The role of cortical inhibition in the pathophysiology and treatment of schizophrenia
Abstract
Dysfunctional cortical inhibition (CI) has been suggested as a mechanism through which symptoms of schizophrenia (SCZ) are mediated. Cortical inhibition refers to a neurophysiological process in which gamma-aminobutyric acid (GABA) inhibitory interneurons selectively attenuate the activity of other neurons (e.g., pyramidal neurons) in the cortex. Here we review the neuroanatomic and neurophysiological evidence suggesting CI deficits among persons with SCZ. We also review genetic studies that have linked CI deficits to a polymorphism in the alpha(7)-nicotinic cholinergic receptor, thereby positing that a specific genetic mechanism underlies SCZ-related GABA interneuron dysfunction. We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications.
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There is evidence of subtle cortical hyperexcitability in patients with schizophrenia.
“a variety of evidence exists indicating subtle cortical hyperexcitability in patients with schizophrenia”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Daskalakis et al., 2007
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- Authors
- Daskalakis, Z. J., Fitzgerald, P. B., & Christensen, B. K.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- The Alfred Hospital (AU)
- Corresponding author
- Daskalakis, Zafiris J.
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 56
- Issue
- 2
- Pages
- 427-442
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2083937777
- Cited by
- 111
- References
- 151
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cortical inhibition, schizophrenia, GABAergic interneurons, alpha7 nicotinic acetylcholine receptor, genetic polymorphism, antipsychotic mechanism of action, pyramidal neurons, schizophrenia pathophysiology, schizophrenia treatment
- MeSH terms
- Animals, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Interneurons, Schizophrenia, Glutamic Acid
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