed Central) · Cited by 48
Liu, D., Zhao, D., Zhao, Y., Wang, Y., Zhao, Y., & Wen, C. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503145207 · Cited by 49
miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer׳s disease
Zong, Y., Yü, P., Cheng, H., Wang, H., Wang, X., Liang, C., Zhu, H., Qin, Y., & Qin, C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.022 · Cited by 47
Self-citationMaldonado, I. C., Atienza, M., Sanchez-Espinosa, M. P., & Cantero, J. L. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy323 · Cited by 49
Deciphering the Function and Regulation of microRNAs in Alzheimer’s Disease and Parkinson’s Disease
Qiu, L., Zhang, W., Tan, E., & Zeng, L. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500149w · Cited by 45
Zhao, Y., Jaber, V. R., LeBeauf, A., Sharfman, N. M., & Lukiw, W. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00028 · Cited by 44
The Role of microRNAs in Drug Addiction
Pietrzykowski, A. Z. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91001-5 · Cited by 44
Bazrgar, M., Khodabakhsh, P., Prudencio, M., Mohagheghi, F., & Ahmadiani, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105805 · Cited by 45
Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121122910 · Cited by 42
miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy
Bielefeld, P., Mooney, C., Henshall, D. C., & Fitzsimons, C. P. (2016) · Brain Plasticity · doi:10.3233/bpl-160036 · Cited by 41
Epigenetics in Parkinson’s and Alzheimer’s Diseases
Marques, S., & Outeiro, T. F. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_22 · Cited by 38
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150451 · Cited by 29
Navarro, A., Clot, G., Prieto, M., Royo, C., Vegliante, M. C., Amador, V., Hartmann, E., Salaverría, I., Beà, S., Martín-Subero, J. I., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3077 · Cited by 40
Yuan, J., Wu, Y., Li, L., & Liu, C. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02134-5 · Cited by 42
Rasheed, M., Asghar, R., Firdoos, S., Ahmad, N., Nazir, A., Ullah, K. M., Li, N., Zhuang, F., Chen, Z., & Deng, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031294 · Cited by 41
Jęśko, H. M., Wencel, P. L., Lukiw, W. J., & Strosznajder, R. P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1040-x · Cited by 39
Yu, C. D., Miao, W. H., Zhang, Y. Y., Zou, M., & Yan, X. (2018) · Bone and Joint Research · doi:10.1302/2046-3758.76.bjr-2017-0138.r1 · Cited by 39
miRNAs Identify Shared Pathways in Alzheimer’s and Parkinson’s Diseases
Sadlon, A., Takousis, P., Alexopoulos, P., Εvangelou, Ε., Prokopenko, I., & Perneczky, R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.006 · Cited by 40
Dombkowski, A. A., Batista, C. E. A., Cukovic, D., Carruthers, N. J., Ranganathan, R., Shukla, U., Stemmer, P. M., Chugani, H. T., & Chugani, D. C. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu276 · Cited by 38
miR‐34a/BCL‐2 signaling axis contributes to apoptosis in MPP+‐induced SH‐SY5Y cells
Shanesazzade, Z., Peymani, M., Ghaedi, K., & Nasr‐Esfahani, M. H. (2018) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.469 · Cited by 38
Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging
Singh, T., & Yadav, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101068 · Cited by 41
Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
Alimoradi, N., Firouzabadi, N., & Fatehi, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111662 · Cited by 39
Cama, A., Verginelli, F., Lotti, L. V., Napolitano, F., Morgano, A., D’Orazio, A., Vacca, M., Perconti, S., Pepe, F., Romani, F., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1165-y · Cited by 38
Jiang, X., Du, B., Chen, J., Liu, L., Shao, W.-B., & Song, J. (2014) · PubMed Central · Cited by 36
Sin, O., & Nollen, E. A. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1985-0 · Cited by 43
miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline
Kao, Y.-C., Wang, I., & Tsai, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082323 · Cited by 39
Zhang, Y., & Kiryu, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-34021-1 · Cited by 37
Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00116 · Cited by 34
Roh, Y. H., Sim, S. J., Cho, I., Choi, N., & Bong, K. W. (2016) · The Analyst · doi:10.1039/c6an00188b · Cited by 34
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Codocedo, J. F., Ríos, J. A., Godoy, J. A., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9201-7 · Cited by 34
Rizzuti, M., Melzi, V., Gagliardi, D., Resnati, D., Meneri, M., Dioni, L., Masrori, P., Hersmus, N., Poesen, K., Locatelli, M., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04217-1 · Cited by 34
Schmidt, U., Keck, M. E., & Buell, D. R. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.014 · Cited by 33
TREM2 signaling, miRNA-34a and the extinction of phagocytosis
Zhao, Y., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00131 · Cited by 33
HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3)
Santerre, M., Bagashev, A., Gorecki, L., Lysek, K. Z., Wang, Y., Shrestha, J., Carpio‐Cano, F. D., Mukerjee, R., & Sawaya, B. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003744 · Cited by 31
Hill, J. M., Pogue, A. I., & Lukiw, W. J. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00232 · Cited by 31
Upregulation of MicroRNA-34a Sensitizes Ovarian Cancer Cells to Resveratrol by Targeting Bcl-2
Yao, S., Gao, M., Wang, Z., Wang, W., Zhan, L., & Wei, B. (2021) · Yonsei Medical Journal · doi:10.3349/ymj.2021.62.8.691 · Cited by 32
Bazrgar, M., Khodabakhsh, P., Dargahi, L., Mohagheghi, F., & Ahmadiani, A. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111812 · Cited by 32
Wu, K. H., Xiao, Q., Yu, Y., Xu, J., Zhang, F., Liu, C.-M., Zhang, Z.-M., Lu, Y.-Q., & Huang, N. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.11.015 · Cited by 32
Barbato, C., Giacovazzo, G., Albiero, F., Scardigli, R., Scopa, C., Ciotti, M. T., Strimpakos, G., Coccurello, R., & Ruberti, F. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01957-8 · Cited by 29
Micheli, F., Palermo, R., Talora, C., Ferretti, E., Vacca, A., & Napolitano, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.049 · Cited by 30
MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee
Freitas, F. C. D. P., Pires, C. V., Claudianos, C., Cristino, A. S., & Simões, Z. L. P. (2017) · Scientific Reports · doi:10.1038/srep40884 · Cited by 30
Micro RNA s as regulators of cell death mechanisms in amyotrophic lateral sclerosis
Gagliardi, D., Comi, G. P., Bresolin, N., & Corti, S. P. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13976 · Cited by 31
Abdelmaksoud, N. M., Sallam, A.-A. M., Abulsoud, A. I., El‐Dakroury, W. A., Mageed, S. S. A., AL‐Noshokaty, T. M., Elrebehy, M. A., Elshaer, S. S., Mahmoud, N. A., Fathi, D., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155007 · Cited by 30
Gene regulation in adult neural stem cells. Current challenges and possible applications
Encinas, J. M., & Fitzsimons, C. P. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.016 · Cited by 32
Kapoor, R., Arora, S., Ponia, S. S., Kumar, B., Maddika, S., & Banerjea, A. C. (2015) · Biochemical Journal · doi:10.1042/bj20150700 · Cited by 31
Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29
Rivera‐Barahona, A., Fulgencio-Covián, A., Pérez‐Cerdá, C., Ramos, R., Barry, M. A., Ugarte, M., Pérez, B., Richard, E., & Desviat, L. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-06420-8 · Cited by 29
Bazrgar, M., Khodabakhsh, P., Mohagheghi, F., Prudencio, M., & Ahmadiani, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104729 · Cited by 29
How Does p73 Cause Neuronal Defects?
Niklison-Chirou, M. V., Killick, R., Knight, R. A., Nicotera, P., Melino, G., & Agostini, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9381-1 · Cited by 29
Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs
Medrano-Jiménez, E., Meza‐Sosa, K. F., Aragon, J. A. U., Secundino, I., Pedraza-Alva, G., & Pérez-Martínez, L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1021-531r · Cited by 28
Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease
Pereira, R. L., Oliveira, D., Pêgo, A. P., Santos, S. D., & Moreira, F. T. C. (2023) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2023.108553 · Cited by 27
miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells
Xu, B., Mao, Z., Ji, X., Yao, M., Chen, M., Zhang, X., Hang, B., Liu, Y., Tang, W., Tang, Q., et al. (2015) · Scientific Reports · doi:10.1038/srep12938 · Cited by 27
Self-citationYang, K., Feng, S., Ren, J. T., & Zhou, W. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29047 · Cited by 27
Circulating microRNAs in Neurodegenerative Diseases
Grasso, M., Piscopo, P., Crestini, A., Confaloni, A., & Denti, M. A. (2015) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-0955-9_7 · Cited by 26
Li, W., Li, Z., Zhou, D., Zhang, X., Yan, J., & Huang, G. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.002 · Cited by 26
Sharma, M., Tanwar, A. K., Purohit, P. K., Pal, P., Kumar, D., Vaidya, S., Prajapati, S. K., Kumar, A., Dhama, N., Kumar, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105685 · Cited by 27
miR-34a induces spine damages via inhibiting synaptotagmin-1 in depression
Yi, L., Zhu, J., Dong, S., Li, C., Zhang, Q., Cheng, J., & Liu, Q. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100243 · Cited by 27
Sharma, M., Pal, P., & Gupta, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102483 · Cited by 28
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance
Behl, T., Kyada, A., Roopashree, R., Nathiya, D., Arya, R., Kumar, M., Khalid, M., Gulati, M., Sachdeva, M., Fareed, M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102556 · Cited by 31
Xie, Y., Yang, Y., Tang, C., Sheng, H. J., Jiang, Y.-H., Han, K., & Ding, L. (2014) · Clinical & Translational Oncology · doi:10.1007/s12094-014-1166-x · Cited by 25
An emerging role for microRNAs in sexually dimorphic neurobiological systems
Pak, T. R., Rao, Y. S., Prins, S. A., & Mott, N. N. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1227-y · Cited by 24
Qin, T., Prins, S., Groeneveld, G. J., van Westen, G. J. P., de Vries, H. E., Wong, Y. C., Bischoff, L. J. M., & de Lange, E. C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093158 · Cited by 24
MicroRNAs and Molecular Mechanisms of Neurodegeneration
Bicchi, I., Morena, F., Montesano, S., Polidoro, M., & Martino, S. (2013) · Genes · doi:10.3390/genes4020244 · Cited by 23
Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells
Li, L., Tu, Q., Deng, X., Xia, J., Hou, D., Guo, K., & Zi, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.01.034 · Cited by 23
Neault, M., Couteau, F., Bonneau, É., Guire, V. D., & Mallette, F. A. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.04.001 · Cited by 23
Liu, W., Li, L., Liu, S., Wang, Z., Kuang, H., Xia, Y., Tang, C., & Yin, D. (2019) · BioMed Research International · doi:10.1155/2019/7654798 · Cited by 23
Miao, J., Jing, J., Shao, Y.-X., & Sun, H.-C. (2020) · BMC Neuroscience · doi:10.1186/s12868-020-00579-z · Cited by 20
Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease
Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 22
Genome‐wide mi RNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide
Merkerová, M. D., Krejčík, Z., Beličková, M., Hruštincová, A., Kléma, J., Stara, E., Zemanová, Z., Michalova, K., Čermák, J., & Jonasova, A. T. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12458 · Cited by 23
Reinhardt, A., Feuillette, S., Cassar, M., Callens, C., Thomassin, H., Birman, S., Lecourtois, M., Antoniewski, C., & Tricoire, H. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00226 · Cited by 23
MicroRNAs in the pathophysiology of Alzheimer’s disease and Parkinson's disease: an overview
Khezri, M. R., Yousefi, K., Zolbanin, N. M., & Ghasemnejad‐Berenji, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02727-4 · Cited by 22
Cheng, Y., Gu, X., Yang, T., Wei, Q., Cao, B., Zhang, Y., Shang, H., & Chen, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1106497 · Cited by 23
The Potential Role of Dysregulated miRNAs in Alzheimer’s Disease Pathogenesis and Progression
Patel, A. A., Ganepola, G. A. P., Rutledge, J. R., & Chang, D. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181078 · Cited by 22
Preliminary study of hsa-miR-626 change in the cerebrospinal fluid of Parkinson’s disease patients
Qin, L., Tan, J., Zhang, H., Tang, J., Jiang, B., Shen, X., Tang, B., & Wang, C. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.08.082 · Cited by 21
From dysregulated microRNAs to structural alterations in the striatal region of METH-injected rats
Chavoshi, H., Boroujeni, M. E., Abdollahifar, M., Amini, A., Tehrani, A. M., Moghaddam, M. H., Norozian, M., Farahani, R. M., & Aliaghaei, A. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101854 · Cited by 21
Li, Q., Liu, T., Yang, S., & Zhang, Z. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2140427 · Cited by 21
Advances in miRNA research: Unraveling the complexities of gene regulation
Zheng, J., Zhang, G., & Ren, L. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70076 · Cited by 23
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
Wijesinghe, P., Xi, J., Cui, J. Z., Campbell, M., Pham, W. N., & Matsubara, J. A. (2023) · Life Science Alliance · doi:10.26508/lsa.202201757 · Cited by 20
Metadata
- Authors
- Wang, X., Liu, P., Zhu, H., Xu, Y., Ma, C., Dai, X., Huang, L., Liu, Y., Zhang, L., & Qin, C.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Qin, Chuan
- ORCID
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 80
- Issue
- 4-5
- Pages
- 268-273
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W1968383275
- Cited by
- 271
- References
- 29
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 15 · 2015: 24 · 2014: 23 · 2013: 21 · 2012: 17
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-34a, microRNA, Alzheimer's disease, Bcl-2, protein synthesis inhibition, 3' untranslated region, caspase-3, neuronal apoptosis, SH-SY5Y cells, cerebral cortex
- MeSH terms
- Alzheimer Disease, Animals, Cells, Cultured, Mice, Transgenic, Proto-Oncogene Proteins, Protein Biosynthesis, Blotting, Western, Amyloid beta-Peptides, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Microarray Analysis, Mice, Caspase 3, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
