Cited by 271MicroRNA in disease regulationAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

Wang, Xiaoying, Liu, Peng, Zhu, Hua, Xu, Yanfeng, Ma, Chunmei, Dai, Xiaowei, Huang, Lan, Liu, Yali, Zhang, Lianfeng, Qin, Chuan·2009·Brain Research Bulletin

DOI 10.1016/j.brainresbull.2009.08.006

Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are short noncoding regulatory RNA molecules that modulate protein expression by inhibiting mRNA translation or promoting mRNA degradation. However, little is understood about the roles of miRNAs in Alzheimer's disease. During a research for miRNAs that are differentially expressed in cerebral cortex of APPswe/PSDeltaE9 mice (a model for Alzheimer's disease) and age-matched controls, one candidate miRNA that is relatively highly expressed, miR-34a, was studied further because sequence analysis suggested a likely interaction with the 3'-untranslated region of bcl2 mRNA. We show that the expression of miR-34a is inversely correlated with the protein level of bcl2 in APPswe/PSDeltaE9 mice and age-matched controls, and miR-34a expression directly inhibits bcl2 translation in SH-SY5Y cells. No effect on bcl2 mRNA level was observed. Western blot analysis of active caspase-3 showed higher levels in APPswe/PSDeltaE9 mice and stable transfecant cell line of miR-34a than in controls. Consistently, miR-34a knockdown through antisense LNA oligonucleotides increased the level of bcl2 protein in SH-SY5Y cells, which was accompanied by a decrease of active caspase-3. These findings suggested that bcl2 is an important functional target for miR-34a, and the abnormal expression of miR-34a may contribute to the pathogenesis of Alzheimer's disease, at least in part by affecting the expression of bcl2.

Integrity signals

Registry

Crossref · 10.1016/j.brainresbull.2009.08.006

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,365
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Bommer, G. T., Gerin, I., Feng, Y., Kaczorowski, A. J., Kuick, R. D., Love, R. E., Zhai, Y., Giordano, T. J., Qin, Z. S., Moore, B. B., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.068 · Cited by 1,135
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040
The neuronal microRNA system
Kosik, K. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2037 · Cited by 834
Short RNAs Repress Translation after Initiation in Mammalian Cells
Petersen, C. P., Bordeleau, M.-È., Pelletier, J., & Sharp, P. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.031 · Cited by 824
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
Welch, C., Chen, Y., & Stallings, R. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210293 · Cited by 805
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
Lodygin, D., Tarasov, V., Epanchintsev, A., Berking, C., Knyazeva, T., Koerner, H., Knyazev, P. G., Diebold, J., & Hermeking, H. (2008) · Cell Cycle · doi:10.4161/cc.7.16.6533 · Cited by 795

Show all 29 references

Sorted by citations

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
Hsu, S., Tseng, Y., Shrestha, S., Lin, Y., Khaleel, A., Chou, C., Chu, C.-F., Huang, H., Lin, C.-M., Ho, S.-Y., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1266 · Cited by 1,044
Epigenetics and aging
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860
MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification
Wang, T., Shao, W., Huang, Z., Tang, H., Zhang, J., Ding, Z., & Huang, K. (2021) · Nature Communications · doi:10.1038/s41467-021-23774-w · Cited by 671
Alteration of the microRNA network during the progression of Alzheimer's disease
Lau, P., Bossers, K., Janky, R., Salta, E., Frigerio, C. S., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201974 · Cited by 474
Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis
Gong, J., Tong, Y., Zhang, H., Wang, K., Hu, T., Shan, G., Sun, J., & Guo, A. (2011) · Human Mutation · doi:10.1002/humu.21641 · Cited by 384
Physical Activity and Brain Health
Liegro, C. M. D., Schiera, G., Proia, P., & Liegro, I. D. (2019) · Genes · doi:10.3390/genes10090720 · Cited by 451
The p53/miR-34 axis in development and disease
Rokavec, M., Li, H., Jiang, L., & Hermeking, H. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju003 · Cited by 358
Molecular Basis of Familial and Sporadic Alzheimer's Disease
Dorszewska, J., Prendecki, M., Oczkowska, A., Dezor, M., & Kozubski, W. P. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314150501 · Cited by 340
miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model
Lee, S., Chu, K., Jung, K., Kim, J. H., Huh, J., Yoon, H., Park, D., Lim, J., Kim, J., Jeon, D., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23588 · Cited by 326
MicroRNAs in Alzheimer’s Disease
Wang, M., Qin, L., & Tang, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00153 · Cited by 312
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
Somel, M., Guo, S., Fu, N., Yan, Z., Hu, H. Y., Xu, Y., Yuan, Y., Ning, Z., Hu, Y., Menzel, C., et al. (2010) · Genome Research · doi:10.1101/gr.106849.110 · Cited by 297
Self-citation
Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Singh, S., & Singh, T. G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200207120949 · Cited by 307
De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease
Wong, H.-K. A., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., Vanderburg, C., & Krichevsky, A. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt164 · Cited by 271
Epigenetic changes during aging and their reprogramming potential
Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283
RNA-Seq and human complex diseases: recent accomplishments and future perspectives
Costa, V., Aprile, M., Esposito, R., & Ciccodicola, A. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.129 · Cited by 277
MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease
Kiko, T., Nakagawa, K., Tsuduki, T., Furukawa, K., Arai, H., & Miyazawa, T. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-130932 · Cited by 256
Non-coding RNAs with essential roles in neurodegenerative disorders
Salta, E., & Strooper, B. D. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70286-1 · Cited by 251
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Chiu, C., & Chuang, D. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.006 · Cited by 232
Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases
Wu, Y.-Y., & Kuo, H.-C. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00636-z · Cited by 213
MiR‐34a attenuates paclitaxel‐resistance of hormone‐refractory prostate cancer PC3 cells through direct and indirect mechanisms
Kojima, K., Fujita, Y., Nozawa, Y., Deguchi, T., & Ito, M. (2010) · The Prostate · doi:10.1002/pros.21185 · Cited by 205
MicroRNAs and neurodegeneration: role and impact
Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190
Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
Goodall, E. F., Heath, P. R., Bandmann, O., Kirby, J., & Shaw, P. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00178 · Cited by 187
MicroRNAs in Alzheimer's disease
Delay, C., Mandemakers, W., & Hébert, S. S. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.003 · Cited by 185
RETRACTED ARTICLE: MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus
Hu, K., Xie, Y., Zhang, C., Ouyang, D., Long, H., Sun, D., Long, L., Feng, L., Li, Y., & Xiao, B. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-115 · Cited by 182
Retracted
Epigenetics of Alzheimer’s Disease
Perković, M. N., Paska, A. V., Konjevod, M., Kouter, K., Štrac, D. Š., Erjavec, G. N., & Pivac, N. (2021) · Biomolecules · doi:10.3390/biom11020195 · Cited by 192
Genomic integrity and the ageing brain
Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4020 · Cited by 174
miRNA-34a is associated with docetaxel resistance in human breast cancer cells
Kastl, L., Brown, I. M., & Schofield, A. C. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1424-3 · Cited by 174
miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
Kim, J., Yoon, H., Ramírez, C. M., Lee, S.-M., Hoe, H.-S., Fernández-Hernando, C., & Kim, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.010 · Cited by 173
“Interestingly, miR-106b levels were significantly decreased in brains of AD cases and AD mouse model (Hebert et al., 2009; Wang et al., 2009, 2011).”
Background
Stress-induced changes in miRNA biogenesis and functioning
Olejniczak, M., Kotowska‐Zimmer, A., & Krzyżosiak, W. J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2591-0 · Cited by 184
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
Agostini, M., Tucci, P., Killick, R., Candi, E., Sayan, B. S., Cervo, P. R. D. V., Nicotera, P., McKeon, F., Knight, R. A., Mak, T. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112061109 · Cited by 176
Non-coding RNAs in Alzheimer's Disease
Tan, L., Yu, J.-T., Hu, N., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8359-5 · Cited by 175
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
Yang, J., Chen, D., He, Y., Meléndez, A., Feng, Z., Hong, Q., Bai, X., Li, Q., Cai, G., Wang, J., et al. (2011) · AGE · doi:10.1007/s11357-011-9324-3 · Cited by 161
Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer’s Disease: Potential and Limitations
Cosín‐Tomás, M., Antonell, A., Lladó, A., Alcolea, D. A., Fortea, J., Ezquerra, M., Lleó, A., Martı́, M. J., Pallàs, M., Sánchez‐Valle, R., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0088-8 · Cited by 161
Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma
Bhatnagar, S., Chertkow, H. M., Schipper, H. M., Yuan, Z., Shetty, V., Jenkins, S. F., Jones, T. W., & Wang, E. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00002 · Cited by 150
miR-497 and miR-302b Regulate Ethanol-induced Neuronal Cell Death through BCL2 Protein and Cyclin D2
Yadav, S., Pandey, A., Shukla, A., Talwelkar, S. S., Kumar, A., Pant, A. B., & Parmar, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.235531 · Cited by 147
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration
Bhattacharjee, S., Zhao, Y., Dua, P., Rogaev, E. I., & Lukiw, W. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150211 · Cited by 147
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 151
microRNAs: Innovative Targets for Cerebral Ischemia and Stroke
Ouyang, Y., Stary, C. M., Yang, G., & Giffard, R. G. (2012) · Current Drug Targets · doi:10.2174/138945013804806424 · Cited by 140
A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease
Reddy, P. H., Tonk, S., Kumar, S., Vijayan, M., Kandimalla, R., Kuruva, C. S., & Reddy, A. P. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.067 · Cited by 143
Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease
Giau, V. V., & An, S. S. A. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.12.005 · Cited by 133
miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor
Wang, H., Liu, J., Zong, Y., Xu, Y., Deng, W., Zhu, H., Liu, Y. M., Ma, C., Huang, L. J., Zhang, L., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.023 · Cited by 130
Self-citation
Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases
Tan, L., Yu, J.-T., & Tan, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8803-9 · Cited by 128
MicroRNAs and deregulated gene expression networks in neurodegeneration
Sonntag, K. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.106 · Cited by 130
Epigenetically regulated microRNAs in Alzheimer's disease
van den Hove, D., Kompotis, K., Lardenoije, R., Kenis, G., Mill, J. S., Steinbusch, H. W. M., Lesch, K., Fitzsimons, C. P., Strooper, B. D., & Rutten, B. P. F. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.082 · Cited by 121
Regulation of IGF -1 signaling by microRNAs
Jung, H. J., & Suh, Y. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2014.00472 · Cited by 124
Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations
Li, K., Wei, Q., Liu, F., Hu, F., Xie, A., Zhu, L., & Liu, D. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0533-3 · Cited by 121
The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials
Shaik, M. M., Tamargo, I. A., Abubakar, M. B., Kamal, M. A., Greig, N. H., & Gan, S. H. (2018) · Genes · doi:10.3390/genes9040174 · Cited by 117
Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer’s disease via modulating the expression of miR-106b
Huang, W., Li, Z., Zhao, L., & Zhao, W. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.060 · Cited by 114
microRNA and aging: A novel modulator in regulating the aging network
Chen, L.-H., Chiou, G., Chen, Y., Li, H.-Y., & Chiou, S. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.002 · Cited by 117
RNA and Oxidative Stress in Alzheimer’s Disease: Focus on microRNAs
Nunomura, A., & Perry, G. L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2638130 · Cited by 111
MicroRNA-34a: the bad guy in age-related vascular diseases
Raucci, A., Macrì, F., Castiglione, S., Badi, I., Vinci, M. C., & Zuccolo, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03979-4 · Cited by 118
MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2
Liang, C., Zhu, H., Xu, Y., Huang, L. J., Ma, C., Deng, W., Liu, Y. M., & Qin, C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.10.051 · Cited by 111
Self-citation
Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway
Kou, X., Liu, X., Chen, X., Li, J., Yang, X., Fan, J., Yang, Y., & Chen, N. (2016) · Oncotarget · doi:10.18632/oncotarget.12811 · Cited by 109
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107
Cell death decision by p53 via control of the mitochondrial membrane
Dashzeveg, N. K., & Yoshida, K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.019 · Cited by 108
Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer’s disease (AD) and Age-Related Macular Degeneration (AMD)
Pogue, A. I., & Lukiw, W. J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0572-3 · Cited by 105
miR-29c regulates BACE1 protein expression
Zong, Y., Wang, H., Dong, W., Quan, X., Zhu, H., Xu, Y., Huang, L., Ma, C., & Qin, C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.035 · Cited by 117
Self-citation
Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy
Iranifar, E., Seresht, B. M., Momeni, F., Fadaei, E., Mehr, M. H., Ebrahimi, Z., Rahmati, M., Kharazinejad, E., & Mirzaei, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27214 · Cited by 93
microRNAs and Neurodegenerative Diseases
Qiu, L., Tan, E., & Zeng, L. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_6 · Cited by 102
MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells
Xie, Y., Tobin, L. A., Camps, J., Wangsa, D., Yang, J., Rao, M., Witasp, E., Awad, K. S., Yoo, N., Ried, T., et al. (2012) · Oncogene · doi:10.1038/onc.2012.258 · Cited by 97
Role of microRNAs in central nervous system development and pathology
Meza‐Sosa, K. F., Valle‐García, D., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22701 · Cited by 99
The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury
Huibregtse, M. E., Bazarian, J. J., Shultz, S. R., & Kawata, K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.029 · Cited by 100
MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease
Schönrock, N., Matamales, M., Ittner, L. M., & Götz, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.013 · Cited by 96
Micro-RNA – A potential for forensic science?
Courts, C., & Madea, B. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.07.002 · Cited by 96
MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease
Reddy, P. H., Williams, J. M., Smith, F., Bhatti, J. S., Kumar, S., Vijayan, M., Kandimalla, R. J. L., Kuruva, C. S., Wang, R., Mańczak, M., et al. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.009 · Cited by 89
Exploring Biomarkers for Alzheimer’s Disease
Sharma, N. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18828.8166 · Cited by 91
Non-coding RNA in neural function, disease, and aging
Szafranski, K. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00087 · Cited by 86
Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease
Delavar, M. R., Baghi, M., Safaeinejad, Z., Kiani‐Esfahani, A., Ghaedi, K., & Nasr‐Esfahani, M. H. (2018) · Gene · doi:10.1016/j.gene.2018.04.010 · Cited by 85
MicroRNA‑34a‑5p expression in the plasma and in its extracellular vesicle fractions in subjects with Parkinson's disease: An exploratory study
Grossi, I., Radeghieri, A., Paolini, L., Porrini, V., Pilotto, A., Padovani, A., Marengoni, A., Barbon, A., Bellucci, A., Pizzi, M., et al. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4806 · Cited by 84
MicroRNAs and Multiple Sclerosis
Tüfekçi, K. U., Öner, M. G., Genç, Ş., & Genç, K. (2010) · Autoimmune Diseases · doi:10.4061/2011/807426 · Cited by 83
Evodiamine improves congnitive abilities in SAMP8 and APPswe/PS1ΔE9 transgenic mouse models of Alzheimer's disease
Yuan, S.-M., Gao, K., Wang, D., Quan, X., Liu, J., Ma, C., Qin, C., & Zhang, L. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.230 · Cited by 82
Self-citation
Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells
Alural, B., Özerdem, A., Allmer, J., Genç, K., & Genç, Ş. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00209 · Cited by 81
Role of miRNAs in Neurodegeneration: From Disease Cause to Tools of Biomarker Discovery and Therapeutics
Roy, B., Lee, E. J., Li, T., & Rampersaud, M. (2022) · Genes · doi:10.3390/genes13030425 · Cited by 83
miR-34a in Neurophysiology and Neuropathology
Chua, C. E. L., & Tang, B. L. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1231-y · Cited by 84
Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
Grabowska, W., Want, A., Leszek, J., & Wojda, U. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103691 · Cited by 81
MicroRNA Function in the Nervous System
Fiore, R., Khudayberdiev, S., Saba, R., & Schratt, G. M. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-415795-8.00004-0 · Cited by 80
Neuroprotective action of lithium in disorders of the central nervous system.
Chiu, C., & Chuang, D. (2011) · PubMed · doi:10.3969/j.issn.1672-7347.2011.06.001 · Cited by 78
Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome
Merkerová, M. D., Krejčík, Z., Votavová, H., Beličková, M., Vašíková, A., & Čermák, J. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.209 · Cited by 76
Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models
Barak, B., Shvarts-Serebro, I., Modai, S., Gilam, A., Okun, E., Michaelson, D. M., Mattson, M. P., Shomron, N., & Ashery, U. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.77 · Cited by 75
MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons
Volvert, M.-L., Prévot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Kruzy, N., Sacheli, R., Moonen, G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.075 · Cited by 82
MicroRNAs underlying memory deficits in neurodegenerative disorders
Hernandez-Rapp, J., Rainone, S., & Hébert, S. S. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.011 · Cited by 74
MicroRNA-98 induces an Alzheimer’s disease-like disturbance by targeting insulin-like growth factor 1
Hu, Y., Wang, X., Li, L., Du, Y., Ye, H.-T., & Li, C. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1348-5 · Cited by 72
Self-citation
Alzheimer’s disease: presence and role of microRNAs
Basavaraju, M., & de Lencastre, A. (2016) · BioMolecular Concepts · doi:10.1515/bmc-2016-0014 · Cited by 72
Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2
Mao, S., Sun, Q., Xiao, H., Zhang, C., & Li, L. (2015) · Protein & Cell · doi:10.1007/s13238-015-0168-y · Cited by 74
Swimming attenuates d -galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics
Kou, X., Li, J., Liu, X., Chang, J., Zhao, Q., Jia, S., Fan, J., & Chen, N. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00018.2017 · Cited by 73
MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases
Provost, P. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.069 · Cited by 70
HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis
Periyasamy, P., Thangaraj, A., Bendi, V. S., & Buch, S. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.011 · Cited by 70
Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a
Modi, P. K., Jaiswal, S., & Sharma, P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00589-15 · Cited by 73
The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
Zhao, Y., Zhang, Y., Zhang, L., Dong, Y., Ji, H., & Shen, L. (2018) · Aging and Disease · doi:10.14336/ad.2018.1105 · Cited by 70
Self-citation
MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer’s disease
Zhao, Z., Wu, L., Xiong, R., Wang, L.-L., Zhang, B., Wang, C., Li, H., Liang, L., & Chen, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.013 · Cited by 68
Soluble Beta-Amyloid Peptides, but Not Insoluble Fibrils, Have Specific Effect on Neuronal MicroRNA Expression
Li, J. J., Dolios, G., Wang, R., & Liao, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090770 · Cited by 65
Screening the expression characteristics of several miRNAs in G93A‐SOD1 transgenic mouse: altered expression of miRNA‐124 is associated with astrocyte differentiation by targeting Sox2 and Sox9
Zhou, F., Zhang, C., Guan, Y., Chen, Y., Lü, Q., Jie, L., Gao, H., Du, H., Zhang, H., Liu, Y., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14229 · Cited by 64
Self-citation
miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2
Kim, Y. J., Kim, S. H., Park, Y., Park, J., Lee, J. H., Kim, B. C., & Song, W. K. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110954 · Cited by 65
Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL
He, M., Gao, L., Zhang, S., Tao, L., Wang, J., Yang, J., & Zhu, M.-H. (2013) · Gastric Cancer · doi:10.1007/s10120-013-0313-3 · Cited by 64
The epigenetic dimension of Alzheimer's disease: causal, consequence, or curiosity?
Millan, M. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/mmillan · Cited by 66
miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Xu, Y., Chen, P., Wang, X., Yao, J., & Zhuang, S. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.045 · Cited by 65
Self-citation
MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy
Hu, J., Hu, X., & Kan, T. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24968 · Cited by 65
MicroRNAs and Alzheimer′s Disease Mouse Models: Current Insights and Future Research Avenues
Delay, C., & Hébert, S. S. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/894938 · Cited by 63
A plasma microRNA signature of acute lentiviral infection
Witwer, K. W., Sarbanes, S. L., Liu, J., & Clements, J. E. (2011) · AIDS · doi:10.1097/qad.0b013e32834b95bf · Cited by 63
MicroRNAs tune cerebral cortical neurogenesis
Volvert, M.-L., Rogister, F., Moonen, G., Malgrange, B., & Nguyen, L. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.96 · Cited by 64

Authors: Wang, X., Liu, P., Zhu, H., Xu, Y., Ma, C., Dai, X., Huang, L., Liu, Y., Zhang, L., & Qin, C.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Qin, Chuan
ORCID: Wang, Xiaoying
Liu, Peng
Zhu, Hua
Xu, Yanfeng
Dai, Xiaowei
Huang, Lan
Liu, Yali
Zhang, Lianfeng
Qin, Chuan
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2009-10
Volume: 80
Issue: 4-5
Pages: 268-273
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/j.brainresbull.2009.08.006
OpenAlex: W1968383275
Cited by: 271
References: 29
Citations by year: 2026: 4 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 15 · 2015: 24 · 2014: 23 · 2013: 21 · 2012: 17
FWCI: 5.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: miR-34a, microRNA, Alzheimer's disease, Bcl-2, protein synthesis inhibition, 3' untranslated region, caspase-3, neuronal apoptosis, SH-SY5Y cells, cerebral cortex
MeSH terms: Alzheimer Disease, Animals, Cells, Cultured, Mice, Transgenic, Proto-Oncogene Proteins, Protein Biosynthesis, Blotting, Western, Amyloid beta-Peptides, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Microarray Analysis, Mice, Caspase 3, Presenilin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks