Reelin is preferentially expressed in neurons synthesizing γ-aminobutyric acid in cortex and hippocampus of adult rats
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During embryonic development of brain laminated structures, the protein Reelin, secreted into the extracellular matrix of the cortex and hippocampus by Cajal–Retzius (CR) cells located in the marginal zone, contributes to the regulation of migration and positioning of cortical and hippocampal neurons that do not synthesize Reelin. Soon after birth, the CR cells decrease, and they virtually disappear during the following 3 weeks. Despite their disappearance, we can quantify Reelin mRNA (approximately 200 amol/μg of total RNA) and visualize it by in situ hybridization, and we detect the translated product of this mRNA by immunocytochemistry preferentially in γ-aminobutyric acid (GABA)ergic neurons of adult rat cortex and hippocampus. In adult rat cerebellum, Reelin is expressed in glutamatergic neurons (granule cells). The translated product of this mRNA is readily exported from the granule cell somata to the parallel fibers, where it has been detected by electron microscopy in axon terminals located presynaptically to Purkinje cell dendrites.
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Reln is expressed in inhibitory neurons in the adult brain.
“Given that Reln is expressed in inhibitory neurons in the adult brain”
From Deletion of neuronal <i>Idol</i> ameliorates Alzheimer's disease–related pathologies via APOE receptors (2025) · cites this paper as [81]
Inhibitory GABAergic interneurons begin to express and secrete Reelin postnatally as Cajal-Retzius cells die out in the cerebral cortex and later in the hippocampus.
“At this point, inhibitory GABAergic interneurons begin to express and secrete Reelin (6) as the Cajal-Retzius cells begin to die out in the cerebral cortex and later in the hippocampus (7).”
From Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses (2017) · cites this paper as [6]
Reelin is expressed in GABAergic and glutamatergic cells.
“Reelin is an important protein expressed in GABAergic and glutamatergic cells [133, 134].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [133]
Reelin is an ECM glycoprotein secreted by GABAergic interneurons in the adult brain.
“Reelin, an ECM glycoprotein secreted by GABAergic interneurons in the adult brain (Pesold et al., 1998)”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Pesold et al., 1998
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Cites
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748 · see citing works
Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K. (1995) · Neuron · doi:10.1016/0896-6273(95)90329-1 · Cited by 889 · see citing works
Neuronal position in the developing brain is regulated by mouse disabled-1
Howell, B. W., Hawkes, R., Soriano, P., & Cooper, J. A. (1997) · Nature · doi:10.1038/39607 · Cited by 692 · see citing works
Mechanisms of Cortical Development: A View From Mutations in Mice
Caviness, V. S., & RAKIC, P. T. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001501 · Cited by 653 · see citing works
Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
Sheldon, M., Rice, D. S., D'Arcangelo, G., Yoneshima, H., Nakajima, K., Mikoshiba, K., Howell, B. W., Cooper, J. A., Goldowitz, D., & Curran, T. (1997) · Nature · doi:10.1038/39601 · Cited by 638 · see citing works
Falconer, D. S. (1951) · Journal of Genetics · doi:10.1007/bf02996215 · Cited by 539 · see citing works
Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody
D’Arcangelo, G., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., & Curran, T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00023.1997 · Cited by 515 · see citing works
A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472 · see citing works
The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons
Hirotsune, S., Takahara, T., Sasaki, N., Hirose, K., Yoshiki, A., Ohashi, T., Kusakabe, M., Murakami, Y., Muramatsu, M., Watanabe, S., et al. (1995) · Nature Genetics · doi:10.1038/ng0595-77 · Cited by 345 · see citing works
Mouse disabled (mDab1): a Src binding protein implicated in neuronal development
Howell, B. W., Gertler, F. B., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.1.121 · Cited by 339 · see citing works
Cortical development: View from neurological mutants two decades later
Rakic, P., & Caviness, V. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90258-9 · Cited by 287 · see citing works
Reelin mRNA Expression During Mouse Brain Development
Schiffmann, S. N., Bernier, B., & Goffinet, A. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01456.x · Cited by 227 · see citing works
Regulation of Purkinje Cell Alignment by Reelin as Revealed with CR-50 Antibody
Miyata, T., Nakajima, K., Mikoshiba, K., & Ogawa, M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03599.1997 · Cited by 183 · see citing works
Disruption of hippocampal development <i>in vivo</i> by CR-50 mAb against Reelin
Nakajima, K., Mikoshiba, K., Miyata, T., Kudo, C., & Ogawa, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8196 · Cited by 171 · see citing works
Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration
Sweet, H. O., Bronson, R. T., Johnson, K. R., Cook, S. A., & Davisson, M. T. (1996) · Mammalian Genome · doi:10.1007/s003359900240 · Cited by 155 · see citing works
The human reelin gene: isolation, sequencing, and mapping on chromosome 7.Preprint
DeSilva, U., D’Arcangelo, G., Braden, V. V., Chen, J., Miao, G. G., Curran, T., & Green, E. D. (1997) · Genome Research · doi:10.1101/gr.7.2.157 · Cited by 144 · see citing works
Dual role of Cajal-Retzius cells and reelin in cortical development
Frotscher, M. (1997) · Cell and Tissue Research · doi:10.1007/s004410050936 · Cited by 135 · see citing works
Differential survival of Cajal-Retzius cells in organotypic cultures of hippocampus and neocortex
Del Rı́o, J. A., Heimrich, B., Supèr, H., Borrell, V., Frotscher, M., & Soriano, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06896.1996 · Cited by 133 · see citing works
A truncated Reelin protein is produced but not secreted in the ‘Orleans’ reeler mutation (Reln)
de Bergeyck, V., Nakajima, K., de Rouvroit, C. L., Naerhuyzen, B., Goffinet, A. M., Miyata, T., Ogawa, M., & Mikoshiba, K. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00166-6 · Cited by 128 · see citing works
Impagnatiello, F., Pesold, C., Longone, P., Caruncho, H. J., Fritschy, J., Costa, E., & Guidotti, A. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09071-6 · Cited by 124 · see citing works
Self-citationParnavelas, J. G., & Edmunds, S. M. (1983) · Journal of Neurocytology · doi:10.1007/bf01258156 · Cited by 95 · see citing works
Bar, I., de Rouvroit, C. L., Royaux, I. E., Krizman, D. B., Dernoncourt, C., Ruelle, D., Beckers, M. C., & Goffinet, A. M. (1995) · Genomics · doi:10.1016/0888-7543(95)80173-j · Cited by 84 · see citing works
Drakew, A., Frotscher, M., Deller, T., Ogawa, M., & Heimrich, B. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00326-6 · Cited by 76 · see citing works
Bender, R. A., Plaschke, M., Naumann, T., Wahle, P., & Frotscher, M. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960819)372:2 · Cited by 36 · see citing works
High-resolution genetic map and YAC contig around the mouse neurological locus reeler
Montgomery, J. C., Guarn�eri, M. H., Tartaglia, K., et al. (1994) · Mammalian Genome · doi:10.1007/bf00292008 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [19]Caruncho H J, Pesold C, Impagnatiello F, Pisu M G, Miyata T, Ogawa M, Costa E, Guidotti A. Soc Neurosci Abstr. 1997;28:14. [Google Scholar]
- [26]Impagnatiello F, Pesold C, Longone P, Caruncho H, Fritschy J M, Costa E, Guidotti A. Mol Pharmacol. 1996;49:822–831. [PubMed] [Google Scholar]
- [27]Grayson D R, Bovolin P, Santi M R. Methods Neurosci. 1993;12:191–208. [Google Scholar]
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Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
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Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082 · see citing works
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Rice, D. S., & Curran, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1005 · Cited by 667 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works
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Howell, B. W., Herrick, T. M., & Cooper, J. A. (1999) · Genes & Development · doi:10.1101/gad.13.6.643 · Cited by 411 · see citing works
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Niu, S., Renfro, A., Quattrocchi, C. C., Sheldon, M., & D'Arcangelo, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00819-5 · Cited by 375 · see citing works
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Folsom, T. D., & Fatemi, S. H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.015 · Cited by 275 · see citing works
Weaver, I. C. G. (2007) · Epigenetics · doi:10.4161/epi.2.1.3881 · Cited by 239 · see citing works
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Inan, M., Welagen, J., & Anderson, S. A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr148 · Cited by 161 · see citing works
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Tinnes, S., Schäfer, M. K. E., Flubacher, A., Münzner, G., Frotscher, M., & Haas, C. A. (2011) · The FASEB Journal · doi:10.1096/fj.10-168294 · Cited by 58 · see citing works
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Orcinha, C., Münzner, G., Gerlach, J., Kilias, A., Follo, M., Egert, U., & Haas, C. A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00183 · Cited by 26 · see citing works
Camacho, J., Ejaz, E., Ariza, J., Noctor, S. C., & Martínez-Cerdeño, V. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.031 · Cited by 25 · see citing works
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“Given that Reln is expressedininhibitoryneuronsintheadultbrain 81–83 andoursnRNA-seqanalysisidentifiedthemostsignificantchangesininhibitoryneuron populations in 5XFAD;Neu cKO mice (Figure 7), VLDLR and APOER2 likely play a role in the observed phenotypes.”
- Authors
- Pesold, C., Impagnatiello, F., Pisu, M. G., Uzunov, D. P., Costa, E., Guidotti, A., & Caruncho, H. J.
- Affiliations
- University of Illinois Chicago (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-03-17
- Volume
- 95
- Issue
- 6
- Pages
- 3221-3226
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC19723
- OpenAlex
- W2053256857
- Cited by
- 391
- References
- 25
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 8 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 12 · 2017: 15 · 2016: 29 · 2015: 15 · 2014: 12 · 2013: 18 · 2012: 13
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- reelin, GABA, GABAergic neurons, hippocampus, cerebral cortex, Cajal-Retzius cells, marginal zone, cerebellum, granule cells, Purkinje cells, parallel fibers, axon terminals, extracellular matrix, brain development, gene expression
- MeSH terms
- Reelin Protein, Animals, Animals, Newborn, Cerebellar Cortex, Cerebral Cortex, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Hippocampus, Immunohistochemistry, Interneurons, Nerve Tissue Proteins, Neurons, RNA, Messenger, Serine Endopeptidases, Telencephalon, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, In Situ Hybridization, Fluorescence, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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